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Items: 26

1.

Correction of copy number induced false positives in CRISPR screens.

de Weck A, Golji J, Jones MD, Korn JM, Billy E, McDonald ER 3rd, Schmelzle T, Bitter H, Kauffmann A.

PLoS Comput Biol. 2018 Jul 19;14(7):e1006279. doi: 10.1371/journal.pcbi.1006279. eCollection 2018 Jul.

2.

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.

3.

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR.

Cancer Discov. 2016 Aug;6(8):900-13. doi: 10.1158/2159-8290.CD-16-0178. Epub 2016 Jun 3.

4.

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.

Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR.

Science. 2016 Mar 11;351(6278):1208-13. doi: 10.1126/science.aad5944. Epub 2016 Feb 11.

5.

Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2.

Hortobagyi GN, Chen D, Piccart M, Rugo HS, Burris HA 3rd, Pritchard KI, Campone M, Noguchi S, Perez AT, Deleu I, Shtivelband M, Masuda N, Dakhil S, Anderson I, Robinson DM, He W, Garg A, McDonald ER 3rd, Bitter H, Huang A, Taran T, Bachelot T, Lebrun F, Lebwohl D, Baselga J.

J Clin Oncol. 2016 Feb 10;34(5):419-26. doi: 10.1200/JCO.2014.60.1971. Epub 2015 Oct 26.

6.

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW, Elledge SJ.

Science. 2011 Jun 10;332(6035):1313-7. doi: 10.1126/science.1203430.

7.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.

Science. 2007 May 25;316(5828):1160-6.

8.

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.

Nature. 2007 Apr 19;446(7138):876-81.

PMID:
17443180
9.

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.

Cell. 2007 Apr 20;129(2):289-301. Epub 2007 Apr 5.

10.

CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.

Yang W, Rozan LM, McDonald ER 3rd, Navaraj A, Liu JJ, Matthew EM, Wang W, Dicker DT, El-Deiry WS.

J Biol Chem. 2007 Feb 2;282(5):3273-81. Epub 2006 Nov 22.

11.

Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2.

Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y.

Structure. 2004 Dec;12(12):2257-63.

13.

Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

McDonald ER 3rd, El-Deiry WS.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5. Epub 2004 Apr 6.

14.

Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.

Corn PG, McDonald ER 3rd, Herman JG, El-Deiry WS.

Nat Genet. 2003 Nov;35(3):229-37. Epub 2003 Oct 12.

PMID:
14556007
15.

Yeast two-hybrid screening as a means of deciphering tumor suppressor pathways.

McDonald ER 3rd, El-Deiry WS.

Methods Mol Biol. 2003;223:173-85. No abstract available.

PMID:
12777729
16.

Amyotrophic lateral sclerosis and hopelessness: psychosocial factors.

Plahuta JM, McCulloch BJ, Kasarskis EJ, Ross MA, Walter RA, McDonald ER.

Soc Sci Med. 2002 Dec;55(12):2131-40.

PMID:
12409126
17.

Checkpoint genes in cancer.

McDonald ER 3rd, El-Deiry WS.

Ann Med. 2001 Mar;33(2):113-22. Review.

PMID:
11327114
18.

Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.

McDonald ER 3rd, Chui PC, Martelli PF, Dicker DT, El-Deiry WS.

J Biol Chem. 2001 May 4;276(18):14939-45. Epub 2001 Feb 13.

19.
20.

Cell cycle control as a basis for cancer drug development (Review).

McDonald ER 3rd, El-Deiry WS.

Int J Oncol. 2000 May;16(5):871-86. Review.

PMID:
10762622
21.

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.

Wu GS, Burns TF, McDonald ER 3rd, Meng RD, Kao G, Muschel R, Yen T, el-Deiry WS.

Oncogene. 1999 Nov 11;18(47):6411-8.

22.

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.

Wu GS, Burns TF, McDonald ER 3rd, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G, el-Deiry WS.

Nat Genet. 1997 Oct;17(2):141-3. No abstract available.

PMID:
9326928
23.

Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

McDonald ER 3rd, Wu GS, Waldman T, El-Deiry WS.

Cancer Res. 1996 May 15;56(10):2250-5.

24.

Evaluation of the psychological status of ventilatory-supported patients with ALS/MND.

McDonald ER, Hillel A, Wiedenfeld SA.

Palliat Med. 1996 Jan;10(1):35-41.

PMID:
8821186
25.

Quality of life from the patient's perspective.

McDonald ER.

J Neurosci Nurs. 1995 Aug;27(4):222-3. No abstract available. Erratum in: J Neurosci Nurs 1996 Feb;28(1):4.

PMID:
7499926
26.

Survival in amyotrophic lateral sclerosis. The role of psychological factors.

McDonald ER, Wiedenfeld SA, Hillel A, Carpenter CL, Walter RA.

Arch Neurol. 1994 Jan;51(1):17-23.

PMID:
8274106

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