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Items: 50


The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.

McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201820843. doi: 10.1073/pnas.1820843116. [Epub ahead of print]


Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Clifford RL, Patel J, MacIsaac JL, McEwen LM, Johnson SR, Shaw D, Knox AJ, Hackett TL, Kobor MS.

Sci Rep. 2019 Oct 8;9(1):14409. doi: 10.1038/s41598-019-50873-y.


A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.

Hari Dass SA, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP.

EBioMedicine. 2019 Apr;42:188-202. doi: 10.1016/j.ebiom.2019.03.051. Epub 2019 Mar 26.


Electronic Physician Profiles: Developing an Interactive Web-Based Report for Physicians at Island Health.

McEwen LM, O'Donnell JC, Lifoawing L, Matias D, Wagar B.

Stud Health Technol Inform. 2019;257:310-313.


Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.

Husquin LT, Rotival M, Fagny M, Quach H, Zidane N, McEwen LM, MacIsaac JL, Kobor MS, Aschard H, Patin E, Quintana-Murci L.

Genome Biol. 2018 Dec 18;19(1):222. doi: 10.1186/s13059-018-1601-3.


The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Bush NR, Edgar RD, Park M, MacIsaac JL, McEwen LM, Adler NE, Essex MJ, Kobor MS, Boyce WT.

Epigenomics. 2018 Nov;10(11):1445-1461. doi: 10.2217/epi-2018-0042. Epub 2018 Oct 23.


Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.

McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS.

Clin Epigenetics. 2018 Oct 16;10(1):123. doi: 10.1186/s13148-018-0556-2.


PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.

Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O'Donnell KJ.

BMC Bioinformatics. 2018 Aug 8;19(1):295. doi: 10.1186/s12859-018-2289-9.


The early care environment and DNA methylome variation in childhood.

Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ; Mavan Study Team.

Dev Psychopathol. 2018 Aug;30(3):891-903. doi: 10.1017/S0954579418000627.


Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes.

Austin MK, Chen E, Ross KM, McEwen LM, Maclsaac JL, Kobor MS, Miller GE.

Psychoneuroendocrinology. 2018 Nov;97:131-134. doi: 10.1016/j.psyneuen.2018.07.007. Epub 2018 Jul 5.


Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ.

Clin Epigenetics. 2018 Mar 5;10:32. doi: 10.1186/s13148-018-0464-5. eCollection 2018.


Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.

Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT.

Epigenetics. 2018;13(1):19-32. doi: 10.1080/15592294.2017.1411443. Epub 2018 Jan 30.


DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.

Transl Psychiatry. 2018 Jan 10;8(1):15. doi: 10.1038/s41398-017-0063-9.


Epigenetic correlates of neonatal contact in humans.

Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS.

Dev Psychopathol. 2017 Dec;29(5):1517-1538. doi: 10.1017/S0954579417001213.


DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.

McEwen LM, Gatev EG, Jones MJ, MacIsaac JL, McAllister MM, Goulding RE, Madden KM, Dawes MG, Kobor MS, Ashe MC.

Appl Physiol Nutr Metab. 2018 Mar;43(3):233-239. doi: 10.1139/apnm-2017-0436. Epub 2017 Oct 19.


DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.

Verschoor CP, McEwen LM, Kobor MS, Loeb MB, Bowdish DME.

Exp Gerontol. 2018 May;105:47-52. doi: 10.1016/j.exger.2017.10.010. Epub 2017 Oct 12.


Exploring genetic influences underlying acute aerobic exercise effects on motor learning.

Mang CS, McEwen LM, MacIsaac JL, Snow NJ, Campbell KL, Kobor MS, Ross CJD, Boyd LA.

Sci Rep. 2017 Sep 21;7(1):12123. doi: 10.1038/s41598-017-12422-3.


Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume.

Davis EG, Humphreys KL, McEwen LM, Sacchet MD, Camacho MC, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH.

Transl Psychiatry. 2017 Aug 29;7(8):e1223. doi: 10.1038/tp.2017.188.


Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.

Morin AM, Gatev E, McEwen LM, MacIsaac JL, Lin DTS, Koen N, Czamara D, Räikkönen K, Zar HJ, Koenen K, Stein DJ, Kobor MS, Jones MJ.

Clin Epigenetics. 2017 Jul 25;9:75. doi: 10.1186/s13148-017-0370-2. eCollection 2017.


The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.

Verschoor CP, McEwen LM, Kohli V, Wolfson C, Bowdish DM, Raina P, Kobor MS, Balion C.

BMC Genet. 2017 Jun 21;18(1):57. doi: 10.1186/s12863-017-0525-3.


Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.

Gopalan S, Carja O, Fagny M, Patin E, Myrick JW, McEwen LM, Mah SM, Kobor MS, Froment A, Feldman MW, Quintana-Murci L, Henn BM.

Genetics. 2017 Jul;206(3):1659-1674. doi: 10.1534/genetics.116.195594. Epub 2017 May 22.


Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.

McEwen LM, Morin AM, Edgar RD, MacIsaac JL, Jones MJ, Dow WH, Rosero-Bixby L, Kobor MS, Rehkopf DH.

Epigenetics Chromatin. 2017 Apr 27;10:21. doi: 10.1186/s13072-017-0128-2. eCollection 2017.


Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.

