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Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes.

Chen Z, Lu X, McGee-Lawrence ME, Watsky MA.

Sci Rep. 2020 Feb 18;10(1):2840. doi: 10.1038/s41598-020-59570-7.


Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo.

Pierce JL, Roberts RL, Yu K, Kendall RK, Kaiser H, Davis C, Johnson MH, Hill WD, Isales CM, Bollag WB, Hamrick MW, McGee-Lawrence ME.

Exp Gerontol. 2020 Feb;130:110818. doi: 10.1016/j.exger.2019.110818. Epub 2019 Dec 17.


Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.

Sharma AK, Shi X, Isales CM, McGee-Lawrence ME.

Curr Osteoporos Rep. 2019 Dec;17(6):438-445. doi: 10.1007/s11914-019-00554-6. Review.


Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton.

Hagan ML, Yu K, Zhu J, Vinson BN, Roberts RL, Montesinos Cartagena M, Johnson MH, Wang L, Isales CM, Hamrick MW, McNeil PL, McGee-Lawrence ME.

Aging Cell. 2020 Jan;19(1):e13056. doi: 10.1111/acel.13056. Epub 2019 Nov 19.


Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation.

Kaiser H, Yu K, Pandya C, Mendhe B, Isales CM, McGee-Lawrence ME, Johnson M, Fulzele S, Hamrick MW.

Oxid Med Cell Longev. 2019 Oct 13;2019:9894238. doi: 10.1155/2019/9894238. eCollection 2019.


The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat.

Pierce JL, Ding KH, Xu J, Sharma AK, Yu K, Del Mazo Arbona N, Rodriguez-Santos Z, Bernard P, Bollag WB, Johnson MH, Hamrick MW, Begun DL, Shi XM, Isales CM, McGee-Lawrence ME.

J Endocrinol. 2019 Jul 1. pii: JOE-19-0230.R1. doi: 10.1530/JOE-19-0230. [Epub ahead of print]


Monomethylfumarate protects against ovariectomy-related changes in body composition.

Bollag AE, Guo T, Ding KH, Choudhary V, Chen X, Zhong Q, Xu J, Yu K, Awad ME, Elsalanty M, Johnson MH, McGee-Lawrence ME, Bollag WB, Isales CM.

J Endocrinol. 2019 Jul 1. pii: JOE-18-0691.R3. doi: 10.1530/JOE-18-0691. [Epub ahead of print]


Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology.

Gilbert W, Bragg R, Elmansi AM, McGee-Lawrence ME, Isales CM, Hamrick MW, Hill WD, Fulzele S.

Cytokine. 2019 Nov;123:154783. doi: 10.1016/j.cyto.2019.154783. Epub 2019 Jul 20. Review.


Commonly used adjuvants (liquid soap, foam sanitizer, or ultrasound gel) do not improve strength or curing time of fiberglass cast material.

Meng MRI, Elphingstone JW, Sinkler MA, Byrd BM, McGee-Lawrence ME.

J Orthop Surg Res. 2019 May 30;14(1):166. doi: 10.1186/s13018-019-1202-1.


What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands.

Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD.

Pharmacol Ther. 2019 Jun;198:90-108. doi: 10.1016/j.pharmthera.2019.02.005. Epub 2019 Feb 10.


Reduced bone formation in males and increased bone resorption in females drive bone loss in hemophilia A mice.

Weitzmann MN, Roser-Page S, Vikulina T, Weiss D, Hao L, Baldwin WH, Yu K, Del Mazo Arbona N, McGee-Lawrence ME, Meeks SL, Kempton CL.

Blood Adv. 2019 Feb 12;3(3):288-300. doi: 10.1182/bloodadvances.2018027557.


Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival.

Hagan ML, Bahraini A, Pierce JL, Bass SM, Yu K, Elsayed R, Elsalanty M, Johnson MH, McNeil A, McNeil PL, McGee-Lawrence ME.

Calcif Tissue Int. 2019 Feb;104(2):224-234. doi: 10.1007/s00223-018-0487-0. Epub 2018 Oct 24.


Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Camilleri ET, Dudakovic A, Riester SM, Galeano-Garces C, Paradise CR, Bradley EW, McGee-Lawrence ME, Im HJ, Karperien M, Krych AJ, Westendorf JJ, Larson AN, van Wijnen AJ.

J Biol Chem. 2018 Dec 7;293(49):19001-19011. doi: 10.1074/jbc.RA118.003909. Epub 2018 Oct 16.


Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice.

Dudakovic A, Camilleri ET, Paradise CR, Samsonraj RM, Gluscevic M, Paggi CA, Begun DL, Khani F, Pichurin O, Ahmed FS, Elsayed R, Elsalanty M, McGee-Lawrence ME, Karperien M, Riester SM, Thaler R, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2018 Aug 17;293(33):12894-12907. doi: 10.1074/jbc.RA118.002983. Epub 2018 Jun 13.


Defining osteoblast and adipocyte lineages in the bone marrow.

Pierce JL, Begun DL, Westendorf JJ, McGee-Lawrence ME.

Bone. 2019 Jan;118:2-7. doi: 10.1016/j.bone.2018.05.019. Epub 2018 May 18. Review.


Blocking Bone Loss with l-BAIBA.

Hamrick MW, McGee-Lawrence ME.

Trends Endocrinol Metab. 2018 May;29(5):284-286. doi: 10.1016/j.tem.2018.03.005. Epub 2018 Mar 21.


Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy.

Bollag WB, Ding KH, Choudhary V, Xu J, Zhong Q, Elsayed R, Bailey LJ, Elsalanty M, Yu K, Johnson MH, McGee-Lawrence ME, Isales CM.

Mol Cell Endocrinol. 2018 Oct 15;474:176-183. doi: 10.1016/j.mce.2018.03.006. Epub 2018 Mar 9.


Neutralization of CD40 ligand costimulation promotes bone formation and accretion of vertebral bone mass in mice.

Roser-Page S, Vikulina T, Yu K, McGee-Lawrence ME, Weitzmann MN.

Rheumatology (Oxford). 2018 Jun 1;57(6):1105-1114. doi: 10.1093/rheumatology/kex525.


Mimicking the effects of spaceflight on bone: Combined effects of disuse and chronic low-dose rate radiation exposure on bone mass in mice.

Yu K, Doherty AH, Genik PC, Gookin SE, Roteliuk DM, Wojda SJ, Jiang ZS, McGee-Lawrence ME, Weil MM, Donahue SW.

Life Sci Space Res (Amst). 2017 Nov;15:62-68. doi: 10.1016/j.lssr.2017.08.004. Epub 2017 Aug 12.


Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.

McGee-Lawrence ME, Pierce JL, Yu K, Culpepper NR, Bradley EW, Westendorf JJ.

J Cell Physiol. 2018 Apr;233(4):2671-2680. doi: 10.1002/jcp.26148. Epub 2017 Sep 12.


Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo.

Bollag WB, Choudhary V, Zhong Q, Ding KH, Xu J, Elsayed R, Yu K, Su Y, Bailey LJ, Shi XM, Elsalanty M, Johnson MH, McGee-Lawrence ME, Isales CM.

Mol Cell Endocrinol. 2018 Feb 5;461:22-31. doi: 10.1016/j.mce.2017.08.005. Epub 2017 Aug 12.


Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone.

Yu K, Sellman DP, Bahraini A, Hagan ML, Elsherbini A, Vanpelt KT, Marshall PL, Hamrick MW, McNeil A, McNeil PL, McGee-Lawrence ME.

J Orthop Res. 2018 Feb;36(2):653-662. doi: 10.1002/jor.23665. Epub 2017 Aug 11.


Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.

Refaey ME, McGee-Lawrence ME, Fulzele S, Kennedy EJ, Bollag WB, Elsalanty M, Zhong Q, Ding KH, Bendzunas NG, Shi XM, Xu J, Hill WD, Johnson MH, Hunter M, Pierce JL, Yu K, Hamrick MW, Isales CM.

J Bone Miner Res. 2017 Nov;32(11):2182-2193. doi: 10.1002/jbmr.3224. Epub 2017 Aug 14.


