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Items: 1 to 50 of 111

1.

Human 5' UTR design and variant effect prediction from a massively parallel translation assay.

Sample PJ, Wang B, Reid DW, Presnyak V, McFadyen IJ, Morris DR, Seelig G.

Nat Biotechnol. 2019 Jul;37(7):803-809. doi: 10.1038/s41587-019-0164-5. Epub 2019 Jul 1.

PMID:
31267113
2.

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines.

Hassett KJ, Benenato KE, Jacquinet E, Lee A, Woods A, Yuzhakov O, Himansu S, Deterling J, Geilich BM, Ketova T, Mihai C, Lynn A, McFadyen I, Moore MJ, Senn JJ, Stanton MG, Almarsson Ö, Ciaramella G, Brito LA.

Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. doi: 10.1016/j.omtn.2019.01.013. Epub 2019 Feb 7.

3.

Analysis of RNA nearest neighbor parameters reveals interdependencies and quantifies the uncertainty in RNA secondary structure prediction.

Zuber J, Cabral BJ, McFadyen I, Mauger DM, Mathews DH.

RNA. 2018 Nov;24(11):1568-1582. doi: 10.1261/rna.065102.117. Epub 2018 Aug 13.

PMID:
30104207
4.

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates.

Sabnis S, Kumarasinghe ES, Salerno T, Mihai C, Ketova T, Senn JJ, Lynn A, Bulychev A, McFadyen I, Chan J, Almarsson Ö, Stanton MG, Benenato KE.

Mol Ther. 2018 Jun 6;26(6):1509-1519. doi: 10.1016/j.ymthe.2018.03.010. Epub 2018 Mar 14.

5.

Fracture-related infection: A consensus on definition from an international expert group.

Metsemakers WJ, Morgenstern M, McNally MA, Moriarty TF, McFadyen I, Scarborough M, Athanasou NA, Ochsner PE, Kuehl R, Raschke M, Borens O, Xie Z, Velkes S, Hungerer S, Kates SL, Zalavras C, Giannoudis PV, Richards RG, Verhofstad MHJ.

Injury. 2018 Mar;49(3):505-510. doi: 10.1016/j.injury.2017.08.040. Epub 2017 Aug 24.

6.
7.

Demystifying damage control in musculoskeletal trauma.

Bates P, Parker P, McFadyen I, Pallister I.

Ann R Coll Surg Engl. 2016 May;98(5):291-4. doi: 10.1308/rcsann.2016.0111. Epub 2016 Mar 29. Review.

8.

Temporal variation in major trauma admissions.

Kieffer WK, Michalik DV, Gallagher K, McFadyen I, Bernard J, Rogers BA.

Ann R Coll Surg Engl. 2016 Feb;98(2):128-37. doi: 10.1308/rcsann.2016.0040. Epub 2016 Jan 7.

9.

Ionising radiation exposure in paediatric trauma.

Patel NG, Mohamed AM, Cooper G, McFadyen I.

Ann R Coll Surg Engl. 2014 Apr;96(3):190-3. doi: 10.1308/003588414X13814021677313.

10.

Sernbo score predicts survival after intracapsular hip fracture in the elderly.

Dawe EJ, Lindisfarne E, Singh T, McFadyen I, Stott P.

Ann R Coll Surg Engl. 2013 Jan;95(1):29-33. doi: 10.1308/003588413X13511609954653.

11.

Intramedullary nailing for pathological fractures of the ulna.

Bennet S, McCann PA, McFadyen I.

Hand Surg. 2011;16(3):323-6.

PMID:
22072468
12.

Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay.

Schlehuber LD, McFadyen IJ, Shu Y, Carignan J, Duprex WP, Forsyth WR, Ho JH, Kitsos CM, Lee GY, Levinson DA, Lucier SC, Moore CB, Nguyen NT, Ramos J, Weinstock BA, Zhang J, Monagle JA, Gardner CR, Alvarez JC.

Vaccine. 2011 Jul 12;29(31):5031-9. doi: 10.1016/j.vaccine.2011.04.079. Epub 2011 May 25.

13.

Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies.

Gibson TJ, Mccarty K, Mcfadyen IJ, Cash E, Dalmonte P, Hinds KD, Dinerman AA, Alvarez JC, Volkin DB.

