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Characterization of a Subset of Patients With Rheumatoid Arthritis for Whom Current Management Strategies are Inadequate.

Bradford CM, McDonnell T, Raj D, Robinson GA, Cole A, Ramakrishnan S, González-Serrano R, Mak J, Eskiocak YC, Isenberg DA, Ciurtin C, Jury EC, Manson JJ.

ACR Open Rheumatol. 2019 Apr 22;1(3):145-155. doi: 10.1002/acr2.1021. eCollection 2019 May.


Maternal employment and childcare during infancy and childhood overweight.

McDonnell T, Doyle O.

Soc Sci Med. 2019 Dec;243:112639. doi: 10.1016/j.socscimed.2019.112639. Epub 2019 Oct 24.


Flex-Array® - a novel multi-well vessel system for the immobilization and multi-modal testing of intact formalin-fixed paraffin-embedded (FFPE) cells or tissues.

Genty C, McDonnell TJ.

J Histotechnol. 2019 Nov 4:1-11. doi: 10.1080/01478885.2019.1679470. [Epub ahead of print]


Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort.

Segura BT, Bernstein BS, McDonnell T, Wincup C, M Ripoll V, Giles I, Isenberg D, Rahman A.

Rheumatology (Oxford). 2019 Oct 19. pii: kez516. doi: 10.1093/rheumatology/kez516. [Epub ahead of print] No abstract available.


The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS.

McDonnell T, Wincup C, Buchholz I, Pericleous C, Giles I, Ripoll V, Cohen H, Delcea M, Rahman A.

Blood Rev. 2019 Aug 16:100610. doi: 10.1016/j.blre.2019.100610. [Epub ahead of print] Review.


Oxygen Therapy in Ireland: A Nationwide Review of Delivery, Monitoring and Cost Implications

O’Donnell C, Davis P, McDonnell T.

Ir Med J. 2019 May 9;112(5):933.


Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort.

Segura BT, Bernstein BS, McDonnell T, Wincup C, Ripoll V, Giles I, Isenberg D, Rahman A.

Rheumatology (Oxford). 2019 Aug 3. pii: kez292. doi: 10.1093/rheumatology/kez292. [Epub ahead of print]


Antiphospholipid antibody levels in early systemic lupus erythematosus: are they associated with subsequent mortality and vascular events?

Pericleous C, D'Souza A, McDonnell T, Ripoll VM, Leach O, Isenberg D, Giles I, Rahman A.

Rheumatology (Oxford). 2020 Jan 1;59(1):146-152. doi: 10.1093/rheumatology/kez239.


Menorrhagia: an underappreciated problem in pre-menopausal women with systemic lupus erythematosus.

Wincup C, McDonnell TCR, Rahman A.

Lupus. 2019 Jun;28(7):916-917. doi: 10.1177/0961203319851868. Epub 2019 May 27. No abstract available.


Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation.

Albay A, Artim-Esen B, Pericleous C, Wincup C, Giles I, Rahman A, McDonnell T.

Lupus. 2019 Jun;28(7):893-897. doi: 10.1177/0961203319851571. Epub 2019 May 24.


Diet and lupus: what do the patients think?

Robinson GA, Mcdonnell T, Wincup C, Martin-Gutierrez L, Wilton J, Kalea AZ, Ciurtin C, Pineda-Torra I, Jury EC.

Lupus. 2019 May;28(6):755-763. doi: 10.1177/0961203319845473. Epub 2019 Apr 26.


Does maternal attachment to her infant mediate the link between perceptions of infant crying at 6 months and parenting stress at 24 months? A structural equation modelling approach.

Bailhache M, Doyle O, Salmi LR, McDonnell T.

Child Care Health Dev. 2019 Jul;45(4):540-550. doi: 10.1111/cch.12676. Epub 2019 May 21.


'When you hear hooves, think zebras, not horses'; two challenging cases of interstitial lung disease (ILD).

O'Callaghan M, Fabre A, Keane M, McDonnell TJ.

BMJ Case Rep. 2019 Feb 11;12(2). pii: bcr-2018-224507. doi: 10.1136/bcr-2018-224507.


PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome.

McDonnell TCR, Willis R, Pericleous C, Ripoll VM, Giles IP, Isenberg DA, Brasier AR, Gonzalez EB, Papalardo E, Romay-Penabad Z, Jamaluddin M, Ioannou Y, Rahman A.

