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Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin-dependent inflammation and thrombosis.

Setiadi H, Yago T, Liu Z, McEver RP.

Blood Adv. 2019 Jan 22;3(2):168-183. doi: 10.1182/bloodadvances.2018026294.


Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice.

Yago T, Liu Z, Ahamed J, McEver RP.

Blood. 2018 Sep 27;132(13):1426-1437. doi: 10.1182/blood-2018-05-850859. Epub 2018 Aug 1.


Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.

Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L.

JCI Insight. 2018 Jul 26;3(14). pii: 121596. doi: 10.1172/jci.insight.121596. eCollection 2018 Jul 26.


Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils.

Yago T, Zhang N, Zhao L, Abrams CS, McEver RP.

Blood Adv. 2018 Apr 10;2(7):731-744. doi: 10.1182/bloodadvances.2017015602.


C-Type Lectins.

Cummings RD, McEver RP.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 34.


Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.

Li Y, Fu J, Ling Y, Yago T, McDaniel JM, Song J, Bai X, Kondo Y, Qin Y, Hoover C, McGee S, Shao B, Liu Z, Sonon R, Azadi P, Marth JD, McEver RP, Ruan C, Xia L.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8360-8365. doi: 10.1073/pnas.1707662114. Epub 2017 Jul 17.


Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice.

Panicker SR, Mehta-D'souza P, Zhang N, Klopocki AG, Shao B, McEver RP.

Blood. 2017 Jul 13;130(2):181-191. doi: 10.1182/blood-2017-02-770479. Epub 2017 May 17.


L-selectin mechanochemistry restricts neutrophil priming in vivo.

Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D'souza P, Xia L, Zhu C, McEver RP.

Nat Commun. 2017 May 12;8:15196. doi: 10.1038/ncomms15196.


Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP.

J Biol Chem. 2017 Feb 10;292(6):2510-2518. doi: 10.1074/jbc.M116.767186. Epub 2016 Dec 23.


Dampening neutrophil integrins.

McEver RP.

Blood. 2016 Jul 28;128(4):467-8. doi: 10.1182/blood-2016-06-719849. No abstract available.


P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E-Deficient Mice.

Zhang N, Liu Z, Yao L, Mehta-D'souza P, McEver RP.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1114-21. doi: 10.1161/ATVBAHA.116.307437. Epub 2016 Apr 21.


Motif mimetic of epsin perturbs tumor growth and metastasis.

Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87344. Epub 2016 Mar 21. No abstract available.


Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice.

Liu Z, Zhang N, Shao B, Panicker SR, Fu J, McEver RP.

J Biol Chem. 2016 Jan 15;291(3):1441-7. doi: 10.1074/jbc.M115.702126. Epub 2015 Dec 2.


Motif mimetic of epsin perturbs tumor growth and metastasis.

Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H.

J Clin Invest. 2015 Dec;125(12):4349-64. doi: 10.1172/JCI80349. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.


Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow.

Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson LF, McEver RP.

J Immunol. 2015 Oct 15;195(8):3880-9. doi: 10.4049/jimmunol.1500775. Epub 2015 Sep 9.


Blocking neutrophil integrin activation prevents ischemia-reperfusion injury.

Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP.

J Exp Med. 2015 Jul 27;212(8):1267-81. doi: 10.1084/jem.20142358. Epub 2015 Jul 13.


O-glycans direct selectin ligands to lipid rafts on leukocytes.

Shao B, Yago T, Setiadi H, Wang Y, Mehta-D'souza P, Fu J, Crocker PR, Rodgers W, Xia L, McEver RP.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8661-6. doi: 10.1073/pnas.1507712112. Epub 2015 Jun 29.


Selectins: initiators of leucocyte adhesion and signalling at the vascular wall.

McEver RP.

Cardiovasc Res. 2015 Aug 1;107(3):331-9. doi: 10.1093/cvr/cvv154. Epub 2015 May 20. Review.


Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T, Sperandio M.

