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Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia.

Wang H, Zhao D, Nguyen LX, Wu H, Li L, Dong D, Troadec E, Zhu Y, Hoang DH, Stein AS, Al Malki M, Aldoss I, Lin A, Ghoda LY, McDonald T, Pichiorri F, Carlesso N, Kuo YH, Zhang B, Jin J, Marcucci G.

Leukemia. 2019 Jul 23. doi: 10.1038/s41375-019-0522-9. [Epub ahead of print]


The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata.

Armaleo D, Müller O, Lutzoni F, Andrésson ÓS, Blanc G, Bode HB, Collart FR, Dal Grande F, Dietrich F, Grigoriev IV, Joneson S, Kuo A, Larsen PE, Logsdon JM Jr, Lopez D, Martin F, May SP, McDonald TR, Merchant SS, Miao V, Morin E, Oono R, Pellegrini M, Rubinstein N, Sanchez-Puerta MV, Savelkoul E, Schmitt I, Slot JC, Soanes D, Szövényi P, Talbot NJ, Veneault-Fourrey C, Xavier BB.

BMC Genomics. 2019 Jul 23;20(1):605. doi: 10.1186/s12864-019-5629-x.


Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection.

Gerstein AC, Jackson KM, McDonald TR, Wang Y, Lueck BD, Bohjanen S, Smith KD, Akampurira A, Meya DB, Xue C, Boulware DR, Nielsen K.

MBio. 2019 Jul 16;10(4). pii: e01440-19. doi: 10.1128/mBio.01440-19.


Long-Term Care Quality-of-Life Scale utility in community home care.

McDonald T, Russell F.

Nurs Health Sci. 2019 Jul 8. doi: 10.1111/nhs.12628. [Epub ahead of print]


The History and Future of the Gene.

McDonald T.

Perspect Biol Med. 2019;62(2):366-378. doi: 10.1353/pbm.2019.0020.


Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population.

Yaghootkar H, Abbasi F, Ghaemi N, Rabbani A, Wakeling MN, Eshraghi P, Enayati S, Vakili S, Heidari S, Patel K, Sayarifard F, Borhan-Dayani S, McDonald TJ, Ellard S, Hattersley AT, Amoli MM, Vakili R, Colclough K.

Diabet Med. 2019 Jul 5. doi: 10.1111/dme.14071. [Epub ahead of print]


Treatment of Distal Femur Fractures With the DePuy-Synthes Variable Angle Locking Compression Plate.

McDonald TC, Lambert JJ, Hulick RM, Graves ML, Russell GV, Spitler CA, Bergin PF.

J Orthop Trauma. 2019 Sep;33(9):432-437. doi: 10.1097/BOT.0000000000001510.


Understanding the Phase and Morphological Behavior of Dispersions of Synergistic Dual-Stimuli-Responsive Poly(N-isopropylacrylamide) Nanogels.

Town A, Niezabitowska E, Kavanagh J, Barrow M, Kearns VR, García-Tuñón E, McDonald TO.

J Phys Chem B. 2019 Jul 25;123(29):6303-6313. doi: 10.1021/acs.jpcb.9b04051. Epub 2019 Jul 11.


Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335.

Myngheer N, Allegaert K, Hattersley A, McDonald T, Kramer H, Ashcroft FM, Verhaeghe J, Mathieu C, Casteels K.

Diabetes Care. 2019 Jul;42(7):1352. doi: 10.2337/dc19-er07. Epub 2019 May 21. No abstract available.


Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium.

Diabetologia. 2019 Sep;62(9):1601-1615. doi: 10.1007/s00125-019-4906-1. Epub 2019 Jun 15.


Microfluidic droplet liquid reactors for active pharmaceutical ingredient crystallization by diffusion controlled solvent extraction.

Tona RM, McDonald TAO, Akhavein N, Larkin JD, Lai D.

Lab Chip. 2019 Jun 11;19(12):2127-2137. doi: 10.1039/c9lc00204a.


Smart Trauma: Improving the Delivery of Evidence-Based Trauma Care.

Dekonenko C, McDonald T, Winfield RD.

J Surg Res. 2019 Oct;242:252-257. doi: 10.1016/j.jss.2019.04.064. Epub 2019 May 16.


