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Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Chauhan A, Lalor T, Watson S, Adams D, Farrah TE, Anand A, Kimmitt R, Mills NL, Webb DJ, Dhaun N, Kalla R, Adams A, Vatn S, Bonfliglio F, Nimmo E, Kennedy N, Ventham N, Vatn M, Ricanek P, Halfvarson J, Soderhollm J, Pierik M, Torkvist L, Gomollon F, Gut I, Jahnsen J, Satsangi J, Body R, Almashali M, McDowell G, Taylor P, Lacey A, Rees A, Dayan C, Lazarus J, Nelson S, Okosieme O, Corcoran D, Young R, Ciadella P, McCartney P, Bajrangee A, Hennigan B, Collison D, Carrick D, Shaukat A, Good R, Watkins S, McEntegart M, Watt J, Welsh P, Sattar N, McConnachie A, Oldroyd K, Berry C, Parks T, Auckland K, Mentzer AJ, Kado J, Mirabel MM, Kauwe JK, Robson KJ, Mittal B, Steer AC, Hill AVS, Akbar M, Forrester M, Virlan AT, Gilmour A, Wallace C, Paterson C, Reid D, Siebert S, Porter D, Liversidge J, McInnes I, Goodyear C, Athwal V, Pritchett J, Zaitoun A, Irving W, Guha IN, Hanley NA, Hanley KP, Briggs T, Reynolds J, Rice G, Bondet V, Bruce E, Crow Y, Duffy D, Parker B, Bruce I, Martin K, Pritchett J, Aoibheann Mullan M, Llewellyn J, Athwal V, Zeef L, Farrow S, Streuli C, Henderson N, Friedman S, Hanley N, Hanley KP.

QJM. 2018 Dec 1;111(12):920-924. doi: 10.1093/qjmed/hcy193. No abstract available.


Diagnostic Accuracy of a High-Sensitivity Cardiac Troponin Assay with a Single Serum Test in the Emergency Department.

Body R, Twerenbold R, Austin C, Boeddinghaus J, Almashali M, Nestelberger T, Morris N, Badertscher P, McDowell G, Wildi K, Moss P, Gimenez MR, Jarman H, Bigler N, Einemann R, Koechlin L, Pourmahram G, Todd J, Mueller C, Freemont A.

Clin Chem. 2019 May 22. pii: clinchem.2018.294272. doi: 10.1373/clinchem.2018.294272. [Epub ahead of print]


Guest Editorial: Physician Guidance on the Use of Off-Labeled Drugs in Intrathecal Drug Delivery Systems for Chronic Pain.

Deer T, Kim P, Pope JE, Hayek S, McDowell G, Mekhail N, Diwan S, Saulino M, Moeschler S, Schultz D, Gritsenko K, Prager J, Peterson EA, Staats P, Poree L, Fishman MA, Vallejo R, Calodney A, Slavin K, de Leon Cassadala O, Levy R, Buvanendran A, Sitzman BT, Sayed D, Ferrante FM, Kloth D, Gilligan CJ, Kapural L, Kloster DR, Leong M, Rosenow JM, Lamer TJ, Stearns L.

Neuromodulation. 2019 Apr 30. doi: 10.1111/ner.12961. [Epub ahead of print] No abstract available.


Formation of the Inclusive Environments and Metrics in Biology Education and Research (iEMBER) Network: Building a Culture of Diversity, Equity, and Inclusion.

Tennial RE, Solomon ED, Hammonds-Odie L, McDowell GS, Moore M, Roca AI, Marcette J.

CBE Life Sci Educ. 2019 Mar;18(1):mr1. doi: 10.1187/cbe.18-03-0042.


Defending harassers harms victims.

Barolo S, Bohr T, Folk J, Libarkin J, McDowell G, McLaughlin B.

Science. 2019 Jan 25;363(6425):355. doi: 10.1126/science.aav7283. No abstract available.


Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay.

Body R, Almashali M, Morris N, Moss P, Jarman H, Appelboam A, Parris R, Chan L, Walker A, Harrison M, Wootten A, McDowell G.

Heart. 2019 May;105(10):768-774. doi: 10.1136/heartjnl-2018-313825. Epub 2019 Jan 12.


Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic?

Slevin M, Iemma RS, Zeinolabediny Y, Liu D, Ferris GR, Caprio V, Phillips N, Di Napoli M, Guo B, Zeng X, AlBaradie R, Binsaleh NK, McDowell G, Fang WH.

Front Immunol. 2018 Sep 26;9:2124. doi: 10.3389/fimmu.2018.02124. eCollection 2018.


Intrathecal Therapy for Chronic Pain: A Review of Morphine and Ziconotide as Firstline Options.

