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Items: 44

1.

Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials.

Gadalla R, Noamani B, MacLeod BL, Dickson RJ, Guo M, Xu W, Lukhele S, Elsaesser HJ, Razak ARA, Hirano N, McGaha TL, Wang B, Butler M, Guidos CJ, Ohashi PS, Siu LL, Brooks DG.

Front Oncol. 2019 May 17;9:415. doi: 10.3389/fonc.2019.00415. eCollection 2019.

2.

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.

Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C.

Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201819473. doi: 10.1073/pnas.1819473116. [Epub ahead of print]

3.

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment.

Shinde R, McGaha TL.

Trends Immunol. 2018 Dec;39(12):1005-1020. doi: 10.1016/j.it.2018.10.010. Epub 2018 Nov 5. Review.

PMID:
30409559
4.

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity.

Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG.

Immunity. 2018 Oct 16;49(4):678-694.e5. doi: 10.1016/j.immuni.2018.08.002. Epub 2018 Oct 9.

PMID:
30314757
5.

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.

Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL.

Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14.

6.

Type I Interferon in Chronic Virus Infection and Cancer.

Snell LM, McGaha TL, Brooks DG.

Trends Immunol. 2017 Aug;38(8):542-557. doi: 10.1016/j.it.2017.05.005. Epub 2017 May 31. Review.

PMID:
28579323
7.

Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.

Duhlin A, Chen Y, Wermeling F, Sedimbi SK, Lindh E, Shinde R, Halaby MJ, Kaiser Y, Winqvist O, McGaha TL, Karlsson MC.

J Immunol. 2016 Oct 1;197(7):2618-26. doi: 10.4049/jimmunol.1401129. Epub 2016 Aug 24.

8.

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis.

Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N.

Oncogenesis. 2016 Jun 27;5(6):e238. doi: 10.1038/oncsis.2016.38.

9.
10.

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.

Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH.

Sci Adv. 2015 Nov 6;1(10):e1500845. doi: 10.1126/sciadv.1500845. eCollection 2015 Nov.

11.

IDO-GCN2 and autophagy in inflammation.

McGaha TL.

Oncotarget. 2015 Sep 8;6(26):21771-2. No abstract available.

12.

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.

Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Koritzinsky M, Madaio MP, McGaha TL.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10774-9. doi: 10.1073/pnas.1504276112. Epub 2015 Aug 10.

13.

B Cell-Intrinsic IDO1 Regulates Humoral Immunity to T Cell-Independent Antigens.

Shinde R, Shimoda M, Chaudhary K, Liu H, Mohamed E, Bradley J, Kandala S, Li X, Liu K, McGaha TL.

J Immunol. 2015 Sep 1;195(5):2374-82. doi: 10.4049/jimmunol.1402854. Epub 2015 Jul 27.

14.

Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.

Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McMenamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL.

J Immunol. 2015 Jun 15;194(12):5713-24. doi: 10.4049/jimmunol.1500277. Epub 2015 May 15.

15.

Lupus Nephritis: Animal Modeling of a Complex Disease Syndrome Pathology.

McGaha TL, Madaio MP.

Drug Discov Today Dis Models. 2014 Spring;11:13-18.

16.

Screening for methicillin-resistant Staphylococcus aureus colonization using sponges.

Lee CS, Montalmont B, O'Hara JA, Syed A, Chaussard C, McGaha TL, Pakstis DL, Lee JH, Shutt KA, Doi Y.

Infect Control Hosp Epidemiol. 2015 Jan;36(1):28-33. doi: 10.1017/ice.2014.4.

17.

Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA.

Lemos H, Huang L, McGaha TL, Mellor AL.

Eur J Immunol. 2014 Oct;44(10):2847-53. doi: 10.1002/eji.201344407. Epub 2014 Aug 25. Review.

18.

Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity.

Jha V, Workman CJ, McGaha TL, Li L, Vas J, Vignali DA, Monestier M.

PLoS One. 2014 Aug 14;9(8):e104484. doi: 10.1371/journal.pone.0104484. eCollection 2014.

19.

Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.

Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4215-20. doi: 10.1073/pnas.1320924111. Epub 2014 Mar 3.

20.

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology.

Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL.

Mol Cell Biol. 2014 Feb;34(3):428-38. doi: 10.1128/MCB.00946-13. Epub 2013 Nov 18.

21.

Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses.

Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL.

J Immunol. 2013 Oct 1;191(7):3509-13. doi: 10.4049/jimmunol.1301419. Epub 2013 Aug 28.

22.

A human monoclonal antibody against the collagen type IV α3NC1 domain is a non-invasive optical biomarker for glomerular diseases.

