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Development of a target-free high-throughput screening platform for the discovery of antileishmanial compounds.

Corman HN, Shoue DA, Norris-Mullins B, Melancon BJ, Morales MA, McDowell MA.

Int J Antimicrob Agents. 2019 Oct;54(4):496-501. doi: 10.1016/j.ijantimicag.2019.07.013. Epub 2019 Jul 16.


The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin.

McDowell MA, Byrne AM, Mylona E, Johnson R, Sagfors A, Crepin VF, Lea S, Frankel G.

Life Sci Alliance. 2019 May 29;2(3). pii: e201800272. doi: 10.26508/lsa.201800272. Print 2019 Jun.


Population genetics analysis of Phlebotomus papatasi sand flies from Egypt and Jordan based on mitochondrial cytochrome b haplotypes.

Flanley CM, Ramalho-Ortigao M, Coutinho-Abreu IV, Mukbel R, Hanafi HA, El-Hossary SS, Fawaz EEY, Hoel DF, Bray AW, Stayback G, Shoue DA, Kamhawi S, Karakuş M, Jaouadi K, Yaghoobie-Ershadi MR, Krüger A, Amro A, Kenawy MA, Dokhan MR, Warburg A, Hamarsheh O, McDowell MA.

Parasit Vectors. 2018 Mar 27;11(1):214. doi: 10.1186/s13071-018-2785-9.


Development of polymorphic EST microsatellite markers for the sand fly, Phlebotomus papatasi (Diptera: Psychodidae).

Hamarsheh O, Karakuş M, Azmi K, Jaouadi K, Yaghoobi-Ershadi MR, Krüger A, Amro A, Kenawy MA, Dokhan MR, Abdeen Z, McDowell MA.

Parasit Vectors. 2018 Mar 9;11(1):160. doi: 10.1186/s13071-018-2770-3.


Mannose receptor (MR) and Toll-like receptor 2 (TLR2) influence phagosome maturation during Leishmania infection.

Polando RE, Jones BC, Ricardo C, Whitcomb J, Ballhorn W, McDowell MA.

Parasite Immunol. 2018 Apr;40(4):e12521. doi: 10.1111/pim.12521. Epub 2018 Mar 25.


Do Porous Tantalum Metaphyseal Cones Improve Outcomes in Revision Total Knee Arthroplasty?

Bohl DD, Brown NM, McDowell MA, Levine BR, Sporer SM, Paprosky WG, Della Valle CJ.

J Arthroplasty. 2018 Jan;33(1):171-177. doi: 10.1016/j.arth.2017.07.033. Epub 2017 Jul 28.


The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors.

Ngai M, McDowell MA.

Mem Inst Oswaldo Cruz. 2017 Jan 1;112(1):1-7. doi: 10.1590/0074-02760160345. Review.


Human immune response to salivary proteins of wild-caught Phlebotomus papatasi.

Mukbel RM, Khasharmeh RH, Hijjawi NS, Khalifeh MS, Hatmal MM, McDowell MA.

Parasitol Res. 2016 Sep;115(9):3345-55. doi: 10.1007/s00436-016-5094-2. Epub 2016 May 10.


The mirn23a microRNA cluster antagonizes B cell development.

Kurkewich JL, Bikorimana E, Nguyen T, Klopfenstein N, Zhang H, Hallas WM, Stayback G, McDowell MA, Dahl R.

J Leukoc Biol. 2016 Oct;100(4):665-677. Epub 2016 Apr 15.


Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.

Favila MA, Geraci NS, Jayakumar A, Hickerson S, Mostrom J, Turco SJ, Beverley SM, McDowell MA.

PLoS Negl Trop Dis. 2015 Dec 2;9(12):e0004238. doi: 10.1371/journal.pntd.0004238. eCollection 2015 Dec.


Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

McDowell MA, Marcoux J, McVicker G, Johnson S, Fong YH, Stevens R, Bowman LA, Degiacomi MT, Yan J, Wise A, Friede ME, Benesch JL, Deane JE, Tang CM, Robinson CV, Lea SM.

Mol Microbiol. 2016 Feb;99(4):749-66. doi: 10.1111/mmi.13267. Epub 2015 Dec 23.


Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major.

