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Items: 1 to 50 of 107


Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA.

El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC Jr, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED.

Nat Chem Biol. 2020 Feb;16(2):143-149. doi: 10.1038/s41589-019-0401-8. Epub 2019 Nov 25.


Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence.

Goncheva MI, Flannagan RS, Sterling BE, Laakso HA, Friedrich NC, Kaiser JC, Watson DW, Wilson CH, Sheldon JR, McGavin MJ, Kiser PK, Heinrichs DE.

Nat Commun. 2019 Feb 15;10(1):775. doi: 10.1038/s41467-019-08724-x.


DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus.

Alnaseri H, Kuiack RC, Ferguson KA, Schneider JET, Heinrichs DE, McGavin MJ.

J Bacteriol. 2019 Jan 11;201(3). pii: e00602-18. doi: 10.1128/JB.00602-18. Print 2019 Feb 1.


Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages.

Flannagan RS, Kuiack RC, McGavin MJ, Heinrichs DE.

mBio. 2018 Jul 17;9(4). pii: e01143-18. doi: 10.1128/mBio.01143-18.


Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.

Alnaseri H, Arsic B, Schneider JE, Kaiser JC, Scinocca ZC, Heinrichs DE, McGavin MJ.

J Bacteriol. 2015 Jun;197(11):1893-905. doi: 10.1128/JB.02607-14. Epub 2015 Mar 23.


Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1.

Sayedyahossein S, Xu SX, Rudkouskaya A, McGavin MJ, McCormick JK, Dagnino L.

FASEB J. 2015 Feb;29(2):711-23. doi: 10.1096/fj.14-262774. Epub 2014 Nov 21.


Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids.

Cadieux B, Vijayakumaran V, Bernards MA, McGavin MJ, Heinrichs DE.

J Bacteriol. 2014 Dec;196(23):4044-56. doi: 10.1128/JB.02044-14. Epub 2014 Sep 15.


Factors affecting visibility of a target tissue in histologic sections.

McGavin MD.

Vet Pathol. 2014 Jan;51(1):9-27. doi: 10.1177/0300985813506916. Review.


Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G.

Nature. 2013 Nov 21;503(7476):397-401. doi: 10.1038/nature12655. Epub 2013 Oct 30.


Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus.

Arsic B, Zhu Y, Heinrichs DE, McGavin MJ.

PLoS One. 2012;7(9):e45952. doi: 10.1371/journal.pone.0045952. Epub 2012 Sep 24.


The staphylococci and staphylococcal pathogenesis.

McGavin MJ, Heinrichs DE.

Front Cell Infect Microbiol. 2012 May 18;2:66. doi: 10.3389/fcimb.2012.00066. eCollection 2012. No abstract available.


Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30.

McGavin MJ, Arsic B, Nickerson NN.

Front Cell Infect Microbiol. 2012 Apr 9;2:48. doi: 10.3389/fcimb.2012.00048. eCollection 2012.


Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus.

DeLeo FR, Kennedy AD, Chen L, Bubeck Wardenburg J, Kobayashi SD, Mathema B, Braughton KR, Whitney AR, Villaruz AE, Martens CA, Porcella SF, McGavin MJ, Otto M, Musser JM, Kreiswirth BN.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18091-6. doi: 10.1073/pnas.1111084108. Epub 2011 Oct 24.


Impact of accessory gene regulator (agr) dysfunction on vancomycin pharmacodynamics among Canadian community and health-care associated methicillin-resistant Staphylococcus aureus.

Tsuji BT, MacLean RD, Dresser LD, McGavin MJ, Simor AE.

Ann Clin Microbiol Antimicrob. 2011 May 20;10:20. doi: 10.1186/1476-0711-10-20.


Colonization with community-acquired methicillin-resistant Staphylococcus aureus in children with atopic dermatitis: a cross-sectional study.

Balma-Mena A, Lara-Corrales I, Zeller J, Richardson S, McGavin MJ, Weinstein M, Pope E.

Int J Dermatol. 2011 Jun;50(6):682-8. doi: 10.1111/j.1365-4632.2010.04751.x.


Identification of major clonal complexes and toxin producing strains among Staphylococcus aureus associated with atopic dermatitis.

Yeung M, Balma-Mena A, Shear N, Simor A, Pope E, Walsh S, McGavin MJ.

Microbes Infect. 2011 Feb;13(2):189-97. doi: 10.1016/j.micinf.2010.10.023. Epub 2010 Nov 18.


Axonal degeneration in sheep caused by the ingestion of Halimium brasiliense.

Riet-Correa F, Barros SS, Méndez MC, Gevehr-Fernandes C, Pereira Neto OA, Soares MP, McGavin MD.

J Vet Diagn Invest. 2009 Jul;21(4):478-86.


Rapid autocatalytic activation of the M4 metalloprotease aureolysin is controlled by a conserved N-terminal fungalysin-thermolysin-propeptide domain.

