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Perspective: The promise of multi-cellular engineered living systems.

Kamm RD, Bashir R, Arora N, Dar RD, Gillette MU, Griffith LG, Kemp ML, Kinlaw K, Levin M, Martin AC, McDevitt TC, Nerem RM, Powers MJ, Saif TA, Sharpe J, Takayama S, Takeuchi S, Weiss R, Ye K, Yevick HG, Zaman MH.

APL Bioeng. 2018 Oct 11;2(4):040901. doi: 10.1063/1.5038337. eCollection 2018 Dec.


A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications.

Hettiaratchi MH, Schudel A, Rouse T, García AJ, Thomas SN, Guldberg RE, McDevitt TC.

APL Bioeng. 2018 Jun 12;2(2):026110. doi: 10.1063/1.4999925. eCollection 2018 Jun.


Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function.

Hookway TA, Matthys OB, Mendoza-Camacho FN, Rains S, Sepulveda JE, Joy DA, McDevitt TC.

Tissue Eng Part A. 2019 May;25(9-10):773-785. doi: 10.1089/ten.TEA.2018.0362.


Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies.

Silva AC, Oliveira MJ, McDevitt TC, Barbosa MA, Nascimento DS, Pinto-do-Ó P.

J Vis Exp. 2019 Mar 21;(145). doi: 10.3791/56924. Erratum in: J Vis Exp. 2019 Apr 23;(146):.


Author Correction: Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.

Glen CM, McDevitt TC, Kemp ML.

Nat Commun. 2018 Nov 16;9(1):4901. doi: 10.1038/s41467-018-07442-0.


Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC.

Elife. 2018 Oct 9;7. pii: e36045. doi: 10.7554/eLife.36045.


Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.

Glen CM, McDevitt TC, Kemp ML.

Nat Commun. 2018 Oct 5;9(1):4111. doi: 10.1038/s41467-018-06693-1. Erratum in: Nat Commun. 2018 Nov 16;9(1):4901.


Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures.

Bongiorno T, Gura J, Talwar P, Chambers D, Young KM, Arafat D, Wang G, Jackson-Holmes EL, Qiu P, McDevitt TC, Sulchek T.

PLoS One. 2018 Mar 8;13(3):e0192631. doi: 10.1371/journal.pone.0192631. eCollection 2018.


Microparticle-mediated sequestration of cell-secreted proteins to modulate chondrocytic differentiation.

Rinker TE, Philbrick BD, Hettiaratchi MH, Smalley DM, McDevitt TC, Temenoff JS.

Acta Biomater. 2018 Mar 1;68:125-136. doi: 10.1016/j.actbio.2017.12.038. Epub 2017 Dec 30.


Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells.

Khalil AS, Yu X, Xie AW, Fontana G, Umhoefer JM, Johnson HJ, Hookway TA, McDevitt TC, Murphy WL.

Sci Rep. 2017 Oct 27;7(1):14211. doi: 10.1038/s41598-017-14153-x.


Tridimensional configurations of human mesenchymal stem/stromal cells to enhance cell paracrine potential towards wound healing processes.

Costa MHG, McDevitt TC, Cabral JMS, da Silva CL, Ferreira FC.

J Biotechnol. 2017 Nov 20;262:28-39. doi: 10.1016/j.jbiotec.2017.09.020. Epub 2017 Sep 28.


A microfluidic trap array for longitudinal monitoring and multi-modal phenotypic analysis of individual stem cell aggregates.

Jackson-Holmes EL, McDevitt TC, Lu H.

Lab Chip. 2017 Oct 25;17(21):3634-3642. doi: 10.1039/c7lc00763a.


Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect.

Hettiaratchi MH, Rouse T, Chou C, Krishnan L, Stevens HY, Li MA, McDevitt TC, Guldberg RE.

Acta Biomater. 2017 Sep 1;59:21-32. doi: 10.1016/j.actbio.2017.06.028. Epub 2017 Jun 20.


The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids.

Griffin FE, Schiavi J, McDevitt TC, McGarry JP, McNamara LM.

J Biomech. 2017 Jul 5;59:71-79. doi: 10.1016/j.jbiomech.2017.05.014. Epub 2017 May 22.


Differentiation of V2a interneurons from human pluripotent stem cells.

Butts JC, McCreedy DA, Martinez-Vargas JA, Mendoza-Camacho FN, Hookway TA, Gifford CA, Taneja P, Noble-Haeusslein L, McDevitt TC.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4969-4974. doi: 10.1073/pnas.1608254114. Epub 2017 Apr 24.


Competitive Protein Binding Influences Heparin-Based Modulation of Spatial Growth Factor Delivery for Bone Regeneration.

Hettiaratchi MH, Chou C, Servies N, Smeekens JM, Cheng A, Esancy C, Wu R, McDevitt TC, Guldberg RE, Krishnan L.

Tissue Eng Part A. 2017 Jul;23(13-14):683-695. doi: 10.1089/ten.tea.2016.0507. Epub 2017 Mar 24.


