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Items: 1 to 50 of 528

1.

Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease.

Villa NY, McFadden G.

Curr Pathobiol Rep. 2018;6(4):247-263. doi: 10.1007/s40139-018-0186-6. Epub 2018 Nov 19. Review.

2.

Genome of tiny predator with big appetite.

McFadden GI.

BMC Biol. 2018 Nov 28;16(1):140. doi: 10.1186/s12915-018-0610-8.

3.

Plasmodium: More Don'ts.

McFadden GI.

Trends Parasitol. 2019 Jan;35(1):4-6. doi: 10.1016/j.pt.2018.10.002. Epub 2018 Nov 12. No abstract available.

PMID:
30442527
4.

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma.

Phelps MP, Yang H, Patel S, Rahman MM, McFadden G, Chen E.

Mol Ther Oncolytics. 2018 Sep 15;11:52-61. doi: 10.1016/j.omto.2018.09.001. eCollection 2018 Dec 21.

5.

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.

Holz LE, Prier JE, Freestone D, Steiner TM, English K, Johnson DN, Mollard V, Cozijnsen A, Davey GM, Godfrey DI, Yui K, Mackay LK, Lahoud MH, Caminschi I, McFadden GI, Bertolino P, Fernandez-Ruiz D, Heath WR.

Cell Rep. 2018 Oct 2;25(1):68-79.e4. doi: 10.1016/j.celrep.2018.08.094.

6.

Serpins: Development for Therapeutic Applications.

Lucas A, Yaron JR, Zhang L, Macaulay C, McFadden G.

Methods Mol Biol. 2018;1826:255-265. doi: 10.1007/978-1-4939-8645-3_17.

PMID:
30194606
7.

White paper on microbial anti-cancer therapy and prevention.

Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G.

J Immunother Cancer. 2018 Aug 6;6(1):78. doi: 10.1186/s40425-018-0381-3.

8.

Isolating the Plasmodium falciparum Apicoplast Using Magnetic Beads.

Botté CY, McFadden GI, Yamaryo-Botté Y.

Methods Mol Biol. 2018;1829:205-212. doi: 10.1007/978-1-4939-8654-5_14.

PMID:
29987724
9.

The wide utility of rabbits as models of human diseases.

Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R.

Exp Mol Med. 2018 May 22;50(5):66. doi: 10.1038/s12276-018-0094-1. Review.

10.

Host biotin is required for liver stage development in malaria parasites.

Dellibovi-Ragheb TA, Jhun H, Goodman CD, Walters MS, Ragheb DRT, Matthews KA, Rajaram K, Mishra S, McFadden GI, Sinnis P, Prigge ST.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2604-E2613. doi: 10.1073/pnas.1800717115. Epub 2018 Feb 26.

11.

Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell.

Andreadaki M, Hanssen E, Deligianni E, Claudet C, Wengelnik K, Mollard V, McFadden GI, Abkarian M, Braun-Breton C, Siden-Kiamos I.

Sci Rep. 2018 Feb 23;8(1):3543. doi: 10.1038/s41598-018-21801-3.

12.

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR.

Biochemistry. 2018 Feb 20;57(7):1096-1107. doi: 10.1021/acs.biochem.7b01171. Epub 2018 Feb 6.

PMID:
29227673
13.

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells.

Rahman MM, Bagdassarian E, Ali MAM, McFadden G.

Sci Rep. 2017 Nov 16;7(1):15710. doi: 10.1038/s41598-017-15941-1.

14.

Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.

Uddin T, McFadden GI, Goodman CD.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01161-17. doi: 10.1128/AAC.01161-17. Print 2018 Jan.

15.

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.

16.

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Yeoh LM, Goodman CD, Mollard V, McFadden GI, Ralph SA.

BMC Genomics. 2017 Sep 18;18(1):734. doi: 10.1186/s12864-017-4100-0.

17.

A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites.

Sayers CP, Mollard V, Buchanan HD, McFadden GI, Goodman CD.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12789. Epub 2017 Nov 9.

