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Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.

Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF, Nyon MP, McDonnell JM, Kemper C, Gooptu B, Hawrylowicz CM.

J Steroid Biochem Mol Biol. 2019 May;189:1-9. doi: 10.1016/j.jsbmb.2019.01.014. Epub 2019 Jan 25.


A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase.

Hansen K, Lau AM, Giles K, McDonnell JM, Struwe WB, Sutton BJ, Politis A.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17194-17199. doi: 10.1002/anie.201812018. Epub 2018 Nov 27.


Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.

Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM.

Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4.


Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.

Doré KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM.

Mol Immunol. 2018 Jan;93:216-222. doi: 10.1016/j.molimm.2017.11.022. Epub 2017 Dec 5.


Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G.

Pollpeter D, Parsons M, Sobala AE, Coxhead S, Lang RD, Bruns AM, Papaioannou S, McDonnell JM, Apolonia L, Chowdhury JA, Horvath CM, Malim MH.

Nat Microbiol. 2018 Feb;3(2):220-233. doi: 10.1038/s41564-017-0063-9. Epub 2017 Nov 20.


Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

Doré KA, Davies AM, Drinkwater N, Beavil AJ, McDonnell JM, Sutton BJ.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1336-1347. doi: 10.1016/j.bbapap.2017.08.005. Epub 2017 Aug 24.


IgE Trimers Drive SPE-7 Cytokinergic Activity.

Bax HJ, Bowen H, Beavil RL, Chung R, Ward M, Davies AM, Dodev TS, McDonnell JM, Beavil AJ, Sutton BJ, Gould HJ.

Sci Rep. 2017 Aug 15;7(1):8164. doi: 10.1038/s41598-017-08212-6.


Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies AM, Allan EG, Keeble AH, Delgado J, Cossins BP, Mitropoulou AN, Pang MOY, Ceska T, Beavil AJ, Craggs G, Westwood M, Henry AJ, McDonnell JM, Sutton BJ.

J Biol Chem. 2017 Jun 16;292(24):9975-9987. doi: 10.1074/jbc.M117.776476. Epub 2017 Apr 24.


IgE binds asymmetrically to its B cell receptor CD23.

Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ.

Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533.


Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps.

Chen JB, James LK, Davies AM, Wu YB, Rimmer J, Lund VJ, Chen JH, McDonnell JM, Chan YC, Hutchins GH, Chang TW, Sutton BJ, Kariyawasam HH, Gould HJ.

J Allergy Clin Immunol. 2017 Apr;139(4):1195-1204.e11. doi: 10.1016/j.jaci.2016.06.066. Epub 2016 Sep 19.


Ontogeny of human IgE-expressing B cells and plasma cells.

Ramadani F, Bowen H, Upton N, Hobson PS, Chan YC, Chen JB, Chang TW, McDonnell JM, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2017 Jan;72(1):66-76. doi: 10.1111/all.12911. Epub 2016 Jun 8.


Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

Hussein D, Starr A, Heikal L, McNeill E, Channon KM, Brown PR, Sutton BJ, McDonnell JM, Nandi M.

Br J Pharmacol. 2015 Aug;172(16):4146-57. doi: 10.1111/bph.13202. Epub 2015 Jul 14.


Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class.

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ, Gould HJ, James LK.

Allergy. 2015 Jun;70(6):720-4. doi: 10.1111/all.12607. Epub 2015 Mar 28.


Human immunoglobulin E flexes between acutely bent and extended conformations.

Drinkwater N, Cossins B, Keeble AH, Wright M, Cain K, Hailu H, Oxbrow A, Delgado J, Shuttleworth LK, Kao MW, McDonnell JM, Beavil AJ, Henry AJ, Sutton BJ.

Nat Struct Mol Biol. 2014 Apr;21(4):397-404. doi: 10.1038/nsmb.2795. Epub 2014 Mar 16.


Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ.

