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Items: 1 to 50 of 159

1.

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.

Edgar RJ, van Hensbergen VP, Ruda A, Turner AG, Deng P, Le Breton Y, El-Sayed NM, Belew AT, McIver KS, McEwan AG, Morris AJ, Lambeau G, Walker MJ, Rush JS, Korotkov KV, Widmalm G, van Sorge NM, Korotkova N.

Nat Chem Biol. 2019 May;15(5):463-471. doi: 10.1038/s41589-019-0251-4. Epub 2019 Apr 1.

PMID:
30936502
2.

Metabolic analyses reveal common adaptations in two invasive Haemophilus influenzae strains.

Muda NM, Nasreen M, Dhouib R, Hosmer J, Hill J, Mahawar M, Schirra HJ, McEwan AG, Kappler U.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz015. doi: 10.1093/femspd/ftz015.

PMID:
30915434
3.

Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination.

Stocks CJ, Phan MD, Achard MES, Nhu NTK, Condon ND, Gawthorne JA, Lo AW, Peters KM, McEwan AG, Kapetanovic R, Schembri MA, Sweet MJ.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6341-6350. doi: 10.1073/pnas.1820870116. Epub 2019 Mar 7.

4.

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress.

Turner AG, Djoko KY, Ong CY, Barnett TC, Walker MJ, McEwan AG.

Biochem J. 2019 Feb 14;476(3):595-611. doi: 10.1042/BCJ20180902.

PMID:
30670571
5.

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.

Bohlmann L, De Oliveira DMP, El-Deeb IM, Brazel EB, Harbison-Price N, Ong CY, Rivera-Hernandez T, Ferguson SA, Cork AJ, Phan MD, Soderholm AT, Davies MR, Nimmo GR, Dougan G, Schembri MA, Cook GM, McEwan AG, von Itzstein M, McDevitt CA, Walker MJ.

MBio. 2018 Dec 11;9(6). pii: e02391-18. doi: 10.1128/mBio.02391-18.

6.

Handling of nutrient copper in the bacterial envelope.

Stewart LJ, Thaqi D, Kobe B, McEwan AG, Waldron KJ, Djoko KY.

Metallomics. 2019 Jan 23;11(1):50-63. doi: 10.1039/c8mt00218e. Review.

PMID:
30334058
7.

New Insights into the Role of Zinc Acquisition and Zinc Tolerance in Group A Streptococcal Infection.

Ong CY, Berking O, Walker MJ, McEwan AG.

Infect Immun. 2018 May 22;86(6). pii: e00048-18. doi: 10.1128/IAI.00048-18. Print 2018 Jun.

8.

Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

Djoko KY, Achard MES, Phan MD, Lo AW, Miraula M, Prombhul S, Hancock SJ, Peters KM, Sidjabat HE, Harris PN, Mitić N, Walsh TR, Anderson GJ, Shafer WM, Paterson DL, Schenk G, McEwan AG, Schembri MA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02280-17. doi: 10.1128/AAC.02280-17. Print 2018 Feb.

9.

Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.

Marsh JW, Djoko KY, McEwan AG, Huston WM.

Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx084.

PMID:
28830076
10.

Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli.

Djoko KY, Phan MD, Peters KM, Walker MJ, Schembri MA, McEwan AG.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6818-6823. doi: 10.1073/pnas.1620232114. Epub 2017 Jun 13.

11.

Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae.

Turner AG, Ong CY, Walker MJ, Djoko KY, McEwan AG.

Adv Microb Physiol. 2017;70:123-191. doi: 10.1016/bs.ampbs.2017.01.002. Epub 2017 Feb 20. Review.

PMID:
28528647
12.

The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes.

Turner AG, Ong CY, Djoko KY, West NP, Davies MR, McEwan AG, Walker MJ.

Infect Immun. 2017 May 23;85(6). pii: e00140-17. doi: 10.1128/IAI.00140-17. Print 2017 Jun.

13.

Draft Genome Sequences of Three Nontypeable Strains of Haemophilus influenzae, C188, R535, and 1200, Isolated from Different Types of Disease.

Kappler U, Dhouib R, Nair RP, McEwan AG.

Genome Announc. 2017 Mar 23;5(12). pii: e00035-17. doi: 10.1128/genomeA.00035-17.

14.

A Novel, Molybdenum-Containing Methionine Sulfoxide Reductase Supports Survival of Haemophilus influenzae in an In vivo Model of Infection.

Dhouib R, Othman DS, Lin V, Lai XJ, Wijesinghe HG, Essilfie AT, Davis A, Nasreen M, Bernhardt PV, Hansbro PM, McEwan AG, Kappler U.

Front Microbiol. 2016 Nov 14;7:1743. eCollection 2016.

15.

The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection.

Shepherd M, Achard ME, Idris A, Totsika M, Phan MD, Peters KM, Sarkar S, Ribeiro CA, Holyoake LV, Ladakis D, Ulett GC, Sweet MJ, Poole RK, McEwan AG, Schembri MA.

Sci Rep. 2016 Oct 21;6:35285. doi: 10.1038/srep35285.

16.

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region.

