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Items: 1 to 50 of 74

1.

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R.

Elife. 2019 Oct 30;8. pii: e50051. doi: 10.7554/eLife.50051.

2.

Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice.

Agarwal AK, Tunison K, Mitsche MA, McDonald JG, Garg A.

J Lipid Res. 2019 Dec;60(12):2057-2073. doi: 10.1194/jlr.RA119000399. Epub 2019 Oct 25.

PMID:
31653658
3.

Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass.

Harris LA, Kayser BD, Cefalo C, Marini L, Watrous JD, Ding J, Jain M, McDonald JG, Thompson BM, Fabbrini E, Eagon JC, Patterson BW, Mittendorfer B, Mingrone G, Klein S.

Cell Metab. 2019 Nov 5;30(5):855-864.e3. doi: 10.1016/j.cmet.2019.09.002. Epub 2019 Oct 3.

PMID:
31588013
4.

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.

Sakai M, Troutman TD, Seidman JS, Ouyang Z, Spann NJ, Abe Y, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, Glass CK.

Immunity. 2019 Oct 15;51(4):655-670.e8. doi: 10.1016/j.immuni.2019.09.002. Epub 2019 Oct 3.

PMID:
31587991
5.

Uptake of HDL-cholesterol contributes to lipid accumulation in clear cell renal cell carcinoma.

Kim J, Thompson B, Han S, Lotan Y, McDonald JG, Ye J.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158525. doi: 10.1016/j.bbalip.2019.158525. Epub 2019 Sep 9.

PMID:
31513923
6.

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.

Ugrankar R, Bowerman J, Hariri H, Chandra M, Chen K, Bossanyi MF, Datta S, Rogers S, Eckert KM, Vale G, Victoria A, Fresquez J, McDonald JG, Jean S, Collins BM, Henne WM.

Dev Cell. 2019 Sep 9;50(5):557-572.e5. doi: 10.1016/j.devcel.2019.07.021. Epub 2019 Aug 15.

PMID:
31422916
7.

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.

Long T, Hassan A, Thompson BM, McDonald JG, Wang J, Li X.

Nat Commun. 2019 Jun 5;10(1):2452. doi: 10.1038/s41467-019-10279-w.

8.

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.

Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ.

Cell Rep. 2019 Apr 30;27(5):1376-1386.e6. doi: 10.1016/j.celrep.2019.04.005.

9.

Targeted Determination of Tissue Energy Status by LC-MS/MS.

Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC.

Anal Chem. 2019 May 7;91(9):5881-5887. doi: 10.1021/acs.analchem.9b00217. Epub 2019 Apr 12.

10.

Target identification reveals lanosterol synthase as a vulnerability in glioma.

Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, Allis CD.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7957-7962. doi: 10.1073/pnas.1820989116. Epub 2019 Mar 28.

11.

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice.

Jo Y, Hamilton JS, Hwang S, Garland K, Smith GA, Su S, Fuentes I, Neelam S, Thompson BM, McDonald JG, DeBose-Boyd RA.

Elife. 2019 Feb 20;8. pii: e44396. doi: 10.7554/eLife.44396.

12.

Three-phase liquid extraction: a simple and fast method for lipidomic workflows.

Vale G, Martin SA, Mitsche MA, Thompson BM, Eckert KM, McDonald JG.

J Lipid Res. 2019 Mar;60(3):694-706. doi: 10.1194/jlr.D090795. Epub 2019 Jan 4.

PMID:
30610084
13.

Cilia-Associated Oxysterols Activate Smoothened.

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF.

Mol Cell. 2018 Oct 18;72(2):316-327.e5. doi: 10.1016/j.molcel.2018.08.034.

14.

27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative.

Chang PY, Feldman D, Stefanick ML, McDonnell DP, Thompson BM, McDonald JG, Lee JS.

J Bone Miner Res. 2019 Jan;34(1):59-66. doi: 10.1002/jbmr.3576. Epub 2018 Dec 7.

