Sort by
Items per page

Send to

Choose Destination

Search results

Items: 24


The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.

Katsinelos T, Tuck BJ, Mukadam AS, McEwan WA.

Front Immunol. 2019 May 31;10:1139. doi: 10.3389/fimmu.2019.01139. eCollection 2019. Review.


Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away.

Clift D, So C, McEwan WA, James LC, Schuh M.

Nat Protoc. 2019 Aug;14(8):2596. doi: 10.1038/s41596-018-0092-8.


Acute and rapid degradation of endogenous proteins by Trim-Away.

Clift D, So C, McEwan WA, James LC, Schuh M.

Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. Erratum in: Nat Protoc. 2018 Nov 30;:.


IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.

Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC.

Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335.


Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.


A Method for the Acute and Rapid Degradation of Endogenous Proteins.

Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.

Cell. 2017 Dec 14;171(7):1692-1706.e18. doi: 10.1016/j.cell.2017.10.033. Epub 2017 Nov 16.


Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3.


HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.

Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC.

Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.


TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.

Watkinson RE, McEwan WA, Tam JC, Vaysburd M, James LC.

PLoS Pathog. 2015 Oct 27;11(10):e1005253. doi: 10.1371/journal.ppat.1005253. eCollection 2015 Oct.


TRIM21-dependent intracellular antibody neutralization of virus infection.

McEwan WA, James LC.

Prog Mol Biol Transl Sci. 2015;129:167-87. doi: 10.1016/bs.pmbts.2014.10.006. Epub 2014 Dec 12. Review.


Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC.

PLoS Pathog. 2014 Oct 30;10(10):e1004459. doi: 10.1371/journal.ppat.1004459. eCollection 2014 Oct.


Intracellular sensing of complement C3 activates cell autonomous immunity.

Tam JC, Bidgood SR, McEwan WA, James LC.

Science. 2014 Sep 5;345(6201):1256070. doi: 10.1126/science.1256070. Epub 2014 Sep 4.


Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells.

Bidgood SR, Tam JC, McEwan WA, Mallery DL, James LC.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8. doi: 10.1073/pnas.1410980111. Epub 2014 Aug 28.


Intracellular antibody immunity.

Watkinson RE, McEwan WA, James LC.

J Clin Immunol. 2014 Jul;34 Suppl 1:S30-4. doi: 10.1007/s10875-014-0017-4. Epub 2014 Apr 11. Review.


Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.

McEwan WA, Tam JC, Watkinson RE, Bidgood SR, Mallery DL, James LC.

Nat Immunol. 2013 Apr;14(4):327-36. doi: 10.1038/ni.2548. Epub 2013 Mar 3.


AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.

Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22.


Regulation of virus neutralization and the persistent fraction by TRIM21.

McEwan WA, Hauler F, Williams CR, Bidgood SR, Mallery DL, Crowther RA, James LC.

J Virol. 2012 Aug;86(16):8482-91. doi: 10.1128/JVI.00728-12. Epub 2012 May 30.


Diverse HIV viruses are targeted by a conformationally dynamic antiviral.

Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC.

Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6. doi: 10.1038/nsmb.2253.


Intracellular antibody-mediated immunity and the role of TRIM21.

McEwan WA, Mallery DL, Rhodes DA, Trowsdale J, James LC.

Bioessays. 2011 Nov;33(11):803-9. doi: 10.1002/bies.201100093. Epub 2011 Aug 29.


Restriction of the felid lentiviruses by a synthetic feline TRIM5-CypA fusion.

Dietrich I, McEwan WA, Hosie MJ, Willett BJ.

Vet Immunol Immunopathol. 2011 Oct 15;143(3-4):235-42. doi: 10.1016/j.vetimm.2011.06.017. Epub 2011 Jun 12. Review.


Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).

Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19985-90. doi: 10.1073/pnas.1014074107. Epub 2010 Nov 2.


Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion.

Dietrich I, Macintyre A, McMonagle E, Price AJ, James LC, McEwan WA, Hosie MJ, Willett BJ.

J Virol. 2010 Sep;84(17):8980-5. doi: 10.1128/JVI.00858-10. Epub 2010 Jun 16.


Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat.

McEwan WA, Schaller T, Ylinen LM, Hosie MJ, Towers GJ, Willett BJ.

J Virol. 2009 Aug;83(16):8270-5. doi: 10.1128/JVI.00670-09. Epub 2009 Jun 3.


Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors.

McEwan WA, McMonagle EL, Logan N, Serra RC, Kat P, Vandewoude S, Hosie MJ, Willett BJ.

J Virol. 2008 Nov;82(21):10953-8. doi: 10.1128/JVI.01312-08. Epub 2008 Aug 20.

Supplemental Content

Loading ...
Support Center