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Items: 1 to 50 of 255

1.

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation.

O'Neill KM, Campbell DC, Edgar KS, Gill EK, Moez A, McLoughlin KJ, O'Neill CL, Dellett M, Hargey CJ, Abudalo RA, O'Hare M, Doyle P, Toh T, Khoo J, Wong J, McCrudden CM, Meloni M, Brunssen C, Morawietz H, Yoder MC, McDonald DM, Watson CJ, Stitt AW, Margariti A, Medina RJ, Grieve DJ.

Cardiovasc Res. 2019 Apr 1. pii: cvz090. doi: 10.1093/cvr/cvz090. [Epub ahead of print]

PMID:
30937452
2.

Synthesis of a Self-Adjuvanting MUC1 Vaccine via Diselenide-Selenoester Ligation-Deselenization.

McDonald DM, Hanna CC, Ashhurst AS, Corcilius L, Byrne SN, Payne RJ.

ACS Chem Biol. 2018 Dec 21;13(12):3279-3285. doi: 10.1021/acschembio.8b00675. Epub 2018 Nov 14.

PMID:
30359529
3.

Imaging Lymphatics in Mouse Lungs.

Baluk P, McDonald DM.

Methods Mol Biol. 2018;1846:161-180. doi: 10.1007/978-1-4939-8712-2_11.

4.

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M.

Sci Adv. 2018 Aug 8;4(8):eaat4758. doi: 10.1126/sciadv.aat4758. eCollection 2018 Aug.

5.

Tighter lymphatic junctions prevent obesity.

McDonald DM.

Science. 2018 Aug 10;361(6402):551-552. doi: 10.1126/science.aau5583. No abstract available.

6.

Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms.

Kim M, Nitschké M, Sennino B, Murer P, Schriver BJ, Bell A, Subramanian A, McDonald CE, Wang J, Cha H, Bourgeois-Daigneault MC, Kirn DH, Bell JC, De Silva N, Breitbach CJ, McDonald DM.

Cancer Res. 2018 Feb 15;78(4):922-937. doi: 10.1158/0008-5472.CAN-15-3308. Epub 2017 Dec 19.

7.

The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.

Shepherd J, Fisher M, Welford A, McDonald DM, Kanthou C, Tozer GM.

Oncotarget. 2017 Sep 21;8(56):95648-95661. doi: 10.18632/oncotarget.21172. eCollection 2017 Nov 10.

8.

Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract.

Baluk P, Yao LC, Flores JC, Choi D, Hong YK, McDonald DM.

JCI Insight. 2017 Aug 17;2(16). pii: 90103. doi: 10.1172/jci.insight.90103. eCollection 2017 Aug 17.

9.

Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.

Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM.

Am J Pathol. 2017 Sep;187(9):1984-1997. doi: 10.1016/j.ajpath.2017.05.009. Epub 2017 Jul 3.

10.

BH4-Mediated Enhancement of Endothelial Nitric Oxide Synthase Activity Reduces Hyperoxia-Induced Endothelial Damage and Preserves Vascular Integrity in the Neonate.

Edgar KS, Galvin OM, Collins A, Katusic ZS, McDonald DM.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):230-241. doi: 10.1167/iovs.16-20523.

11.

Tie1 controls angiopoietin function in vascular remodeling and inflammation.

Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P.

J Clin Invest. 2016 Sep 1;126(9):3495-510. doi: 10.1172/JCI84923. Epub 2016 Aug 22.

12.

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM.

J Clin Invest. 2016 Sep 1;126(9):3511-25. doi: 10.1172/JCI84871. Epub 2016 Aug 22.

13.

Development of polymeric-cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery.

Jain AK, Massey A, Yusuf H, McDonald DM, McCarthy HO, Kett VL.

Int J Nanomedicine. 2015 Nov 24;10:7183-96. doi: 10.2147/IJN.S95245. eCollection 2015.

14.

Synthetic self-adjuvanting glycopeptide cancer vaccines.

McDonald DM, Byrne SN, Payne RJ.

Front Chem. 2015 Oct 23;3:60. doi: 10.3389/fchem.2015.00060. eCollection 2015. Review.

15.

Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors.

Moen I, Gebre M, Alonso-Camino V, Chen D, Epstein D, McDonald DM.

Clin Exp Metastasis. 2015 Dec;32(8):799-817. doi: 10.1007/s10585-015-9752-z. Epub 2015 Oct 7.

16.

Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.