Turner KG, Vacchina P, Robles-Murguia M, Wadsworth M, McDowell MA, Morales MA.

PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003948. doi: 10.1371/journal.pntd.0003948. eCollection 2015.


Phlebotomus papatasi SP15: mRNA expression variability and amino acid sequence polymorphisms of field populations.

Ramalho-Ortigão M, Coutinho-Abreu IV, Balbino VQ, Figueiredo CA Jr, Mukbel R, Dayem H, Hanafi HA, El-Hossary SS, Fawaz Eel-D, Abo-Shehada M, Hoel DF, Stayback G, Wadsworth M, Shoue DA, Abrudan J, Lobo NF, Mahon AR, Emrich SJ, Kamhawi S, Collins FH, McDowell MA.

Parasit Vectors. 2015 May 29;8:298. doi: 10.1186/s13071-015-0914-2.


Vector-transmitted disease vaccines: targeting salivary proteins in transmission (SPIT).

McDowell MA.

Trends Parasitol. 2015 Aug;31(8):363-72. doi: 10.1016/ Epub 2015 May 20. Review.


Recent advances in phlebotomine sand fly research related to leishmaniasis control.

Bates PA, Depaquit J, Galati EA, Kamhawi S, Maroli M, McDowell MA, Picado A, Ready PD, Salomón OD, Shaw JJ, Traub-Csekö YM, Warburg A.

Parasit Vectors. 2015 Feb 27;8:131. doi: 10.1186/s13071-015-0712-x.


Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach.

Kastner KW, Shoue DA, Estiu GL, Wolford J, Fuerst MF, Markley LD, Izaguirre JA, McDowell MA.

Malar J. 2014 Nov 18;13:434. doi: 10.1186/1475-2875-13-434.


Characterization of microRNA expression profiles in Leishmania-infected human phagocytes.

Geraci NS, Tan JC, McDowell MA.

Parasite Immunol. 2015 Jan;37(1):43-51. doi: 10.1111/pim.12156.


Meta-analysis of the effects of insect vector saliva on host immune responses and infection of vector-transmitted pathogens: a focus on leishmaniasis.

Ockenfels B, Michael E, McDowell MA.

PLoS Negl Trop Dis. 2014 Oct 2;8(10):e3197. doi: 10.1371/journal.pntd.0003197. eCollection 2014 Oct.


Human dendritic cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction.

Favila MA, Geraci NS, Zeng E, Harker B, Condon D, Cotton RN, Jayakumar A, Tripathi V, McDowell MA.

J Immunol. 2014 Jun 15;192(12):5863-72. doi: 10.4049/jimmunol.1203230. Epub 2014 May 7.


CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

Xia M, Hu S, Fu Y, Jin W, Yi Q, Matsui Y, Yang J, McDowell MA, Sarkar S, Kalia V, Xiong N.

J Allergy Clin Immunol. 2014 Sep;134(3):634-644.e10. doi: 10.1016/j.jaci.2014.03.010. Epub 2014 Apr 24.


Building a secreting nanomachine: a structural overview of the T3SS.

Abrusci P, McDowell MA, Lea SM, Johnson S.

Curr Opin Struct Biol. 2014 Apr;25:111-7. doi: 10.1016/ Epub 2014 Apr 1. Review.


Profiling of human acquired immunity against the salivary proteins of Phlebotomus papatasi reveals clusters of differential immunoreactivity.

Geraci NS, Mukbel RM, Kemp MT, Wadsworth MN, Lesho E, Stayback GM, Champion MM, Bernard MA, Abo-Shehada M, Coutinho-Abreu IV, Ramalho-Ortigão M, Hanafi HA, Fawaz EY, El-Hossary SS, Wortmann G, Hoel DF, McDowell MA.

Am J Trop Med Hyg. 2014 May;90(5):923-938. doi: 10.4269/ajtmh.13-0130. Epub 2014 Mar 10.


Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species.

Berry JL, Cehovin A, McDowell MA, Lea SM, Pelicic V.

PLoS Genet. 2013;9(12):e1004014. doi: 10.1371/journal.pgen.1004014. Epub 2013 Dec 19.


Leishmania major inhibits IL-12 in macrophages by signalling through CR3 (CD11b/CD18) and down-regulation of ETS-mediated transcription.

