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Items: 20


Biomarkers in Motor Neuron Disease: A State of the Art Review.

Verber NS, Shepheard SR, Sassani M, McDonough HE, Moore SA, Alix JJP, Wilkinson ID, Jenkins TM, Shaw PJ.

Front Neurol. 2019 Apr 3;10:291. doi: 10.3389/fneur.2019.00291. eCollection 2019. Review.


Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC.

PLoS Genet. 2018 Sep 17;14(9):e1007664. doi: 10.1371/journal.pgen.1007664. eCollection 2018 Sep.


Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP.

Shi CH, Schisler JC, Rubel CE, Tan S, Song B, McDonough H, Xu L, Portbury AL, Mao CY, True C, Wang RH, Wang QZ, Sun SL, Seminara SB, Patterson C, Xu YM.

Hum Mol Genet. 2014 Feb 15;23(4):1013-24. doi: 10.1093/hmg/ddt497. Epub 2013 Oct 9.


The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.

Ronnebaum SM, Wu Y, McDonough H, Patterson C.

Mol Cell Biol. 2013 Nov;33(22):4461-72. doi: 10.1128/MCB.00480-13. Epub 2013 Sep 16.


Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise.

Willis MS, Min JN, Wang S, McDonough H, Lockyer P, Wadosky KM, Patterson C.

Cell Biochem Funct. 2013 Dec;31(8):724-35. doi: 10.1002/cbf.2962. Epub 2013 Apr 2.


Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.

McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury A, Cyr DM, Patterson C.

J Biol Chem. 2009 Jul 31;284(31):20649-59. doi: 10.1074/jbc.M109.011767. Epub 2009 May 22.


Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.

Li HH, Willis MS, Lockyer P, Miller N, McDonough H, Glass DJ, Patterson C.

J Clin Invest. 2007 Nov;117(11):3211-23.


PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation.

Wu Y, Ferguson JE 3rd, Wang H, Kelley R, Ren R, McDonough H, Meeker J, Charles PC, Wang H, Patterson C.

J Mol Cell Cardiol. 2008 Jan;44(1):47-58. Epub 2007 Jun 30.


CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70.

Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C.

Nature. 2006 Mar 23;440(7083):551-5.


Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

Potts MB, Vaughn AE, McDonough H, Patterson C, Deshmukh M.

J Cell Biol. 2005 Dec 19;171(6):925-30. Epub 2005 Dec 12.


Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.

Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C.

J Biol Chem. 2005 Nov 18;280(46):38673-81. Epub 2005 Sep 16.


Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.

Kedar V, McDonough H, Arya R, Li HH, Rockman HA, Patterson C.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18135-40. Epub 2004 Dec 15.


Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy.

Arya R, Kedar V, Hwang JR, McDonough H, Li HH, Taylor J, Patterson C.

J Cell Biol. 2004 Dec 20;167(6):1147-59. Epub 2004 Dec 13.


Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.

Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C.

J Clin Invest. 2004 Oct;114(8):1058-71.


CHIP: a link between the chaperone and proteasome systems.

McDonough H, Patterson C.

Cell Stress Chaperones. 2003 Winter;8(4):303-8. Review.


CHIP activates HSF1 and confers protection against apoptosis and cellular stress.

Dai Q, Zhang C, Wu Y, McDonough H, Whaley RA, Godfrey V, Li HH, Madamanchi N, Xu W, Neckers L, Cyr D, Patterson C.

EMBO J. 2003 Oct 15;22(20):5446-58.


Phenotype of FAECB (Facility for Automated Experiments in Cell Biology) Chinese hamster ovary mutants with minimal UV-sensitivity.

Busch DB, White Ziffer D, Coleman D, Wills L, McDonough HG, Jones NJ.

Mutat Res. 2001 Nov 1;487(1-2):31-9.


Ionic diffusion in transverse tubules of cardiac ventricular myocytes.

Shepherd N, McDonough HB.

Am J Physiol. 1998 Sep;275(3):H852-60. doi: 10.1152/ajpheart.1998.275.3.H852.


Therapeutic management of sexual abuse allegations in custody and visitation disputes.

Awad GA, McDonough H.

Am J Psychother. 1991 Jan;45(1):113-23.


The challenge of sexual abuse: protection and therapy in a child welfare setting.

McDonough H, Love AJ.

Child Welfare. 1987 May-Jun;66(3):225-35.


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