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Items: 1 to 50 of 179

1.

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2019 Oct 15;51(4):780. doi: 10.1016/j.immuni.2019.09.019. No abstract available.

PMID:
31618655
2.

A new marine prasinophyte genus alternates between a flagellate and a dominant benthic stage with microrhizoids for adhesion.

Wetherbee R, Rossetto Marcelino V, Costa JF, Grant B, Crawford S, Waller RF, Andersen RA, Berry D, McFadden GI, Verbruggen H.

J Phycol. 2019 Aug 8. doi: 10.1111/jpy.12909. [Epub ahead of print]

PMID:
31393007
3.

Alternative splicing is required for stage differentiation in malaria parasites.

Yeoh LM, Goodman CD, Mollard V, McHugh E, Lee VV, Sturm A, Cozijnsen A, McFadden GI, Ralph SA.

Genome Biol. 2019 Aug 1;20(1):151. doi: 10.1186/s13059-019-1756-6.

4.

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides.

Goodman CD, Hoang AT, Diallo D, Malterud KE, McFadden GI, Wangensteen H.

Planta Med. 2019 Sep;85(13):1073-1079. doi: 10.1055/a-0973-0067. Epub 2019 Jul 31.

PMID:
31365939
5.

Bed Nets, Insecticides, and Antimalarials: Where to Next?

Buchanan HD, McFadden GI, Goodman CD.

Trends Parasitol. 2019 Sep;35(9):668-670. doi: 10.1016/j.pt.2019.06.009. Epub 2019 Jul 11.

PMID:
31303446
6.

Alternative Splicing in Apicomplexan Parasites.

Yeoh LM, Lee VV, McFadden GI, Ralph SA.

MBio. 2019 Feb 19;10(1). pii: e02866-18. doi: 10.1128/mBio.02866-18. Review.

7.

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii.

Katris NJ, Ke H, McFadden GI, van Dooren GG, Waller RF.

Cell Microbiol. 2019 Jun;21(6):e13011. doi: 10.1111/cmi.13011. Epub 2019 Feb 12.

8.

Genome of tiny predator with big appetite.

McFadden GI.

BMC Biol. 2018 Nov 28;16(1):140. doi: 10.1186/s12915-018-0610-8.

9.

Plasmodium: More Don'ts.

McFadden GI.

Trends Parasitol. 2019 Jan;35(1):4-6. doi: 10.1016/j.pt.2018.10.002. Epub 2018 Nov 12. No abstract available.

PMID:
30442527
10.

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.

Holz LE, Prier JE, Freestone D, Steiner TM, English K, Johnson DN, Mollard V, Cozijnsen A, Davey GM, Godfrey DI, Yui K, Mackay LK, Lahoud MH, Caminschi I, McFadden GI, Bertolino P, Fernandez-Ruiz D, Heath WR.

Cell Rep. 2018 Oct 2;25(1):68-79.e4. doi: 10.1016/j.celrep.2018.08.094.

11.

Isolating the Plasmodium falciparum Apicoplast Using Magnetic Beads.

Botté CY, McFadden GI, Yamaryo-Botté Y.

Methods Mol Biol. 2018;1829:205-212. doi: 10.1007/978-1-4939-8654-5_14.

PMID:
29987724
12.

Host biotin is required for liver stage development in malaria parasites.

Dellibovi-Ragheb TA, Jhun H, Goodman CD, Walters MS, Ragheb DRT, Matthews KA, Rajaram K, Mishra S, McFadden GI, Sinnis P, Prigge ST.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2604-E2613. doi: 10.1073/pnas.1800717115. Epub 2018 Feb 26.

13.

Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell.

Andreadaki M, Hanssen E, Deligianni E, Claudet C, Wengelnik K, Mollard V, McFadden GI, Abkarian M, Braun-Breton C, Siden-Kiamos I.

Sci Rep. 2018 Feb 23;8(1):3543. doi: 10.1038/s41598-018-21801-3.

14.

Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.

Uddin T, McFadden GI, Goodman CD.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01161-17. doi: 10.1128/AAC.01161-17. Print 2018 Jan.

15.

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.

16.

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Yeoh LM, Goodman CD, Mollard V, McFadden GI, Ralph SA.