PMID:
30138538
15.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.

Muse ED, Yu S, Edillor CR, Tao J, Spann NJ, Troutman TD, Seidman JS, Henke A, Roland JT, Ozeki KA, Thompson BM, McDonald JG, Bahadorani J, Tsimikas S, Grossman TR, Tremblay MS, Glass CK.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689. doi: 10.1073/pnas.1714518115. Epub 2018 Apr 9.

16.

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.

Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL.

Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065.

17.

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

Dang EV, McDonald JG, Russell DW, Cyster JG.

Cell. 2017 Nov 16;171(5):1057-1071.e11. doi: 10.1016/j.cell.2017.09.029. Epub 2017 Oct 12.

18.

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma.

Ou W, Mulik RS, Anwar A, McDonald JG, He X, Corbin IR.

Free Radic Biol Med. 2017 Nov;112:597-607. doi: 10.1016/j.freeradbiomed.2017.09.002. Epub 2017 Sep 8.

19.

27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW, Morrison SJ.

J Clin Invest. 2017 Sep 1;127(9):3392-3401. doi: 10.1172/JCI94027. Epub 2017 Aug 7.

20.

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.

Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I.

JCI Insight. 2017 Aug 3;2(15). pii: 94278. doi: 10.1172/jci.insight.94278. eCollection 2017 Aug 3.

21.

Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen.

Lu E, Dang EV, McDonald JG, Cyster JG.

Sci Immunol. 2017 Apr 7;2(10). pii: eaal5237. doi: 10.1126/sciimmunol.aal5237.

22.

Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine.

Rong S, McDonald JG, Engelking LJ.

J Lipid Res. 2017 Oct;58(10):1988-1998. doi: 10.1194/jlr.M077610. Epub 2017 Jun 19.

23.

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

Rong S, Cortés VA, Rashid S, Anderson NN, McDonald JG, Liang G, Moon YA, Hammer RE, Horton JD.

Elife. 2017 Feb 28;6. pii: e25015. doi: 10.7554/eLife.25015.

24.

Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways.

Shen ZJ, Hu J, Kashi VP, Kelly EA, Denlinger LC, Lutchman K, McDonald JG, Jarjour NN, Malter JS.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1576-1585. doi: 10.1164/rccm.201608-1580OC.

25.

Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase.

Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE.

Mol Metab. 2015 Aug 29;4(11):771-8. doi: 10.1016/j.molmet.2015.08.004. eCollection 2015 Nov.

26.

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.

Xia JY, Holland WL, Kusminski CM, Sun K, Sharma AX, Pearson MJ, Sifuentes AJ, McDonald JG, Gordillo R, Scherer PE.

Cell Metab. 2015 Aug 4;22(2):266-278. doi: 10.1016/j.cmet.2015.06.007. Epub 2015 Jul 16.

27.

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways.

Mitsche MA, McDonald JG, Hobbs HH, Cohen JC.

Elife. 2015 Jun 26;4:e07999. doi: 10.7554/eLife.07999.

28.

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.

Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH Jr, Russell DW, Subramaniam S, Brown HA.

J Lipid Res. 2015 Mar;56(3):722-36. doi: 10.1194/jlr.P056002. Epub 2015 Jan 17.

29.

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels.

Stiles AR, Kozlitina J, Thompson BM, McDonald JG, King KS, Russell DW.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4006-14. doi: 10.1073/pnas.1413561111. Epub 2014 Sep 8.

30.

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.

Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG.

Science. 2014 Aug 8;345(6197):679-84. doi: 10.1126/science.1254790.

31.

Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.

Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17.

32.

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.

Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi: 10.1073/pnas.1324245111. Epub 2014 Feb 3.

33.

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.

Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW.

Cell Rep. 2013 Nov 14;5(3):637-45. doi: 10.1016/j.celrep.2013.10.006. Epub 2013 Nov 7.

