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G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells.

Manfredi LH, Ang J, Peker N, Dagda RK, McFarlane C.

Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C674-C686. doi: 10.1152/ajpcell.00516.2018. Epub 2019 Jul 3.


Miniaturisation of high-throughput plasmid DNA library preparation for next-generation sequencing using multifactorial optimisation.

Suckling L, McFarlane C, Sawyer C, Chambers SP, Kitney RI, McClymont DW, Freemont PS.

Synth Syst Biotechnol. 2019 Jan 22;4(1):57-66. doi: 10.1016/j.synbio.2019.01.002. eCollection 2019 Mar.


Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis.

McFarlane C, Ramos CI, Johnson DW, Campbell KL.

J Ren Nutr. 2019 May;29(3):209-220. doi: 10.1053/j.jrn.2018.08.008. Epub 2018 Oct 23.


Establishing Concurrent Validity for a Brief PTSD Screen Among Women in a Domestic Violence Shelter.

Symes L, McFarlane J, Maddoux J, Levine LB, Landrum KS, McFarlane CD.

J Interpers Violence. 2018 Jun 1:886260518779595. doi: 10.1177/0886260518779595. [Epub ahead of print]


Loss of Parkin impairs mitochondrial function and leads to muscle atrophy.

Peker N, Donipadi V, Sharma M, McFarlane C, Kambadur R.

Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C164-C185. doi: 10.1152/ajpcell.00064.2017. Epub 2018 Mar 21.


Irisin treatment improves healing of dystrophic skeletal muscle.

Reza MM, Sim CM, Subramaniyam N, Ge X, Sharma M, Kambadur R, McFarlane C.

Oncotarget. 2017 Oct 6;8(58):98553-98566. doi: 10.18632/oncotarget.21636. eCollection 2017 Nov 17.


Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.

Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb.


Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy.

Reza MM, Subramaniyam N, Sim CM, Ge X, Sathiakumar D, McFarlane C, Sharma M, Kambadur R.

Nat Commun. 2017 Oct 24;8(1):1104. doi: 10.1038/s41467-017-01131-0.


Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.

Julien SG, Kim SY, Brunmeir R, Sinnakannu JR, Ge X, Li H, Ma W, Yaligar J, Kn BP, Velan SS, Röder PV, Zhang Q, Sim CK, Wu J, Garcia-Miralles M, Pouladi MA, Xie W, McFarlane C, Han W, Xu F.

PLoS Biol. 2017 Feb 16;15(2):e1002597. doi: 10.1371/journal.pbio.1002597. eCollection 2017 Feb.


Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes.

Ge X, Sathiakumar D, Lua BJ, Kukreti H, Lee M, McFarlane C.

Int J Obes (Lond). 2017 Jan;41(1):137-148. doi: 10.1038/ijo.2016.110. Epub 2016 Jun 14.


The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.

Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stünkel W.

Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18.


Costing Dengue Fever Cases and Outbreaks: Recommendations from a Costing Dengue Working Group in the Americas.

Constenla D, Armien B, Arredondo J, Carabali M, Carrasquilla G, Castro R, Durand L, Durán-Arenas L, García ME, Gallegos RV, Gontes ML, López JG, McFarlane C, Montoya R, Sartori AM, Siqueira JB, Martelli CT.

Value Health Reg Issues. 2015 Dec;8:80-91. doi: 10.1016/j.vhri.2015.06.001. Epub 2015 Jul 28.


CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices.

McFarlane S, McFarlane C, Montgomery N, Hill A, Waugh DJ.

Oncotarget. 2015 Nov 3;6(34):36762-73. doi: 10.18632/oncotarget.5461.


Myostatin: expanding horizons.

Sharma M, McFarlane C, Kambadur R, Kukreti H, Bonala S, Srinivasan S.

IUBMB Life. 2015 Aug;67(8):589-600. doi: 10.1002/iub.1392. Epub 2015 Aug 25. Review.


Inactivation of PPARβ/δ adversely affects satellite cells and reduces postnatal myogenesis.

Chandrashekar P, Manickam R, Ge X, Bonala S, McFarlane C, Sharma M, Wahli W, Kambadur R.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E122-31. doi: 10.1152/ajpendo.00586.2014. Epub 2015 Apr 28.


CD44 increases the efficiency of distant metastasis of breast cancer.

McFarlane S, Coulter JA, Tibbits P, O'Grady A, McFarlane C, Montgomery N, Hill A, McCarthy HO, Young LS, Kay EW, Isacke CM, Waugh DJ.

Oncotarget. 2015 May 10;6(13):11465-76.


Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.