BMC Genomics. 2017 Sep 18;18(1):734. doi: 10.1186/s12864-017-4100-0.

17.

A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites.

Sayers CP, Mollard V, Buchanan HD, McFadden GI, Goodman CD.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12789. Epub 2017 Nov 9.

PMID:
28902970
18.

The cryptomonad nucleomorph.

McFadden GI.

Protoplasma. 2017 Sep;254(5):1903-1907. doi: 10.1007/s00709-017-1153-5. Epub 2017 Aug 21.

PMID:
28828570
19.

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O.

Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030.

21.

Evolution: Of X-Cells and X-Men.

McFadden GI, Later N.

Curr Biol. 2017 Jun 5;27(11):R408-R409. doi: 10.1016/j.cub.2017.04.033.

22.

Erratum to: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite.

Goodman CD, Austarheim I, Mollard V, Mikolo B, Malterud KE, McFadden GI, Wangensteen H.

Malar J. 2016 Nov 17;15(1):560. No abstract available.

23.

Targeting Protein Translation in Organelles of the Apicomplexa.

Goodman CD, Pasaje CFA, Kennedy K, McFadden GI, Ralph SA.

Trends Parasitol. 2016 Dec;32(12):953-965. doi: 10.1016/j.pt.2016.09.011. Epub 2016 Oct 25. Review.

PMID:
27793563
24.

Is the Mitochondrion a Good Malaria Drug Target?

Goodman CD, Buchanan HD, McFadden GI.

Trends Parasitol. 2017 Mar;33(3):185-193. doi: 10.1016/j.pt.2016.10.002. Epub 2016 Oct 24. Review.

PMID:
27789127
25.

The apicoplast: now you see it, now you don't.

McFadden GI, Yeh E.

Int J Parasitol. 2017 Feb;47(2-3):137-144. doi: 10.1016/j.ijpara.2016.08.005. Epub 2016 Oct 20. Review.

26.

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2016 Oct 18;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. Epub 2016 Sep 27. Erratum in: Immunity. 2019 Oct 15;51(4):780.

27.

Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite.

Goodman CD, Austarheim I, Mollard V, Mikolo B, Malterud KE, McFadden GI, Wangensteen H.

Malar J. 2016 Sep 20;15:481. doi: 10.1186/s12936-016-1533-x. Erratum in: Malar J. 2016 Nov 17;15(1):560.

28.

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

Amiar S, MacRae JI, Callahan DL, Dubois D, van Dooren GG, Shears MJ, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y, Botté CY.

PLoS Pathog. 2016 Aug 4;12(8):e1005765. doi: 10.1371/journal.ppat.1005765. eCollection 2016 Aug.

29.

The Import of Proteins into the Mitochondrion of Toxoplasma gondii.

van Dooren GG, Yeoh LM, Striepen B, McFadden GI.

J Biol Chem. 2016 Sep 9;291(37):19335-50. doi: 10.1074/jbc.M116.725069. Epub 2016 Jul 25.

30.

Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum.

Lim L, Sayers CP, Goodman CD, McFadden GI.

PLoS One. 2016 Jul 21;11(7):e0159603. doi: 10.1371/journal.pone.0159603. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0161420.

31.

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

Morse D, Webster W, Kalanon M, Langsley G, McFadden GI.

PLoS One. 2016 Jun 27;11(6):e0158174. doi: 10.1371/journal.pone.0158174. eCollection 2016.

32.

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.

33.

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes.

Goodman CD, Siregar JE, Mollard V, Vega-Rodríguez J, Syafruddin D, Matsuoka H, Matsuzaki M, Toyama T, Sturm A, Cozijnsen A, Jacobs-Lorena M, Kita K, Marzuki S, McFadden GI.

Science. 2016 Apr 15;352(6283):349-53. doi: 10.1126/science.aad9279.

34.

The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice.

Kalanon M, Bargieri D, Sturm A, Matthews K, Ghosh S, Goodman CD, Thiberge S, Mollard V, McFadden GI, Ménard R, de Koning-Ward TF.

Cell Microbiol. 2016 Mar;18(3):399-412. doi: 10.1111/cmi.12520. Epub 2015 Oct 14.

PMID:
26347246
35.