Front Immunol. 2018 Oct 22;9:2413. doi: 10.3389/fimmu.2018.02413. eCollection 2018.


Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I.

McDonnell T, Artim-Esen B, Wincup C, Ripoll VM, Isenberg D, Giles IP, Rahman A, Pericleous C.

Front Immunol. 2018 Sep 28;9:2244. doi: 10.3389/fimmu.2018.02244. eCollection 2018.


Clinician-Facilitated Physical Activity Intervention Versus Pulmonary Rehabilitation for Improving Physical Activity in COPD: A Feasibility Study.

O'Neill B, O'Shea O, McDonough S, McGarvey L, Bradbury I, Arden M, Troosters T, Cosgrove D, McManus T, McDonnell T, Bradley J.

COPD. 2018 Jun;15(3):254-264. doi: 10.1080/15412555.2018.1486396. Epub 2018 Sep 5.


Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome.

Efthymiou M, Arachchillage DRJ, Lane PJ, O'Keeffe AG, McDonnell T, Cohen H, Mackie IJ.

Thromb Res. 2018 Oct;170:60-68. doi: 10.1016/j.thromres.2018.08.003. Epub 2018 Aug 7.


NO Releasing and Anticancer Properties of Octahedral Ruthenium-Nitrosyl Complexes with Equatorial 1 H-Indazole Ligands.

Orlowska E, Babak MV, Dömötör O, Enyedy EA, Rapta P, Zalibera M, Bučinský L, Malček M, Govind C, Karunakaran V, Farid YCS, McDonnell TE, Luneau D, Schaniel D, Ang WH, Arion VB.

Inorg Chem. 2018 Sep 4;57(17):10702-10717. doi: 10.1021/acs.inorgchem.8b01341. Epub 2018 Aug 14.


Gene expression profiling identifies distinct molecular signatures in thrombotic and obstetric antiphospholipid syndrome.

Ripoll VM, Pregnolato F, Mazza S, Bodio C, Grossi C, McDonnell T, Pericleous C, Meroni PL, Isenberg DA, Rahman A, Giles IP.

J Autoimmun. 2018 Sep;93:114-123. doi: 10.1016/j.jaut.2018.07.002. Epub 2018 Jul 19.


Vegetation dynamics associated with changes in atmospheric nitrogen deposition and climate in hardwood forests of Shenandoah and Great Smoky Mountains National Parks, USA.

McDonnell TC, Belyazid S, Sullivan TJ, Bell M, Clark C, Blett T, Evans T, Cass W, Hyduke A, Sverdrup H.

Environ Pollut. 2018 Jun;237:662-674. doi: 10.1016/j.envpol.2018.01.112. Epub 2018 Mar 15.


Cytogenetics-based risk prediction of blastic transformation of chronic myeloid leukemia in the era of TKI therapy.

Gong Z, Medeiros LJ, Cortes JE, Chen Z, Zheng L, Li Y, Bai S, Lin P, Miranda RN, Jorgensen JL, McDonnell TJ, Wang W, Kantarjian HM, Hu S.

Blood Adv. 2017 Dec 8;1(26):2541-2552. doi: 10.1182/bloodadvances.2017011858. eCollection 2017 Dec 12.


Going viral in rheumatology: using social media to show that mechanistic research is relevant to patients with lupus and antiphospholipid syndrome.

McDonnell TCR, Wincup C, Rahman A, Giles I.

Rheumatol Adv Pract. 2018;2(1):rky003. doi: 10.1093/rap/rky003. Epub 2018 Mar 5.


Feasibility of coupled empirical and dynamic modeling to assess climate change and air pollution impacts on temperate forest vegetation of the eastern United States.

McDonnell TC, Reinds GJ, Sullivan TJ, Clark CM, Bonten LTC, Mol-Dijkstra JP, Wamelink GWW, Dovciak M.

Environ Pollut. 2018 Mar;234:902-914. doi: 10.1016/j.envpol.2017.12.002. Epub 2017 Dec 21.


Comparison of outpatient and home-based exercise training programmes for COPD: A systematic review and meta-analysis.

Wuytack F, Devane D, Stovold E, McDonnell M, Casey M, McDonnell TJ, Gillespie P, Raymakers A, Lacasse Y, McCarthy B.