Stability of urinary albumin and creatinine after 12 months storage at -20 °C and -80 °C.

Chapman DP, Gooding KM, McDonald TJ, Shore AC.

Pract Lab Med. 2019 Mar 22;15:e00120. doi: 10.1016/j.plabm.2019.e00120. eCollection 2019 May.


Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes.

Thomas NJ, Lynam AL, Hill AV, Weedon MN, Shields BM, Oram RA, McDonald TJ, Hattersley AT, Jones AG.

Diabetologia. 2019 Jul;62(7):1167-1172. doi: 10.1007/s00125-019-4863-8. Epub 2019 Apr 10.


Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

Marren SM, Hammersley S, McDonald TJ, Shields BM, Knight BA, Hill A, Bolt R, Tree TI, Roep BO, Hattersley AT, Jones AG, Oram RA; TIGI consortium.

Diabet Med. 2019 Sep;36(9):1092-1099. doi: 10.1111/dme.13960. Epub 2019 Jun 27.


Feasibility of Portable Fingerstick Cholinesterase Testing in Adolescents in South Texas.

Trueblood AB, Ross JA, Shipp EM, McDonald TJ.

J Prim Care Community Health. 2019 Jan-Dec;10:2150132719838716. doi: 10.1177/2150132719838716.


Triheptanoin alters [U-13C6]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model.

McDonald T, Hodson MP, Bederman I, Puchowicz M, Borges K.

J Cereb Blood Flow Metab. 2019 Mar 19:271678X19837380. doi: 10.1177/0271678X19837380. [Epub ahead of print]


The association between GAD65 antibody levels and incident Type 2 Diabetes Mellitus in an adult population: A meta-analysis.

Koopman ADM, Beulens JW, Voerman E, Rauh SP, van der Heijden AA, McDonald TJ, Langendoen-Gort M, Rutters F.

Metabolism. 2019 Jun;95:1-7. doi: 10.1016/j.metabol.2019.03.001. Epub 2019 Mar 8. Review.


The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence.

Mukaremera L, McDonald TR, Nielsen JN, Molenaar CJ, Akampurira A, Schutz C, Taseera K, Muzoora C, Meintjes G, Meya DB, Boulware DR, Nielsen K.

Infect Immun. 2019 Apr 23;87(5). pii: e00046-19. doi: 10.1128/IAI.00046-19. Print 2019 Mar.


Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.

Kennedy NA, Heap GA, Green HD, Hamilton B, Bewshea C, Walker GJ, Thomas A, Nice R, Perry MH, Bouri S, Chanchlani N, Heerasing NM, Hendy P, Lin S, Gaya DR, Cummings JRF, Selinger CP, Lees CW, Hart AL, Parkes M, Sebastian S, Mansfield JC, Irving PM, Lindsay J, Russell RK, McDonald TJ, McGovern D, Goodhand JR, Ahmad T; UK Inflammatory Bowel Disease Pharmacogenetics Study Group.

Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3. Epub 2019 Feb 27.


Enhancement of acid re-assimilation and biosolvent production in Clostridium saccharoperbutylacetonicum through metabolic engineering for efficient biofuel production from lignocellulosic biomass.

Wang P, Zhang J, Feng J, Wang S, Guo L, Wang Y, Lee YY, Taylor S, McDonald T, Wang Y.

Bioresour Technol. 2019 Jun;281:217-225. doi: 10.1016/j.biortech.2019.02.096. Epub 2019 Feb 23.


DIFFpop: A stochastic computational approach to simulate differentiation hierarchies with single cell barcoding.

Ferlic J, Shi J, McDonald TO, Michor F.

Bioinformatics. 2019 Feb 28. pii: btz074. doi: 10.1093/bioinformatics/btz074. [Epub ahead of print]


KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Sébastien Vigneau, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2019 Feb 11;35(2):330-332. doi: 10.1016/j.ccell.2019.01.012. No abstract available.



Osterbur ML, Zheng R, Marion R, Walsh C, McDonald TV.

Hum Mutat. 2019 Mar;40(3):357. doi: 10.1002/humu.23711. No abstract available.