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG.

BMC Biol. 2015 Jul 18;13:52. doi: 10.1186/s12915-015-0162-0.

36.

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate.

Gornik SG, Febrimarsa, Cassin AM, MacRae JI, Ramaprasad A, Rchiad Z, McConville MJ, Bacic A, McFadden GI, Pain A, Waller RF.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5767-72. doi: 10.1073/pnas.1423400112. Epub 2015 Apr 20.

37.

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

Yeoh LM, Goodman CD, Hall NE, van Dooren GG, McFadden GI, Ralph SA.

Nucleic Acids Res. 2015 May 19;43(9):4661-75. doi: 10.1093/nar/gkv311. Epub 2015 Apr 13.

38.

Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts.

Shears MJ, Botté CY, McFadden GI.

Mol Biochem Parasitol. 2015 Jan-Feb;199(1-2):34-50. doi: 10.1016/j.molbiopara.2015.03.004. Epub 2015 Apr 2. Review.

39.

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase.

Sturm A, Mollard V, Cozijnsen A, Goodman CD, McFadden GI.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10216-23. doi: 10.1073/pnas.1423959112. Epub 2015 Mar 23.

40.

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Smith CM, Jerkovic A, Puy H, Winship I, Deybach JC, Gouya L, van Dooren G, Goodman CD, Sturm A, Manceau H, McFadden GI, David P, Mercereau-Puijalon O, Burgio G, McMorran BJ, Foote SJ.

Blood. 2015 Jan 15;125(3):534-41. doi: 10.1182/blood-2014-04-567149. Epub 2014 Nov 20.

41.

From the genome to the phenome: tools to understand the basic biology of Plasmodium falciparum.

Webster WA, McFadden GI.

J Eukaryot Microbiol. 2014 Nov-Dec;61(6):655-71. doi: 10.1111/jeu.12176. Epub 2014 Oct 16. Review.

PMID:
25227912
42.

Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii.

Warring SD, Dou Z, Carruthers VB, McFadden GI, van Dooren GG.

Eukaryot Cell. 2014 Nov;13(11):1360-70. doi: 10.1128/EC.00027-14. Epub 2014 May 23.

43.

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR.

PLoS Pathog. 2014 May 22;10(5):e1004135. doi: 10.1371/journal.ppat.1004135. eCollection 2014 May.

44.

Synthesis and antimalarial activity of prodigiosenes.

Marchal E, Smithen DA, Uddin MI, Robertson AW, Jakeman DL, Mollard V, Goodman CD, MacDougall KS, McFarland SA, McFadden GI, Thompson A.

Org Biomol Chem. 2014 Jun 28;12(24):4132-42. doi: 10.1039/c3ob42548g.

PMID:
24834447
45.

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT.

Antimicrob Agents Chemother. 2014 Jul;58(7):3666-78. doi: 10.1128/AAC.02721-13. Epub 2014 Apr 14.

46.
47.

Apicoplast.

McFadden GI.

Curr Biol. 2014 Mar 31;24(7):R262-3. doi: 10.1016/j.cub.2014.01.024. No abstract available.

48.

Origin and evolution of plastids and photosynthesis in eukaryotes.

McFadden GI.

Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a016105. doi: 10.1101/cshperspect.a016105. Review.

49.

Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility.

Kan A, Tan YH, Angrisano F, Hanssen E, Rogers KL, Whitehead L, Mollard VP, Cozijnsen A, Delves MJ, Crawford S, Sinden RE, McFadden GI, Leckie C, Bailey J, Baum J.

Cell Microbiol. 2014 May;16(5):734-50. doi: 10.1111/cmi.12283. Epub 2014 Mar 28.

50.

Evolution of galactoglycerolipid biosynthetic pathways--from cyanobacteria to primary plastids and from primary to secondary plastids.

Petroutsos D, Amiar S, Abida H, Dolch LJ, Bastien O, Rébeillé F, Jouhet J, Falconet D, Block MA, McFadden GI, Bowler C, Botté C, Maréchal E.

Prog Lipid Res. 2014 Apr;54:68-85. doi: 10.1016/j.plipres.2014.02.001. Epub 2014 Mar 2. Review.

PMID:
24594266

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