Nat Commun. 2015 Apr 20;6:6915. doi: 10.1038/ncomms7915.


Neutrophils scan for activated platelets to initiate inflammation.

Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A.

Science. 2014 Dec 5;346(6214):1234-8. doi: 10.1126/science.1256478. Epub 2014 Dec 4.


Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.

Wang Y, Yago T, Zhang N, Abdisalaam S, Alexandrakis G, Rodgers W, McEver RP.

J Biol Chem. 2014 Dec 19;289(51):35159-71. doi: 10.1074/jbc.M114.600767. Epub 2014 Oct 30.


Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.

Pan Y, Yago T, Fu J, Herzog B, McDaniel JM, Mehta-D'Souza P, Cai X, Ruan C, McEver RP, West C, Dai K, Chen H, Xia L.

Blood. 2014 Dec 4;124(24):3656-65. doi: 10.1182/blood-2014-04-572107. Epub 2014 Oct 21.


Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice.

Yao L, Yago T, Shao B, Liu Z, Silasi-Mansat R, Setiadi H, Lupu F, McEver RP.

Blood. 2013 Nov 28;122(23):3832-42. doi: 10.1182/blood-2012-12-473835. Epub 2013 Sep 30.


Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L.

Nature. 2013 Oct 3;502(7469):105-9. doi: 10.1038/nature12501. Epub 2013 Sep 1.


P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.

Zhang Y, Jiang N, Zarnitsyna VI, Klopocki AG, McEver RP, Zhu C.

PLoS One. 2013;8(2):e57202. doi: 10.1371/journal.pone.0057202. Epub 2013 Feb 25.


Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.

Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS.

Blood. 2013 Apr 4;121(14):2743-52. doi: 10.1182/blood-2012-07-445205. Epub 2013 Jan 31.


Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-selectin on the cell membrane.

Xiao B, Tong C, Jia X, Guo R, Lü S, Zhang Y, McEver RP, Zhu C, Long M.

Biophys J. 2012 Aug 22;103(4):777-85. doi: 10.1016/j.bpj.2012.07.028.


Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.

Shao B, Yago T, Coghill PA, Klopocki AG, Mehta-D'souza P, Schmidtke DW, Rodgers W, McEver RP.

J Biol Chem. 2012 Jun 1;287(23):19585-98. doi: 10.1074/jbc.M112.361519. Epub 2012 Apr 16.


Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.

Zarbock A, Ley K, McEver RP, Hidalgo A.

Blood. 2011 Dec 22;118(26):6743-51. doi: 10.1182/blood-2011-07-343566. Epub 2011 Oct 20. Review.


Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.

Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP.

Blood. 2011 Oct 13;118(15):4015-23. doi: 10.1182/blood-2011-07-368514. Epub 2011 Aug 22.


Regulation of catch bonds by rate of force application.

Sarangapani KK, Qian J, Chen W, Zarnitsyna VI, Mehta P, Yago T, McEver RP, Zhu C.

J Biol Chem. 2011 Sep 16;286(37):32749-61. doi: 10.1074/jbc.M111.240044. Epub 2011 Jul 20.


Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum.

Miner JJ, Shao B, Wang Y, Chichili GR, Liu Z, Klopocki AG, Yago T, McDaniel JM, Rodgers W, Xia L, McEver RP.

J Biol Chem. 2011 Mar 18;286(11):9577-86. doi: 10.1074/jbc.M110.208777. Epub 2011 Jan 10.


Molecular stiffness of selectins.

Sarangapani KK, Marshall BT, McEver RP, Zhu C.

J Biol Chem. 2011 Mar 18;286(11):9567-76. doi: 10.1074/jbc.M110.196485. Epub 2011 Jan 7.


Differential regulation of human and murine P-selectin expression and function in vivo.

Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, McEver RP.

J Exp Med. 2010 Dec 20;207(13):2975-87. doi: 10.1084/jem.20101545. Epub 2010 Dec 13.


Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.

Wayman AM, Chen W, McEver RP, Zhu C.