Le CT, Laidlaw G, Morehouse CA, Naiman B, Brohawn P, Mustelin T, Connor JR, McDonald DM.

Am J Pathol. 2015 Nov;185(11):2949-68. doi: 10.1016/j.ajpath.2015.07.010. Epub 2015 Sep 5.

17.

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.

J Am Soc Nephrol. 2016 Jan;27(1):69-77. doi: 10.1681/ASN.2014090856. Epub 2015 Jun 2.

18.

Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.

Raymond WW, Xu X, Nimishakavi S, Le C, McDonald DM, Caughey GH.

PLoS One. 2015 May 4;10(5):e0125797. doi: 10.1371/journal.pone.0125797. eCollection 2015.

19.

Hyperoxia depletes (6R)-5,6,7,8-tetrahydrobiopterin levels in the neonatal retina: implications for nitric oxide synthase function in retinopathy.

Edgar KS, Matesanz N, Gardiner TA, Katusic ZS, McDonald DM.

Am J Pathol. 2015 Jun;185(6):1769-82. doi: 10.1016/j.ajpath.2015.02.021. Epub 2015 Apr 23.

PMID:
25913075
20.

Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.

Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF.

PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. eCollection 2015.

21.

Development of a method to quantify the DNA content in cationic peptide-DNA nanoparticles.

Jain AK, Yusuf H, Pattani A, McCarthy HO, McDonald DM, Kett VL.

J Pharm Biomed Anal. 2014 Nov;100:236-242. doi: 10.1016/j.jpba.2014.07.036. Epub 2014 Aug 9.

PMID:
25171486
22.

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald DM, McGuffog CM, Meyer NJ, Alexander IE, Parish IA, Heath WR, Weninger W, Bishop GA, Gamble JR, McCaughan GW, Bertolino P, Bowen DG.

J Immunol. 2014 Sep 1;193(5):2087-95. doi: 10.4049/jimmunol.1400037. Epub 2014 Jul 28.

23.

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates.

McDonald DM, Wilkinson BL, Corcilius L, Thaysen-Andersen M, Byrne SN, Payne RJ.

Chem Commun (Camb). 2014 Sep 14;50(71):10273-6. doi: 10.1039/c4cc03510k.

PMID:
25056269
24.

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Tay SS, Wong YC, McDonald DM, Wood NA, Roediger B, Sierro F, Mcguffog C, Alexander IE, Bishop GA, Gamble JR, Weninger W, McCaughan GW, Bertolino P, Bowen DG.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2540-9. doi: 10.1073/pnas.1406674111. Epub 2014 Jun 10.

25.

Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.

Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald DM.

Am J Pathol. 2014 Jun;184(6):1877-89. doi: 10.1016/j.ajpath.2014.02.010. Epub 2014 Apr 13.

26.

Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.

Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM.

Am J Pathol. 2014 May;184(5):1577-92. doi: 10.1016/j.ajpath.2014.01.021. Epub 2014 Mar 11.

27.

Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period.

Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM.

Circ Res. 2014 Feb 28;114(5):806-22. doi: 10.1161/CIRCRESAHA.114.303119. Epub 2014 Jan 15.

28.

Plasticity of airway lymphatics in development and disease.

Yao LC, McDonald DM.

Adv Anat Embryol Cell Biol. 2014;214:41-54. doi: 10.1007/978-3-7091-1646-3_4. Review.

29.

Iron administration before stem cell harvest enables MR imaging tracking after transplantation.

Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald DM, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE.

Radiology. 2013 Oct;269(1):186-97. doi: 10.1148/radiol.13130858. Epub 2013 Jul 12.

30.

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.

Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM.

Int Immunol. 2013 Aug;25(8):471-83. doi: 10.1093/intimm/dxt012. Epub 2013 May 8.

31.

Molecular determinants of lung development.

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS.

Ann Am Thorac Soc. 2013 Apr;10(2):S12-6. doi: 10.1513/AnnalsATS.201207-036OT. Review.

32.

Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.

Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):437-44. doi: 10.1165/rcmb.2013-0016OC.

33.

Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice.

Sennino B, Ishiguro-Oonuma T, Schriver BJ, Christensen JG, McDonald DM.

Cancer Res. 2013 Jun 15;73(12):3692-703. doi: 10.1158/0008-5472.CAN-12-2160. Epub 2013 Apr 10.

34.

Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.

Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM.

Am J Pathol. 2013 Apr;182(4):1434-47. doi: 10.1016/j.ajpath.2012.12.003. Epub 2013 Feb 4.