Respirology. 2018 Mar;23(3):272-283. doi: 10.1111/resp.13224. Epub 2017 Nov 30. Review.


Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.

Artim-Esen B, Smoktunowicz N, McDonnell T, Ripoll VM, Pericleous C, Mackie I, Robinson E, Isenberg D, Rahman A, Ioannou Y, Chambers RC, Giles I.

Sci Rep. 2017 Sep 7;7(1):10788. doi: 10.1038/s41598-017-11315-9.


Alport's syndrome with type 4 renal tubular acidosis.

McDonnell T, Chukwu C, Wong C.

BMJ Case Rep. 2017 May 31;2017. pii: bcr-2017-220146. doi: 10.1136/bcr-2017-220146.


A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.

Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN.

Nat Immunol. 2017 Mar;18(3):354-363. doi: 10.1038/ni.3665. Epub 2017 Jan 23.


Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK.

Bourke LT, McDonnell T, McCormick J, Pericleous C, Ripoll VM, Giles I, Rahman A, Stephanou A, Ioannou Y.

Cell Death Dis. 2017 Jan 12;8(1):e2549. doi: 10.1038/cddis.2016.235.


Restrained Terminal Differentiation and Sustained Stemness in Neonatal Skin by Ha-Ras and Bcl-2.

Lee S, Rodriguez-Villanueva J, McDonnell T.

Am J Dermatopathol. 2017 Mar;39(3):199-203. doi: 10.1097/DAD.0000000000000678.


Case of coccidioidomycosis in Ireland.

Duggan PT, Deegan AP, McDonnell TJ.

BMJ Case Rep. 2016 Aug 11;2016. pii: bcr2016215898. doi: 10.1136/bcr-2016-215898.


Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma.

Hidalgo Lopez JE, Yabe M, Carballo-Zarate AA, Wang SA, Jorgensen JL, Ahmed S, Lee J, Li S, Schlette E, McDonnell T, Miranda RN, Medeiros LJ, Bueso-Ramos CE, Yin CC.

J Natl Compr Canc Netw. 2016 Aug;14(8):939-44.


Measuring IgA Anti-β2-Glycoprotein I and IgG/IgA Anti-Domain I Antibodies Adds Value to Current Serological Assays for the Antiphospholipid Syndrome.

Pericleous C, Ferreira I, Borghi O, Pregnolato F, McDonnell T, Garza-Garcia A, Driscoll P, Pierangeli S, Isenberg D, Ioannou Y, Giles I, Meroni PL, Rahman A.

PLoS One. 2016 Jun 2;11(6):e0156407. doi: 10.1371/journal.pone.0156407. eCollection 2016.


ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.

Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y, Allen JE, Wang Z, Ma W, Lee HC, Orlowski R, Sarbassov dos D, Lorenzi PL, Huang X, Neelapu SS, McDonnell T, Miranda RN, Wang M, Kantarjian H, Konopleva M, Davis RE, Andreeff M.

Sci Signal. 2016 Feb 16;9(415):ra17. doi: 10.1126/scisignal.aac4380.


Patients Hospitalised with an Acute Exacerbation of COPD: Is There a Need for a Discharge Bundle of Care?

Migone C, O'Connor M, Kelly E, McDonnell T J.

Ir Med J. 2015 Oct;108(9):273-5.


Development of a high yield expression and purification system for Domain I of Beta-2-glycoprotein I for the treatment of APS.

McDonnell T, Pericleous C, Laurine E, Tommasi R, Garza-Garcia A, Giles I, Ioannou Y, Rahman A.

BMC Biotechnol. 2015 Nov 14;15:104. doi: 10.1186/s12896-015-0222-0.


Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP.

Xu-Monette ZY, Dabaja BS, Wang X, Tu M, Manyam GC, Tzankov A, Xia Y, Zhang L, Sun R, Visco C, Dybkaer K, Yin L, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Zhao X, Winter JN, Piris MA, McDonnell TJ, Miranda RN, Li Y, Medeiros LJ, Young KH.

Mod Pathol. 2015 Dec;28(12):1555-73. doi: 10.1038/modpathol.2015.118. Epub 2015 Nov 6.


A Survey of Lung Health and COPD Awareness amongst Participants at a Mobile Spirometry Clinic.