Ricardo-Carter C, Favila M, Polando RE, Cotton RN, Bogard Horner K, Condon D, Ballhorn W, Whitcomb JP, Yadav M, Geister RL, Schorey JS, McDowell MA.

Parasite Immunol. 2013 Dec;35(12):409-20. doi: 10.1111/pim.12049.


Identification of novel arthropod vector G protein-coupled receptors.

Nowling RJ, Abrudan JL, Shoue DA, Abdul-Wahid B, Wadsworth M, Stayback G, Collins FH, McDowell MA, Izaguirre JA.

Parasit Vectors. 2013 May 24;6:150. doi: 10.1186/1756-3305-6-150.


Adherence to national diet and physical activity objectives among active duty military personnel: what are the implications?

McDowell MA, Hubbard VS.

J Acad Nutr Diet. 2013 Jul;113(7):903-6. doi: 10.1016/j.jand.2013.03.003. Epub 2013 May 4. No abstract available.


The roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation.

Polando R, Dixit UG, Carter CR, Jones B, Whitcomb JP, Ballhorn W, Harintho M, Jerde CL, Wilson ME, McDowell MA.

J Leukoc Biol. 2013 Jun;93(6):921-32. doi: 10.1189/jlb.0212086. Epub 2013 Mar 29.


The characterization of the Phlebotomus papatasi transcriptome.

Abrudan J, Ramalho-Ortigão M, O'Neil S, Stayback G, Wadsworth M, Bernard M, Shoue D, Emrich S, Lawyer P, Kamhawi S, Rowton ED, Lehane MJ, Bates PA, Valenzeula JG, Tomlinson C, Appelbaum E, Moeller D, Thiesing B, Dillon R, Clifton S, Lobo NF, Wilson RK, Collins FH, McDowell MA.

Insect Mol Biol. 2013 Apr;22(2):211-32. doi: 10.1111/imb.12015. Epub 2013 Feb 7.


Specific DNA recognition mediated by a type IV pilin.

Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic V.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3065-70. doi: 10.1073/pnas.1218832110. Epub 2013 Feb 5.


Structure of the TatC core of the twin-arginine protein transport system.

Rollauer SE, Tarry MJ, Graham JE, Jääskeläinen M, Jäger F, Johnson S, Krehenbrink M, Liu SM, Lukey MJ, Marcoux J, McDowell MA, Rodriguez F, Roversi P, Stansfeld PJ, Robinson CV, Sansom MS, Palmer T, Högbom M, Berks BC, Lea SM.

Nature. 2012 Dec 13;492(7428):210-4. doi: 10.1038/nature11683. Epub 2012 Dec 2.


Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells.

Donovan MJ, Tripathi V, Favila MA, Geraci NS, Lange MC, Ballhorn W, McDowell MA.

Parasite Immunol. 2012 Oct;34(10):464-72. doi: 10.1111/j.1365-3024.2012.01380.x.


The Salmonella type III secretion system inner rod protein PrgJ is partially folded.

Zhong D, Lefebre M, Kaur K, McDowell MA, Gdowski C, Jo S, Wang Y, Benedict SH, Lea SM, Galan JE, De Guzman RN.

J Biol Chem. 2012 Jul 20;287(30):25303-11. doi: 10.1074/jbc.M112.381574. Epub 2012 May 31.


The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection.

Whitcomb JP, Deagostino M, Ballentine M, Fu J, Tenniswood M, Welsh J, Cantorna M, McDowell MA.

J Parasitol Res. 2012;2012:134645. doi: 10.1155/2012/134645. Epub 2011 Oct 11.


Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season.

Coutinho-Abreu IV, Mukbel R, Hanafi HA, Fawaz EY, El-Hossary SS, Wadsworth M, Stayback G, Pitts DA, Abo-Shehada M, Hoel DF, Kamhawi S, Ramalho-Ortigão M, McDowell MA.

BMC Ecol. 2011 Oct 10;11:24. doi: 10.1186/1472-6785-11-24.


Leishmaniasis: Middle East and North Africa research and development priorities.

McDowell MA, Rafati S, Ramalho-Ortigao M, Ben Salah A.