Variability in the management of line-related upper extremity deep vein thrombosis.

Cires-Drouet R, Sharma J, McDonald T, Sorkin JD, Lal BK.

Phlebology. 2019 Sep;34(8):552-558. doi: 10.1177/0268355519827155. Epub 2019 Jan 31. No abstract available.


Benchmarking life quality support interventions in long-term care using the Long-Term Care Quality of Life scale.

McDonald T, Shaw D.

Nurs Health Sci. 2019 Jun;21(2):239-244. doi: 10.1111/nhs.12588. Epub 2018 Dec 10.


KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2018 Dec 10;34(6):939-953.e9. doi: 10.1016/j.ccell.2018.10.014. Epub 2018 Nov 21. Erratum in: Cancer Cell. 2019 Feb 11;35(2):330-332.


Domestic Exposures to Polycyclic Aromatic Hydrocarbons in a Houston, Texas, Environmental Justice Neighborhood.

Sansom GT, Kirsch KR, Stone KW, McDonald TJ, Horney JA.

Environ Justice. 2018 Oct;11(5):183-191. doi: 10.1089/env.2018.0004. Epub 2018 Oct 16.


Splenic Embolization After Trauma: An Opportunity to Improve Best Immunization Practices.

Crooker KG, Howard JM, Alvarado AR, McDonald TJ, Berry SD, Green JL, Winfield RD.

J Surg Res. 2018 Dec;232:293-297. doi: 10.1016/j.jss.2018.06.036. Epub 2018 Jul 14.


Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes.

Patel KA, Weedon MN, Shields BM, Pearson ER, Hattersley AT, McDonald TJ; UNITED study team.

Diabetes Care. 2019 Feb;42(2):e16-e17. doi: 10.2337/dc18-0373. Epub 2018 Nov 8. No abstract available.


Can Communication-And-Resolution Programs Achieve Their Potential? Five Key Questions.

Gallagher TH, Mello MM, Sage WM, Bell SK, McDonald TB, Thomas EJ.

Health Aff (Millwood). 2018 Nov;37(11):1845-1852. doi: 10.1377/hlthaff.2018.0727.


Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention.

Gu Q, Spinelli JJ, Dummer TBJ, McDonald TE, Moore SC, Murphy RA.

Sci Rep. 2018 Nov 2;8(1):16293. doi: 10.1038/s41598-018-34662-7.


Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution.

McDonald TO, Chakrabarti S, Michor F.

Nat Genet. 2018 Dec;50(12):1620-1623. doi: 10.1038/s41588-018-0217-6. No abstract available.


A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.

Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, 't Hart LM, Pearson ER, Shields BM, Jones AG.

Diabetes Care. 2019 Feb;42(2):208-214. doi: 10.2337/dc18-0431. Epub 2018 Oct 23.


Correction to: Trend estimation for complex survey designs of water chemistry indicators from Sierra Nevada Lakes.

Starcevich LAH, McDonald T, Chung-MacCoubrey A, Heard A, Nesmith J, Philippi T.

Environ Monit Assess. 2018 Oct 22;190(11):664. doi: 10.1007/s10661-018-7018-3.


Chlorination of Source Water Containing Iodinated X-ray Contrast Media: Mutagenicity and Identification of New Iodinated Disinfection Byproducts.

Postigo C, DeMarini DM, Armstrong MD, Liberatore HK, Lamann K, Kimura SY, Cuthbertson AA, Warren SH, Richardson SD, McDonald T, Sey YM, Ackerson NOB, Duirk SE, Simmons JE.

Environ Sci Technol. 2018 Nov 20;52(22):13047-13056. doi: 10.1021/acs.est.8b04625. Epub 2018 Nov 5.


Predicting state transitions in brain dynamics through spectral difference of phase-space graphs.

Luckett P, Pavelescu E, McDonald T, Hively L, Ochoa J.

J Comput Neurosci. 2019 Feb;46(1):91-106. doi: 10.1007/s10827-018-0700-1. Epub 2018 Oct 12.


Daratumumab induces CD38 internalization and impairs myeloma cell adhesion.