PMID:
28902970
18.

The cryptomonad nucleomorph.

McFadden GI.

Protoplasma. 2017 Sep;254(5):1903-1907. doi: 10.1007/s00709-017-1153-5. Epub 2017 Aug 21.

PMID:
28828570
19.

Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes.

Curra C, McMillan PJ, Spanos L, Mollard V, Deligianni E, McFadden G, Tilley L, Siden-Kiamos I.

Exp Parasitol. 2017 Oct;181:82-87. doi: 10.1016/j.exppara.2017.08.001. Epub 2017 Aug 10.

PMID:
28803903
20.

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O.

Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030.

22.

Evolution: Of X-Cells and X-Men.

McFadden GI, Later N.

Curr Biol. 2017 Jun 5;27(11):R408-R409. doi: 10.1016/j.cub.2017.04.033.

23.

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor.

Lilly CL, Villa NY, Lemos de Matos A, Ali HM, Dhillon JS, Hofland T, Rahman MM, Chan W, Bogen B, Cogle C, McFadden G.

Mol Ther Oncolytics. 2016 Dec 14;4:31-40. doi: 10.1016/j.omto.2016.12.002. eCollection 2017 Mar 17.

24.
25.

Erratum to: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite.

Goodman CD, Austarheim I, Mollard V, Mikolo B, Malterud KE, McFadden GI, Wangensteen H.

Malar J. 2016 Nov 17;15(1):560. No abstract available.

26.

Targeting Protein Translation in Organelles of the Apicomplexa.

Goodman CD, Pasaje CFA, Kennedy K, McFadden GI, Ralph SA.

Trends Parasitol. 2016 Dec;32(12):953-965. doi: 10.1016/j.pt.2016.09.011. Epub 2016 Oct 25. Review.

PMID:
27793563
27.

Is the Mitochondrion a Good Malaria Drug Target?

Goodman CD, Buchanan HD, McFadden GI.

Trends Parasitol. 2017 Mar;33(3):185-193. doi: 10.1016/j.pt.2016.10.002. Epub 2016 Oct 24. Review.

PMID:
27789127
28.

The apicoplast: now you see it, now you don't.

McFadden GI, Yeh E.

Int J Parasitol. 2017 Feb;47(2-3):137-144. doi: 10.1016/j.ijpara.2016.08.005. Epub 2016 Oct 20. Review.

29.

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2016 Oct 18;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. Epub 2016 Sep 27.

30.

Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite.

Goodman CD, Austarheim I, Mollard V, Mikolo B, Malterud KE, McFadden GI, Wangensteen H.

Malar J. 2016 Sep 20;15:481. doi: 10.1186/s12936-016-1533-x. Erratum in: Malar J. 2016 Nov 17;15(1):560.

31.

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

Amiar S, MacRae JI, Callahan DL, Dubois D, van Dooren GG, Shears MJ, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y, Botté CY.

PLoS Pathog. 2016 Aug 4;12(8):e1005765. doi: 10.1371/journal.ppat.1005765. eCollection 2016 Aug.

32.

Vaccinia virus dissemination requires p21-activated kinase 1.

Andrade LG, Albarnaz JD, Mügge FL, David BA, Abrahão JS, da Fonseca FG, Kroon EG, Menezes GB, McFadden G, Bonjardim CA.

Arch Virol. 2016 Nov;161(11):2991-3002. doi: 10.1007/s00705-016-2996-3. Epub 2016 Jul 27.

PMID:
27465567
33.

The Import of Proteins into the Mitochondrion of Toxoplasma gondii.

van Dooren GG, Yeoh LM, Striepen B, McFadden GI.

J Biol Chem. 2016 Sep 9;291(37):19335-50. doi: 10.1074/jbc.M116.725069. Epub 2016 Jul 25.

34.

Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum.

Lim L, Sayers CP, Goodman CD, McFadden GI.

PLoS One. 2016 Jul 21;11(7):e0159603. doi: 10.1371/journal.pone.0159603. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0161420.

35.

