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Items: 39


Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts.

Hedlund EE, McDonald PC, Nemirovsky O, Awrey S, Jensen LDE, Dedhar S.

Cancers (Basel). 2019 Jul 17;11(7). pii: E1002. doi: 10.3390/cancers11071002.


Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Chafe SC, McDonald PC, Saberi S, Nemirovsky O, Venkateswaran G, Burugu S, Gao D, Delaidelli A, Kyle AH, Baker JHE, Gillespie JA, Bashashati A, Minchinton AI, Zhou Y, Shah SP, Dedhar S.

Cancer Immunol Res. 2019 Jul;7(7):1064-1078. doi: 10.1158/2326-6066.CIR-18-0657. Epub 2019 May 14.


Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.

McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S.

Gastroenterology. 2019 Sep;157(3):823-837. doi: 10.1053/j.gastro.2019.05.004. Epub 2019 May 9.


Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

Bozdag M, Carta F, Ceruso M, Ferraroni M, McDonald PC, Dedhar S, Supuran CT.

J Med Chem. 2018 Jul 26;61(14):6328-6338. doi: 10.1021/acs.jmedchem.8b00770. Epub 2018 Jul 17.


Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

McDonald PC, Swayampakula M, Dedhar S.

Metabolites. 2018 Mar 8;8(1). pii: E20. doi: 10.3390/metabo8010020. Review.


Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Libby CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, Nabors B, Bhat KP, Bar EE, Darley-Usmar V, Xu B, Gordon E, Cooper SJ, Dedhar S, Hjelmeland AB.

JCI Insight. 2017 Dec 21;2(24). pii: 92928. doi: 10.1172/jci.insight.92928.


The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, Lou Y, Bennewith KL, Supuran CT, Nabi IR, Raught B, Dedhar S.

Oncogene. 2017 Nov 9;36(45):6244-6261. doi: 10.1038/onc.2017.219. Epub 2017 Jul 10.


Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O.

Oncotarget. 2017 Mar 7;8(10):17140-17155. doi: 10.18632/oncotarget.15084.


A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA.

Sci Rep. 2016 Aug 30;6:32118. doi: 10.1038/srep32118.


Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction.

McDonald PC, Chafe SC, Dedhar S.

Front Cell Dev Biol. 2016 Mar 31;4:27. doi: 10.3389/fcell.2016.00027. eCollection 2016. Review.


Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.

Chafe SC, Lou Y, Sceneay J, Vallejo M, Hamilton MJ, McDonald PC, Bennewith KL, Möller A, Dedhar S.

Cancer Res. 2015 Mar 15;75(6):996-1008. doi: 10.1158/0008-5472.CAN-14-3000. Epub 2015 Jan 26.


LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.


Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S.

Nat Commun. 2013;4:2976. doi: 10.1038/ncomms3976.


Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

McDonald PC, Dedhar S.

Subcell Biochem. 2014;75:255-69. doi: 10.1007/978-94-007-7359-2_13. Review.


Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

Lock FE, McDonald PC, Lou Y, Serrano I, Chafe SC, Ostlund C, Aparicio S, Winum JY, Supuran CT, Dedhar S.

Oncogene. 2013 Oct 31;32(44):5210-9. doi: 10.1038/onc.2012.550. Epub 2012 Dec 3.


Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

Serrano I, McDonald PC, Lock FE, Dedhar S.

Oncogene. 2013 Jan 3;32(1):50-60. doi: 10.1038/onc.2012.30. Epub 2012 Feb 6.


Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.

McDonald PC, Winum JY, Supuran CT, Dedhar S.

Oncotarget. 2012 Jan;3(1):84-97. Review.


Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

Touisni N, Maresca A, McDonald PC, Lou Y, Scozzafava A, Dedhar S, Winum JY, Supuran CT.

J Med Chem. 2011 Dec 22;54(24):8271-7. doi: 10.1021/jm200983e. Epub 2011 Nov 22.


Integrin-linked kinase: not so 'pseudo' after all.

Hannigan GE, McDonald PC, Walsh MP, Dedhar S.

Oncogene. 2011 Oct 27;30(43):4375-85. doi: 10.1038/onc.2011.177. Epub 2011 May 23. Review.


Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S.

Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Erratum in: Cancer Res. 2011 Jul 1;71(13):4733. Cancer Res. 2011 Jun 15;71(12):4325.


Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT.

J Med Chem. 2011 Mar 24;54(6):1896-902. doi: 10.1021/jm101541x. Epub 2011 Mar 1.


Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation.

Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP, Dedhar S.

PLoS One. 2010 Aug 23;5(8):e12356. doi: 10.1371/journal.pone.0012356.


Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma.

McDonald PC, Dedhar S, Keller C.

J Clin Invest. 2009 Jun;119(6):1452-5.


Integrin-linked kinase--essential roles in physiology and cancer biology.

McDonald PC, Fielding AB, Dedhar S.

J Cell Sci. 2008 Oct 1;121(Pt 19):3121-32. doi: 10.1242/jcs.017996. Review.


Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S.

Dev Dyn. 2008 Oct;237(10):2755-68. doi: 10.1002/dvdy.21658.


Integrin-linked kinase regulates E-cadherin expression through PARP-1.

McPhee TR, McDonald PC, Oloumi A, Dedhar S.

Dev Dyn. 2008 Oct;237(10):2737-47. doi: 10.1002/dvdy.21685.


Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.

McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, Wederell ED, Bally MB, Foster LJ, Dedhar S.

Cancer Res. 2008 Mar 15;68(6):1618-24. doi: 10.1158/0008-5472.CAN-07-5869.


Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization.

Fielding AB, Dobreva I, McDonald PC, Foster LJ, Dedhar S.

J Cell Biol. 2008 Feb 25;180(4):681-9. doi: 10.1083/jcb.200710074. Epub 2008 Feb 18.


Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.

Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, Kucab JE, Dunn SE, Emerman JT, Bally MB, Dedhar S.

Cancer Res. 2006 Jan 1;66(1):393-403.


Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells.

Rahmani M, Read JT, Carthy JM, McDonald PC, Wong BW, Esfandiarei M, Si X, Luo Z, Luo H, Rennie PS, McManus BM.

J Biol Chem. 2005 Apr 1;280(13):13019-28. Epub 2005 Jan 24.


Transplant vascular disease: role of lipids and proteoglycans.

Rahmani M, McDonald PC, Wong BW, McManus BM.

Can J Cardiol. 2004 Aug;20 Suppl B:58B-65B. Review.


Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts.

Lai JC, Tranfield EM, Walker DC, Dyck J, Kerjner A, Loo S, English D, Wong D, McDonald PC, Moghadasian MH, Wilson JE, McManus BM; Heart Stroke Foundation of British Columbia and Yukon, Program Project Grant Investigators.

J Heart Lung Transplant. 2003 Sep;22(9):993-1004.


Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.

Choy JC, McDonald PC, Suarez AC, Hung VH, Wilson JE, McManus BM, Granville DJ.

Mod Pathol. 2003 May;16(5):460-70.


Quantitative analysis of human heart valves: does anorexigen exposure produce a distinctive morphological lesion?

McDonald PC, Wilson JE, Gao M, McNeill S, Spinelli JJ, Williams OD, Harji S, Kenyon J, McManus BM.

Cardiovasc Pathol. 2002 Sep-Oct;11(5):251-62.


The challenge of defining normality for human mitral and aortic valves: geometrical and compositional analysis.

McDonald PC, Wilson JE, McNeill S, Gao M, Spinelli JJ, Rosenberg F, Wiebe H, McManus BM.

Cardiovasc Pathol. 2002 Jul-Aug;11(4):193-209.


Use of en face silver nitrate staining to assess endothelial gaps and vascular permeability in rat coronary artery transplant vasculopathy.

Dyck J, Loo S, Zacher N, Wong D, McDonald PC, Walker DC, Wilson JE, McManus BM.

J Heart Lung Transplant. 2001 Feb;20(2):229-230. No abstract available.


Immunohistochemical localization of oxidized low-density lipoprotein (OXLDL) and macrophages in coronary arteries: human heart allografts versus human native hearts.

McDonald PC, Huang Y, Steinbrecher U, Lougheed M, Rahimian R, Wong D, Zacher N, Wilson J, McManus B.

J Heart Lung Transplant. 2001 Feb;20(2):187. No abstract available.


The role of lipids in transplant vascular disease.

McDonald PC, Kenyon JA, McManus BM.

Lab Invest. 1998 Oct;78(10):1187-201. Review. No abstract available.


Improved purification protocol of the HSV-1 protease catalytic domain, using immunoaffinity.

McKercher G, Bonneau PR, Lagacé L, Thibeault D, Massariol MJ, Krogsrud R, Lawetz C, McDonald PC, Cordingley MG.

Biochem Cell Biol. 1997;75(6):795-801.


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