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Items: 1 to 50 of 102

1.

Value of Axillary Ultrasound after Negative Axillary MRI for Evaluating Nodal Status in High-Risk Breast Cancer.

Almerey T, Villacreses D, Li Z, Patel B, McDonough MA, Gibson T, Maimone S, Gray R, McLaughlin SA.

J Am Coll Surg. 2019 Feb 21. pii: S1072-7515(19)30154-1. doi: 10.1016/j.jamcollsurg.2019.01.022. [Epub ahead of print]

PMID:
30797947
2.

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7.

3.

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens.

Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ.

Hypoxia (Auckl). 2018 Nov 9;6:57-71. doi: 10.2147/HP.S174655. eCollection 2018.

4.

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ.

Elife. 2018 Dec 3;7. pii: e39865. doi: 10.7554/eLife.39865.

5.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

6.

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2928-2936. doi: 10.1016/j.bmc.2018.02.043. Epub 2018 Feb 23.

7.

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.

Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ.

Extremophiles. 2018 May;22(3):553-562. doi: 10.1007/s00792-018-1016-9. Epub 2018 Mar 9.

8.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.

J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10.

9.

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.

Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ.

Org Biomol Chem. 2017 Jul 19;15(28):6024-6032. doi: 10.1039/c7ob01514c.

PMID:
28678295
10.

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ.

Chem Commun (Camb). 2017 May 30;53(43):5806-5809. doi: 10.1039/c7cc02394d.

11.

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors.

Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ.

Chem Sci. 2017 Feb 1;8(2):928-937. doi: 10.1039/c6sc04524c. Epub 2016 Dec 14.

12.

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4667-4672. doi: 10.1073/pnas.1617760114. Epub 2017 Apr 18.

13.

Tracking to Excellence: Automating Breast Imaging Wait-time Monitoring.

McDonough MA, Yang G, Palmieri JM, DeYoung D, Zwart CM, Pizzitola V.

Radiol Technol. 2017 Mar;88(4):431-434. No abstract available.

PMID:
28298503
14.

Cyclic Boronates Inhibit All Classes of β-Lactamases.

Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02260-16. doi: 10.1128/AAC.02260-16. Print 2017 Apr.

15.

Use of ferrous iron by metallo-β-lactamases.

Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J.

J Inorg Biochem. 2016 Oct;163:185-193. doi: 10.1016/j.jinorgbio.2016.07.013. Epub 2016 Jul 26.

16.

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ.

Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406.

17.

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1377-84. doi: 10.1128/AAC.01768-15.

18.

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis.

Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J.

Chemistry. 2016 Jan 22;22(4):1270-6. doi: 10.1002/chem.201503761. Epub 2015 Dec 14.

19.

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.

Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan.

20.

Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay.

Daoud H, Zhang D, McMurray F, Yu A, Luco SM, Vanstone J, Jarinova O, Carson N, Wickens J, Shishodia S, Choi H, McDonough MA, Schofield CJ, Harper ME, Dyment DA, Armour CM.

J Med Genet. 2016 Mar;53(3):200-7. doi: 10.1136/jmedgenet-2015-103399. Epub 2015 Sep 16.

PMID:
26378117
21.

Pharmacological inhibition of FTO.

McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD.

PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015.

22.

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases.

Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA.

Structure. 2015 Apr 7;23(4):639-52. doi: 10.1016/j.str.2015.01.014. Epub 2015 Feb 26.

24.

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

Pettinati I, Brem J, McDonough MA, Schofield CJ.

Hum Mol Genet. 2015 May 1;24(9):2458-69. doi: 10.1093/hmg/ddv007. Epub 2015 Jan 16.

25.

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ.

Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17.

PMID:
25411887
26.

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.

Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, Horita S, Ho CH, Kershaw NJ, Tang CM, Claridge TD, Preston GM, McDonough MA, Schofield CJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13331-6. doi: 10.1073/pnas.1409916111. Epub 2014 Sep 2.

27.

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.

Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125. Epub 2014 Aug 27.

28.

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.

Rydzik AM, Leung IK, Kochan GT, Loik ND, Henry L, McDonough MA, Claridge TD, Schofield CJ.

Org Biomol Chem. 2014 Sep 7;12(33):6354-8. doi: 10.1039/c4ob01167h.

PMID:
25030770
29.

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JRC, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ.