Chaudhary K, Kleven DT, McGaha TL, Madaio MP.

Kidney Int. 2013 Aug;84(2):403-8. doi: 10.1038/ki.2013.99. Epub 2013 Mar 20.

23.

O death where is thy sting? Immunologic tolerance to apoptotic self.

Ravishankar B, McGaha TL.

Cell Mol Life Sci. 2013 Oct;70(19):3571-89. doi: 10.1007/s00018-013-1261-0. Epub 2013 Feb 3. Review.

24.

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL.

Immunol Rev. 2012 Sep;249(1):135-57. doi: 10.1111/j.1600-065X.2012.01149.x. Review.

25.

Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells.

Huang L, Lemos HP, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL.

J Immunol. 2012 May 15;188(10):4913-20. doi: 10.4049/jimmunol.1103668. Epub 2012 Apr 18.

26.

Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo.

Yang D, Torres CM, Bardhan K, Zimmerman M, McGaha TL, Liu K.

J Immunol. 2012 May 1;188(9):4441-9. doi: 10.4049/jimmunol.1103035. Epub 2012 Mar 28.

27.

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3909-14. doi: 10.1073/pnas.1117736109. Epub 2012 Feb 21.

28.

Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice.

McGaha TL, Ma Z, Ravishankar B, Gabunia K, McMenamin M, Madaio MP.

Autoimmunity. 2012 Jun;45(4):279-89. doi: 10.3109/08916934.2012.654864. Epub 2012 Feb 23.

PMID:
22283427
29.

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

Enoksson SL, Grasset EK, Hägglöf T, Mattsson N, Kaiser Y, Gabrielsson S, McGaha TL, Scheynius A, Karlsson MC.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1399-407. doi: 10.1073/pnas.1107830108. Epub 2011 Dec 1.

30.

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MC.

Blood. 2011 May 19;117(20):5403-12. doi: 10.1182/blood-2010-11-320028. Epub 2011 Mar 28.

31.

Screening for Acinetobacter baumannii colonization by use of sponges.

Doi Y, Onuoha EO, Adams-Haduch JM, Pakstis DL, McGaha TL, Werner CA, Parker BN, Brooks MM, Shutt KA, Pasculle AW, Muto CA, Harrison LH.

J Clin Microbiol. 2011 Jan;49(1):154-8. doi: 10.1128/JCM.01043-10. Epub 2010 Oct 27.

32.

A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis.

Shao WH, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL.

Clin Immunol. 2010 Aug;136(2):236-44. doi: 10.1016/j.clim.2010.04.002. Epub 2010 May 4.

33.

An anatomical view on macrophages in tolerance.

Wermeling F, Karlsson MC, McGaha TL.

Autoimmun Rev. 2009 Sep;9(1):49-52. doi: 10.1016/j.autrev.2009.03.004. Epub 2009 Mar 10. Review.

PMID:
19281880
34.

FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice.

McGaha TL, Karlsson MC, Ravetch JV.

J Immunol. 2008 Apr 15;180(8):5670-9.

35.

APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells.

Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA.

Blood. 2008 Mar 1;111(5):2755-64. doi: 10.1182/blood-2007-09-110858. Epub 2008 Jan 7.

36.

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV.

J Exp Med. 2006 Mar 20;203(3):553-61. Epub 2006 Feb 21.

37.

Molecular aspects of regulation of collagen gene expression in fibrosis.

Bhogal RK, Stoica CM, McGaha TL, Bona CA.

J Clin Immunol. 2005 Nov;25(6):592-603. Review.

PMID:
16380822
38.

Restoration of tolerance in lupus by targeted inhibitory receptor expression.

McGaha TL, Sorrentino B, Ravetch JV.

Science. 2005 Jan 28;307(5709):590-3.

39.

Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice.

Zhu H, Bona C, McGaha TL.

Autoimmunity. 2004 Feb;37(1):51-5.

PMID:
15115312
40.

Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.

McGaha TL, Le M, Kodera T, Stoica C, Zhu J, Paul WE, Bona CA.

Arthritis Rheum. 2003 Aug;48(8):2275-84.

41.

Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma.

McGaha TL, Bona CA.

Autoimmun Rev. 2002 May;1(3):174-81. Review.

PMID:
12849012
42.

Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism.

McGaha TL, Kodera T, Spiera H, Stan AC, Pines M, Bona CA.

Arthritis Rheum. 2002 Oct;46(10):2748-61.

43.

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts.

Kodera T, McGaha TL, Phelps R, Paul WE, Bona CA.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3800-5. Epub 2002 Mar 12.

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