Couñago RM, Chen NH, Chang CW, Djoko KY, McEwan AG, Kobe B.

Nucleic Acids Res. 2016 Aug 19;44(14):6981-93. doi: 10.1093/nar/gkw543. Epub 2016 Jun 15.

17.

Functional analysis of an feoB mutant in Clostridium perfringens strain 13.

Awad MM, Cheung JK, Tan JE, McEwan AG, Lyras D, Rood JI.

Anaerobe. 2016 Oct;41:10-17. doi: 10.1016/j.anaerobe.2016.05.005. Epub 2016 May 10.

PMID:
27178230
18.

Formaldehyde Stress Responses in Bacterial Pathogens.

Chen NH, Djoko KY, Veyrier FJ, McEwan AG.

Front Microbiol. 2016 Mar 3;7:257. doi: 10.3389/fmicb.2016.00257. eCollection 2016. Review.

19.

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.

Kapetanovic R, Bokil NJ, Achard ME, Ong CL, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ.

FASEB J. 2016 May;30(5):1901-12. doi: 10.1096/fj.201500061. Epub 2016 Feb 2.

PMID:
26839376
20.

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

Zhang MM, Ong CL, Walker MJ, McEwan AG.

Pathog Dis. 2016 Mar;74(2). pii: ftv122. doi: 10.1093/femspd/ftv122. Epub 2015 Dec 23.

PMID:
26702634
21.

Maturation of molybdoenzymes and its influence on the pathogenesis of non-typeable Haemophilus influenzae.

Dhouib R, Pg Othman DS, Essilfie AT, Hansbro PM, Hanson JO, McEwan AG, Kappler U.

Front Microbiol. 2015 Nov 5;6:1219. doi: 10.3389/fmicb.2015.01219. eCollection 2015.

22.

Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.

Djoko KY, Goytia MM, Donnelly PS, Schembri MA, Shafer WM, McEwan AG.

Antimicrob Agents Chemother. 2015 Oct;59(10):6444-53. doi: 10.1128/AAC.01289-15. Epub 2015 Aug 3.

23.

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.

24.

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

Djoko KY, Ong CL, Walker MJ, McEwan AG.

J Biol Chem. 2015 Jul 31;290(31):18954-61. doi: 10.1074/jbc.R115.647099. Epub 2015 Jun 8. Review.

25.

A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria.

Jen FE, Djoko KY, Bent SJ, Day CJ, McEwan AG, Jennings MP.

FASEB J. 2015 Sep;29(9):3828-38. doi: 10.1096/fj.15-270751. Epub 2015 Jun 1.

PMID:
26031293
26.

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

Ong CL, Walker MJ, McEwan AG.

Sci Rep. 2015 Jun 1;5:10799. doi: 10.1038/srep10799.

27.

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence.

Turner AG, Ong CL, Gillen CM, Davies MR, West NP, McEwan AG, Walker MJ.

MBio. 2015 Mar 24;6(2). pii: e00278-15. doi: 10.1128/mBio.00278-15.

28.

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach.

Bajaj M, Mamidyala SK, Zuegg J, Begg SL, Ween MP, Luo Z, Huang JX, McEwan AG, Kobe B, Paton JC, McDevitt CA, Cooper MA.

ACS Chem Biol. 2015 Jun 19;10(6):1511-20. doi: 10.1021/cb501032x. Epub 2015 Mar 30.

PMID:
25786639
29.

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.

Begg SL, Eijkelkamp BA, Luo Z, Couñago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA.

Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418.

30.

Electrochemically mediated enantioselective reduction of chiral sulfoxides.

Chen KI, Challinor VL, Kielmann L, Sharpe PC, De Voss JJ, Kappler U, McEwan AG, Bernhardt PV.

J Biol Inorg Chem. 2015 Mar;20(2):395-402. doi: 10.1007/s00775-014-1215-5. Epub 2014 Nov 20.

PMID:
25410832
31.

Inhibition of respiratory complex I by copper(ii)-bis(thiosemicarbazonato) complexes.

Djoko KY, Donnelly PS, McEwan AG.

Metallomics. 2014 Dec;6(12):2250-9. doi: 10.1039/c4mt00226a. Epub 2014 Nov 4.

PMID:
25366244
32.

A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells.

Atack JM, Ibranovic I, Ong CL, Djoko KY, Chen NH, Vanden Hoven R, Jennings MP, Edwards JL, McEwan AG.

J Infect Dis. 2014 Oct 15;210(8):1311-8. doi: 10.1093/infdis/jiu230. Epub 2014 Apr 15.

33.

Metabolic versatility in Haemophilus influenzae: a metabolomic and genomic analysis.

Othman DS, Schirra H, McEwan AG, Kappler U.

Front Microbiol. 2014 Mar 4;5:69. doi: 10.3389/fmicb.2014.00069. eCollection 2014.

34.

Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae.

Eijkelkamp BA, Morey JR, Ween MP, Ong CL, McEwan AG, Paton JC, McDevitt CA.

PLoS One. 2014 Feb 18;9(2):e89427. doi: 10.1371/journal.pone.0089427. eCollection 2014.

35.

An antimicrobial role for zinc in innate immune defense against group A streptococcus.