Mol Immunol. 2013 Dec;56(4):693-7. doi: 10.1016/j.molimm.2013.07.005. Epub 2013 Aug 7.


Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.

Yuan D, Keeble AH, Hibbert RG, Fabiane S, Gould HJ, McDonnell JM, Beavil AJ, Sutton BJ, Dhaliwal B.

J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.


Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange.

Davies AM, Rispens T, den Bleker TH, McDonnell JM, Gould HJ, Aalberse RC, Sutton BJ.

Mol Immunol. 2013 May;54(1):1-7. doi: 10.1016/j.molimm.2012.10.029. Epub 2012 Nov 17.


The CD46-Jagged1 interaction is critical for human TH1 immunity.

Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C.

Nat Immunol. 2012 Dec;13(12):1213-21. doi: 10.1038/ni.2454. Epub 2012 Oct 21.


Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction.

Borthakur S, Hibbert RG, Pang MO, Yahya N, Bax HJ, Kao MW, Cooper AM, Beavil AJ, Sutton BJ, Gould HJ, McDonnell JM.

J Biol Chem. 2012 Sep 7;287(37):31457-61. doi: 10.1074/jbc.C112.397059. Epub 2012 Jul 19.


Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI.

Dhaliwal B, Yuan D, Pang MO, Henry AJ, Cain K, Oxbrow A, Fabiane SM, Beavil AJ, McDonnell JM, Gould HJ, Sutton BJ.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12686-91. doi: 10.1073/pnas.1207278109. Epub 2012 Jul 16.


Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

James LK, Bowen H, Calvert RA, Dodev TS, Shamji MH, Beavil AJ, McDonnell JM, Durham SR, Gould HJ.

J Allergy Clin Immunol. 2012 Sep;130(3):663-670.e3. doi: 10.1016/j.jaci.2012.04.006. Epub 2012 May 13.


Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Cooper AM, Hobson PS, Jutton MR, Kao MW, Drung B, Schmidt B, Fear DJ, Beavil AJ, McDonnell JM, Sutton BJ, Gould HJ.

J Immunol. 2012 Apr 1;188(7):3199-207. doi: 10.4049/jimmunol.1102689. Epub 2012 Mar 5.


MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

Watson AF, Liu J, Bennaceur K, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lu X, McDonnell JM, Newell DR, Noble ME, Revill CH, Riedinger C, Xu Q, Zhao Y, Lunec J, Hardcastle IR.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5916-9. doi: 10.1016/j.bmcl.2011.07.084. Epub 2011 Aug 9.


Structural and functional studies on the N-terminal domain of the Shigella type III secretion protein MxiG.

McDowell MA, Johnson S, Deane JE, Cheung M, Roehrich AD, Blocker AJ, McDonnell JM, Lea SM.

J Biol Chem. 2011 Sep 2;286(35):30606-14. doi: 10.1074/jbc.M111.243865. Epub 2011 Jul 5.


Basis of the intrinsic flexibility of the Cε3 domain of IgE.

Borthakur S, Andrejeva G, McDonnell JM.

Biochemistry. 2011 May 31;50(21):4608-14. doi: 10.1021/bi200019y. Epub 2011 May 5.


Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ.

Nat Struct Mol Biol. 2011 May;18(5):571-6. doi: 10.1038/nsmb.2044. Epub 2011 Apr 24.


Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement.

Badar A, DeFreitas S, McDonnell JM, Yahya N, Thakor D, Razavi R, Smith R, Sacks S, Mullen GE.

PLoS One. 2011 Apr 6;6(4):e18275. doi: 10.1371/journal.pone.0018275.


Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.

Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J.

J Med Chem. 2011 Mar 10;54(5):1233-43. doi: 10.1021/jm1011929. Epub 2011 Feb 11.


Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.

Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle IR, Endicott JA, McDonnell JM.

Chem Biol Drug Des. 2011 May;77(5):301-8. doi: 10.1111/j.1747-0285.2011.01091.x. Epub 2011 Mar 1.