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

Morse D, Webster W, Kalanon M, Langsley G, McFadden GI.

PLoS One. 2016 Jun 27;11(6):e0158174. doi: 10.1371/journal.pone.0158174. eCollection 2016.

36.

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.

37.

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes.

Goodman CD, Siregar JE, Mollard V, Vega-Rodríguez J, Syafruddin D, Matsuoka H, Matsuzaki M, Toyama T, Sturm A, Cozijnsen A, Jacobs-Lorena M, Kita K, Marzuki S, McFadden GI.

Science. 2016 Apr 15;352(6283):349-53. doi: 10.1126/science.aad9279.

38.

Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic Strategies.

Villa NY, Rahman MM, McFadden G, Cogle CR.

Viruses. 2016 Mar 22;8(3):85. doi: 10.3390/v8030085. Review.

39.

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma.

Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA.

Neuro Oncol. 2016 Mar 8. pii: now006. [Epub ahead of print]

40.

Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates.

Peng C, Haller SL, Rahman MM, McFadden G, Rothenburg S.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3855-60. doi: 10.1073/pnas.1515613113. Epub 2016 Feb 22.

41.

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells.

Villa NY, Bais S, Chan WM, Meacham AM, Wise E, Rahman MM, Moreb JS, Rosenau EH, Wingard JR, McFadden G, Cogle CR.

Cytotherapy. 2016 Mar;18(3):465-80. doi: 10.1016/j.jcyt.2015.12.007.

42.

The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice.

Kalanon M, Bargieri D, Sturm A, Matthews K, Ghosh S, Goodman CD, Thiberge S, Mollard V, McFadden GI, Ménard R, de Koning-Ward TF.

Cell Microbiol. 2016 Mar;18(3):399-412. doi: 10.1111/cmi.12520. Epub 2015 Oct 14.

PMID:
26347246
43.

Editorial overview: Oncolytic viruses--replicating virus therapeutics for the treatment of cancer.

Bell JC, McFadden G.

Curr Opin Virol. 2015 Aug;13:viii-ix. doi: 10.1016/j.coviro.2015.07.005. Epub 2015 Aug 7. No abstract available.

PMID:
26260227
44.

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG.

BMC Biol. 2015 Jul 18;13:52. doi: 10.1186/s12915-015-0162-0.

45.

The Curious Road from Basic Pathogen Research to Clinical Translation.

McFadden G.

PLoS Pathog. 2015 Jun 25;11(6):e1004997. doi: 10.1371/journal.ppat.1004997. eCollection 2015 Jun. No abstract available.

46.

Predicted Role of NAD Utilization in the Control of Circadian Rhythms during DNA Damage Response.

Luna A, McFadden GB, Aladjem MI, Kohn KW.

PLoS Comput Biol. 2015 May 28;11(5):e1004144. doi: 10.1371/journal.pcbi.1004144. eCollection 2015 May.

47.

Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells.

Villa NY, Wasserfall CH, Meacham AM, Wise E, Chan W, Wingard JR, McFadden G, Cogle CR.

Blood. 2015 Jun 11;125(24):3778-88. doi: 10.1182/blood-2014-07-587329. Epub 2015 Apr 22.

48.

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate.

Gornik SG, Febrimarsa, Cassin AM, MacRae JI, Ramaprasad A, Rchiad Z, McConville MJ, Bacic A, McFadden GI, Pain A, Waller RF.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5767-72. doi: 10.1073/pnas.1423400112. Epub 2015 Apr 20.

49.

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

Yeoh LM, Goodman CD, Hall NE, van Dooren GG, McFadden GI, Ralph SA.

Nucleic Acids Res. 2015 May 19;43(9):4661-75. doi: 10.1093/nar/gkv311. Epub 2015 Apr 13.

50.

Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease.

Kim M, Rahman MM, Cogle CR, McFadden G.

Biochem Biophys Res Commun. 2015 Jul 10;462(4):283-7. doi: 10.1016/j.bbrc.2015.03.146. Epub 2015 Apr 2.

PMID:
25843801

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