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Items: 44


The Alzheimer's Disease-Associated Protein BACE1 Modulates T Cell Activation and Th17 Function.

Hernandez-Mir G, Raphael I, Revu S, Poholek CH, Avery L, Hawse WF, Kane LP, McGeachy MJ.

J Immunol. 2019 Jun 17. pii: ji1800363. doi: 10.4049/jimmunol.1800363. [Epub ahead of print]


The IL-17 Family of Cytokines in Health and Disease.

McGeachy MJ, Cua DJ, Gaffen SL.

Immunity. 2019 Apr 16;50(4):892-906. doi: 10.1016/j.immuni.2019.03.021. Review.


IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.

Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, Gaffen SL, Biswas PS, McGeachy MJ.

Nat Immunol. 2019 May;20(5):534-545. doi: 10.1038/s41590-019-0367-4. Epub 2019 Apr 8.


Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.


IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms.

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL.

J Immunol. 2018 Jul 15;201(2):627-634. doi: 10.4049/jimmunol.1800515. Epub 2018 Jun 11.


IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation.

Revu S, Wu J, Henkel M, Rittenhouse N, Menk A, Delgoffe GM, Poholek AC, McGeachy MJ.

Cell Rep. 2018 Mar 6;22(10):2642-2653. doi: 10.1016/j.celrep.2018.02.044.


Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.

Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL.

Sci Immunol. 2017 Nov 3;2(17). pii: eaam8834. doi: 10.1126/sciimmunol.aam8834.


The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RSB, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Sep;13(9):572. doi: 10.1038/nrneurol.2017.116. Epub 2017 Aug 4.


A Hippo in the Fox(p3) house.

McGeachy MJ.

Nat Immunol. 2017 Jun 20;18(7):709-711. doi: 10.1038/ni.3769. No abstract available.


CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis.

Hernandez-Mir G, McGeachy MJ.

PLoS One. 2017 Mar 13;12(3):e0173655. doi: 10.1371/journal.pone.0173655. eCollection 2017.


The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Mar;13(3):171-191. doi: 10.1038/nrneurol.2017.13. Epub 2017 Feb 10. Review. Erratum in: Nat Rev Neurol. 2017 Aug 04;:.


CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE.

Simpson-Abelson MR, Hernandez-Mir G, Childs EE, Cruz JA, Poholek AC, Chattopadhyay A, Gaffen SL, McGeachy MJ.

Cytokine. 2017 Apr;92:24-32. doi: 10.1016/j.cyto.2017.01.005. Epub 2017 Jan 12.


Analysis of CXCR5+Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis.

Singh D, Henkel M, Sendon B, Feng J, Fabio A, Metes D, Moreland LW, McGeachy MJ.

Sci Rep. 2016 Dec 22;6:39474. doi: 10.1038/srep39474.


Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function.

Du F, Garg AV, Kosar K, Majumder S, Kugler DG, Mir GH, Maggio M, Henkel M, Lacy-Hulbert A, McGeachy MJ.

Cell Rep. 2016 Aug 2;16(5):1339-1351. doi: 10.1016/j.celrep.2016.06.065. Epub 2016 Jul 21.


Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.

Jain R, Chen Y, Kanno Y, Joyce-Shaikh B, Vahedi G, Hirahara K, Blumenschein WM, Sukumar S, Haines CJ, Sadekova S, McClanahan TK, McGeachy MJ, O'Shea JJ, Cua DJ.

Immunity. 2016 Jan 19;44(1):131-142. doi: 10.1016/j.immuni.2015.11.009. Epub 2015 Dec 29.


Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism.

Whibley N, Jaycox JR, Reid D, Garg AV, Taylor JA, Clancy CJ, Nguyen MH, Biswas PS, McGeachy MJ, Brown GD, Gaffen SL.

J Immunol. 2015 Oct 15;195(8):3781-92. doi: 10.4049/jimmunol.1500870. Epub 2015 Sep 2.


MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.

Garg AV, Amatya N, Chen K, Cruz JA, Grover P, Whibley N, Conti HR, Hernandez Mir G, Sirakova T, Childs EC, Smithgall TE, Biswas PS, Kolls JK, McGeachy MJ, Kolattukudy PE, Gaffen SL.

Immunity. 2015 Sep 15;43(3):475-87. doi: 10.1016/j.immuni.2015.07.021. Epub 2015 Aug 25.


A Candida albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth during Disseminated Infection.

Huppler AR, Whibley N, Woolford CA, Childs EE, He J, Biswas PS, McGeachy MJ, Mitchell AP, Gaffen SL.

Infect Immun. 2015 Sep;83(9):3684-92. doi: 10.1128/IAI.03057-14. Epub 2015 Jul 6.


mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.

Raïch-Regué D, Rosborough BR, Watson AR, McGeachy MJ, Turnquist HR, Thomson AW.

J Immunol. 2015 May 15;194(10):4767-76. doi: 10.4049/jimmunol.1402551. Epub 2015 Apr 3.


