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Items: 46

1.

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.

Megiorni F, Gravina GL, Camero S, Ceccarelli S, Del Fattore A, Desiderio V, Papaccio F, McDowell HP, Shukla R, Pizzuti A, Beirinckx F, Pujuguet P, Saniere L, der Aar EV, Maggio R, De Felice F, Marchese C, Dominici C, Tombolini V, Festuccia C, Marampon F.

J Hematol Oncol. 2017 Oct 6;10(1):161. doi: 10.1186/s13045-017-0530-z.

2.

A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma.

Megiorni F, Colaiacovo M, Cialfi S, McDowell HP, Guffanti A, Camero S, Felsani A, Losty PD, Pizer B, Shukla R, Cappelli C, Ferrara E, Pizzuti A, Moles A, Dominici C.

Oncol Rep. 2017 Jul;38(1):3-20. doi: 10.3892/or.2017.5701. Epub 2017 Jun 6.

3.

HDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells.

Marampon F, Megiorni F, Camero S, Crescioli C, McDowell HP, Sferra R, Vetuschi A, Pompili S, Ventura L, De Felice F, Tombolini V, Dominici C, Maggio R, Festuccia C, Gravina GL.

Cancer Lett. 2017 Jul 1;397:1-11. doi: 10.1016/j.canlet.2017.03.028. Epub 2017 Mar 23.

PMID:
28342984
4.

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.

Megiorni F, Camero S, Ceccarelli S, McDowell HP, Mannarino O, Marampon F, Pizer B, Shukla R, Pizzuti A, Marchese C, Clerico A, Dominici C.

Oncotarget. 2016 Nov 29;7(48):79342-79356. doi: 10.18632/oncotarget.12688.

5.

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.

Megiorni F, McDowell HP, Camero S, Mannarino O, Ceccarelli S, Paiano M, Losty PD, Pizer B, Shukla R, Pizzuti A, Clerico A, Dominici C.

J Exp Clin Cancer Res. 2015 Oct 6;34:112. doi: 10.1186/s13046-015-0228-4.

6.

Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members.

Megiorni F, Cialfi S, McDowell HP, Felsani A, Camero S, Guffanti A, Pizer B, Clerico A, De Grazia A, Pizzuti A, Moles A, Dominici C.

BMC Cancer. 2014 Nov 25;14:880. doi: 10.1186/1471-2407-14-880.

7.

Wilms' tumor--lessons and outcomes--a 25-year single center UK experience.

Fawkner-Corbett DW, Howell L, Pizer BL, Dominici C, McDowell HP, Losty PD.

Pediatr Hematol Oncol. 2014 Aug;31(5):400-8. doi: 10.3109/08880018.2014.912709. Epub 2014 Jun 16.

PMID:
24933082
8.

Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors.

Veschi V, Petroni M, Bartolazzi A, Altavista P, Dominici C, Capalbo C, Boldrini R, Castellano A, McDowell HP, Pizer B, Frati L, Screpanti I, Gulino A, Giannini G.

Cell Death Dis. 2014 Mar 6;5:e1100. doi: 10.1038/cddis.2014.68.

9.

Characterization of Wnt/β-catenin signaling in rhabdomyosarcoma.

Annavarapu SR, Cialfi S, Dominici C, Kokai GK, Uccini S, Ceccarelli S, McDowell HP, Helliwell TR.

Lab Invest. 2013 Oct;93(10):1090-9. doi: 10.1038/labinvest.2013.97. Epub 2013 Sep 2.

10.

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.

Cattelani S, Ferrari-Amorotti G, Galavotti S, Defferrari R, Tanno B, Cialfi S, Vergalli J, Fragliasso V, Guerzoni C, Manzotti G, Soliera AR, Menin C, Bertorelle R, McDowell HP, Inserra A, Belli ML, Varesio L, Tweddle D, Tonini GP, Altavista P, Dominici C, Raschellà G, Calabretta B.

Neoplasia. 2012 Jul;14(7):634-43.

11.

Vascular endothelial growth factor serum levels in children with newly diagnosed rhabdomyosarcoma.

Schiavetti A, McDowell HP, Conti L, Altavista P, Antenucci A, Pizer B, Dominici C.

Pediatr Blood Cancer. 2012 Oct;59(4):627-30. doi: 10.1002/pbc.24072. Epub 2012 Jan 9.

PMID:
22231858
12.

Neuroblastoma: a 20-year experience in a UK regional centre.

Salim A, Mullassery D, Pizer B, McDowell HP, Losty PD.

Pediatr Blood Cancer. 2011 Dec 15;57(7):1254-60. doi: 10.1002/pbc.23149. Epub 2011 Apr 26.

PMID:
21523901
13.

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Petroni M, Veschi V, Prodosmo A, Rinaldo C, Massimi I, Carbonari M, Dominici C, McDowell HP, Rinaldi C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Soddu S, Giannini G.

Mol Cancer Res. 2011 Jan;9(1):67-77. doi: 10.1158/1541-7786.MCR-10-0227. Epub 2010 Dec 20.

14.

Outcomes in paediatric metastatic rhabdomyosarcoma: results of The International Society of Paediatric Oncology (SIOP) study MMT-98.