34.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

35.

Lipidomics technologies at the end of the first decade and the beginning of the next.

Merrill AH, Dennis EA, McDonald JG, Fahy E.

Adv Nutr. 2013 Sep 1;4(5):565-7. doi: 10.3945/an.113.004333.

36.

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.

Buchovecky CM, Turley SD, Brown HM, Kyle SM, McDonald JG, Liu B, Pieper AA, Huang W, Katz DM, Russell DW, Shendure J, Justice MJ.

Nat Genet. 2013 Sep;45(9):1013-20. doi: 10.1038/ng.2714. Epub 2013 Jul 28.

37.

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK.

Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054.

38.

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma.

McDonald JG, Smith DD, Stiles AR, Russell DW.

J Lipid Res. 2012 Jul;53(7):1399-409. doi: 10.1194/jlr.D022285. Epub 2012 Apr 19.

39.

Steroid profiling by gas chromatography-mass spectrometry and high performance liquid chromatography-mass spectrometry for adrenal diseases.

McDonald JG, Matthew S, Auchus RJ.

Horm Cancer. 2011 Dec;2(6):324-32. doi: 10.1007/s12672-011-0099-x. Review.

40.

Detecting oxysterols in the human circulation.

Björkhem I, Diczfalusy U, Olsson T, Russell DW, McDonald JG, Wang Y, Griffiths WJ.

Nat Immunol. 2011 Jun 20;12(7):577; author reply 577-8. doi: 10.1038/ni0711-577a. No abstract available.

PMID:
21685947
41.

Editorial: 25-Hydroxycholesterol: a new life in immunology.

McDonald JG, Russell DW.

J Leukoc Biol. 2010 Dec;88(6):1071-2. doi: 10.1189/jlb.0710418. No abstract available.

42.

Diabetes and insulin in regulation of brain cholesterol metabolism.

Suzuki R, Lee K, Jing E, Biddinger SB, McDonald JG, Montine TJ, Craft S, Kahn CR.

Cell Metab. 2010 Dec 1;12(6):567-79. doi: 10.1016/j.cmet.2010.11.006.

43.

A mouse macrophage lipidome.

Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S.

J Biol Chem. 2010 Dec 17;285(51):39976-85. doi: 10.1074/jbc.M110.182915. Epub 2010 Oct 5.

44.

Lipidomics reveals a remarkable diversity of lipids in human plasma.

Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA.

J Lipid Res. 2010 Nov;51(11):3299-305. doi: 10.1194/jlr.M009449. Epub 2010 Jul 29.

45.

Subcellular organelle lipidomics in TLR-4-activated macrophages.

Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA.

J Lipid Res. 2010 Sep;51(9):2785-97. doi: 10.1194/jlr.M008748. Epub 2010 Jun 23.

46.

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.

Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ.

Cancer Res. 2009 Oct 15;69(20):7986-93. doi: 10.1158/0008-5472.CAN-09-2266. Epub 2009 Oct 13. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275. Bachoo, Robert G [corrected to Bachoo, Robert M].

47.

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.

Bauman DR, Bitmansour AD, McDonald JG, Thompson BM, Liang G, Russell DW.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16764-9. doi: 10.1073/pnas.0909142106. Epub 2009 Sep 15.

48.

CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions.

Stiles AR, McDonald JG, Bauman DR, Russell DW.

J Biol Chem. 2009 Oct 16;284(42):28485-9. doi: 10.1074/jbc.R109.042168. Epub 2009 Aug 16. Review.

49.

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.

Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS.

Cell Metab. 2008 Dec;8(6):512-21. doi: 10.1016/j.cmet.2008.10.008.

50.

Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene.

McDonald JG, Cummins CL, Barkley RM, Thompson BM, Lincoln HA.

Anal Chem. 2008 Jul 15;80(14):5532-41. doi: 10.1021/ac8005632. Epub 2008 Jun 6.

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