Inhibitors of MDM2 and MDMX: a structural perspective.

Riedinger C, McDonnell JM.

Future Med Chem. 2009 Sep;1(6):1075-94. doi: 10.4155/fmc.09.75. Review.


Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.

Riedinger C, Endicott JA, Kemp SJ, Smyth LA, Watson A, Valeur E, Golding BT, Griffin RJ, Hardcastle IR, Noble ME, McDonnell JM.

J Am Chem Soc. 2008 Nov 26;130(47):16038-44. doi: 10.1021/ja8062088.


Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.

Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM.

J Biol Chem. 2007 Jul 27;282(30):22023-32. Epub 2007 Apr 20.


The intrinsic flexibility of IgE and its role in binding FcepsilonRI.

Harwood NE, McDonnell JM.

Biomed Pharmacother. 2007 Jan;61(1):61-7. Epub 2006 Dec 8. Review.


Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, McDonnell JM, Dwek RA, Rudd PM.

Biochemistry. 2006 Dec 26;45(51):15249-58. Epub 2006 Dec 6.


NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL.

Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D.

Magn Reson Chem. 2006 Jul;44 Spec No:S101-7.


Direct analysis of a GPCR-agonist interaction by surface plasmon resonance.

Harding PJ, Hadingham TC, McDonnell JM, Watts A.

Eur Biophys J. 2006 Oct;35(8):709-12. Epub 2006 May 18.


Catalytic folding of the Cepsilon3 domain by its high affinity receptor.

Harwood NE, Price NC, McDonnell JM.

FEBS Lett. 2006 Apr 3;580(8):2129-34. Epub 2006 Mar 15.


The structure of human CD23 and its interactions with IgE and CD21.

Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM.

J Exp Med. 2005 Sep 19;202(6):751-60.


Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide.

Cook AG, Johnson LN, McDonnell JM.

FEBS J. 2005 Mar;272(6):1511-22.


The key role of protein flexibility in modulating IgE interactions.

Price NE, Price NC, Kelly SM, McDonnell JM.

J Biol Chem. 2005 Jan 21;280(3):2324-30. Epub 2004 Nov 1.


Screening and optimizing protein production in E. coli.

Hewitt L, McDonnell JM.

Methods Mol Biol. 2004;278:1-16.


Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding.

Mackay GA, Hulett MD, Cook JP, Trist HM, Henry AJ, McDonnell JM, Beavil AJ, Beavil RL, Sutton BJ, Hogarth PM, Gould HJ.

J Immunol. 2002 Feb 15;168(4):1787-95.


The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.

McDonnell JM, Calvert R, Beavil RL, Beavil AJ, Henry AJ, Sutton BJ, Gould HJ, Cowburn D.

Nat Struct Biol. 2001 May;8(5):437-41.


Conformation of the isolated cepsilon3 domain of IgE and its complex with the high-affinity receptor, FcepsilonRI.

Henry AJ, McDonnell JM, Ghirlando R, Sutton BJ, Gould HJ.

Biochemistry. 2000 Jun 27;39(25):7406-13.


Cross-reactivity of antiidiotypic antibodies with DNA in systemic lupus erythematosus.

Eivazova ER, McDonnell JM, Sutton BJ, Staines NA.

Arthritis Rheum. 2000 Feb;43(2):429-39.


BCL-2 family members and the mitochondria in apoptosis.

Gross A, McDonnell JM, Korsmeyer SJ.

Genes Dev. 1999 Aug 1;13(15):1899-911. Review. No abstract available.


Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.

McDonnell JM, Fushman D, Milliman CL, Korsmeyer SJ, Cowburn D.

Cell. 1999 Mar 5;96(5):625-34.


Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.

McDonnell JM, Fushman D, Cahill SM, Zhou W, Wolven A, Wilson CB, Nelle TD, Resh MD, Wills J, Cowburn D.

J Mol Biol. 1998 Jun 19;279(4):921-8.


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