Deer TR, Pope JE, Hanes MC, McDowell GC.

Pain Med. 2019 Apr 1;20(4):784-798. doi: 10.1093/pm/pny132.


Changing the Culture of Science Communication Training for Junior Scientists.

Bankston A, McDowell GS.

J Microbiol Biol Educ. 2018 Mar 30;19(1). pii: 19.1.43. doi: 10.1128/jmbe.v19i1.1413. eCollection 2018.


Calculating the Degradation Rate of Individual Proteins Using Xenopus Extract Systems.

McDowell GS, Philpott A.

Cold Spring Harb Protoc. 2019 Jun 3;2019(6):pdb.prot103481. doi: 10.1101/pdb.prot103481.


Assessing Ubiquitylation of Individual Proteins Using Xenopus Extract Systems.

McDowell GS, Philpott A.

Cold Spring Harb Protoc. 2019 Jun 3;2019(6):pdb.prot104513. doi: 10.1101/pdb.prot104513.


Role of primary care physicians in intrathecal pain management: a narrative review of the literature.

McDowell GC 2nd, Winchell J.

Postgrad Med. 2018 May;130(4):411-419. doi: 10.1080/00325481.2018.1448207. Epub 2018 Mar 28. Review.


Evaluation of a 27-gene inherited cancer panel across 630 consecutive patients referred for testing in a clinical diagnostic laboratory.

Gardner SA, Weymouth KS, Kelly WS, Bogdanova E, Chen W, Lupu D, Suhl J, Zeng Q, Geigenmüller U, Boles D, Okamoto PM, McDowell G, Hayden MA, Nagan N.

Hered Cancer Clin Pract. 2018 Jan 4;16:1. doi: 10.1186/s13053-017-0083-8. eCollection 2018.


Discrete element modelling of under sleeper pads using a box test.

Li H, McDowell GR.

Granul Matter. 2018;20(2):26. doi: 10.1007/s10035-018-0795-0. Epub 2018 Mar 17.


What's in a name?

Schaller MD, McDowell G, Porter A, Shippen D, Friedman KL, Gentry MS, Serio TR, Sundquist WI.

Elife. 2017 Oct 24;6. pii: e32437. doi: 10.7554/eLife.32437.


Monitoring the compliance of the academic enterprise with the Fair Labor Standards Act.

Bankston A, McDowell GS.

Version 2. F1000Res. 2016 Nov 17 [revised 2017 Jan 1];5:2690. doi: 10.12688/f1000research.10086.2. eCollection 2016.


Effectiveness and Safety of Intrathecal Ziconotide: Interim Analysis of the Patient Registry of Intrathecal Ziconotide Management (PRIZM).

Deer T, Rauck RL, Kim P, Saulino MF, Wallace M, Grigsby EJ, Huang IZ, Mori F, Vanhove GF, McDowell GC 2nd.

Pain Pract. 2018 Feb;18(2):230-238. doi: 10.1111/papr.12599. Epub 2017 Jul 14.


Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging.

Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S.

Reprod Biomed Online. 2017 May;34(5):455-462. doi: 10.1016/j.rbmo.2017.02.011. Epub 2017 Mar 1.


Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms.

Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S.

Fertil Steril. 2017 Mar;107(3):613-621. doi: 10.1016/j.fertnstert.2016.11.014. Epub 2017 Jan 6.


The Rise and Fall of Cardiac Troponin T.

Body R, McDowell G.

Clin Chem. 2017 Jan;63(1):437. doi: 10.1373/clinchem.2016.265629. No abstract available.


The new face of US science.

Heggeness ML, Gunsalus KT, Pacas J, McDowell G.

Nature. 2017 Jan 3;541(7635):21-23. doi: 10.1038/541021a. No abstract available.


The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines.

Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G II, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N.

Neuromodulation. 2017 Feb;20(2):96-132. doi: 10.1111/ner.12538. Epub 2017 Jan 2. Review. Erratum in: Neuromodulation. 2017 Jun;20(4):405-406.


Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis.

Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S.

Hum Fertil (Camb). 2017 Sep;20(3):179-185. doi: 10.1080/14647273.2016.1258735. Epub 2016 Nov 24.


From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning.

McDowell G, Rajadurai S, Levin M.

Philos Trans R Soc Lond B Biol Sci. 2016 Dec 19;371(1710). pii: 20150409. Review.


Ubiquitin-mediated proteolysis in Xenopus extract.

McDowell GS, Philpott A.

Int J Dev Biol. 2016;60(7-8-9):263-270. Review.


Community-based adaptation research in the Canadian Arctic.

