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Items: 46


Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.

Tikunov AP, Shim YS, Bhattarai N, Siler SQ, Soldatow V, LeCluyse EL, McDunn JE, Watkins PB, Macdonald JM.

Toxicol In Vitro. 2017 Dec;45(Pt 1):119-127. doi: 10.1016/j.tiv.2017.08.021. Epub 2017 Sep 1.


Renal systems biology of patients with systemic inflammatory response syndrome.

Tsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, Dinwiddie DL, Miller NA, Mayer ES, Glickman SW, Jaehne AK, Glew RH, Sopori ML, Otero RM, Harrod KS, Cairns CB, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Langley RJ.

Kidney Int. 2015 Oct;88(4):804-14. doi: 10.1038/ki.2015.150. Epub 2015 May 20.


Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer.

McDunn JE, Stirdivant SM, Ford LA, Wolfert RL.

EJIFCC. 2015 Mar 10;26(2):92-104. eCollection 2015 Mar.


Bladder cancer biomarker discovery using global metabolomic profiling of urine.

Wittmann BM, Stirdivant SM, Mitchell MW, Wulff JE, McDunn JE, Li Z, Dennis-Barrie A, Neri BP, Milburn MV, Lotan Y, Wolfert RL.

PLoS One. 2014 Dec 26;9(12):e115870. doi: 10.1371/journal.pone.0115870. eCollection 2014.


Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats.

Garvey SM, Dugle JE, Kennedy AD, McDunn JE, Kline W, Guo L, Guttridge DC, Pereira SL, Edens NK.

Biogerontology. 2014 Jun;15(3):217-32. doi: 10.1007/s10522-014-9492-5. Epub 2014 Mar 21.


Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer.

Zeng C, Vangveravong S, McDunn JE, Hawkins WG, Mach RH.

Br J Cancer. 2013 Oct 29;109(9):2368-77. doi: 10.1038/bjc.2013.593. Epub 2013 Oct 8.


Metabolomic signatures of aggressive prostate cancer.

McDunn JE, Li Z, Adam KP, Neri BP, Wolfert RL, Milburn MV, Lotan Y, Wheeler TM.

Prostate. 2013 Oct;73(14):1547-60. doi: 10.1002/pros.22704. Epub 2013 Jul 3.


Microfluidic amperometric sensor for analysis of nitric oxide in whole blood.

Hunter RA, Privett BJ, Henley WH, Breed ER, Liang Z, Mittal R, Yoseph BP, McDunn JE, Burd EM, Coopersmith CM, Ramsey JM, Schoenfisch MH.

Anal Chem. 2013 Jun 18;85(12):6066-72. doi: 10.1021/ac400932s. Epub 2013 Jun 6.


Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Szabova L, Yin C, Bupp S, Guerin TM, Schlomer JJ, Householder DB, Baran ML, Yi M, Song Y, Sun W, McDunn JE, Martin PL, Van Dyke T, Difilippantonio S.

Cancer Res. 2012 Aug 15;72(16):4141-53. doi: 10.1158/0008-5472.CAN-11-3834. Epub 2012 May 22.


Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies.

Brown MV, McDunn JE, Gunst PR, Smith EM, Milburn MV, Troyer DA, Lawton KA.

Genome Med. 2012 Apr 30;4(4):33.


Integrative assessment of chlorine-induced acute lung injury in mice.

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):234-44. doi: 10.1165/rcmb.2012-0026OC. Epub 2012 Mar 23.


Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

Spitzer D, Simon PO Jr, Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure P, Hotchkiss RS, Mach RH, Hawkins WG.

Cancer Res. 2012 Jan 1;72(1):201-9. doi: 10.1158/0008-5472.CAN-11-1354. Epub 2011 Nov 7.


Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity.

Parman T, Bunin DI, Ng HH, McDunn JE, Wulff JE, Wang A, Swezey R, Rasay L, Fairchild DG, Kapetanovic IM, Green CE.

Toxicol Sci. 2011 Dec;124(2):487-501. doi: 10.1093/toxsci/kfr238. Epub 2011 Sep 13.


Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury.

Fabisiak JP, Medvedovic M, Alexander DC, McDunn JE, Concel VJ, Bein K, Jang AS, Berndt A, Vuga LJ, Brant KA, Pope-Varsalona H, Dopico RA Jr, Ganguly K, Upadhyay S, Li Q, Hu Z, Kaminski N, Leikauf GD.

Mol Nutr Food Res. 2011 Sep;55(9):1423-34. doi: 10.1002/mnfr.201100291. Epub 2011 Aug 8.


A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

Spitzer D, McDunn JE, Plambeck-Suess S, Goedegebuure PS, Hotchkiss RS, Hawkins WG.

Mol Cancer Ther. 2010 Jul;9(7):2142-51. doi: 10.1158/1535-7163.MCT-10-0225. Epub 2010 Jun 22.


Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.

Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2010 Aug;88(2):233-40. doi: 10.1189/jlb.0110037. Epub 2010 May 18.


Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy.

Feng Y, McDunn JE, Teitelbaum DH.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G833-41. doi: 10.1152/ajpgi.00030.2010. Epub 2010 Mar 18.


IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS.

J Immunol. 2010 Apr 1;184(7):3768-79. doi: 10.4049/jimmunol.0903151. Epub 2010 Mar 3.


Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.

Bradfute SB, Swanson PE, Smith MA, Watanabe E, McDunn JE, Hotchkiss RS, Bavari S.

J Immunol. 2010 Jan 1;184(1):327-35. doi: 10.4049/jimmunol.0901231.


IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS.

J Immunol. 2010 Feb 1;184(3):1401-9. doi: 10.4049/jimmunol.0902307. Epub 2009 Dec 21.


Cell death.

Hotchkiss RS, Strasser A, McDunn JE, Swanson PE.

N Engl J Med. 2009 Oct 15;361(16):1570-83. doi: 10.1056/NEJMra0901217. Review. No abstract available.


Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses.

McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, Dipasco PJ, Osberghaus WF, Sherman B, Martin JR, Walter MJ, Cobb JP, Buchman TG, Hotchkiss RS, Coopersmith CM.

Crit Care Med. 2010 Jan;38(1):223-41. doi: 10.1097/CCM.0b013e3181b4a76b.


Leukocyte phenotyping to stratify septic shock patients.

McDunn JE, Hotchkiss RS.

Crit Care. 2009;13(2):127. doi: 10.1186/cc7748. Epub 2009 Apr 3.


The sepsis seesaw: tilting toward immunosuppression.

Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA.

Nat Med. 2009 May;15(5):496-7. doi: 10.1038/nm0509-496. No abstract available.


Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.

Simon PO Jr, McDunn JE, Kashiwagi H, Chang K, Goedegebuure PS, Hotchkiss RS, Hawkins WG.

Int J Cancer. 2009 Aug 15;125(4):942-51. doi: 10.1002/ijc.24424.


Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma.

Kashiwagi H, McDunn JE, Simon PO Jr, Goedegebuure PS, Vangveravong S, Chang K, Hotchkiss RS, Mach RH, Hawkins WG.

J Transl Med. 2009 Mar 26;7:24. doi: 10.1186/1479-5876-7-24.


An anti-apoptotic peptide improves survival in lethal total body irradiation.

McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS.

Biochem Biophys Res Commun. 2009 May 15;382(4):657-62. doi: 10.1016/j.bbrc.2009.03.080. Epub 2009 Mar 19.


Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study.

Watanabe E, Muenzer JT, Hawkins WG, Davis CG, Dixon DJ, McDunn JE, Brackett DJ, Lerner MR, Swanson PE, Hotchkiss RS.

Lab Invest. 2009 May;89(5):549-61. doi: 10.1038/labinvest.2009.8. Epub 2009 Feb 2.


Using systems biology to simplify complex disease: immune cartography.

Polpitiya AD, McDunn JE, Burykin A, Ghosh BK, Cobb JP.

