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Items: 23


A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition.

McFaline-Figueroa JL, Hill AJ, Qiu X, Jackson D, Shendure J, Trapnell C.

Nat Genet. 2019 Sep;51(9):1389-1398. doi: 10.1038/s41588-019-0489-5. Epub 2019 Sep 2.


Letter: When Less is More: Dexamethasone Dosing for Brain Tumors.

Lim-Fat MJ, Bi WL, Lo J, Lee EQ, Ahluwalia MS, Batchelor TT, Chang SM, Chiocca EA, Chukwueke U, Cloughesy TF, Colman H, Deangelis LM, Galanis E, Gilbert MR, De Groot JF, Lassman AB, Liau LM, Mason W, McFaline-Figueroa JR, Mehta MP, Mellinghoff IK, Nabors LB, Nayak L, Reardon DA, Wen PY.

Neurosurgery. 2019 Sep 1;85(3):E607-E608. doi: 10.1093/neuros/nyz186. No abstract available.


Thyroid hormone regulates distinct paths to maturation in pigment cell lineages.

Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS, Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C, Parichy DM.

Elife. 2019 May 29;8. pii: e45181. doi: 10.7554/eLife.45181.


Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana.

Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb KL, Trapnell C, Fields S, Queitsch C, Cuperus JT.

Plant Cell. 2019 May;31(5):993-1011. doi: 10.1105/tpc.18.00785. Epub 2019 Mar 28.


A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.

Gasperini M, Hill AJ, McFaline-Figueroa JL, Martin B, Kim S, Zhang MD, Jackson D, Leith A, Schreiber J, Noble WS, Trapnell C, Ahituv N, Shendure J.

Cell. 2019 Mar 7;176(6):1516. doi: 10.1016/j.cell.2019.02.027. No abstract available.


A low percentage of metastases in deep brain and temporal lobe structures.

Yanagihara TK, McFaline-Figueroa JR, Giacalone NJ, Lee AW, Soni V, Hwang ME, Hsieh KT, Saraf A, Wu CC, Yang D, Wen PY, Ashamalla H, Aizer AA, Wang TJC, Huang RY.

Neuro Oncol. 2019 May 6;21(5):640-647. doi: 10.1093/neuonc/noz023.


A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.

Gasperini M, Hill AJ, McFaline-Figueroa JL, Martin B, Kim S, Zhang MD, Jackson D, Leith A, Schreiber J, Noble WS, Trapnell C, Ahituv N, Shendure J.

Cell. 2019 Jan 10;176(1-2):377-390.e19. doi: 10.1016/j.cell.2018.11.029. Epub 2019 Jan 3. Erratum in: Cell. 2019 Mar 7;176(6):1516.


Full-thickness rotator cuff tear in rat results in distinct temporal expression of multiple proteases in tendon, muscle, and cartilage.

Treviño EA, McFaline-Figueroa J, Guldberg RE, Platt MO, Temenoff JS.

J Orthop Res. 2019 Feb;37(2):490-502. doi: 10.1002/jor.24179. Epub 2018 Dec 27.


Joint profiling of chromatin accessibility and gene expression in thousands of single cells.

Cao J, Cusanovich DA, Ramani V, Aghamirzaie D, Pliner HA, Hill AJ, Daza RM, McFaline-Figueroa JL, Packer JS, Christiansen L, Steemers FJ, Adey AC, Trapnell C, Shendure J.

Science. 2018 Sep 28;361(6409):1380-1385. doi: 10.1126/science.aau0730. Epub 2018 Aug 30.


Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data.

Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C.

Mol Cell. 2018 Sep 6;71(5):858-871.e8. doi: 10.1016/j.molcel.2018.06.044. Epub 2018 Aug 2.


Is it time to reconsider the role of irinotecan for the treatment of high-grade gliomas?

Lee EQ, McFaline-Figueroa JR, Cloughesy TF, Wen PY.