PLoS Negl Trop Dis. 2011 Jul;5(7):e1219. doi: 10.1371/journal.pntd.0001219. Epub 2011 Jul 26. No abstract available.


Structural and functional studies on the N-terminal domain of the Shigella type III secretion protein MxiG.

McDowell MA, Johnson S, Deane JE, Cheung M, Roehrich AD, Blocker AJ, McDonnell JM, Lea SM.

J Biol Chem. 2011 Sep 2;286(35):30606-14. doi: 10.1074/jbc.M111.243865. Epub 2011 Jul 5.


Insights into the transcriptome of oenocytes from Aedes aegypti pupae.

Martins GF, Ramalho-Ortigão JM, Lobo NF, Severson DW, McDowell MA, Pimenta PF.

Mem Inst Oswaldo Cruz. 2011 May;106(3):308-15.


Feasibility of an Audio Computer-Assisted Self-Interview method to self-assess sexual maturation.

Lamb MM, Beers L, Reed-Gillette D, McDowell MA.

J Adolesc Health. 2011 Apr;48(4):325-30. doi: 10.1016/j.jadohealth.2010.09.020. Epub 2010 Dec 30.


Differential expression of salivary gland genes in the female sand fly Phlebotomus papatasi (Diptera: Psychodidae).

Coutinho-Abreu IV, Wadsworth M, Stayback G, Ramalho-Ortigao M, McDowell MA.

J Med Entomol. 2010 Nov;47(6):1146-55.


Total folate and folic acid intakes from foods and dietary supplements of US children aged 1-13 y.

Bailey RL, McDowell MA, Dodd KW, Gahche JJ, Dwyer JT, Picciano MF.

Am J Clin Nutr. 2010 Aug;92(2):353-8. doi: 10.3945/ajcn.2010.29652. Epub 2010 Jun 9.


Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006.

Bailey RL, Dodd KW, Gahche JJ, Dwyer JT, McDowell MA, Yetley EA, Sempos CA, Burt VL, Radimer KL, Picciano MF.

Am J Clin Nutr. 2010 Jan;91(1):231-7. doi: 10.3945/ajcn.2009.28427. Epub 2009 Nov 18.


Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice.

Carter CR, Whitcomb JP, Campbell JA, Mukbel RM, McDowell MA.

Infect Immun. 2009 Dec;77(12):5668-75. doi: 10.1128/IAI.00802-08. Epub 2009 Sep 21.


Anthropometric reference data for children and adults: United States, 1988-1994.

McDowell MA, Fryar CD, Ogden CL.

Vital Health Stat 11. 2009 Apr;(249):1-68.


Leishmania infection inhibits cycloheximide-induced macrophage apoptosis in a strain-dependent manner.

Donovan MJ, Maciuba BZ, Mahan CE, McDowell MA.

Exp Parasitol. 2009 Sep;123(1):58-64. doi: 10.1016/j.exppara.2009.05.012. Epub 2009 Jun 3.


Blood folate levels: the latest NHANES results.

McDowell MA, Lacher DA, Pfeiffer CM, Mulinare J, Picciano MF, Rader JI, Yetley EA, Kennedy-Stephenson J, Johnson CL.

NCHS Data Brief. 2008 May;(6):1-8.


Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.

Bruce D, Whitcomb JP, August A, McDowell MA, Cantorna MT.

Int Immunol. 2009 Feb;21(2):113-22. doi: 10.1093/intimm/dxn129. Epub 2008 Dec 15.


Trends of elevated blood pressure among children and adolescents: data from the National Health and Nutrition Examination Survey1988-2006.

Ostchega Y, Carroll M, Prineas RJ, McDowell MA, Louis T, Tilert T.

Am J Hypertens. 2009 Jan;22(1):59-67. doi: 10.1038/ajh.2008.312. Epub 2008 Nov 27.


The association between serum folate levels and periodontal disease is not clearly established.

Dye BA, Ervin B, McDowell MA.

J Evid Based Dent Pract. 2008 Dec;8(4):255-7. doi: 10.1016/j.jebdp.2008.09.017. No abstract available.


Anthropometric reference data for children and adults: United States, 2003–2006.

McDowell MA, Fryar CD, Ogden CL, Flegal KM.

Natl Health Stat Report. 2008 Oct 22;(10):1-48.


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