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Items: 1 to 50 of 75

1.

Physical and functional interaction sites in cytoplasmic domains of KCNQ1 and KCNE1 channel subunits.

Chen J, Liu Z, Creagh J, Zheng R, McDonald TV.

Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H212-H222. doi: 10.1152/ajpheart.00459.2019. Epub 2019 Dec 13.

PMID:
31834838
2.

Corrigendum.

Osterbur ML, Zheng R, Marion R, Walsh C, McDonald TV.

Hum Mutat. 2019 Mar;40(3):357. doi: 10.1002/humu.23711. No abstract available.

PMID:
30740826
3.

Phenotypic variations in carriers of predicted protein-truncating genetic variants in MYBPC3: an autopsy-based case series.

Williams N, Marion R, McDonald TV, Wang D, Zhou B, Eng LS, Um SY, Lin Y, Ruiter K, Rojas L, Sampson BA, Tang Y.

Cardiovasc Pathol. 2018 Nov - Dec;37:30-33. doi: 10.1016/j.carpath.2018.09.001. Epub 2018 Sep 13.

PMID:
30282064
4.

Functionally Aberrant Mutant KCNQ1 With Intermediate Heterozygous and Homozygous Phenotypes.

Liu Z, Zheng R, Grushko MJ, Uversky VN, McDonald TV.

Can J Cardiol. 2018 Sep;34(9):1174-1184. doi: 10.1016/j.cjca.2018.06.015. Epub 2018 Jun 30.

PMID:
30170673
5.

Synonymous nucleotide modification of the KCNH2 gene affects both mRNA characteristics and translation of the encoded hERG ion channel.

Bertalovitz AC, Badhey MLO, McDonald TV.

J Biol Chem. 2018 Aug 3;293(31):12120-12136. doi: 10.1074/jbc.RA118.001805. Epub 2018 Jun 15.

6.

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ.

Circ Genom Precis Med. 2018 Apr;11(4):e002178. doi: 10.1161/CIRCGEN.118.002178. Review.

7.

Applying High-Resolution Variant Classification to Cardiac Arrhythmogenic Gene Testing in a Demographically Diverse Cohort of Sudden Unexplained Deaths.

Lin Y, Williams N, Wang D, Coetzee W, Zhou B, Eng LS, Um SY, Bao R, Devinsky O, McDonald TV, Sampson BA, Tang Y.

Circ Cardiovasc Genet. 2017 Dec;10(6). pii: e001839. doi: 10.1161/CIRCGENETICS.117.001839.

PMID:
29247119
8.

Compound heterozygous CASQ2 mutations and long-term course of catecholaminergic polymorphic ventricular tachycardia.

Josephs K, Patel K, Janson CM, Montagna C, McDonald TV.

Mol Genet Genomic Med. 2017 Nov;5(6):788-794. doi: 10.1002/mgg3.323. Epub 2017 Aug 22.

9.

Express with caution: Epitope tags and cDNA variants effects on hERG channel trafficking, half-life and function.

Osterbur Badhey ML, Bertalovitz AC, McDonald TV.

J Cardiovasc Electrophysiol. 2017 Sep;28(9):1070-1082. doi: 10.1111/jce.13259. Epub 2017 Jun 23.

10.

Infant sudden death: Mutations responsible for impaired Nav1.5 channel trafficking and function.

Gando I, Morganstein J, Jana K, McDonald TV, Tang Y, Coetzee WA.

Pacing Clin Electrophysiol. 2017 Jun;40(6):703-712. doi: 10.1111/pace.13087. Epub 2017 May 16.

PMID:
28370132
11.

Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel SJ, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM.

Front Behav Neurosci. 2016 Jun 30;10:136. doi: 10.3389/fnbeh.2016.00136. eCollection 2016.

12.

Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.

Monyak RE, Emerson D, Schoenfeld BP, Zheng X, Chambers DB, Rosenfelt C, Langer S, Hinchey P, Choi CH, McDonald TV, Bolduc FV, Sehgal A, McBride SMJ, Jongens TA.

Mol Psychiatry. 2017 Aug;22(8):1140-1148. doi: 10.1038/mp.2016.51. Epub 2016 Apr 19.

13.

Development of a Targeted Multi-Disorder High-Throughput Sequencing Assay for the Effective Identification of Disease-Causing Variants.

Delio M, Patel K, Maslov A, Marion RW, McDonald TV, Cadoff EM, Golden A, Greally JM, Vijg J, Morrow B, Montagna C.

PLoS One. 2015 Jul 27;10(7):e0133742. doi: 10.1371/journal.pone.0133742. eCollection 2015.

14.

An Interdomain KCNH2 Mutation Produces an Intermediate Long QT Syndrome.

Osterbur ML, Zheng R, Marion R, Walsh C, McDonald TV.