Codd EE, Ng HH, McFarlane C, Riccio ES, Doppalapudi R, Mirsalis JC, Horton RJ, Gonzalez AE, Garcia HH, Gilman RH; Cysticercosis Working Group in Peru.

Int J Toxicol. 2015 Mar-Apr;34(2):129-37. doi: 10.1177/1091581815569582. Epub 2015 Feb 20.


1) Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2015 Feb 15;466(1):201. No abstract available.


The Use of Caffeinated Substances by Surgeons for Cognitive Enhancement.

Franke AG, Bagusat C, McFarlane C, Tassone-Steiger T, Kneist W, Lieb K.

Ann Surg. 2015 Jun;261(6):1091-5. doi: 10.1097/SLA.0000000000000830.


USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.

Jaworski J, de la Vega M, Fletcher SJ, McFarlane C, Greene MK, Smyth AW, Van Schaeybroeck S, Johnston JA, Scott CJ, Rappoport JZ, Burrows JF.

Oncotarget. 2014 Aug 30;5(16):6964-75.


Mega roles of microRNAs in regulation of skeletal muscle health and disease.

Sharma M, Juvvuna PK, Kukreti H, McFarlane C.

Front Physiol. 2014 Jun 26;5:239. doi: 10.3389/fphys.2014.00239. eCollection 2014. Review.


Lack of myostatin reduces MyoD induced myogenic potential of primary muscle fibroblasts.

Shenoy P S, Bose B, Sharma M, McFarlane C, Kambadur R.

J Cell Biochem. 2014 Nov;115(11):1908-17. doi: 10.1002/jcb.24860.


The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils.

Dib K, Perecko T, Jenei V, McFarlane C, Comer D, Brown V, Katebe M, Scheithauer T, Thurmond RL, Chazot PL, Ennis M.

J Leukoc Biol. 2014 Sep;96(3):411-8. doi: 10.1189/jlb.2AB0813-432RR. Epub 2014 May 5.


Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27.

McFarlane C, Vajjala A, Arigela H, Lokireddy S, Ge X, Bonala S, Manickam R, Kambadur R, Sharma M.

PLoS One. 2014 Jan 31;9(1):e87687. doi: 10.1371/journal.pone.0087687. eCollection 2014.


Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake.

Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R.

J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. Retraction in: J Biol Chem. 2016 Jul 1;291(27):14392.


Myostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle.

Sriram S, Subramanian S, Juvvuna PK, Ge X, Lokireddy S, McFarlane CD, Wahli W, Kambadur R, Sharma M.

Mol Endocrinol. 2014 Mar;28(3):317-30. doi: 10.1210/me.2013-1179. Epub 2014 Jan 17. Erratum in: Mol Endocrinol. 2016 Feb;30(2):272-3.


Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.

Sriram S, Subramanian S, Juvvuna PK, McFarlane C, Salerno MS, Kambadur R, Sharma M.

J Biol Chem. 2014 Feb 28;289(9):5784-98. doi: 10.1074/jbc.M113.483115. Epub 2014 Jan 14. Retraction in: J Biol Chem. 2015 Nov 6;290(45):27012.


Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study.

Khoo CM, Leow MK, Sadananthan SA, Lim R, Venkataraman K, Khoo EY, Velan SS, Ong YT, Kambadur R, McFarlane C, Gluckman PD, Lee YS, Chong YS, Tai ES.

Diabetes. 2014 Mar;63(3):1093-102. doi: 10.2337/db13-1483. Epub 2013 Dec 18. Erratum in: Diabetes. 2014 Jun;63(6):2183. Lee, Yun Seng [corrected to Lee, Yung Seng].


A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.

Jaworski J, Govender U, McFarlane C, de la Vega M, Greene MK, Rawlings ND, Johnston JA, Scott CJ, Burrows JF.

Biochem J. 2014 Jan 15;457(2):289-300. doi: 10.1042/BJ20131213.


The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.

McFarlane C, McFarlane S, Paul I, Arthur K, Scheaff M, Kerr K, Stevenson M, Fennell DA, Johnston JA.

Oncotarget. 2013 Oct;4(10):1836-43.


Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity.

Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R.

Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Aug;30(8):949.


Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.

Small DM, Burden RE, Jaworski J, Hegarty SM, Spence S, Burrows JF, McFarlane C, Kissenpfennig A, McCarthy HO, Johnston JA, Walker B, Scott CJ.

Int J Cancer. 2013 Nov;133(9):2102-12. doi: 10.1002/ijc.28238. Epub 2013 May 29.


Survival following spinal cord infarction.

New PW, McFarlane CL.