Regulation of the Glycerol Transporter, Aquaporin-3, by Histone Deacetylase-3 and p53 in Keratinocytes.

Choudhary V, Olala LO, Kagha K, Pan ZQ, Chen X, Yang R, Cline A, Helwa I, Marshall L, Kaddour-Djebbar I, McGee-Lawrence ME, Bollag WB.

J Invest Dermatol. 2017 Sep;137(9):1935-1944. doi: 10.1016/j.jid.2017.04.031. Epub 2017 May 16.


Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

McGee-Lawrence ME, Wenger KH, Misra S, Davis CL, Pollock NK, Elsalanty M, Ding K, Isales CM, Hamrick MW, Wosiski-Kuhn M, Arounleut P, Mattson MP, Cutler RG, Yu JC, Stranahan AM.

Endocrinology. 2017 May 1;158(5):1160-1171. doi: 10.1210/en.2016-1250.


Scapula fracture incidence in reverse total shoulder arthroplasty using screws above or below metaglene central cage: clinical and biomechanical outcomes.

Kennon JC, Lu C, McGee-Lawrence ME, Crosby LA.

J Shoulder Elbow Surg. 2017 Jun;26(6):1023-1030. doi: 10.1016/j.jse.2016.10.018. Epub 2017 Jan 26.


Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.

Dudakovic A, Camilleri ET, Riester SM, Paradise CR, Gluscevic M, O'Toole TM, Thaler R, Evans JM, Yan H, Subramaniam M, Hawse JR, Stein GS, Montecino MA, McGee-Lawrence ME, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2016 Nov 18;291(47):24594-24606. Epub 2016 Oct 10.


Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ.

Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273.


Fatty Infiltration of Skeletal Muscle: Mechanisms and Comparisons with Bone Marrow Adiposity.

Hamrick MW, McGee-Lawrence ME, Frechette DM.

Front Endocrinol (Lausanne). 2016 Jun 20;7:69. doi: 10.3389/fendo.2016.00069. eCollection 2016. Review.


Arctic Ground Squirrels Limit Bone Loss during the Prolonged Physical Inactivity Associated with Hibernation.

Wojda SJ, Gridley RA, McGee-Lawrence ME, Drummer TD, Hess A, Kohl F, Barnes BM, Donahue SW.

Physiol Biochem Zool. 2016 Jan-Feb;89(1):72-80. doi: 10.1086/684619. Epub 2015 Dec 14.


Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.

Bradley EW, Carpio LR, McGee-Lawrence ME, Castillejo Becerra C, Amanatullah DF, Ta LE, Otero M, Goldring MB, Kakar S, Westendorf JJ.

Osteoarthritis Cartilage. 2016 Jun;24(6):1021-8. doi: 10.1016/j.joca.2015.12.014. Epub 2015 Dec 31.


Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.

Dudakovic A, Camilleri ET, Xu F, Riester SM, McGee-Lawrence ME, Bradley EW, Paradise CR, Lewallen EA, Thaler R, Deyle DR, Larson AN, Lewallen DG, Dietz AB, Stein GS, Montecino MA, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2015 Nov 13;290(46):27604-17. doi: 10.1074/jbc.M115.672345. Epub 2015 Sep 30.


Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice.

Nicks KM, Fujita K, Fraser D, McGregor U, Drake MT, McGee-Lawrence ME, Westendorf JJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Mar;31(3):606-14. doi: 10.1002/jbmr.2723. Epub 2015 Oct 13.


Histone Deacetylases in Bone Development and Skeletal Disorders.

Bradley EW, Carpio LR, van Wijnen AJ, McGee-Lawrence ME, Westendorf JJ.

Physiol Rev. 2015 Oct;95(4):1359-81. doi: 10.1152/physrev.00004.2015. Review.


Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ.

J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20.


Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.

McGee-Lawrence ME, White TA, LeBrasseur NK, Westendorf JJ.

Mol Cell Endocrinol. 2015 Jul 15;410:42-51. doi: 10.1016/j.mce.2015.02.001. Epub 2015 Feb 7. Review.


Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration.

McGee-Lawrence ME, Razidlo DF.