Integrating p38α MAPK immune signals in nonimmune cells.

Gaffen SL, McGeachy MJ.

Sci Signal. 2015 Mar 3;8(366):fs5. doi: 10.1126/scisignal.aaa8398. Review.


Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.

Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL.

J Exp Med. 2014 Sep 22;211(10):2075-84. doi: 10.1084/jem.20130877. Epub 2014 Sep 8.


Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses.

Bishu S, Su EW, Wilkerson ER, Reckley KA, Jones DM, McGeachy MJ, Gaffen SL, Levesque MC.

Arthritis Res Ther. 2014 Feb 11;16(1):R50. doi: 10.1186/ar4480.


Th17 memory cells: live long and proliferate.

McGeachy MJ.

J Leukoc Biol. 2013 Nov;94(5):921-6. doi: 10.1189/jlb.0313113. Epub 2013 Sep 4. Review.


Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23.

Haines CJ, Chen Y, Blumenschein WM, Jain R, Chang C, Joyce-Shaikh B, Porth K, Boniface K, Mattson J, Basham B, Anderton SM, McClanahan TK, Sadekova S, Cua DJ, McGeachy MJ.

Cell Rep. 2013 May 30;3(5):1378-88. doi: 10.1016/j.celrep.2013.03.035. Epub 2013 Apr 25.


Microbial-induced Th17: superhero or supervillain?

McGeachy MJ, McSorley SJ.

J Immunol. 2012 Oct 1;189(7):3285-91. Review.


Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.

Cheung R, Shen F, Phillips JH, McGeachy MJ, Cua DJ, Heyworth PG, Pierce RH.

J Clin Invest. 2011 Nov;121(11):4446-61. doi: 10.1172/JCI57682. Epub 2011 Oct 17.


GM-CSF: the secret weapon in the T(H)17 arsenal.

McGeachy MJ.

Nat Immunol. 2011 Jun;12(6):521-2. doi: 10.1038/ni.2044.


Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

Chen Y, Haines CJ, Gutcher I, Hochweller K, Blumenschein WM, McClanahan T, Hämmerling G, Li MO, Cua DJ, McGeachy MJ.

Immunity. 2011 Mar 25;34(3):409-21. doi: 10.1016/j.immuni.2011.02.011.


Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ.

Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447.


Interleukin-23 drives intestinal inflammation through direct activity on T cells.

Ahern PP, Schiering C, Buonocore S, McGeachy MJ, Cua DJ, Maloy KJ, Powrie F.

Immunity. 2010 Aug 27;33(2):279-88. doi: 10.1016/j.immuni.2010.08.010. Erratum in: Immunity. 2011 Mar 25;34(3):448.


Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage.

Boniface K, Blumenschein WM, Brovont-Porth K, McGeachy MJ, Basham B, Desai B, Pierce R, McClanahan TK, Sadekova S, de Waal Malefyt R.

J Immunol. 2010 Jul 1;185(1):679-87. doi: 10.4049/jimmunol.1000366. Epub 2010 May 28.


The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X.

Immunity. 2010 Jan 29;32(1):54-66. doi: 10.1016/j.immuni.2009.12.003. Epub 2010 Jan 7.


IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.

Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA.

J Immunol. 2009 May 1;182(9):5748-56. doi: 10.4049/jimmunol.0801162.


Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.

J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.


The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.

McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ.

Nat Immunol. 2009 Mar;10(3):314-24. doi: 10.1038/ni.1698. Epub 2009 Feb 1.


Cytokines that regulate autoimmunity.

Diveu C, McGeachy MJ, Cua DJ.

Curr Opin Immunol. 2008 Dec;20(6):663-8. doi: 10.1016/j.coi.2008.09.003. Epub 2008 Oct 17. Review.


Th17 cell differentiation: the long and winding road.

McGeachy MJ, Cua DJ.

Immunity. 2008 Apr;28(4):445-53. doi: 10.1016/j.immuni.2008.03.001. Review.


The link between IL-23 and Th17 cell-mediated immune pathologies.

McGeachy MJ, Cua DJ.

Semin Immunol. 2007 Dec;19(6):372-6. doi: 10.1016/j.smim.2007.10.012. Epub 2007 Dec 3. Review.


TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.

McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ.

Nat Immunol. 2007 Dec;8(12):1390-7. Epub 2007 Nov 11.


Antigen-based therapy and immune-regulation in experimental autoimmune encephalomyelitis.

McGeachy MJ, O'Connor R, Stephens LA, Anderton SM.

Methods Mol Biol. 2007;380:313-26. Review.


Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis.

McGeachy MJ, Anderton SM.

Cytokine. 2005 Oct 21;32(2):81-4. Epub 2005 Sep 8. Review.


B cells regulate autoimmunity by provision of IL-10.

Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM.

Nat Immunol. 2002 Oct;3(10):944-50. Epub 2002 Sep 3.


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