Enhanced Immunosuppression of T Cells by Sustained Presentation of Bioactive Interferon-γ Within Three-Dimensional Mesenchymal Stem Cell Constructs.

Zimmermann JA, Hettiaratchi MH, McDevitt TC.

Stem Cells Transl Med. 2017 Jan;6(1):223-237. doi: 10.5966/sctm.2016-0044. Epub 2016 Aug 8.


Hydrolysis and Sulfation Pattern Effects on Release of Bioactive Bone Morphogenetic Protein-2 from Heparin-Based Microparticles.

Tellier LE, Miller T, McDevitt TC, Temenoff JS.

J Mater Chem B. 2015 Oct 28;3(40):8001-8009. Epub 2015 Aug 28.


Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells.

Matthys OB, Hookway TA, McDevitt TC.

Curr Stem Cell Rep. 2016 Mar;2(1):43-51. Epub 2016 Jan 27.


A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening.

Chi T, Park JS, Butts JC, Hookway TA, Su A, Zhu C, Styczynski MP, McDevitt TC, Wang H.

IEEE Trans Biomed Circuits Syst. 2015 Dec;9(6):801-14. doi: 10.1109/TBCAS.2015.2504984. Epub 2016 Jan 22.


Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny.

Hookway TA, Butts JC, Lee E, Tang H, McDevitt TC.

Methods. 2016 May 15;101:11-20. doi: 10.1016/j.ymeth.2015.11.027. Epub 2015 Dec 2.


Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates.

Wang Y, Yu X, Baker C, Murphy WL, McDevitt TC.

Acta Biomater. 2016 Jan;29:42-51. doi: 10.1016/j.actbio.2015.10.039. Epub 2015 Oct 24.


MMP-mediated mesenchymal morphogenesis of pluripotent stem cell aggregates stimulated by gelatin methacrylate microparticle incorporation.

Nguyen AH, Wang Y, White DE, Platt MO, McDevitt TC.

Biomaterials. 2016 Jan;76:66-75. doi: 10.1016/j.biomaterials.2015.10.043. Epub 2015 Oct 21.


Quantitative multivariate analysis of dynamic multicellular morphogenic trajectories.

White DE, Sylvester JB, Levario TJ, Lu H, Streelman JT, McDevitt TC, Kemp ML.

Integr Biol (Camb). 2015 Jul;7(7):825-33. doi: 10.1039/c5ib00072f.


Osteogenic embryoid body-derived material induces bone formation in vivo.

Sutha K, Schwartz Z, Wang Y, Hyzy S, Boyan BD, McDevitt TC.

Sci Rep. 2015 May 11;5:9960. doi: 10.1038/srep09960.


Cell-derived matrices for tissue engineering and regenerative medicine applications.

Fitzpatrick LE, McDevitt TC.

Biomater Sci. 2015 Jan;3(1):12-24. doi: 10.1039/C4BM00246F.


Gelatin methacrylate microspheres for controlled growth factor release.

Nguyen AH, McKinney J, Miller T, Bongiorno T, McDevitt TC.

Acta Biomater. 2015 Feb;13:101-10. doi: 10.1016/j.actbio.2014.11.028. Epub 2014 Nov 20.


Differential expression of extracellular matrix and growth factors by embryoid bodies in hydrodynamic and static cultures.

Fridley KM, Nair R, McDevitt TC.

Tissue Eng Part C Methods. 2014 Dec;20(12):931-40. doi: 10.1089/ten.tec.2013.0392.


Chondroitin sulfate microparticles modulate transforming growth factor-β1-induced chondrogenesis of human mesenchymal stem cell spheroids.

Goude MC, McDevitt TC, Temenoff JS.

Cells Tissues Organs. 2014;199(2-3):117-30. doi: 10.1159/000365966. Epub 2014 Nov 18.


Microscale generation of cardiospheres promotes robust enrichment of cardiomyocytes derived from human pluripotent stem cells.

Nguyen DC, Hookway TA, Wu Q, Jha R, Preininger MK, Chen X, Easley CA, Spearman P, Deshpande SR, Maher K, Wagner MB, McDevitt TC, Xu C.

Stem Cell Reports. 2014 Aug 12;3(2):260-8. doi: 10.1016/j.stemcr.2014.06.002. Epub 2014 Jul 4.


Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.

Hettiaratchi MH, Miller T, Temenoff JS, Guldberg RE, McDevitt TC.

Biomaterials. 2014 Aug;35(25):7228-38. doi: 10.1016/j.biomaterials.2014.05.011. Epub 2014 May 28.


Materials as stem cell regulators.

Murphy WL, McDevitt TC, Engler AJ.

Nat Mater. 2014 Jun;13(6):547-57. doi: 10.1038/nmat3937. Review. Erratum in: Nat Mater. 2014 Jul;13(7):756.


Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche.

Kinney MA, Saeed R, McDevitt TC.

Sci Rep. 2014 Mar 6;4:4290. doi: 10.1038/srep04290.


Soluble factors secreted by differentiating embryonic stem cells stimulate exogenous cell proliferation and migration.