Methods Mol Biol. 2015;1226:183-92. doi: 10.1007/978-1-4939-1619-1_14.


Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ.

Bone. 2014 Sep;66:277-86. doi: 10.1016/j.bone.2014.06.022. Epub 2014 Jun 25.


Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells.

Dudakovic A, Camilleri ET, Lewallen EA, McGee-Lawrence ME, Riester SM, Kakar S, Montecino M, Stein GS, Ryoo HM, Dietz AB, Westendorf JJ, van Wijnen AJ.

J Cell Physiol. 2015 Jan;230(1):52-62. doi: 10.1002/jcp.24680.


Osteoblasts protect AML cells from SDF-1-induced apoptosis.

Kremer KN, Dudakovic A, McGee-Lawrence ME, Philips RL, Hess AD, Smith BD, van Wijnen AJ, Karp JE, Kaufmann SH, Westendorf JJ, Hedin KE.

J Cell Biochem. 2014 Jun;115(6):1128-37.


RUNX3 facilitates growth of Ewing sarcoma cells.

Bledsoe KL, McGee-Lawrence ME, Camilleri ET, Wang X, Riester SM, van Wijnen AJ, Oliveira AM, Westendorf JJ.

J Cell Physiol. 2014 Dec;229(12):2049-56. doi: 10.1002/jcp.24663.


Aberrant bone density in aging mice lacking the adenosine transporter ENT1.

Hinton DJ, McGee-Lawrence ME, Lee MR, Kwong HK, Westendorf JJ, Choi DS.

PLoS One. 2014 Feb 19;9(2):e88818. doi: 10.1371/journal.pone.0088818. eCollection 2014.


Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification.

McGee-Lawrence ME, Ryan ZC, Carpio LR, Kakar S, Westendorf JJ, Kumar R.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):886-90. doi: 10.1016/j.bbrc.2013.10.155. Epub 2013 Nov 6.


Reply to vorinostat induced bone loss in mice.

McGee-Lawrence ME, Westendorf JJ.

Bone. 2013 Dec;57(2):531-2. doi: 10.1016/j.bone.2013.08.019. Epub 2013 Aug 23. No abstract available.


Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation.

Dudakovic A, Evans JM, Li Y, Middha S, McGee-Lawrence ME, van Wijnen AJ, Westendorf JJ.

J Biol Chem. 2013 Oct 4;288(40):28783-91. doi: 10.1074/jbc.M113.489732. Epub 2013 Aug 12.


Black bears with longer disuse (hibernation) periods have lower femoral osteon population density and greater mineralization and intracortical porosity.

Wojda SJ, Weyland DR, Gray SK, McGee-Lawrence ME, Drummer TD, Donahue SW.

Anat Rec (Hoboken). 2013 Aug;296(8):1148-53. doi: 10.1002/ar.22720. Epub 2013 Jun 1.


Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.

McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ.

J Biol Chem. 2013 Feb 22;288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7.


Histone deacetylase 3 is required for maintenance of bone mass during aging.

McGee-Lawrence ME, Bradley EW, Dudakovic A, Carlson SW, Ryan ZC, Kumar R, Dadsetan M, Yaszemski MJ, Chen Q, An KN, Westendorf JJ.

Bone. 2013 Jan;52(1):296-307. doi: 10.1016/j.bone.2012.10.015. Epub 2012 Oct 18. Erratum in: Bone. 2013 Mar;53(1):320.


Black bear parathyroid hormone has greater anabolic effects on trabecular bone in dystrophin-deficient mice than in wild type mice.

Gray SK, McGee-Lawrence ME, Sanders JL, Condon KW, Tsai CJ, Donahue SW.

Bone. 2012 Sep;51(3):578-85. doi: 10.1016/j.bone.2012.05.003. Epub 2012 May 11.


Update on Wnt signaling in bone cell biology and bone disease.

Monroe DG, McGee-Lawrence ME, Oursler MJ, Westendorf JJ.

Gene. 2012 Jan 15;492(1):1-18. doi: 10.1016/j.gene.2011.10.044. Epub 2011 Nov 3. Review.

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