Ghose J, Viola D, Terrazas C, Caserta E, Troadec E, Khalife J, Gunes EG, Sanchez J, McDonald T, Marcucci G, Kaur B, Rosenzweig M, Keats J, Rosen S, Krishnan A, Satoskar AR, Hofmeister CC, Pichiorri F.

Oncoimmunology. 2018 Jul 23;7(10):e1486948. doi: 10.1080/2162402X.2018.1486948. eCollection 2018.


Phenotypic variations in carriers of predicted protein-truncating genetic variants in MYBPC3: an autopsy-based case series.

Williams N, Marion R, McDonald TV, Wang D, Zhou B, Eng LS, Um SY, Lin Y, Ruiter K, Rojas L, Sampson BA, Tang Y.

Cardiovasc Pathol. 2018 Nov - Dec;37:30-33. doi: 10.1016/j.carpath.2018.09.001. Epub 2018 Sep 13.


Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof.

McDonald T, Puchowicz M, Borges K.

Front Cell Neurosci. 2018 Aug 31;12:274. doi: 10.3389/fncel.2018.00274. eCollection 2018. Review.


Trend estimation for complex survey designs of water chemistry indicators from Sierra Nevada Lakes.

Starcevich LAH, McDonald T, Chung-MacCoubrey A, Heard A, Nesmith J, Philippi T.

Environ Monit Assess. 2018 Sep 19;190(10):596. doi: 10.1007/s10661-018-6963-1. Erratum in: Environ Monit Assess. 2018 Oct 22;190(11):664.


Ketogenic Diets for Adult Neurological Disorders.

McDonald TJW, Cervenka MC.

Neurotherapeutics. 2018 Oct;15(4):1018-1031. doi: 10.1007/s13311-018-0666-8. Review.


Work environment risks for health care workers with cystic fibrosis.

Bell SC, Armstrong D, Harrington G, Jardine L, Divakaran R, Loff B, Middleton PG, McDonald T, Rowland K, Wishart M, Wood ME, Stuart RL.

Respirology. 2018 Dec;23(12):1190-1197. doi: 10.1111/resp.13404. Epub 2018 Sep 14.


Accelerated Oxidation of Organic Contaminants by Ferrate(VI): The Overlooked Role of Reducing Additives.

Feng M, Jinadatha C, McDonald TJ, Sharma VK.

Environ Sci Technol. 2018 Oct 2;52(19):11319-11327. doi: 10.1021/acs.est.8b03770. Epub 2018 Sep 18.


The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project.

Teare HJA, de Masi F, Banasik K, Barnett A, Herrgard S, Jablonka B, Postma JWM, McDonald TJ, Forgie I, Chmura PJ, Rydzka EK, Gupta R, Brunak S, Pearson E, Kaye J.

Life Sci Soc Policy. 2018 Sep 4;14(1):20. doi: 10.1186/s40504-018-0083-0.


Functionally Aberrant Mutant KCNQ1 With Intermediate Heterozygous and Homozygous Phenotypes.

Liu Z, Zheng R, Grushko MJ, Uversky VN, McDonald TV.

Can J Cardiol. 2018 Sep;34(9):1174-1184. doi: 10.1016/j.cjca.2018.06.015. Epub 2018 Jun 30.


Cohort Profile: The British Columbia Generations Project (BCGP).

Dhalla A, McDonald TE, Gallagher RP, Spinelli JJ, Brooks-Wilson AR, Lee TK, Lai C, Borugian MJ, Woods RR, Le ND, Dummer TJB.

Int J Epidemiol. 2018 Aug 28. doi: 10.1093/ije/dyy160. [Epub ahead of print] No abstract available.


SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, Du J, Wang H, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua WK, Zhang B, Feng L, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kortylewski M, Pichiorri F, Kuo YH, Carlesso N, Marcucci G, Jin H, Li L.

Cell Stem Cell. 2018 Sep 6;23(3):355-369.e9. doi: 10.1016/j.stem.2018.07.018. Epub 2018 Aug 23.


The Expanding Role of Ketogenic Diets in Adult Neurological Disorders.

McDonald TJW, Cervenka MC.

Brain Sci. 2018 Aug 8;8(8). pii: E148. doi: 10.3390/brainsci8080148. Review.

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