Neuro Oncol. 2018 Jul 5;20(8):1144. doi: 10.1093/neuonc/noy092. No abstract available.


Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma.

Mikheev AM, Mikheeva SA, Severs LJ, Funk CC, Huang L, McFaline-Figueroa JL, Schwensen J, Trapnell C, Price ND, Wong S, Rostomily RC.

Mol Oncol. 2018 Jun;12(7):1188-1202. doi: 10.1002/1878-0261.12320. Epub 2018 May 29.


Dual Affinity Heparin-Based Hydrogels Achieve Pro-Regenerative Immunomodulation and Microvascular Remodeling.

Ogle ME, Krieger JR, Tellier LE, McFaline-Figueroa J, Temenoff JS, Botchwey EA.

ACS Biomater Sci Eng. 2018 Apr 9;4(4):1241-1250. doi: 10.1021/acsbiomaterials.6b00706. Epub 2017 Feb 20.


On the design of CRISPR-based single-cell molecular screens.

Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C.

Nat Methods. 2018 Apr;15(4):271-274. doi: 10.1038/nmeth.4604. Epub 2018 Feb 19.


Brain Tumors.

McFaline-Figueroa JR, Lee EQ.

Am J Med. 2018 Aug;131(8):874-882. doi: 10.1016/j.amjmed.2017.12.039. Epub 2018 Jan 31. Review.


Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.

O'Donnell-Luria AH, Lin AP, Merugumala SK, Rohr F, Waisbren SE, Lynch R, Tchekmedyian V, Goldberg AD, Bellinger A, McFaline-Figueroa JR, Simon T, Gershanik EF, Levy BD, Cohen DE, Samuels MA, Berry GT, Frank NY.

Mol Genet Metab. 2017 May;121(1):9-15. doi: 10.1016/j.ymgme.2017.03.003. Epub 2017 Mar 10.


The Viral Connection to Glioblastoma.

McFaline-Figueroa JR, Wen PY.

Curr Infect Dis Rep. 2017 Feb;19(2):5. doi: 10.1007/s11908-017-0563-z. Review.


Supraspinatus tendon overuse results in degenerative changes to tendon insertion region and adjacent humeral cartilage in a rat model.

Parks AN, McFaline-Figueroa J, Coogan A, Poe-Yamagata E, Guldberg RE, Platt MO, Temenoff JS.

J Orthop Res. 2017 Sep;35(9):1910-1918. doi: 10.1002/jor.23496. Epub 2016 Dec 21.


Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling.

Krieger JR, Ogle ME, McFaline-Figueroa J, Segar CE, Temenoff JS, Botchwey EA.

Biomaterials. 2016 Jan;77:280-90. doi: 10.1016/j.biomaterials.2015.10.045. Epub 2015 Oct 23.


Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.


Defects in mitochondrial distribution during the prolonged lag phase of Saccharomyces cerevisiae preceding growth in glycerol as the sole source of carbon.

McInnes J, Rehders M, McFaline-Figueroa JR, Brix K, Pon LA, Nevoigt E.

FEMS Yeast Res. 2013 Nov;13(7):706-10. doi: 10.1111/1567-1364.12085. Epub 2013 Sep 24.


Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.

Swayne TC, Zhou C, Boldogh IR, Charalel JK, McFaline-Figueroa JR, Thoms S, Yang C, Leung G, McInnes J, Erdmann R, Pon LA.

Curr Biol. 2011 Dec 6;21(23):1994-9. doi: 10.1016/j.cub.2011.10.019. Epub 2011 Nov 23.


Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast.

McFaline-Figueroa JR, Vevea J, Swayne TC, Zhou C, Liu C, Leung G, Boldogh IR, Pon LA.

Aging Cell. 2011 Oct;10(5):885-95. doi: 10.1111/j.1474-9726.2011.00731.x. Epub 2011 Aug 7.

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