Nickerson NN, Joag V, McGavin MJ.

Mol Microbiol. 2008 Sep;69(6):1530-43. doi: 10.1111/j.1365-2958.2008.06384.x. Epub 2008 Jul 30.


Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.

Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1593-8. Epub 2007 Jan 22.


Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection.

Burlak C, Hammer CH, Robinson MA, Whitney AR, McGavin MJ, Kreiswirth BN, Deleo FR.

Cell Microbiol. 2007 May;9(5):1172-90. Epub 2007 Jan 9.


Interaction of Staphylococcus aureus fibronectin-binding protein with fibronectin: affinity, stoichiometry, and modular requirements.

Ingham KC, Brew S, Vaz D, Sauder DN, McGavin MJ.

J Biol Chem. 2004 Oct 8;279(41):42945-53. Epub 2004 Aug 4.


The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.

Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA.

Immunity. 2003 Jan;18(1):141-54.


Identification of a novel maturation mechanism and restricted substrate specificity for the SspB cysteine protease of Staphylococcus aureus.

Massimi I, Park E, Rice K, Muller-Esterl W, Sauder D, McGavin MJ.

J Biol Chem. 2002 Nov 1;277(44):41770-7. Epub 2002 Aug 30.


WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development.

Zhang J, Shi F, Badour K, Deng Y, McGavin MK, Siminovitch KA.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2240-5. Epub 2002 Feb 12.


The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.

McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA.

J Exp Med. 2001 Dec 17;194(12):1777-87.


Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B streptococcus isolates from Ontario, Canada.

de Azavedo JC, McGavin M, Duncan C, Low DE, McGeer A.

Antimicrob Agents Chemother. 2001 Dec;45(12):3504-8.


Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation.

Cannon JL, Labno CM, Bosco G, Seth A, McGavin MH, Siminovitch KA, Rosen MK, Burkhardt JK.

Immunity. 2001 Aug;15(2):249-59.


Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.

Zhang J, Shehabeldin A, da Cruz LA, Butler J, Somani AK, McGavin M, Kozieradzki I, dos Santos AO, Nagy A, Grinstein S, Penninger JM, Siminovitch KA.

J Exp Med. 1999 Nov 1;190(9):1329-42.


Involvement of the lymphocyte cytoskeleton in antigen-receptor signaling.

da Cruz LA, Penfold S, Zhang J, Somani AK, Shi F, McGavin MK, Song X, Siminovitch KA.

Curr Top Microbiol Immunol. 2000;245(1):135-67. No abstract available.


Transgenic mouse model of AA amyloidosis.

Solomon A, Weiss DT, Schell M, Hrncic R, Murphy CL, Wall J, McGavin MD, Pan HJ, Kabalka GW, Paulus MJ.

Am J Pathol. 1999 Apr;154(4):1267-72.


Magnetic resonance imaging appearance of intracranial hemorrhage secondary to cerebral vascular malformation in a dog.

Thomas WB, Adams WH, McGavin MD, Gompf RE.

Vet Radiol Ultrasound. 1997 Sep-Oct;38(5):371-5.


Bilateral renal metastases of nasal chondrosarcoma in a dog.

Hahn KA, McGavin MD, Adams WH.

Vet Pathol. 1997 Jul;34(4):352-5.


Modification of the Staphylococcus aureus fibronectin binding phenotype by V8 protease.

McGavin MJ, Zahradka C, Rice K, Scott JE.

Infect Immun. 1997 Jul;65(7):2621-8.


Parosteal osteosarcoma of the cervical vertebra in a dog.

Thomas WB, Daniel GB, McGavin MD.

Vet Radiol Ultrasound. 1997 Mar-Apr;38(2):120-3.


Staphylococcus aureus expresses a major histocompatibility complex class II analog.

Jönsson K, McDevitt D, McGavin MH, Patti JM, Höök M.

J Biol Chem. 1995 Sep 15;270(37):21457-60.


Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters.

Schuller HM, McGavin MD, Orloff M, Riechert A, Porter B.

Lab Invest. 1995 Sep;73(3):448-56.


MSCRAMM-mediated adherence of microorganisms to host tissues.

Patti JM, Allen BL, McGavin MJ, Höök M.

Annu Rev Microbiol. 1994;48:585-617. Review.


Fibronectin receptors from Streptococcus dysgalactiae and Staphylococcus aureus. Involvement of conserved residues in ligand binding.

McGavin MJ, Gurusiddappa S, Lindgren PE, Lindberg M, Raucci G, Höök M.

J Biol Chem. 1993 Nov 15;268(32):23946-53.


Two different genes coding for fibronectin-binding proteins from Streptococcus dysgalactiae. The complete nucleotide sequences and characterization of the binding domains.

Lindgren PE, McGavin MJ, Signäs C, Guss B, Gurusiddappa S, Höök M, Lindberg M.

Eur J Biochem. 1993 Jun 15;214(3):819-27.

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