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Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity.

Rua R, Lee JY, Silva AB, Swafford IS, Maric D, Johnson KR, McGavern DB.

Nat Immunol. 2019 Apr;20(4):407-419. doi: 10.1038/s41590-019-0344-y. Epub 2019 Mar 18.


Method to quantify cytokines and chemokines in mouse brain tissue using Bio-Plex multiplex immunoassays.

Manglani M, Rua R, Hendricksen A, Braunschweig D, Gao Q, Tan W, Houser B, McGavern DB, Oh K.

Methods. 2019 Feb 10. pii: S1046-2023(18)30234-2. doi: 10.1016/j.ymeth.2019.02.007. [Epub ahead of print]


PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity.

Preite S, Huang B, Cannons JL, McGavern DB, Schwartzberg PL.

Front Immunol. 2019 Jan 7;9:3079. doi: 10.3389/fimmu.2018.03079. eCollection 2018.


The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok.

Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y, Tran B, Pepper M, Tessarollo L, McGavern DB, Bosselut R.

Immunity. 2019 Jan 15;50(1):91-105.e4. doi: 10.1016/j.immuni.2018.12.019. Epub 2019 Jan 9.


Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.

Greenhalgh AD, Zarruk JG, Healy LM, Baskar Jesudasan SJ, Jhelum P, Salmon CK, Formanek A, Russo MV, Antel JP, McGavern DB, McColl BW, David S.

PLoS Biol. 2018 Oct 17;16(10):e2005264. doi: 10.1371/journal.pbio.2005264. eCollection 2018 Oct.


Leukocyte Isolation from Brain, Spinal Cord, and Meninges for Flow Cytometric Analysis.

Manglani M, Gossa S, McGavern DB.

Curr Protoc Immunol. 2018 Apr;121(1):e44. doi: 10.1002/cpim.44.


BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection.

Urata S, Kenyon E, Nayak D, Cubitt B, Kurosaki Y, Yasuda J, de la Torre JC, McGavern DB.

PLoS Pathog. 2018 Jul 20;14(7):e1007172. doi: 10.1371/journal.ppat.1007172. eCollection 2018 Jul.


Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2018 Aug;19(8):898. doi: 10.1038/s41590-018-0139-6.


Advances in Meningeal Immunity.

Rua R, McGavern DB.

Trends Mol Med. 2018 Jun;24(6):542-559. doi: 10.1016/j.molmed.2018.04.003. Epub 2018 May 3. Review.


Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury.

Russo MV, Latour LL, McGavern DB.

Nat Immunol. 2018 May;19(5):442-452. doi: 10.1038/s41590-018-0086-2. Epub 2018 Apr 16.


Intravital Imaging of Neuroimmune Interactions Through a Thinned Skull.

Manglani M, McGavern DB.

Curr Protoc Immunol. 2018 Feb 21;120:24.2.1-24.2.12. doi: 10.1002/cpim.46.


New advances in CNS immunity against viral infection.

Manglani M, McGavern DB.

Curr Opin Virol. 2018 Feb;28:116-126. doi: 10.1016/j.coviro.2017.12.003. Epub 2017 Dec 29. Review.


Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift.

Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J.

Neuron. 2017 Sep 13;95(6):1246-1265. doi: 10.1016/j.neuron.2017.07.010. Review.


T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2017 Oct;18(10):1117-1127. doi: 10.1038/ni.3816. Epub 2017 Aug 14. Erratum in: Nat Immunol. 2018 Aug;19(8):898.


Transcranial manganese delivery for neuronal tract tracing using MEMRI.

Atanasijevic T, Bouraoud N, McGavern DB, Koretsky AP.

Neuroimage. 2017 Aug 1;156:146-154. doi: 10.1016/j.neuroimage.2017.05.025. Epub 2017 May 13.


Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.

Pandya H, Shen MJ, Ichikawa DM, Sedlock AB, Choi Y, Johnson KR, Kim G, Brown MA, Elkahloun AG, Maric D, Sweeney CL, Gossa S, Malech HL, McGavern DB, Park JK.

Nat Neurosci. 2017 May;20(5):753-759. doi: 10.1038/nn.4534. Epub 2017 Mar 2.


The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL.

Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9.


CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.

Swanson PA 2nd, Hart GT, Russo MV, Nayak D, Yazew T, Peña M, Khan SM, Janse CJ, Pierce SK, McGavern DB.

PLoS Pathog. 2016 Dec 1;12(12):e1006022. doi: 10.1371/journal.ppat.1006022. eCollection 2016 Dec.


Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation.

Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB.

Sci Immunol. 2016 Oct;1(4). pii: eaah3565. Epub 2016 Oct 21.


Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.

Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA.

Nat Microbiol. 2016 Feb 15;1:16001. doi: 10.1038/nmicrobiol.2016.1.


Inflammatory neuroprotection following traumatic brain injury.

Russo MV, McGavern DB.

Science. 2016 Aug 19;353(6301):783-5. doi: 10.1126/science.aaf6260. Review.


Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.


Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction.

Huber BR, Meabon JS, Hoffer ZS, Zhang J, Hoekstra JG, Pagulayan KF, McMillan PJ, Mayer CL, Banks WA, Kraemer BC, Raskind MA, McGavern DB, Peskind ER, Cook DG.

Neuroscience. 2016 Apr 5;319:206-20. doi: 10.1016/j.neuroscience.2016.01.022. Epub 2016 Jan 14.


Immune Surveillance of the CNS following Infection and Injury.

Russo MV, McGavern DB.

Trends Immunol. 2015 Oct;36(10):637-650. doi: 10.1016/ Review.


TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.

Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL.

Cell Rep. 2015 Sep 29;12(12):2099-110. doi: 10.1016/j.celrep.2015.08.049. Epub 2015 Sep 10.


Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN.

Clin Immunol. 2015 Dec;161(2):260-9. doi: 10.1016/j.clim.2015.08.007. Epub 2015 Aug 25.


Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.

Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13.


Elucidation of monocyte/macrophage dynamics and function by intravital imaging.

Rua R, McGavern DB.

J Leukoc Biol. 2015 Sep;98(3):319-32. doi: 10.1189/jlb.4RI0115-006RR. Epub 2015 Jul 10. Review.


Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.

Herz J, Johnson KR, McGavern DB.

J Exp Med. 2015 Jul 27;212(8):1153-69. doi: 10.1084/jem.20142047. Epub 2015 Jun 29.


c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.

Giardino Torchia ML, Munitic I, Castro E, Herz J, McGavern DB, Ashwell JD.

Eur J Immunol. 2015 Sep;45(9):2672-82. doi: 10.1002/eji.201445342. Epub 2015 Jul 7.


Pentraxin 3 innately preps damaged tissue for wound healing.

Rua R, McGavern DB.

J Exp Med. 2015 Jun 1;212(6):829. doi: 10.1084/jem.2126insight2. No abstract available.


Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.

Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D.

J Neuroinflammation. 2015 Apr 29;12:82. doi: 10.1186/s12974-015-0299-3.


Viral diseases of the central nervous system.

Swanson PA 2nd, McGavern DB.

Curr Opin Virol. 2015 Apr;11:44-54. doi: 10.1016/j.coviro.2014.12.009. Epub 2015 Feb 12. Review.


Inflammation and neuroprotection in traumatic brain injury.

Corps KN, Roth TL, McGavern DB.

JAMA Neurol. 2015 Mar;72(3):355-62. doi: 10.1001/jamaneurol.2014.3558. Review.


Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging.

Gossa S, Nayak D, Zinselmeyer BH, McGavern DB.

Sci Rep. 2014 Oct 17;4:6664. doi: 10.1038/srep06664.


Microglia development and function.

Nayak D, Roth TL, McGavern DB.

Annu Rev Immunol. 2014;32:367-402. doi: 10.1146/annurev-immunol-032713-120240. Epub 2014 Jan 22. Review.


Transcranial amelioration of inflammation and cell death after brain injury.

Roth TL, Nayak D, Atanasijevic T, Koretsky AP, Latour LL, McGavern DB.

Nature. 2014 Jan 9;505(7482):223-8. doi: 10.1038/nature12808. Epub 2013 Dec 8.


The great balancing act: regulation and fate of antiviral T-cell interactions.

Moseman EA, McGavern DB.

Immunol Rev. 2013 Sep;255(1):110-24. doi: 10.1111/imr.12093. Review.


Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system.

Nayak D, Johnson KR, Heydari S, Roth TL, Zinselmeyer BH, McGavern DB.

PLoS Pathog. 2013;9(5):e1003395. doi: 10.1371/journal.ppat.1003395. Epub 2013 May 30.


MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.

Navarathna DH, Munasinghe J, Lizak MJ, Nayak D, McGavern DB, Roberts DD.

NMR Biomed. 2013 Sep;26(9):1125-34. doi: 10.1002/nbm.2926. Epub 2013 Apr 22.


PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.

Zinselmeyer BH, Heydari S, Sacristán C, Nayak D, Cammer M, Herz J, Cheng X, Davis SJ, Dustin ML, McGavern DB.

J Exp Med. 2013 Apr 8;210(4):757-74. doi: 10.1084/jem.20121416. Epub 2013 Mar 25.


Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

Oldstone MB, Edelmann KH, McGavern DB, Cruite JT, Welch MJ.

PLoS Pathog. 2012;8(11):e1003044. doi: 10.1371/journal.ppat.1003044. Epub 2012 Nov 29.


Two-photon imaging of microbial immunity in living tissues.

Herz J, Zinselmeyer BH, McGavern DB.

Microsc Microanal. 2012 Aug;18(4):730-41. Review.


Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.

Garidou L, Heydari S, Gossa S, McGavern DB.

J Virol. 2012 Jul;86(13):7060-71. doi: 10.1128/JVI.00164-12. Epub 2012 May 2.


In vivo dynamics of innate immune sentinels in the CNS.

Nayak D, Zinselmeyer BH, Corps KN, McGavern DB.

Intravital. 2012;1(2):95-106. doi: 10.4161/intv.22823.


Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells.

Fahey LM, Wilson EB, Elsaesser H, Fistonich CD, McGavern DB, Brooks DG.

J Exp Med. 2011 May 9;208(5):987-99. doi: 10.1084/jem.20101773. Epub 2011 May 2.


Illuminating viral infections in the nervous system.

McGavern DB, Kang SS.

Nat Rev Immunol. 2011 May;11(5):318-29. doi: 10.1038/nri2971. Review.


Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection.

Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, McGavern DB.

J Exp Med. 2011 Apr 11;208(4):747-59. doi: 10.1084/jem.20101295. Epub 2011 Apr 4.


Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED).

Combs CA, Smirnov A, Chess D, McGavern DB, Schroeder JL, Riley J, Kang SS, Lugar-Hammer M, Gandjbakhche A, Knutson JR, Balaban RS.

J Microsc. 2011 Feb;241(2):153-61. doi: 10.1111/j.1365-2818.2010.03411.x. Epub 2010 Jun 21. Erratum in: J Microsc. 2011 Aug;243(2):220.


Microbial induction of vascular pathology in the CNS.

Kang SS, McGavern DB.

J Neuroimmune Pharmacol. 2010 Sep;5(3):370-86. doi: 10.1007/s11481-010-9208-9. Epub 2010 Apr 18. Review.

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