Biophys J. 2010 Aug 9;99(4):1166-74. doi: 10.1016/j.bpj.2010.05.040.


Core 1-derived O-glycans are essential E-selectin ligands on neutrophils.

Yago T, Fu J, McDaniel JM, Miner JJ, McEver RP, Xia L.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9204-9. doi: 10.1073/pnas.1003110107. Epub 2010 May 3.


C-type Lectins.

Cummings RD, McEver RP.

In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 31.


Rolling back neutrophil adhesion.

McEver RP.

Nat Immunol. 2010 Apr;11(4):282-4. doi: 10.1038/ni0410-282. Review. No abstract available.


E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.

Yago T, Shao B, Miner JJ, Yao L, Klopocki AG, Maeda K, Coggeshall KM, McEver RP.

Blood. 2010 Jul 22;116(3):485-94. doi: 10.1182/blood-2009-12-259556. Epub 2010 Mar 18.


Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle.

Dias-Baruffi M, Stowell SR, Song SC, Arthur CM, Cho M, Rodrigues LC, Montes MA, Rossi MA, James JA, McEver RP, Cummings RD.

Glycobiology. 2010 May;20(5):507-20. doi: 10.1093/glycob/cwp203. Epub 2010 Jan 5.


Platelet functions beyond hemostasis.

Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC; 2009 Platelet Colloquium Participants.

J Thromb Haemost. 2009 Nov;7(11):1759-66. doi: 10.1111/j.1538-7836.2009.03586.x. Epub 2009 Aug 19. Review.


Rolling cell adhesion.

McEver RP, Zhu C.

Annu Rev Cell Dev Biol. 2010;26:363-96. doi: 10.1146/annurev.cellbio.042308.113238. Review.


Bending rigidities of cell surface molecules P-selectin and PSGL-1.

Fang Y, Wu J, McEver RP, Zhu C.

J Biomech. 2009 Feb 9;42(3):303-7. doi: 10.1016/j.jbiomech.2008.11.020. Epub 2009 Jan 13.


Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane.

Stowell SR, Karmakar S, Arthur CM, Ju T, Rodrigues LC, Riul TB, Dias-Baruffi M, Miner J, McEver RP, Cummings RD.

Mol Biol Cell. 2009 Mar;20(5):1408-18. doi: 10.1091/mbc.E08-07-0786. Epub 2008 Dec 30.


Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation.

Stowell SR, Cho M, Feasley CL, Arthur CM, Song X, Colucci JK, Karmakar S, Mehta P, Dias-Baruffi M, McEver RP, Cummings RD.

J Biol Chem. 2009 Feb 20;284(8):4989-99. doi: 10.1074/jbc.M808925200. Epub 2008 Dec 22.


A role for leukocyte-endothelial adhesion mechanisms in epilepsy.

Fabene PF, Navarro Mora G, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G.

Nat Med. 2008 Dec;14(12):1377-83. doi: 10.1038/nm.1878. Epub 2008 Nov 23.


Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.

Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, López JA, Cruz MA, Dong JF, McIntire LV, McEver RP, Zhu C.

J Clin Invest. 2008 Sep;118(9):3195-207. doi: 10.1172/JCI35754.


Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans.

Karmakar S, Stowell SR, Cummings RD, McEver RP.

Glycobiology. 2008 Oct;18(10):770-8. doi: 10.1093/glycob/cwn066. Epub 2008 Jul 16.


Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.

Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R.

Glycobiology. 2008 Oct;18(10):747-9. doi: 10.1093/glycob/cwn065. Epub 2008 Jul 11. No abstract available.


Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow.

Miner JJ, Xia L, Yago T, Kappelmayer J, Liu Z, Klopocki AG, Shao B, McDaniel JM, Setiadi H, Schmidtke DW, McEver RP.

Blood. 2008 Sep 1;112(5):2035-45. doi: 10.1182/blood-2008-04-149468. Epub 2008 Jun 11.

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