Hum Mutat. 2015 Aug;36(8):764-73. doi: 10.1002/humu.22805. Epub 2015 Jun 13. Erratum in: Hum Mutat. 2019 Mar;40(3):357.

15.

PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.

Choi CH, Schoenfeld BP, Weisz ED, Bell AJ, Chambers DB, Hinchey J, Choi RJ, Hinchey P, Kollaros M, Gertner MJ, Ferrick NJ, Terlizzi AM, Yohn N, Koenigsberg E, Liebelt DA, Zukin RS, Woo NH, Tranfaglia MR, Louneva N, Arnold SE, Siegel SJ, Bolduc FV, McDonald TV, Jongens TA, McBride SM.

J Neurosci. 2015 Jan 7;35(1):396-408. doi: 10.1523/JNEUROSCI.1356-12.2015.

16.

Motivation to pursue genetic testing in individuals with a personal or family history of cardiac events or sudden cardiac death.

Erskine KE, Hidayatallah NZ, Walsh CA, McDonald TV, Cohen L, Marion RW, Dolan SM.

J Genet Couns. 2014 Oct;23(5):849-59. doi: 10.1007/s10897-014-9707-6. Epub 2014 Mar 25.

17.

Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths.

Wang D, Shah KR, Um SY, Eng LS, Zhou B, Lin Y, Mitchell AA, Nicaj L, Prinz M, McDonald TV, Sampson BA, Tang Y.

Forensic Sci Int. 2014 Apr;237:90-9. doi: 10.1016/j.forsciint.2014.01.014. Epub 2014 Feb 15.

PMID:
24631775
18.

The Drosophila DmGluRA is required for social interaction and memory.

Schoenfeld BP, Choi RJ, Choi CH, Terlizzi AM, Hinchey P, Kollaros M, Ferrick NJ, Koenigsberg E, Ferreiro D, Leibelt DA, Siegel SJ, Bell AJ, McDonald TV, Jongens TA, McBride SM.

Front Pharmacol. 2013 May 23;4:64. doi: 10.3389/fphar.2013.00064. eCollection 2013.

19.

Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency.

Sroubek J, Krishnan Y, McDonald TV.

FASEB J. 2013 Aug;27(8):3039-53. doi: 10.1096/fj.12-227009. Epub 2013 Apr 22.

20.
21.

Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis.

Krishnan Y, Li Y, Zheng R, Kanda V, McDonald TV.

Biochim Biophys Acta. 2012 Aug;1823(8):1273-84. doi: 10.1016/j.bbamcr.2012.05.012. Epub 2012 May 18.

22.

Binding interface of cardiac potassium channel proteins identified by hydrogen deuterium exchange of synthetic peptides.

Chen J, Angeletti R, McDonald TV, Xiao H.

Anal Bioanal Chem. 2012 May;403(5):1303-9. doi: 10.1007/s00216-012-5857-2. Epub 2012 Mar 6.

PMID:
22392372
23.

The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel.

Sroubek J, Krishnan Y, Chinai J, Buhl S, Scharff MD, McDonald TV.

J Immunol Methods. 2012 Jan 31;375(1-2):215-22. doi: 10.1016/j.jim.2011.10.014. Epub 2011 Nov 15.

24.

Partially dominant mutant channel defect corresponding with intermediate LQT2 phenotype.

Krishnan Y, Zheng R, Walsh C, Tang Y, McDonald TV.

Pacing Clin Electrophysiol. 2012 Jan;35(1):3-16. doi: 10.1111/j.1540-8159.2011.03222.x. Epub 2011 Sep 25.

25.

A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.

Chen J, Weber M, Um SY, Walsh CA, Tang Y, McDonald TV.

Pacing Clin Electrophysiol. 2011 Dec;34(12):1652-64. doi: 10.1111/j.1540-8159.2011.03190.x. Epub 2011 Sep 2.

26.

Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG).

Sroubek J, McDonald TV.

J Biol Chem. 2011 Jun 17;286(24):21927-36. doi: 10.1074/jbc.M110.201699. Epub 2011 May 2.

27.

Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, Gertner MJ, Woo NH, Tranfaglia MR, Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM.

Brain Res. 2011 Mar 22;1380:106-19. doi: 10.1016/j.brainres.2010.11.032. Epub 2010 Nov 12.

28.

Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines.

Ren XQ, Liu GX, Organ-Darling LE, Zheng R, Roder K, Jindal HK, Centracchio J, McDonald TV, Koren G.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1525-34. doi: 10.1152/ajpheart.00479.2009. Epub 2010 Sep 10.

29.

Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.

McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA.

J Neurosci. 2010 Jul 14;30(28):9510-22. doi: 10.1523/JNEUROSCI.1017-10.2010.

30.

Post-transcriptional control of human ether-a-go-go-related gene potassium channel protein by alpha-adrenergic receptor stimulation.