Crit Care Med. 2009 Jan;37(1 Suppl):S16-21. doi: 10.1097/CCM.0b013e3181920cb0.


Targeted delivery of siRNA to cell death proteins in sepsis.

Brahmamdam P, Watanabe E, Unsinger J, Chang KC, Schierding W, Hoekzema AS, Zhou TT, McDonough JS, Holemon H, Heidel JD, Coopersmith CM, McDunn JE, Hotchkiss RS.

Shock. 2009 Aug;32(2):131-9. doi: 10.1097/SHK.0b013e318194bcee.


Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

Peck-Palmer OM, Unsinger J, Chang KC, McDonough JS, Perlman H, McDunn JE, Hotchkiss RS.

Shock. 2009 Apr;31(4):359-66. doi: 10.1097/SHK.0b013e31818ba2a2.


Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram.

McDunn JE, Husain KD, Polpitiya AD, Burykin A, Ruan J, Li Q, Schierding W, Lin N, Dixon D, Zhang W, Coopersmith CM, Dunne WM, Colonna M, Ghosh BK, Cobb JP.

PLoS One. 2008 Feb 13;3(2):e1564. doi: 10.1371/journal.pone.0001564.


Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2008 Apr;83(4):1009-18. doi: 10.1189/jlb.0807528. Epub 2008 Jan 22.


Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, Hotchkiss RS.

Shock. 2008 Aug;30(2):127-34. doi: 10.1097/shk.0b013e318162cf17.


Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.

McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS.

FASEB J. 2008 Feb;22(2):561-8. Epub 2007 Sep 13.


Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.

Kashiwagi H, McDunn JE, Simon PO Jr, Goedegebuure PS, Xu J, Jones L, Chang K, Johnston F, Trinkaus K, Hotchkiss RS, Mach RH, Hawkins WG.

Mol Cancer. 2007 Jul 15;6:48.


The murine plasma protein response to polymicrobial intra-abdominal sepsis.

McDunn JE, Townsend RR, Cobb JP.

Proteomics Clin Appl. 2007 Apr;1(4):373-86. doi: 10.1002/prca.200600494. Epub 2007 Mar 13.


Anti-apoptotic peptides protect against radiation-induced cell death.

McConnell KW, Muenzer JT, Chang KC, Davis CG, McDunn JE, Coopersmith CM, Hilliard CA, Hotchkiss RS, Grigsby PW, Hunt CR.

Biochem Biophys Res Commun. 2007 Apr 6;355(2):501-7. Epub 2007 Feb 8.


TAT-Bim induces extensive apoptosis in cancer cells.

Kashiwagi H, McDunn JE, Goedegebuure PS, Gaffney MC, Chang K, Trinkaus K, Piwnica-Worms D, Hotchkiss RS, Hawkins WG.

Ann Surg Oncol. 2007 May;14(5):1763-71. Epub 2007 Jan 6.


Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.

McDunn JE, Turnbull IR, Polpitiya AD, Tong A, MacMillan SK, Osborne DF, Hotchkiss RS, Colonna M, Cobb JP.

J Am Coll Surg. 2006 Sep;203(3):365-75.


TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.

Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bähr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D.

J Immunol. 2006 May 1;176(9):5471-7.


Physiologic genomics.

McDunn JE, Chung TP, Laramie JM, Townsend RR, Cobb JP.

Surgery. 2006 Feb;139(2):133-9. Review. No abstract available.


DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.

Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M.

J Exp Med. 2005 Aug 1;202(3):363-9.


That which does not kill you makes you stronger: a molecular mechanism for preconditioning.

McDunn JE, Cobb JP.

Sci STKE. 2005 Jul 5;2005(291):pe34. Review.


Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.

Wentworth P Jr, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA.

Science. 2002 Dec 13;298(5601):2195-9. Epub 2002 Nov 14.


Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.

Worrall DS, McDunn JE, List B, Reichart D, Hevener A, Gustafson T, Barbas CF 3rd, Lerner RA, Olefsky JM.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13514-8. Epub 2001 Nov 13.

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