Spinal Cord. 2013 Jun;51(6):453-6. doi: 10.1038/sc.2013.14. Epub 2013 Mar 26.


NF-κB is a critical mediator of BRCA1-induced chemoresistance.

Harte MT, Gorski JJ, Savage KI, Purcell JW, Barros EM, Burn PM, McFarlane C, Mullan PB, Kennedy RD, Perkins ND, Harkin DP.

Oncogene. 2014 Feb 6;33(6):713-723. doi: 10.1038/onc.2013.10. Epub 2013 Feb 25.


Muscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during dexamethasone-mediated atrophy.

Kukreti H, Amuthavalli K, Harikumar A, Sathiyamoorthy S, Feng PZ, Anantharaj R, Tan SL, Lokireddy S, Bonala S, Sriram S, McFarlane C, Kambadur R, Sharma M.

J Biol Chem. 2013 Mar 1;288(9):6663-78. doi: 10.1074/jbc.M112.390369. Epub 2013 Jan 6.


The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli.

Lokireddy S, Wijesoma IW, Teng S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R.

Cell Metab. 2012 Nov 7;16(5):613-24. doi: 10.1016/j.cmet.2012.10.005. Retraction in: Cell Metab. 2015 Dec 1;22(6):1090.


Evidence-based psychological interventions for adult survivors of torture and trauma: a 30-year review.

McFarlane CA, Kaplan I.

Transcult Psychiatry. 2012 Jul;49(3-4):539-67. Review.


Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.

Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C512-29. doi: 10.1152/ajpcell.00402.2011. Epub 2012 Jun 6. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1151.


Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2012 Aug 15;446(1):23-36. doi: 10.1042/BJ20112024. Erratum in: Biochem J. 2015 Feb 15;466(1):201. Retraction in: Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M. Biochem J. 2016 Apr 15;473(8):1111.


Lack of Smad3 signaling leads to impaired skeletal muscle regeneration.

Ge X, Vajjala A, McFarlane C, Wahli W, Sharma M, Kambadur R.

Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E90-102. doi: 10.1152/ajpendo.00113.2012. Epub 2012 Apr 24.


Retrospective case series of outcomes following spinal cord infarction.

New PW, McFarlane CL.

Eur J Neurol. 2012 Sep;19(9):1207-12. doi: 10.1111/j.1468-1331.2012.03702.x. Epub 2012 Mar 21.


Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity.

Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R.

J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. Retraction in: J Biol Chem. 2016 Jul 1;291(27):14391.


Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-β signaling by decorin.

Zhang C, Tan CK, McFarlane C, Sharma M, Tan NS, Kambadur R.

Am J Physiol Cell Physiol. 2012 Apr 15;302(8):C1213-25. doi: 10.1152/ajpcell.00179.2011. Epub 2012 Jan 25. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1153.


Characterization of 12 microsatellite loci for the Pacific lamprey, Entosphenus tridentatus (Petromyzontidae), and cross-amplification in five other lamprey species.

Spice EK, Whitesel TA, McFarlane CT, Docker MF.

Genet Mol Res. 2011 Dec 22;10(4):3246-50. doi: 10.4238/2011.December.22.2.


Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.

Lokireddy S, McFarlane C, Ge X, Zhang H, Sze SK, Sharma M, Kambadur R.

Mol Endocrinol. 2011 Nov;25(11):1936-49. doi: 10.1210/me.2011-1124. Epub 2011 Sep 29. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Feb;30(2):274.


Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice.

Zhang C, McFarlane C, Lokireddy S, Masuda S, Ge X, Gluckman PD, Sharma M, Kambadur R.

Diabetologia. 2012 Jan;55(1):183-93. doi: 10.1007/s00125-011-2304-4. Epub 2011 Sep 17. Erratum in: Diabetologia. 2015 Mar;58(3):643.


Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins.

Lokireddy S, Mouly V, Butler-Browne G, Gluckman PD, Sharma M, Kambadur R, McFarlane C.

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1316-24. doi: 10.1152/ajpcell.00114.2011. Epub 2011 Sep 7. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1152.


Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB.

Sriram S, Subramanian S, Sathiakumar D, Venkatesh R, Salerno MS, McFarlane CD, Kambadur R, Sharma M.

Aging Cell. 2011 Dec;10(6):931-48. doi: 10.1111/j.1474-9726.2011.00734.x. Epub 2011 Aug 16. Erratum in: Aging Cell. 2016 Oct;15(5):981-2.


Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1.

Dash-Koney M, Deevi RK, McFarlane C, Dib K.

J Leukoc Biol. 2011 Oct;90(4):741-9. doi: 10.1189/jlb.0211108. Epub 2011 Jul 12.


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