Ford JD, Stephenson E, Cunsolo Willox A, Edge V, Farahbakhsh K, Furgal C, Harper S, Chatwood S, Mauro I, Pearce T, Austin S, Bunce A, Bussalleu A, Diaz J, Finner K, Gordon A, Huet C, Kitching K, Lardeau MP, McDowell G, McDonald E, Nakoneczny L, Sherman M.

Wiley Interdiscip Rev Clim Change. 2016 Mar-Apr;7(2):175-191. Epub 2015 Nov 25. Review.


Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells.

Fang WH, Kumar S, McDowell G, Smith D, Krupinski J, Olah P, Al-Baradie RS, Al-Rukban MO, Petcu EB, Slevin M.

Stem Cells Int. 2016;2016:2165462. doi: 10.1155/2016/2165462. Epub 2016 Aug 29.


Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker re-derivation and external validation in three cohorts.

Body R, Carlton E, Sperrin M, Lewis PS, Burrows G, Carley S, McDowell G, Buchan I, Greaves K, Mackway-Jones K.

Emerg Med J. 2017 Jun;34(6):349-356. doi: 10.1136/emermed-2016-205983. Epub 2016 Aug 26.


The interobserver reliability of a novel qualitative point of care assay for heart-type fatty acid binding protein.

Al Mashali M, Morris N, McDowell G, Body R.

Clin Biochem. 2016 Oct;49(15):1199-1201. doi: 10.1016/j.clinbiochem.2016.06.010. Epub 2016 Jun 27.


Junior researchers: Fewer papers would scotch early careers.

McDowell GS, Polka JK.

Nature. 2016 Jun 30;534(7609):621. doi: 10.1038/534621b. No abstract available.


New Insights Into the Role of Ubiquitylation of Proteins.

McDowell GS, Philpott A.

Int Rev Cell Mol Biol. 2016;325:35-88. doi: 10.1016/bs.ircmb.2016.02.002. Epub 2016 Mar 8. Review.


Conserved roles for cytoskeletal components in determining laterality.

McDowell GS, Lemire JM, Paré JF, Cammarata G, Lowery LA, Levin M.

Integr Biol (Camb). 2016 Mar 14;8(3):267-86. doi: 10.1039/c5ib00281h. Review.


Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.

Davison A, McDowell GS, Holden JM, Johnson HF, Koutsovoulos GD, Liu MM, Hulpiau P, Van Roy F, Wade CM, Banerjee R, Yang F, Chiba S, Davey JW, Jackson DJ, Levin M, Blaxter ML.

Curr Biol. 2016 Mar 7;26(5):654-60. doi: 10.1016/j.cub.2015.12.071. Epub 2016 Feb 25.


Intrathecal Ziconotide: Dosing and Administration Strategies in Patients With Refractory Chronic Pain.

McDowell GC 2nd, Pope JE.

Neuromodulation. 2016 Jul;19(5):522-32. doi: 10.1111/ner.12392. Epub 2016 Feb 9. Review.


Why not have a life?

McDowell G.

Science. 2015 Jul 31;349(6247):554. doi: 10.1126/science.349.6247.554. No abstract available.


A call for transparency in tracking student and postdoc career outcomes.

Polka JK, Krukenberg KA, McDowell GS.

Mol Biol Cell. 2015 Apr 15;26(8):1413-5. doi: 10.1091/mbc.E14-10-1432.


Investigation of proposed mechanisms of chemotherapy-induced venous thromboembolism: endothelial cell activation and procoagulant release due to apoptosis.

Kirwan CC, McCollum CN, McDowell G, Byrne GJ.

Clin Appl Thromb Hemost. 2015 Jul;21(5):420-7. doi: 10.1177/1076029615575071. Epub 2015 Mar 5.


Shaping the Future of Research: a perspective from junior scientists.

McDowell GS, Gunsalus KT, MacKellar DC, Mazzilli SA, Pai VP, Goodwin PR, Walsh EM, Robinson-Mosher A, Bowman TA, Kraemer J, Erb ML, Schoenfeld E, Shokri L, Jackson JD, Islam A, Mattozzi MD, Krukenberg KA, Polka JK.

Version 2. F1000Res. 2014 Nov 28 [revised 2015 Jan 1];3:291. doi: 10.12688/f1000research.5878.2. eCollection 2014.


Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.

McDowell GS, Hindley CJ, Lippens G, Landrieu I, Philpott A.

BMC Biochem. 2014 Nov 6;15:24. doi: 10.1186/s12858-014-0024-3.


The appropriate use of neurostimulation: avoidance and treatment of complications of neurostimulation therapies for the treatment of chronic pain. Neuromodulation Appropriateness Consensus Committee.