J Pharm Sci. 2011 Mar;100(3):1009-21. doi: 10.1002/jps.22350. Epub 2010 Oct 25.

PMID:
21280052
14.

Should unstable extra-articular distal radial fractures be treated with fixed-angle volar-locked plates or percutaneous Kirschner wires? A prospective randomised controlled trial.

McFadyen I, Field J, McCann P, Ward J, Nicol S, Curwen C.

Injury. 2011 Feb;42(2):162-6. doi: 10.1016/j.injury.2010.07.236.

PMID:
20691441
15.

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Li W, Li J, Wu Y, Wu J, Hotchandani R, Cunningham K, McFadyen I, Bard J, Morgan P, Schlerman F, Xu X, Tam S, Goldman SJ, Williams C, Sypek J, Mansour TS.

J Med Chem. 2009 Apr 9;52(7):1799-802. doi: 10.1021/jm900093d.

PMID:
19278250
16.

Computer hexapod assisted orthopaedic surgery (CHAOS) in the correction of long bone fracture and deformity.

Rogers MJ, McFadyen I, Livingstone JA, Monsell F, Jackson M, Atkins RM.

J Orthop Trauma. 2007 May;21(5):337-42.

PMID:
17485999
17.

Scaphoid bone bruising--probably not the precursor of asymptomatic non-union of the scaphoid.

La Hei N, McFadyen I, Brock M, Field J.

J Hand Surg Eur Vol. 2007 Jun;32(3):337-40.

PMID:
17335946
18.

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM.

J Med Chem. 2005 Dec 15;48(25):7960-9.

PMID:
16335920
19.

A randomized double blind-cross over trial of soya protein for the treatment of cyclical breast pain.

McFadyen IJ, Chetty U, Setchell KD, Zimmer-Nechemias L, Stanley E, Miller WR.

Breast. 2000 Oct;9(5):271-6.

PMID:
14732177
20.

Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

Gilbert AM, Kirisits M, Toy P, Nunn DS, Failli A, Dushin EG, Novikova E, Petersen PJ, Joseph-McCarthy D, McFadyen I, Fritz CC.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):37-41.

PMID:
14684293
21.

Molecular modeling of opioid receptor-ligand complexes.

McFadyen I, Metzger T, Subramanian G, Poda G, Jorvig E, Ferguson DM.

Prog Med Chem. 2002;40:107-35. Review. No abstract available.

PMID:
12516524
22.

Exploring the unique pharmacology of a novel opioid receptor, ZFOR1, using molecular modeling and the 'message-address' concept.

McFadyen IJ, Metzger TG, Paterlini MG, Ferguson DM.

Protein Eng. 2001 Dec;14(12):953-60.

PMID:
11809925
24.

Tetrapeptide derivatives of [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor.

McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR.

J Pharmacol Exp Ther. 2000 Dec;295(3):960-6.

PMID:
11082429
25.
26.

Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio).

Rodriguez RE, Barrallo A, Garcia-Malvar F, McFadyen IJ, Gonzalez-Sarmiento R, Traynor JR.

Neurosci Lett. 2000 Jul 21;288(3):207-10.

PMID:
10889344
27.
28.

Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.

Wang C, McFadyen IJ, Traynor JR, Mosberg HI.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2685-8.

PMID:
9873603
29.

Preventing RhD haemolytic disease of the newborn. Guidelines are not followed in many cases.

McFadyen IR, Martlew VJ, Howard HL, Clarke CA.

BMJ. 1998 Apr 11;316(7138):1165. No abstract available.

PMID:
9569417
30.

Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels.

Luckas MJ, Sandland R, Hawe J, Neilson JP, McFadyen IR, Meekins JW.

Placenta. 1998 Mar-Apr;19(2-3):143-7.

PMID:
9548180
31.

Consequences for fetus and neonate of maternal red cell allo-immunisation.

Howard H, Martlew V, McFadyen I, Clarke C, Duguid J, Bromilow I, Eggington J.

Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F62-6.

32.
33.

Preventing Rhesus D haemolytic disease of the newborn by giving anti-D immunoglobulin: are the guidelines being adequately followed?

Howard HL, Martlew VJ, McFadyen IR, Clarke CA.

Br J Obstet Gynaecol. 1997 Jan;104(1):37-41.