Rajgopall R, Migone C, O'Connor M, McDonnell T, Peelo D, McCormack S.

Ir Med J. 2015 Sep;108(8):246-8.


Downstream Warming and Headwater Acidity May Diminish Coldwater Habitat in Southern Appalachian Mountain Streams.

McDonnell TC, Sloat MR, Sullivan TJ, Dolloff CA, Hessburg PF, Povak NA, Jackson WA, Sams C.

PLoS One. 2015 Aug 6;10(8):e0134757. doi: 10.1371/journal.pone.0134757. eCollection 2015.


Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors.

Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S.

Blood. 2015 Oct 1;126(14):1699-706. doi: 10.1182/blood-2015-05-646489. Epub 2015 Aug 4.


Nursing intervention to enhance outpatient chemotherapy symptom management: Patient-reported outcomes of a randomized controlled trial.

Traeger L, McDonnell TM, McCarty CE, Greer JA, El-Jawahri A, Temel JS.

Cancer. 2015 Nov 1;121(21):3905-13. doi: 10.1002/cncr.29585. Epub 2015 Jul 20.


Pilot Study of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer.

Greer JA, MacDonald JJ, Vaughn J, Viscosi E, Traeger L, McDonnell T, Pirl WF, Temel JS.

J Pain Symptom Manage. 2015 Dec;50(6):854-60. doi: 10.1016/j.jpainsymman.2015.06.010. Epub 2015 Jul 10.


Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1.

Teo AE, Chen Z, Miranda RN, McDonnell T, Medeiros LJ, McCarty N.

Leukemia. 2016 Mar;30(3):580-93. doi: 10.1038/leu.2015.140. Epub 2015 May 15.


Defining exacerbations in chronic obstructive pulmonary disease.

Hawkins PE, Alam J, McDonnell TJ, Kelly E.

Expert Rev Respir Med. 2015 Jun;9(3):277-86. doi: 10.1586/17476348.2015.1046438. Review.


Pulmonary non-tuberculous mycobacteria in a general respiratory population.

Chong SG, Kent BD, Fitzgerald S, McDonnell TJ.

Ir Med J. 2014 Jul-Aug;107(7):207-9.


Steady-state sulfur critical loads and exceedances for protection of aquatic ecosystems in the U.S. Southern Appalachian Mountains.

McDonnell TC, Sullivan TJ, Hessburg PF, Reynolds KM, Povak NA, Cosby BJ, Jackson W, Salter RB.

J Environ Manage. 2014 Dec 15;146:407-419. doi: 10.1016/j.jenvman.2014.07.019. Epub 2014 Aug 16.


Recurrent pneumothoraces in a 65-year-old female: an unusual case of cystic lung disease.

Giin Chong S, Mitchell P, Fabre A, McDonnell TJ.

Eur Respir Rev. 2014 Jun;23(132):271-2. doi: 10.1183/09059180.00005013. No abstract available.


Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.

Yoshimura M, Ishizawa J, Ruvolo V, Dilip A, Quintás-Cardama A, McDonnell TJ, Neelapu SS, Kwak LW, Shacham S, Kauffman M, Tabe Y, Yokoo M, Kimura S, Andreeff M, Kojima K.

Cancer Sci. 2014 Jul;105(7):795-801. doi: 10.1111/cas.12430. Epub 2014 Jun 3.


Modeled subalpine plant community response to climate change and atmospheric nitrogen deposition in Rocky Mountain National Park, USA.

McDonnell TC, Belyazid S, Sullivan TJ, Sverdrup H, Bowman WD, Porter EM.

Environ Pollut. 2014 Apr;187:55-64. doi: 10.1016/j.envpol.2013.12.021. Epub 2014 Jan 18.


COPD exacerbations -- a comparison of Irish data with European data from the ERS COPD Audit.

Crinion S, Cotter O, Kennedy B, O'Connor B, Curran DR, McCormack S, McDonnell TJ, O'Connor TM.

Ir Med J. 2013 Oct;106(9):268, 270-2.


Combined pulmonary involvement in hereditary lysozyme amyloidosis with associated pulmonary sarcoidosis: a case report.

McCarthy C, Deegan AP, Garvey JF, McDonnell TJ.

Sarcoidosis Vasc Diffuse Lung Dis. 2013 Dec 17;30(4):321-4.


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