McDowell HP, Foot AB, Ellershaw C, Machin D, Giraud C, Bergeron C.

Eur J Cancer. 2010 Jun;46(9):1588-95. doi: 10.1016/j.ejca.2010.02.051. Epub 2010 Mar 24.

PMID:
20338746
15.

Neuroblastoma: contemporary management.

Mullassery D, Dominici C, Jesudason EC, McDowell HP, Losty PD.

Arch Dis Child Educ Pract Ed. 2009 Dec;94(6):177-85. doi: 10.1136/adc.2008.143909. Review. No abstract available.

PMID:
19933390
16.

Gefitinib in combination with oral topotecan and cyclophosphamide in relapsed neuroblastoma: pharmacological rationale and clinical response.

Donfrancesco A, De Ioris MA, McDowell HP, De Pasquale MD, Ilari I, Jenkner A, Castellano A, Cialfi S, De Laurentis C, Dominici C.

Pediatr Blood Cancer. 2010 Jan;54(1):55-61. doi: 10.1002/pbc.22219.

PMID:
19821523
17.

MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness.

Evangelisti C, Florian MC, Massimi I, Dominici C, Giannini G, Galardi S, Buè MC, Massalini S, McDowell HP, Messi E, Gulino A, Farace MG, Ciafrè SA.

FASEB J. 2009 Dec;23(12):4276-87. doi: 10.1096/fj.09-134965. Epub 2009 Aug 27.

18.

RAS signaling dysregulation in human embryonal Rhabdomyosarcoma.

Martinelli S, McDowell HP, Vigne SD, Kokai G, Uccini S, Tartaglia M, Dominici C.

Genes Chromosomes Cancer. 2009 Nov;48(11):975-82. doi: 10.1002/gcc.20702.

PMID:
19681119
19.

Clinical significance of CXC chemokine receptor-4 and c-Met in childhood rhabdomyosarcoma.

Diomedi-Camassei F, McDowell HP, De Ioris MA, Uccini S, Altavista P, Raschellà G, Vitali R, Mannarino O, De Sio L, Cozzi DA, Donfrancesco A, Inserra A, Callea F, Dominici C.

Clin Cancer Res. 2008 Jul 1;14(13):4119-27. doi: 10.1158/1078-0432.CCR-07-4446.

20.

Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.

Cattelani S, Defferrari R, Marsilio S, Bussolari R, Candini O, Corradini F, Ferrari-Amorotti G, Guerzoni C, Pecorari L, Menin C, Bertorelle R, Altavista P, McDowell HP, Boldrini R, Dominici C, Tonini GP, Raschellà G, Calabretta B.

Clin Cancer Res. 2008 Jun 1;14(11):3248-53. doi: 10.1158/1078-0432.CCR-07-4725.

21.

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma.

Berardi AC, Marsilio S, Rofani C, Salvucci O, Altavista P, Perla FM, Diomedi-Camassei F, Uccini S, Kokai G, Landuzzi L, McDowell HP, Dominici C.

Anticancer Res. 2008 Mar-Apr;28(2A):763-9.

22.

Imatinib mesylate potentiates topotecan antitumor activity in rhabdomyosarcoma preclinical models.

McDowell HP, Meco D, Riccardi A, Tanno B, Berardi AC, Raschellà G, Riccardi R, Dominici C.

Int J Cancer. 2007 Mar 1;120(5):1141-9.

23.

Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo.

Tanno B, Mancini C, Vitali R, Mancuso M, McDowell HP, Dominici C, Raschellà G.

Clin Cancer Res. 2006 Nov 15;12(22):6772-80.

24.

Sacrococcygeal teratoma--a 25-year experience in a UK regional center.

Gabra HO, Jesudason EC, McDowell HP, Pizer BL, Losty PD.

J Pediatr Surg. 2006 Sep;41(9):1513-6.

PMID:
16952583
25.

Morphological and molecular assessment of apoptotic mechanisms in peripheral neuroblastic tumours.

Uccini S, Colarossi C, Scarpino S, Boldrini R, Natali PG, Nicotra MR, Perla FM, Mannarino O, Altavista P, Boglino C, Cappelli CA, Cozzi D, Donfrancesco A, Kokai G, Losty PD, McDowell HP, Dominici C.

Br J Cancer. 2006 Jul 3;95(1):49-55. Epub 2006 Jun 6.

26.

Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors.

Martinelli S, Carta C, Flex E, Binni F, Cordisco EL, Moretti S, Puxeddu E, Tonacchera M, Pinchera A, McDowell HP, Dominici C, Rosolen A, Di Rocco C, Riccardi R, Celli P, Picardo M, Genuardi M, Grammatico P, Sorcini M, Tartaglia M.

Cancer Genet Cytogenet. 2006 Apr 15;166(2):124-9.

PMID:
16631468
27.

Surgical interventions for the treatment of radiation-induced alopecia in pediatric practice.

Rannan-Eliya YF, Rannan-Eliya S, Graham K, Pizer B, McDowell HP.

Pediatr Blood Cancer. 2007 Oct 15;49(5):731-6.