Ngangan AV, Waring JC, Cooke MT, Mandrycky CJ, McDevitt TC.

Stem Cell Res Ther. 2014 Feb 24;5(1):26. doi: 10.1186/scrt415.


A global assessment of stem cell engineering.

Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM.

Tissue Eng Part A. 2014 Oct;20(19-20):2575-89. doi: 10.1089/ten.TEA.2013.0468. Epub 2014 Feb 28.


Scalable culture of human pluripotent stem cells in 3D.

McDevitt TC.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20852-3. doi: 10.1073/pnas.1320575111. Epub 2013 Dec 10. No abstract available.


Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics.

Kinney MA, Hookway TA, Wang Y, McDevitt TC.

Ann Biomed Eng. 2014 Feb;42(2):352-67. doi: 10.1007/s10439-013-0953-9. Epub 2013 Dec 3. Review.


Mechanical stiffness as an improved single-cell indicator of osteoblastic human mesenchymal stem cell differentiation.

Bongiorno T, Kazlow J, Mezencev R, Griffiths S, Olivares-Navarrete R, McDonald JF, Schwartz Z, Boyan BD, McDevitt TC, Sulchek T.

J Biomech. 2014 Jun 27;47(9):2197-204. doi: 10.1016/j.jbiomech.2013.11.017. Epub 2013 Nov 17.


Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion.

Zimmermann JA, McDevitt TC.

Cytotherapy. 2014 Mar;16(3):331-45. doi: 10.1016/j.jcyt.2013.09.004. Epub 2013 Nov 9.


Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates.

Wilson JL, Najia MA, Saeed R, McDevitt TC.

Biotechnol Bioeng. 2014 Mar;111(3):618-31. doi: 10.1002/bit.25121. Epub 2013 Oct 25.


Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies.

Nsiah BA, Ahsan T, Griffiths S, Cooke M, Nerem RM, McDevitt TC.

Tissue Eng Part A. 2014 Mar;20(5-6):954-65. doi: 10.1089/ten.TEA.2013.0243. Epub 2014 Jan 24.


Engineering the emergence of stem cell therapeutics.

Healy KE, McDevitt TC, Murphy WL, Nerem RM.

Sci Transl Med. 2013 Oct 16;5(207):207ed17. doi: 10.1126/scitranslmed.3007609. No abstract available.


Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery.

Miller T, Goude MC, McDevitt TC, Temenoff JS.

Acta Biomater. 2014 Apr;10(4):1705-19. doi: 10.1016/j.actbio.2013.09.039. Epub 2013 Oct 9. Review.


Microfluidic-based patterning of embryonic stem cells for in vitro development studies.

Suri S, Singh A, Nguyen AH, Bratt-Leal AM, McDevitt TC, Lu H.

Lab Chip. 2013 Dec 7;13(23):4617-24. doi: 10.1039/c3lc50663k.


Single-cell analysis of embryoid body heterogeneity using microfluidic trapping array.

Wilson JL, Suri S, Singh A, Rivet CA, Lu H, McDevitt TC.

Biomed Microdevices. 2014 Feb;16(1):79-90. doi: 10.1007/s10544-013-9807-3.


Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.

Griffiths S, Baraniak PR, Copland IB, Nerem RM, McDevitt TC.

Cytotherapy. 2013 Dec;15(12):1469-83. doi: 10.1016/j.jcyt.2013.05.020. Epub 2013 Aug 24.


A microparticle approach to morphogen delivery within pluripotent stem cell aggregates.

Bratt-Leal AM, Nguyen AH, Hammersmith KA, Singh A, McDevitt TC.

Biomaterials. 2013 Oct;34(30):7227-35. doi: 10.1016/j.biomaterials.2013.05.079. Epub 2013 Jul 1.


Temporal modulation of β-catenin signaling by multicellular aggregation kinetics impacts embryonic stem cell cardiomyogenesis.

Kinney MA, Sargent CY, McDevitt TC.

Stem Cells Dev. 2013 Oct 1;22(19):2665-77. doi: 10.1089/scd.2013.0007. Epub 2013 Jun 14.


Architectural protein subclasses shape 3D organization of genomes during lineage commitment.

Phillips-Cremins JE, Sauria ME, Sanyal A, Gerasimova TI, Lajoie BR, Bell JS, Ong CT, Hookway TA, Guo C, Sun Y, Bland MJ, Wagstaff W, Dalton S, McDevitt TC, Sen R, Dekker J, Taylor J, Corces VG.

Cell. 2013 Jun 6;153(6):1281-95. doi: 10.1016/j.cell.2013.04.053. Epub 2013 May 23.


Adhesion strength-based, label-free isolation of human pluripotent stem cells.

Singh A, Suri S, Lee T, Chilton JM, Cooke MT, Chen W, Fu J, Stice SL, Lu H, McDevitt TC, García AJ.

Nat Methods. 2013 May;10(5):438-44. doi: 10.1038/nmeth.2437. Epub 2013 Apr 7.

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