35.

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.

Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA.

Oncogene. 2013 Oct 17;32(42):5048-57. doi: 10.1038/onc.2012.530. Epub 2012 Dec 17.

36.

Platelet redox balance in diabetic patients with hypertension improved by n-3 fatty acids.

McDonald DM, O'Kane F, McConville M, Devine AB, McVeigh GE.

Diabetes Care. 2013 Apr;36(4):998-1005. doi: 10.2337/dc12-0304. Epub 2012 Dec 13.

37.

Controlling escape from angiogenesis inhibitors.

Sennino B, McDonald DM.

Nat Rev Cancer. 2012 Oct;12(10):699-709. doi: 10.1038/nrc3366. Review.

38.

eNOS overexpression exacerbates vascular closure in the obliterative phase of OIR and increases angiogenic drive in the subsequent proliferative stage.

Edgar K, Gardiner TA, van Haperen R, de Crom R, McDonald DM.

Invest Ophthalmol Vis Sci. 2012 Oct 3;53(11):6833-50. doi: 10.1167/iovs.12-9797.

39.

A novel dual-fluorescence strategy for functionally validating microRNA targets in 3' untranslated regions: regulation of the inward rectifier potassium channel K(ir)2.1 by miR-212.

Goldoni D, Yarham JM, McGahon MK, O'Connor A, Guduric-Fuchs J, Edgar K, McDonald DM, Simpson DA, Collins A.

Biochem J. 2012 Nov 15;448(1):103-13. doi: 10.1042/BJ20120578.

40.

Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors.

Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM.

Cancer Discov. 2012 Mar;2(3):270-87. doi: 10.1158/2159-8290.CD-11-0240. Epub 2012 Feb 24.

41.

Patterns of care for non-small-cell lung cancer at an academic institution affiliated with a national cancer institute-designated cancer center.

Nguyen KS, Sanford RA, Huberman MS, Goldstein MA, McDonald DM, Farquhar M, Gangadharan SP, Kent MS, Michaud G, Majid A, Berman SM, Aronovitz JA, Nedea EA, Boiselle PM, Cohen DW, Kobayashi S, Costa DB.

J Oncol Pract. 2012 Jan;8(1):57-62. doi: 10.1200/JOP.2011.000274. Epub 2011 Nov 22.

42.

Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.

Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald DM.

Am J Pathol. 2012 Jun;180(6):2561-75. doi: 10.1016/j.ajpath.2012.02.019. Epub 2012 Apr 23.

43.

Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB.

Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald DM, Blau HM.

FASEB J. 2012 Jun;26(6):2486-97. doi: 10.1096/fj.11-197400. Epub 2012 Mar 5.

44.

Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation.

McDonald DM, Yao LC, Baluk P.

Proc Am Thorac Soc. 2011 Nov;8(6):504-7. doi: 10.1513/pats.201102-022MW. Review.

45.

The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling.

Agnew AJ, Robinson E, McVicar CM, Harvey AP, Ali IH, Lindsay JE, McDonald DM, Green BD, Grieve DJ.

Br J Pharmacol. 2012 May;166(1):327-38. doi: 10.1111/j.1476-5381.2011.01761.x.

46.

MET and VEGF: synergistic targets in castration-resistant prostate cancer.

Aftab DT, McDonald DM.

Clin Transl Oncol. 2011 Oct;13(10):703-9. doi: 10.1007/s12094-011-0719-5. Review.

47.

Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF).

Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald DM, Brasch RC, Raatschen HJ.

Eur J Radiol. 2012 May;81(5):891-6. doi: 10.1016/j.ejrad.2011.07.016. Epub 2011 Sep 1.

48.

In situ force mapping of mammary gland transformation.

Lopez JI, Kang I, You WK, McDonald DM, Weaver VM.

Integr Biol (Camb). 2011 Sep;3(9):910-21. doi: 10.1039/c1ib00043h. Epub 2011 Aug 15.

49.

Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B.

Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM.

Am J Pathol. 2011 Jun;178(6):2920-30. doi: 10.1016/j.ajpath.2011.02.019.

50.

VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer.

You WK, Sennino B, Williamson CW, Falcón B, Hashizume H, Yao LC, Aftab DT, McDonald DM.

Cancer Res. 2011 Jul 15;71(14):4758-68. doi: 10.1158/0008-5472.CAN-10-2527. Epub 2011 May 25.

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