PMID:
8988694
34.

Kleihauer Testing and Flow Cytometry. A Comparative Study for Assessment of Feto-Maternal Haemorrhage.

Duguid J, Bromilow I, Eggington J, Martlew V, Mcfadyen I, Clarke C.

Hematology. 1996;1(1):79-83. doi: 10.1080/10245332.1996.11746289.

PMID:
27406303
35.

Spiral artery blood flow in the central and peripheral areas of the placental bed in the second trimester.

Matijevic R, Meekins JW, Walkinshaw SA, Neilson JP, McFadyen IR.

Obstet Gynecol. 1995 Aug;86(2):289-92.

PMID:
7617363
36.

The role of a single progesterone measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability.

al-Sebai MA, Kingsland CR, Diver M, Hipkin L, McFadyen IR.

Br J Obstet Gynaecol. 1995 May;102(5):364-9.

PMID:
7612529
37.

Endothelial cell activation by tumour necrosis factor-alpha (TNF-alpha) and the development of pre-eclampsia.

Meekins JW, McLaughlin PJ, West DC, McFadyen IR, Johnson PM.

Clin Exp Immunol. 1994 Oct;98(1):110-4.

38.

A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies.

Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Asshe A.

Br J Obstet Gynaecol. 1994 Aug;101(8):669-74.

PMID:
7947500
39.

Immunohistochemical detection of lipoprotein(a) in the wall of placental bed spiral arteries in normal and severe preeclamptic pregnancies.

Meekins JW, Pijnenborg R, Hanssens M, van Assche A, McFadyen IR.

Placenta. 1994 Jul;15(5):511-24.

PMID:
7997451
40.

The dangers of intra-amniotic methylene blue.

McFadyen I.

Br J Obstet Gynaecol. 1992 Feb;99(2):89-90. No abstract available.

PMID:
1554680
41.

Progesterone cream for cyclic breast pain.

McFadyen IJ, Raab GM, Macintyre CC, Forrest AP.

BMJ. 1989 Apr 8;298(6678):931. No abstract available.

42.

High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets.

Stammers JP, Hull D, Abraham R, McFadyen IR.

Br J Nutr. 1989 Jan;61(1):89-97.

PMID:
2493804
43.

Prenatal diagnosis of 3-hydroxy-3-methylglutaric aciduria by GC-MS and enzymology on cultured amniocytes and chorionic villi.

Chalmers RA, Tracey BM, Mistry J, Stacey TE, McFadyen IR.

J Inherit Metab Dis. 1989;12(3):286-92.

PMID:
2482386
44.

First trimester prenatal diagnosis of 3-hydroxy-3-methylglutaric aciduria.

Chalmers RA, Mistry J, Penketh R, McFadyen IR.

J Inherit Metab Dis. 1989;12 Suppl 2:283-5. No abstract available.

PMID:
2480477
45.

Screening for Down's syndrome.

McFadyen IR.

BMJ. 1988 Nov 19;297(6659):1335-6. No abstract available.

46.

Assessment of trace metal intake and status in a Gujerati pregnant Asian population and their influence on the outcome of pregnancy.

Ward RJ, Abraham R, McFadyen IR, Haines AD, North WR, Patel M, Bhatt RV.

Br J Obstet Gynaecol. 1988 Jul;95(7):676-82.

PMID:
3415934
47.

Acute bacterial endocarditis on a normal aortic valve following vaginal delivery.

Hughes LO, McFadyen IR, Raftery EB.

Int J Cardiol. 1988 Feb;18(2):261-2.

PMID:
3125116
48.

Is screening for bacteriuria in pregnancy worth while?

Campbell-Brown M, McFadyen IR, Seal DV, Stephenson ML.

Br Med J (Clin Res Ed). 1987 Jun 20;294(6587):1579-82.

49.

Diets of Asian pregnant women in Harrow: iron and vitamins.

Abraham R, Brown MC, North WR, McFadyen IR.

Hum Nutr Appl Nutr. 1987 Jun;41(3):164-73.

PMID:
3623983
50.

Single-dose treatment of bacteriuria in pregnancy.

McFadyen IR, Campbell-Brown M, Stephenson M, Seal DV.

Eur Urol. 1987;13 Suppl 1:22-5.

PMID:
3552699

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