PMID:
16429412
28.

Detection and clinical significance of disseminated tumour cells at diagnosis in bone marrow of children with localised rhabdomyosarcoma.

McDowell HP, Donfrancesco A, Milano GM, Clerico A, Mannarino O, Altavista P, Boldrini R, Cozza R, Inserra A, Dominici C.

Eur J Cancer. 2005 Oct;41(15):2288-96.

PMID:
16169716
29.

Emergent embolisation to control severe haematuria in Wilms' tumour.

Smith NP, Jesudason EC, McDowell HP, Rowlands P, Ashworth M, Losty PD.

Pediatr Surg Int. 2005 Apr;21(4):313-5. Epub 2005 Mar 4.

PMID:
15747124
30.

Clinical and molecular evidence for c-kit receptor as a therapeutic target in neuroblastic tumors.

Uccini S, Mannarino O, McDowell HP, Pauser U, Vitali R, Natali PG, Altavista P, Andreano T, Coco S, Boldrini R, Bosco S, Clerico A, Cozzi D, Donfrancesco A, Inserra A, Kokai G, Losty PD, Nicotra MR, Raschellà G, Tonini GP, Dominici C.

Clin Cancer Res. 2005 Jan 1;11(1):380-9.

31.

Oscillations in NF-kappaB signaling control the dynamics of gene expression.

Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MR.

Science. 2004 Oct 22;306(5696):704-8.

32.

c-Kit is preferentially expressed in MYCN-amplified neuroblastoma and its effect on cell proliferation is inhibited in vitro by STI-571.

Vitali R, Cesi V, Nicotra MR, McDowell HP, Donfrancesco A, Mannarino O, Natali PG, Raschellà G, Dominici C.

Int J Cancer. 2003 Aug 20;106(2):147-52.

33.

Update on childhood rhabdomyosarcoma.

McDowell HP.

Arch Dis Child. 2003 Apr;88(4):354-7. Review.

34.

Secondary parkinsonism: an unusual late complication of craniospinal radiotherapy given to a 16-month child.

Skiming JA, McDowell HP, Wright N, May P.

Med Pediatr Oncol. 2003 Feb;40(2):132-4. No abstract available.

PMID:
12461804
35.

Surviving childhood cancer.

McDowell HP.

Hosp Med. 2002 Sep;63(9):520-1. No abstract available.

PMID:
12357852
36.

Localized paediatric orbital rhabdomyosarcoma: influence of imaging on treatment.

Burns BJ, McHugh K, McDowell HP, Anslow P, Mitchell C.

Clin Radiol. 2001 Dec;56(12):959-64.

PMID:
11795923
37.

Pancreatic inflammatory tumour: a rare entity in childhood.

Shankar KR, Losty PD, Khine MM, Lamont GL, McDowell HP.

J R Coll Surg Edinb. 1998 Dec;43(6):422-3. Review.

PMID:
9990796
38.

High-dose cyclophosphamide for poor-prognosis and recurrent pediatric brain tumors: a dose-escalation study.

Yule SM, Foreman NK, Mitchell C, Gouldon N, May P, McDowell HP.

J Clin Oncol. 1997 Oct;15(10):3258-65.

PMID:
9336363
39.

SIOP Working Committee on psychosocial issues in pediatric oncology: guidelines for communication of the diagnosis.

Masera G, Chesler MA, Jankovic M, Ablin AR, Ben Arush MW, Breatnach F, McDowell HP, Eden T, Epelman C, Fossati Bellani F, Green DM, Kosmidis HV, Nesbit ME, Wandzura C, Wilbur JR, Spinetta JJ.

Med Pediatr Oncol. 1997 May;28(5):382-5.

PMID:
9121407
40.

Clinical evaluation of ticarcillin, with clavulanic acid, and gentamicin in the treatment of febrile episodes in neutropenic children.

Bolton-Maggs PH, van Saene HK, McDowell HP, Martin J.

J Antimicrob Chemother. 1991 May;27(5):669-76.

PMID:
1885425
41.

Isolated pulmonary histiocytosis.

McDowell HP, Macfarlane PI, Martin J.

Arch Dis Child. 1988 Apr;63(4):423-6.

42.

Acute lymphoblastic leukaemia: trimethoprim resistant organisms during treatment.

McDowell HP, Shears P, Hart CA, Martin J.

Arch Dis Child. 1987 Jun;62(6):573-5.

43.

Implantable subcutaneous venous catheters.

McDowell HP, Hart CA, Martin J.

Arch Dis Child. 1986 Oct;61(10):1037-8.

44.

Sugar intolerance complicating acute gastroenteritis.

Evans-Jones G, McDowell HP.

Arch Dis Child. 1986 Jul;61(7):716-7. No abstract available.

45.

Is gradual reintroduction of milk feeds in gastroenteritis necessary?

McDowell HP, Evans-Jones G.

Lancet. 1985 Mar 23;1(8430):690. No abstract available.

PMID:
2858630
46.

Traumatic perforation of the hypopharynx--an unusual form of abuse.

McDowell HP, Fielding DW.

Arch Dis Child. 1984 Sep;59(9):888-9.

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