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Items: 30

1.

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis.

Humphreys LM, Fox JP, Higgins CA, Majkut J, Sessler T, McLaughlin K, McCann C, Roberts JZ, Crawford NT, McDade SS, Scott CJ, Harrison T, Longley DB.

EMBO Rep. 2020 Feb 3:e49254. doi: 10.15252/embr.201949254. [Epub ahead of print]

2.

Comparison of Molecular Assays for HPV Testing in Oropharyngeal Squamous Cell Carcinomas: A Population-Based Study in Northern Ireland.

Craig SG, Anderson LA, Moran M, Graham L, Currie K, Rooney K, Robinson M, Bingham V, Cuschieri KS, McQuaid S, Schache AG, Jones TM, McCance D, Salto-Tellez M, McDade SS, James JA.

Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):31-38. doi: 10.1158/1055-9965.EPI-19-0538. Epub 2019 Oct 30.

PMID:
31666283
3.

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach.

Craig SG, Anderson LA, Schache AG, Moran M, Graham L, Currie K, Rooney K, Robinson M, Upile NS, Brooker R, Mesri M, Bingham V, McQuaid S, Jones T, McCance DJ, Salto-Tellez M, McDade SS, James JA.

Br J Cancer. 2019 Apr;120(8):827-833. doi: 10.1038/s41416-019-0414-9. Epub 2019 Mar 20.

4.

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.

Gilmore AR, Alderdice M, Savage KI, O'Reilly PG, Roddy AC, Dunne PD, Lawler M, McDade SS, Waugh DJ, McArt DG.

Cancer Res. 2019 Apr 15;79(8):2072-2075. doi: 10.1158/0008-5472.CAN-18-1976. Epub 2019 Feb 13.

PMID:
30760519
5.

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists.

McCann C, Crawford N, Majkut J, Holohan C, Armstrong CWD, Maxwell PJ, Ong CW, LaBonte MJ, McDade SS, Waugh DJ, Longley DB.

Cell Death Dis. 2018 Oct 22;9(11):1081. doi: 10.1038/s41419-018-1125-5.

6.

ΔNp63γ/SRC/Slug Signaling Axis Promotes Epithelial-to-Mesenchymal Transition in Squamous Cancers.

Srivastava K, Pickard A, Craig SG, Quinn GP, Lambe SM, James JA, McDade SS, McCance DJ.

Clin Cancer Res. 2018 Aug 15;24(16):3917-3927. doi: 10.1158/1078-0432.CCR-17-3775. Epub 2018 May 8.

7.

Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.

Garcia-Alonso L, Iorio F, Matchan A, Fonseca N, Jaaks P, Peat G, Pignatelli M, Falcone F, Benes CH, Dunham I, Bignell G, McDade SS, Garnett MJ, Saez-Rodriguez J.

Cancer Res. 2018 Feb 1;78(3):769-780. doi: 10.1158/0008-5472.CAN-17-1679. Epub 2017 Dec 11.

8.

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Jain S, Lyons CA, Walker SM, McQuaid S, Hynes SO, Mitchell DM, Pang B, Logan GE, McCavigan AM, O'Rourke D, McArt DG, McDade SS, Mills IG, Prise KM, Knight LA, Steele CJ, Medlow PW, Berge V, Katz B, Loblaw DA, Harkin DP, James JA, O'Sullivan JM, Kennedy RD, Waugh DJ.

Ann Oncol. 2018 Jan 1;29(1):215-222. doi: 10.1093/annonc/mdx637.

9.

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification.

Dunne PD, Alderdice M, O'Reilly PG, Roddy AC, McCorry AMB, Richman S, Maughan T, McDade SS, Johnston PG, Longley DB, Kay E, McArt DG, Lawler M.

Nat Commun. 2017 May 31;8:15657. doi: 10.1038/ncomms15657.

10.

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.

Walker SM, Knight LA, McCavigan AM, Logan GE, Berge V, Sherif A, Pandha H, Warren AY, Davidson C, Uprichard A, Blayney JK, Price B, Jellema GL, Steele CJ, Svindland A, McDade SS, Eden CG, Foster C, Mills IG, Neal DE, Mason MD, Kay EW, Waugh DJ, Harkin DP, Watson RW, Clarke NW, Kennedy RD.

Eur Urol. 2017 Oct;72(4):509-518. doi: 10.1016/j.eururo.2017.03.027. Epub 2017 Apr 10.

11.

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Dunne PD, McArt DG, Bradley CA, O'Reilly PG, Barrett HL, Cummins R, O'Grady T, Arthur K, Loughrey MB, Allen WL, McDade SS, Waugh DJ, Hamilton PW, Longley DB, Kay EW, Johnston PG, Lawler M, Salto-Tellez M, Van Schaeybroeck S.

Clin Cancer Res. 2016 Aug 15;22(16):4095-104. doi: 10.1158/1078-0432.CCR-16-0032. Epub 2016 May 5.

12.

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP.

Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115. Epub 2015 Oct 22.

13.