Ong CL, Gillen CM, Barnett TC, Walker MJ, McEwan AG.

J Infect Dis. 2014 May 15;209(10):1500-8. doi: 10.1093/infdis/jiu053. Epub 2014 Jan 20.

PMID:
24449444
36.

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.

Djoko KY, Paterson BM, Donnelly PS, McEwan AG.

Metallomics. 2014 Apr;6(4):854-63. doi: 10.1039/c3mt00348e.

PMID:
24435165
37.

Imperfect coordination chemistry facilitates metal ion release in the Psa permease.

Couñago RM, Ween MP, Begg SL, Bajaj M, Zuegg J, O'Mara ML, Cooper MA, McEwan AG, Paton JC, Kobe B, McDevitt CA.

Nat Chem Biol. 2014 Jan;10(1):35-41. doi: 10.1038/nchembio.1382. Epub 2013 Nov 10.

PMID:
24212134
38.

Antimicrobial action of copper is amplified via inhibition of heme biosynthesis.

Djoko KY, McEwan AG.

ACS Chem Biol. 2013 Oct 18;8(10):2217-23. doi: 10.1021/cb4002443. Epub 2013 Aug 22.

PMID:
23895035
39.

An antioxidant role for catecholate siderophores in Salmonella.

Achard ME, Chen KW, Sweet MJ, Watts RE, Schroder K, Schembri MA, McEwan AG.

Biochem J. 2013 Sep 15;454(3):543-9.

PMID:
23805839
40.

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper.

Stafford SL, Bokil NJ, Achard ME, Kapetanovic R, Schembri MA, McEwan AG, Sweet MJ.

Biosci Rep. 2013 Jul 16;33(4). pii: e00049. doi: 10.1042/BSR20130014. Review.

41.

Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium.

Shepherd M, Heras B, Achard ME, King GJ, Argente MP, Kurth F, Taylor SL, Howard MJ, King NP, Schembri MA, McEwan AG.

Antioxid Redox Signal. 2013 Nov 1;19(13):1494-506. doi: 10.1089/ars.2012.4939. Epub 2013 Aug 9.

42.

Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria.

Atack JM, Srikhanta YN, Djoko KY, Welch JP, Hasri NH, Steichen CT, Vanden Hoven RN, Grimmond SM, Othman DS, Kappler U, Apicella MA, Jennings MP, Edwards JL, McEwan AG.

J Bacteriol. 2013 Jun;195(11):2632-41. doi: 10.1128/JB.02062-12. Epub 2013 Apr 5.

43.

Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR.

Ong CL, Potter AJ, Trappetti C, Walker MJ, Jennings MP, Paton JC, McEwan AG.

Infect Immun. 2013 Feb;81(2):421-9. doi: 10.1128/IAI.00805-12. Epub 2012 Nov 26.

44.

A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms.

Chen NH, Couñago RM, Djoko KY, Jennings MP, Apicella MA, Kobe B, McEwan AG.

Antioxid Redox Signal. 2013 Mar 1;18(7):743-55. doi: 10.1089/ars.2012.4749. Epub 2012 Nov 20.

45.

A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae.

Kidd SP, Jiang D, Tikhomirova A, Jennings MP, McEwan AG.

BMC Microbiol. 2012 Jul 31;12:159. doi: 10.1186/1471-2180-12-159.

46.

Copper redistribution in murine macrophages in response to Salmonella infection.

Achard ME, Stafford SL, Bokil NJ, Chartres J, Bernhardt PV, Schembri MA, Sweet MJ, McEwan AG.

Biochem J. 2012 May 15;444(1):51-7. doi: 10.1042/BJ20112180.

PMID:
22369063
47.

Phenotypic characterization of a copA mutant of Neisseria gonorrhoeae identifies a link between copper and nitrosative stress.

Djoko KY, Franiek JA, Edwards JL, Falsetta ML, Kidd SP, Potter AJ, Chen NH, Apicella MA, Jennings MP, McEwan AG.

Infect Immun. 2012 Mar;80(3):1065-71. doi: 10.1128/IAI.06163-11. Epub 2011 Dec 19.

48.

A molecular mechanism for bacterial susceptibility to zinc.

McDevitt CA, Ogunniyi AD, Valkov E, Lawrence MC, Kobe B, McEwan AG, Paton JC.

PLoS Pathog. 2011 Nov;7(11):e1002357. doi: 10.1371/journal.ppat.1002357. Epub 2011 Nov 3.

49.

A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae.

Kidd SP, Djoko KY, Ng J, Argente MP, Jennings MP, McEwan AG.

Metallomics. 2011 Oct;3(10):1009-18. doi: 10.1039/c1mt00127b. Epub 2011 Sep 23.

PMID:
21952667
50.

The Composition and Metabolic Phenotype of Neisseria gonorrhoeae Biofilms.

Falsetta ML, Steichen CT, McEwan AG, Cho C, Ketterer M, Shao J, Hunt J, Jennings MP, Apicella MA.

Front Microbiol. 2011 Apr 18;2:75. doi: 10.3389/fmicb.2011.00075. eCollection 2011.

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