Deer TR, Mekhail N, Provenzano D, Pope J, Krames E, Thomson S, Raso L, Burton A, DeAndres J, Buchser E, Buvanendran A, Liem L, Kumar K, Rizvi S, Feler C, Abejon D, Anderson J, Eldabe S, Kim P, Leong M, Hayek S, McDowell G 2nd, Poree L, Brooks ES, McJunkin T, Lynch P, Kapural L, Foreman RD, Caraway D, Alo K, Narouze S, Levy RM, North R; Neuromodulation Appropriateness Consensus Committee.

Neuromodulation. 2014 Aug;17(6):571-97; discussion 597-8. doi: 10.1111/ner.12206.


The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee.

Deer TR, Mekhail N, Provenzano D, Pope J, Krames E, Leong M, Levy RM, Abejon D, Buchser E, Burton A, Buvanendran A, Candido K, Caraway D, Cousins M, DeJongste M, Diwan S, Eldabe S, Gatzinsky K, Foreman RD, Hayek S, Kim P, Kinfe T, Kloth D, Kumar K, Rizvi S, Lad SP, Liem L, Linderoth B, Mackey S, McDowell G, McRoberts P, Poree L, Prager J, Raso L, Rauck R, Russo M, Simpson B, Slavin K, Staats P, Stanton-Hicks M, Verrills P, Wellington J, Williams K, North R; Neuromodulation Appropriateness Consensus Committee.

Neuromodulation. 2014 Aug;17(6):515-50; discussion 550. doi: 10.1111/ner.12208.


Complex domain interactions regulate stability and activity of closely related proneural transcription factors.

McDowell GS, Hardwick LJ, Philpott A.

Biochem Biophys Res Commun. 2014 Aug 8;450(4):1283-90. doi: 10.1016/j.bbrc.2014.06.127. Epub 2014 Jul 3.


The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation.

Body R, Carley S, McDowell G, Pemberton P, Burrows G, Cook G, Lewis PS, Smith A, Mackway-Jones K.

Heart. 2014 Sep 15;100(18):1462-8. doi: 10.1136/heartjnl-2014-305564. Epub 2014 Apr 29.


Predicting glycerophosphoinositol identities in lipidomic datasets using VaLID (Visualization and Phospholipid Identification)--an online bioinformatic search engine.

McDowell GS, Blanchard AP, Taylor GP, Figeys D, Fai S, Bennett SA.

Biomed Res Int. 2014;2014:818670. doi: 10.1155/2014/818670. Epub 2014 Feb 20.


Novel methods for accurate identification, isolation, and genomic analysis of symptomatic microenvironments in atherosclerotic arteries.

Slevin M, Baldellou M, Hill E, Alexander Y, McDowell G, Murgatroyd C, Carroll M, Degens H, Krupinski J, Rovira N, Chowdhury M, Serracino-Inglott F, Badimon L.

Methods Mol Biol. 2014;1135:289-305. doi: 10.1007/978-1-4939-0320-7_24.


Administering ziconotide and monitoring patients treated with ziconotide: expert opinions.

Mitchell AA, Sapienza-Crawford AJ, Hanley KL, Lokey KJ, Wells L, McDowell GC 2nd, Stanton-Hicks M.

Pain Manag Nurs. 2013 Sep;14(3):e84-94. doi: 10.1016/j.pmn.2011.05.004. Epub 2011 Nov 29. Review.


Non-canonical ubiquitylation: mechanisms and consequences.

McDowell GS, Philpott A.

Int J Biochem Cell Biol. 2013 Aug;45(8):1833-42. doi: 10.1016/j.biocel.2013.05.026. Epub 2013 May 31. Review.


iFASP: combining isobaric mass tagging with filter-aided sample preparation.

McDowell GS, Gaun A, Steen H.

J Proteome Res. 2013 Aug 2;12(8):3809-12. doi: 10.1021/pr400032m. Epub 2013 Jul 22.


SweetSEQer, simple de novo filtering and annotation of glycoconjugate mass spectra.

Serang O, Froehlich JW, Muntel J, McDowell G, Steen H, Lee RS, Steen JA.

Mol Cell Proteomics. 2013 Jun;12(6):1735-40. doi: 10.1074/mcp.O112.025940. Epub 2013 Feb 26.


Visualization and Phospholipid Identification (VaLID): online integrated search engine capable of identifying and visualizing glycerophospholipids with given mass.

Blanchard AP, McDowell GS, Valenzuela N, Xu H, Gelbard S, Bertrand M, Slater GW, Figeys D, Fai S, Bennett SA.

Bioinformatics. 2013 Jan 15;29(2):284-5. doi: 10.1093/bioinformatics/bts662. Epub 2012 Nov 18.

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