Clifford RL, Jones MJ, MacIsaac JL, McEwen LM, Goodman SJ, Mostafavi S, Kobor MS, Carlsten C.

J Allergy Clin Immunol. 2017 Jan;139(1):112-121. doi: 10.1016/j.jaci.2016.03.046. Epub 2016 May 10.


DNA methylation profiling in human Huntington's disease brain.

De Souza RA, Islam SA, McEwen LM, Mathelier A, Hill A, Mah SM, Wasserman WW, Kobor MS, Leavitt BR.

Hum Mol Genet. 2016 May 15;25(10):2013-2030. Epub 2016 Mar 6.


The epigenomic landscape of African rainforest hunter-gatherers and farmers.

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L.

Nat Commun. 2015 Nov 30;6:10047. doi: 10.1038/ncomms10047.


Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.

Beery AK, McEwen LM, MacIsaac JL, Francis DD, Kobor MS.

Horm Behav. 2016 Jan;77:42-52. doi: 10.1016/j.yhbeh.2015.05.022. Epub 2015 Jun 27.


A pooling-based approach to mapping genetic variants associated with DNA methylation.

Kaplow IM, MacIsaac JL, Mah SM, McEwen LM, Kobor MS, Fraser HB.

Genome Res. 2015 Jun;25(6):907-17. doi: 10.1101/gr.183749.114. Epub 2015 Apr 24.


Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.

Chen L, Pan H, Tuan TA, Teh AL, MacIsaac JL, Mah SM, McEwen LM, Li Y, Chen H, Broekman BF, Buschdorf JP, Chong YS, Kwek K, Saw SM, Gluckman PD, Fortier MV, Rifkin-Graboi A, Kobor MS, Qiu A, Meaney MJ, Holbrook JD; Gusto Study Group.

Dev Psychopathol. 2015 Feb;27(1):137-50. doi: 10.1017/S0954579414001357.


The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.

Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stünkel W, Kobor MS, Meaney MJ, Gluckman PD, Holbrook JD.

Genome Res. 2014 Jul;24(7):1064-74. doi: 10.1101/gr.171439.113. Epub 2014 Apr 7.


Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in Down syndrome.

Jones MJ, Farré P, McEwen LM, Macisaac JL, Watt K, Neumann SM, Emberly E, Cynader MS, Virji-Babul N, Kobor MS.

BMC Med Genomics. 2013 Dec 27;6:58. doi: 10.1186/1755-8794-6-58.


Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children.

Ippoliti F, Ragno V, Del Nero A, McEwen LM, McEwen H, Businco L.

Allerg Immunol (Paris). 1997 May;29(5):120, 123-5.


Controlled trial of hyposensitisation in children with food-induced hyperkinetic syndrome.

Egger J, Stolla A, McEwen LM.

Lancet. 1992 May 9;339(8802):1150-3.


Guidelines on HIV infection.

McEwen LM.

BMJ. 1989 Jul 15;299(6692):182-3. No abstract available.


Indications for homograft tympanoplasty--a clinical study.

Lesinski SG, McEwen LM.

Otolaryngol Clin North Am. 1977 Oct;10(3):507-15. No abstract available.


Letter: Adrenaline in treatment of anaphylaxis.

McEwen LM.

Br Med J. 1975 Nov 29;4(5995):519. No abstract available.


Letter: Corticosteroids in treatment of anaphylaxis.

McEwen LM.

Br Med J. 1975 Sep 13;3(5984):649. No abstract available.


Enzyme potentiated hyposensitization: V. Five case reports of patients with acute food allergy.

McEwen LM.

Ann Allergy. 1975 Aug;35(2):98-103. No abstract available.


Enzyme-potentiated hyposensitization. 3. Control by sugars and diols of the immunological effect of beta glucuronidase in mice and patients with hay fever.

McEwen LM, Nicholson M, Kitchen I, White S.

Ann Allergy. 1973 Nov;31(11):543-50. No abstract available.


Trimethoprim-sulphamethoxazole mixture in pregnancy.

McEwen LM.

Br Med J. 1971 Nov 20;4(5785):490-1. No abstract available.


Neuropathy after clioquinol.

McEwen LM.

Br Med J. 1971 Oct 16;4(5780):169-70. No abstract available.


The use of a dietary and antibacterial regime in the management of intrinsic allergy.

McEwen LM, Constantinopoulos P.

Int Arch Allergy Appl Immunol. 1971;41(1):160. No abstract available.


The use of a dietary and antibacterial regime in the management of intrinsic allergy.

McEwen LM, Constantinopoulos P.

Ann Allergy. 1970 Jun;28(6):256-66. No abstract available.


Skin reactions to dust and mites.

Frankland AW, McEwen LM, Feinberg JG.

Int Arch Allergy Appl Immunol. 1970;37(4):351-6. No abstract available.


Skin test in the investigation of house dust allergy.

McEwen LM.

Acta Allergol. 1968 May;23(2):136-45. No abstract available.


The treatment of allergic rhinitis and asthma by percutaneous desensitisation.

Wilson CW, Black JH, McEwen LM, Ganderton MA.

J Ir Med Assoc. 1967 Jun;60(360):205-6. No abstract available.


The Schultz-Dale Anaphylactic Test for Carcinoma Antigen.

McEwen LM.

Br Med J. 1959 Oct 3;2(5152):615-7. No abstract available.


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