Chen J, Chen K, Sroubek J, Wu ZY, Thomas D, Bian JS, McDonald TV.

Mol Pharmacol. 2010 Aug;78(2):186-97. doi: 10.1124/mol.109.062216. Epub 2010 May 12.

31.

A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans.

Govorunova EG, Moussaif M, Kullyev A, Nguyen KC, McDonald TV, Hall DH, Sze JY.

PLoS One. 2010 Apr 28;5(4):e10368. doi: 10.1371/journal.pone.0010368.

32.

Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits.

Zheng R, Thompson K, Obeng-Gyimah E, Alessi D, Chen J, Cheng H, McDonald TV.

Biochem J. 2010 Apr 28;428(1):75-84. doi: 10.1042/BJ20090977.

33.

Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue.

Choi CH, McBride SM, Schoenfeld BP, Liebelt DA, Ferreiro D, Ferrick NJ, Hinchey P, Kollaros M, Rudominer RL, Terlizzi AM, Koenigsberg E, Wang Y, Sumida A, Nguyen HT, Bell AJ, McDonald TV, Jongens TA.

Biogerontology. 2010 Jun;11(3):347-62. doi: 10.1007/s10522-009-9259-6. Epub 2009 Dec 29.

34.

Functional interactions between KCNE1 C-terminus and the KCNQ1 channel.

Chen J, Zheng R, Melman YF, McDonald TV.

PLoS One. 2009;4(4):e5143. doi: 10.1371/journal.pone.0005143. Epub 2009 Apr 2.

35.

PKA phosphorylation of HERG protein regulates the rate of channel synthesis.

Chen J, Sroubek J, Krishnan Y, Li Y, Bian J, McDonald TV.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1244-54. doi: 10.1152/ajpheart.01252.2008. Epub 2009 Feb 20.

36.

Plasmodium falciparum: growth response to potassium channel blocking compounds.

Waller KL, Kim K, McDonald TV.

Exp Parasitol. 2008 Nov;120(3):280-5. doi: 10.1016/j.exppara.2008.07.010. Epub 2008 Jul 30.

PMID:
18703053
37.

A-kinase anchoring protein targeting of protein kinase A and regulation of HERG channels.

Li Y, Sroubek J, Krishnan Y, McDonald TV.

J Membr Biol. 2008 May;223(2):107-16. doi: 10.1007/s00232-008-9118-4. Epub 2008 Aug 5.

38.
39.

Characterization of two putative potassium channels in Plasmodium falciparum.

Waller KL, McBride SM, Kim K, McDonald TV.

Malar J. 2008 Jan 24;7:19. doi: 10.1186/1475-2875-7-19.

40.

A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation.

deSouza N, Cui J, Dura M, McDonald TV, Marks AR.

J Cell Biol. 2007 Dec 3;179(5):923-34.

41.

Differential association between HERG and KCNE1 or KCNE2.

Um SY, McDonald TV.

PLoS One. 2007 Sep 26;2(9):e933.

42.

Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K(+) channel.

Bian JS, McDonald TV.

Pflugers Arch. 2007 Oct;455(1):105-13. Epub 2007 Jul 11. Review.

PMID:
17622552
43.

Voltage-gated potassium channels: regulation by accessory subunits.

Li Y, Um SY, McDonald TV.

Neuroscientist. 2006 Jun;12(3):199-210. Review.

PMID:
16684966
44.

Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans.

Ghosh K, Cappiello CD, McBride SM, Occi JL, Cali A, Takvorian PM, McDonald TV, Weiss LM.

Int J Parasitol. 2006 Jan;36(1):57-62. Epub 2005 Sep 19.

45.

Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3.

Kagan A, McDonald TV.

Novartis Found Symp. 2005;266:75-89; discussion 89-99. Review.

PMID:
16050263
46.

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.

McBride SM, Choi CH, Wang Y, Liebelt D, Braunstein E, Ferreiro D, Sehgal A, Siwicki KK, Dockendorff TC, Nguyen HT, McDonald TV, Jongens TA.

Neuron. 2005 Mar 3;45(5):753-64.

47.

S641 contributes HERG K+ channel inactivation.

Bian JS, Cui J, Melman Y, McDonald TV.

Cell Biochem Biophys. 2004;41(1):25-40.

PMID:
15371638
48.

Molecular analysis of PIP2 regulation of HERG and IKr.

Bian JS, Kagan A, McDonald TV.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2154-63. Epub 2004 Jul 1.

49.

KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity.

Melman YF, Um SY, Krumerman A, Kagan A, McDonald TV.

Neuron. 2004 Jun 24;42(6):927-37.

50.

An LQT mutant minK alters KvLQT1 trafficking.

Krumerman A, Gao X, Bian JS, Melman YF, Kagan A, McDonald TV.

Am J Physiol Cell Physiol. 2004 Jun;286(6):C1453-63. Epub 2004 Feb 4.

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