Nature. 2014 Jun 19;510(7505):422-426. doi: 10.1038/nature13263. Epub 2014 May 11.

30.

Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase.

Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ.

Chem Sci. 2014 May 1;5(5):1765-1771.

31.

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4019-24. doi: 10.1073/pnas.1311750111. Epub 2014 Feb 18.

32.

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.

Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA.

Nucleic Acids Res. 2014 Apr;42(7):4741-54. doi: 10.1093/nar/gku085. Epub 2014 Jan 30.

33.

Structural insights into how 5-hydroxymethylation influences transcription factor binding.

Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ.

Chem Commun (Camb). 2014 Feb 21;50(15):1794-6. doi: 10.1039/c3cc48151d. Epub 2013 Nov 29.

PMID:
24287551
34.

Binding of (5S)-penicilloic acid to penicillin binding protein 3.

van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ.

ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15.

PMID:
23899657
35.

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, McDonough MA, Krojer T, Yue WW, Ng SS, Olsen L, Brennan PE, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ, Kawamura A.

Chem Sci. 2013 Aug 1;4(8):3110-3117. doi: 10.1039/C3SC51122G.

36.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Valegård K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1567-79. doi: 10.1107/S0907444913011013. Epub 2013 Jul 20.

PMID:
23897479
37.

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.

Abuhammad A, Lowe ED, McDonough MA, Shaw Stewart PD, Kolek SA, Sim E, Garman EF.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1433-46. doi: 10.1107/S0907444913015126. Epub 2013 Jul 17.

PMID:
23897467
38.

An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin.

Bräutigam L, Johansson C, Kubsch B, McDonough MA, Bill E, Holmgren A, Berndt C.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):491-6. doi: 10.1016/j.bbrc.2013.05.132. Epub 2013 Jun 10.

PMID:
23756812
39.

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, Pugh CW, Ratcliffe PJ, Schofield CJ.

ACS Chem Biol. 2013 Jul 19;8(7):1488-96. doi: 10.1021/cb400088q. Epub 2013 Jun 12.

PMID:
23683440
40.

Structural basis for inhibition of the fat mass and obesity associated protein (FTO).

Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, Lejeune C, Zhang Z, McDonough MA, Schofield CJ.

J Med Chem. 2013 May 9;56(9):3680-8. doi: 10.1021/jm400193d. Epub 2013 Apr 23.

PMID:
23547775
41.

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ.

Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1700-4. doi: 10.1002/anie.201208046. Epub 2013 Jan 7. No abstract available.

PMID:
23296631
42.

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.

Aik W, McDonough MA, Thalhammer A, Chowdhury R, Schofield CJ.

Curr Opin Struct Biol. 2012 Dec;22(6):691-700. doi: 10.1016/j.sbi.2012.10.001. Epub 2012 Nov 9. Review.

PMID:
23142576
43.

The enzymes of β-lactam biosynthesis.

Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ.

Nat Prod Rep. 2013 Jan;30(1):21-107. doi: 10.1039/c2np20065a. Review. Erratum in: Nat Prod Rep. 2014 Sep;31(9):1127.

PMID:
23135477
44.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A.

J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11.

45.

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ.

Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6672-5. doi: 10.1002/anie.201202000. Epub 2012 May 25. No abstract available.

PMID:
22639232
46.

Commentary on Kurdyak et al. (2012): Methadone and other opioids - need for coordinated prescribing.

Dobbin MD, McDonough MA.

Addiction. 2012 Apr;107(4):781-2. doi: 10.1111/j.1360-0443.2012.03779.x. No abstract available.

PMID:
22372704
47.

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ.

J Med Chem. 2012 Mar 8;55(5):2173-84. doi: 10.1021/jm201417e. Epub 2012 Feb 22.

PMID:
22263962
48.

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.

Mantri M, Zhang Z, McDonough MA, Schofield CJ.

FEBS J. 2012 May;279(9):1563-75. doi: 10.1111/j.1742-4658.2012.08496.x. Epub 2012 Feb 20. Review.

49.

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ.

Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi: 10.1002/anie.201107833. Epub 2012 Jan 12. No abstract available.

PMID:
22241642
50.

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ.

J Mol Biol. 2011 Jul 8;410(2):268-79. doi: 10.1016/j.jmb.2011.04.075. Epub 2011 May 13.

PMID:
21601578

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