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Items: 19

1.

A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1.

Bailey TL, Nieto A, McDonald PH.

Assay Drug Dev Technol. 2019 Aug;17(6):275-284. doi: 10.1089/adt.2019.936.

PMID:
31532712
2.

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.

Nieto A, Hara MR, Quereda V, Grant W, Saunders V, Xiao K, McDonald PH, Duckett DR.

Cell Death Differ. 2019 Sep 10. doi: 10.1038/s41418-019-0406-6. [Epub ahead of print]

PMID:
31506606
3.

Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119.

Nieto A, Fernández-Vega V, Spicer TP, Sturchler E, Adhikari P, Kennedy N, Mandat S, Chase P, Scampavia L, Bannister T, Hodder P, McDonald PH.

Assay Drug Dev Technol. 2018 Jul;16(5):278-288. doi: 10.1089/adt.2018.849.

4.

GPCRs: Emerging anti-cancer drug targets.

Nieto Gutierrez A, McDonald PH.

Cell Signal. 2018 Jan;41:65-74. doi: 10.1016/j.cellsig.2017.09.005. Epub 2017 Sep 18. Review.

PMID:
28931490
5.

Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects.

Zhang H, Sturchler E, Zhu J, Nieto A, Cistrone PA, Xie J, He L, Yea K, Jones T, Turn R, Di Stefano PS, Griffin PR, Dawson PE, McDonald PH, Lerner RA.

Nat Commun. 2015 Dec 1;6:8918. doi: 10.1038/ncomms9918.

6.

The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.

Robinson JD, McDonald PH.

Cell Signal. 2015 Jul;27(7):1449-56. doi: 10.1016/j.cellsig.2015.03.026. Epub 2015 Apr 6.

7.

The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).

Di Fruscia P, He Y, Koenig M, Tabrizifard S, Nieto A, McDonald PH, Kamenecka TM.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3974-8. doi: 10.1016/j.bmcl.2014.06.033. Epub 2014 Jun 20.

8.

Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.

Jiang R, Song X, Bali P, Smith A, Bayona CR, Lin L, Cameron MD, McDonald PH, Kenny PJ, Kamenecka TM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3890-4. doi: 10.1016/j.bmcl.2012.04.122. Epub 2012 May 4.

9.

Seeking Ligand Bias: Assessing GPCR Coupling to Beta-Arrestins for Drug Discovery.

Bohn LM, McDonald PH.

Drug Discov Today Technol. 2010 Spring;7(1):e37-e42.

10.

The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.

Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR.

J Pharmacol Exp Ther. 2003 Jul;306(1):147-56. Epub 2003 Mar 28.

PMID:
12665544
11.

Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Kohout TA, Takaoka H, McDonald PH, Perry SJ, Mao L, Lefkowitz RJ, Rockman HA.

Circulation. 2001 Nov 13;104(20):2485-91.

PMID:
11705829
12.

Beta-Arrestins: new roles in regulating heptahelical receptors' functions.

McDonald PH, Lefkowitz RJ.

Cell Signal. 2001 Oct;13(10):683-9. Review.

PMID:
11602178
13.

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.

Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ.

Science. 2001 Nov 9;294(5545):1307-13. Epub 2001 Oct 4.

14.

Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.

Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ.

J Biol Chem. 2001 Jul 27;276(30):27770-7. Epub 2001 May 16.

15.

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ.

Science. 2000 Nov 24;290(5496):1574-7.

16.

Gene transfer and models of gene therapy for the myocardium.

Alexander MY, Webster KA, McDonald PH, Prentice HM.

Clin Exp Pharmacol Physiol. 1999 Sep;26(9):661-8. Review.

PMID:
10499153
17.

Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.

Maurice JP, Hata JA, Shah AS, White DC, McDonald PH, Dolber PC, Wilson KH, Lefkowitz RJ, Glower DD, Koch WJ.

J Clin Invest. 1999 Jul;104(1):21-9.

18.

Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.

McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ.

J Biol Chem. 1999 Apr 16;274(16):10677-80.

19.

Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.

Akhter SA, Skaer CA, Kypson AP, McDonald PH, Peppel KC, Glower DD, Lefkowitz RJ, Koch WJ.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12100-5.

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