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures.

Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ.

PLoS Pathog. 2015 Jun 24;11(6):e1004988. doi: 10.1371/journal.ppat.1004988. eCollection 2015 Jun.

14.

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.

McDade SS, Patel D, Moran M, Campbell J, Fenwick K, Kozarewa I, Orr NJ, Lord CJ, Ashworth AA, McCance DJ.

Nucleic Acids Res. 2014 Jun;42(10):6270-85. doi: 10.1093/nar/gku299. Epub 2014 May 13.

15.

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP.

Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021. Epub 2014 Apr 17.

16.

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.

Savage KI, Matchett KB, Barros EM, Cooper KM, Irwin GW, Gorski JJ, Orr KS, Vohhodina J, Kavanagh JN, Madden AF, Powell A, Manti L, McDade SS, Park BH, Prise KM, McIntosh SA, Salto-Tellez M, Richard DJ, Elliott CT, Harkin DP.

Cancer Res. 2014 May 15;74(10):2773-2784. doi: 10.1158/0008-5472.CAN-13-2611. Epub 2014 Mar 17.

17.

AKT in stromal fibroblasts controls invasion of epithelial cells.

Cichon AC, Pickard A, McDade SS, Sharpe DJ, Moran M, James JA, McCance DJ.

Oncotarget. 2013 Jul;4(7):1103-16.

18.

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner.

Ray S, Johnston R, Campbell DC, Nugent S, McDade SS, Waugh D, Panov KI.

Gene. 2013 Aug 15;526(1):46-53. doi: 10.1016/j.gene.2013.04.018. Epub 2013 Apr 19.

PMID:
23608168
19.

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.

Orr N, Lemnrau A, Cooke R, Fletcher O, Tomczyk K, Jones M, Johnson N, Lord CJ, Mitsopoulos C, Zvelebil M, McDade SS, Buck G, Blancher C; KConFab Consortium, Trainer AH, James PA, Bojesen SE, Bokmand S, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Giannini G, Hollestelle A, Ouweland AM, Novaković S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Easton DF, Pharoah PD, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Houlston RS, Garcia-Closas M, Ashworth A, Swerdlow AJ.

Nat Genet. 2012 Nov;44(11):1182-4. doi: 10.1038/ng.2417. Epub 2012 Sep 23.

20.

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

McDade SS, Henry AE, Pivato GP, Kozarewa I, Mitsopoulos C, Fenwick K, Assiotis I, Hakas J, Zvelebil M, Orr N, Lord CJ, Patel D, Ashworth A, McCance DJ.

Nucleic Acids Res. 2012 Aug;40(15):7190-206. doi: 10.1093/nar/gks389. Epub 2012 May 9.

21.

Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs.

Chacko AD, McDade SS, Chanduloy S, Church SW, Kennedy R, Price J, Hall PA, Russell SE.

Cell Oncol (Dordr). 2012 Apr;35(2):85-93. doi: 10.1007/s13402-011-0066-0. Epub 2012 Jan 26.

PMID:
22278362
22.

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

Gorski JJ, Savage KI, Mulligan JM, McDade SS, Blayney JK, Ge Z, Harkin DP.

Nucleic Acids Res. 2011 Dec;39(22):9536-48. doi: 10.1093/nar/gkr679. Epub 2011 Aug 31.

23.

Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.

Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D.

J Virol. 2011 Nov;85(21):10999-1006. doi: 10.1128/JVI.00160-11. Epub 2011 Aug 24.

24.

p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels.

McDade SS, Patel D, McCance DJ.

J Cell Sci. 2011 May 15;124(Pt 10):1635-43. doi: 10.1242/jcs.084723. Epub 2011 Apr 21.

25.

Role of DeltaNp63gamma in epithelial to mesenchymal transition.

Lindsay J, McDade SS, Pickard A, McCloskey KD, McCance DJ.

J Biol Chem. 2011 Feb 4;286(5):3915-24. doi: 10.1074/jbc.M110.162511. Epub 2010 Dec 2.

26.

MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.

McKenna DJ, McDade SS, Patel D, McCance DJ.

J Virol. 2010 Oct;84(20):10644-52. doi: 10.1128/JVI.00703-10. Epub 2010 Aug 11.

27.

The role of p63 in epidermal morphogenesis and neoplasia.

McDade SS, McCance DJ.

Biochem Soc Trans. 2010 Feb;38(Pt 1):223-8. doi: 10.1042/BST0380223.

PMID:
20074064
28.

Translational control of SEPT9 isoforms is perturbed in disease.

McDade SS, Hall PA, Russell SE.

Hum Mol Genet. 2007 Apr 1;16(7):742-52.

PMID:
17468182
29.

The septin-binding protein anillin is overexpressed in diverse human tumors.

Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, Hillan KJ, Russell SE.

Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6780-6.

30.

SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.

Chacko AD, Hyland PL, McDade SS, Hamilton PW, Russell SH, Hall PA.

J Pathol. 2005 Aug;206(4):458-65.

PMID:
15902694

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