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Items: 45


Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland.

Craig SG, Anderson LA, Moran M, Graham L, Currie K, Rooney K, Robinson M, Bingham V, Cuschieri KS, McQuaid S, Schache AG, Jones TM, McCance D, Salto-Tellez M, McDade SS, James JA.

Cancer Epidemiol Biomarkers Prev. 2019 Oct 30. pii: cebp.0538.2019. doi: 10.1158/1055-9965.EPI-19-0538. [Epub ahead of print]


Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach.

Craig SG, Anderson LA, Schache AG, Moran M, Graham L, Currie K, Rooney K, Robinson M, Upile NS, Brooker R, Mesri M, Bingham V, McQuaid S, Jones T, McCance DJ, Salto-Tellez M, McDade SS, James JA.

Br J Cancer. 2019 Apr;120(8):827-833. doi: 10.1038/s41416-019-0414-9. Epub 2019 Mar 20.


ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.

Gilmore AR, Alderdice M, Savage KI, O'Reilly PG, Roddy AC, Dunne PD, Lawler M, McDade SS, Waugh DJ, McArt DG.

Cancer Res. 2019 Apr 15;79(8):2072-2075. doi: 10.1158/0008-5472.CAN-18-1976. Epub 2019 Feb 13.


Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists.

McCann C, Crawford N, Majkut J, Holohan C, Armstrong CWD, Maxwell PJ, Ong CW, LaBonte MJ, McDade SS, Waugh DJ, Longley DB.

Cell Death Dis. 2018 Oct 22;9(11):1081. doi: 10.1038/s41419-018-1125-5.


Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.

Allen WL, Dunne PD, McDade S, Scanlon E, Loughrey M, Coleman H, McCann C, McLaughlin K, Nemeth Z, Syed N, Jithesh P, Arthur K, Wilson R, Coyle V, McArt D, Murray GI, Samuel L, Nuciforo P, Jimenez J, Argiles G, Dienstmann R, Tabernero J, Messerini L, Nobili S, Mini E, Sheahan K, Ryan E, Johnston PG, Van Schaeybroeck S, Lawler M, Longley DB.

JCO Precis Oncol. 2018 Jun 13;2018. doi: 10.1200/PO.17.00241.


ΔNp63γ/SRC/Slug Signaling Axis Promotes Epithelial-to-Mesenchymal Transition in Squamous Cancers.

Srivastava K, Pickard A, Craig SG, Quinn GP, Lambe SM, James JA, McDade SS, McCance DJ.

Clin Cancer Res. 2018 Aug 15;24(16):3917-3927. doi: 10.1158/1078-0432.CCR-17-3775. Epub 2018 May 8.


Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.

Garcia-Alonso L, Iorio F, Matchan A, Fonseca N, Jaaks P, Peat G, Pignatelli M, Falcone F, Benes CH, Dunham I, Bignell G, McDade SS, Garnett MJ, Saez-Rodriguez J.

Cancer Res. 2018 Feb 1;78(3):769-780. doi: 10.1158/0008-5472.CAN-17-1679. Epub 2017 Dec 11.


Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Jain S, Lyons CA, Walker SM, McQuaid S, Hynes SO, Mitchell DM, Pang B, Logan GE, McCavigan AM, O'Rourke D, McArt DG, McDade SS, Mills IG, Prise KM, Knight LA, Steele CJ, Medlow PW, Berge V, Katz B, Loblaw DA, Harkin DP, James JA, O'Sullivan JM, Kennedy RD, Waugh DJ.

Ann Oncol. 2018 Jan 1;29(1):215-222. doi: 10.1093/annonc/mdx637.


Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification.

Dunne PD, Alderdice M, O'Reilly PG, Roddy AC, McCorry AMB, Richman S, Maughan T, McDade SS, Johnston PG, Longley DB, Kay E, McArt DG, Lawler M.

Nat Commun. 2017 May 31;8:15657. doi: 10.1038/ncomms15657.


Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.

Walker SM, Knight LA, McCavigan AM, Logan GE, Berge V, Sherif A, Pandha H, Warren AY, Davidson C, Uprichard A, Blayney JK, Price B, Jellema GL, Steele CJ, Svindland A, McDade SS, Eden CG, Foster C, Mills IG, Neal DE, Mason MD, Kay EW, Waugh DJ, Harkin DP, Watson RW, Clarke NW, Kennedy RD.

Eur Urol. 2017 Oct;72(4):509-518. doi: 10.1016/j.eururo.2017.03.027. Epub 2017 Apr 10.


Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.

Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, Shokat KM, Bandyopadhyay S, Lord CJ, Ashworth A.

Mol Cancer Ther. 2016 Jul;15(7):1472-84. doi: 10.1158/1535-7163.MCT-15-0554. Epub 2016 Jun 30.


Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

Dunne PD, McArt DG, O'Reilly PG, Coleman HG, Allen WL, Loughrey M, Van Schaeybroeck S, McDade S, Salto-Tellez M, Longley DB, Lawler M, Johnston PG.

Cancer Immunol Res. 2016 Jul;4(7):582-91. doi: 10.1158/2326-6066.CIR-15-0302. Epub 2016 May 13.


Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Dunne PD, McArt DG, Bradley CA, O'Reilly PG, Barrett HL, Cummins R, O'Grady T, Arthur K, Loughrey MB, Allen WL, McDade SS, Waugh DJ, Hamilton PW, Longley DB, Kay EW, Johnston PG, Lawler M, Salto-Tellez M, Van Schaeybroeck S.

Clin Cancer Res. 2016 Aug 15;22(16):4095-104. doi: 10.1158/1078-0432.CCR-16-0032. Epub 2016 May 5.


A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP.

Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115. Epub 2015 Oct 22.


HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures.

Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ.

PLoS Pathog. 2015 Jun 24;11(6):e1004988. doi: 10.1371/journal.ppat.1004988. eCollection 2015 Jun.


p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling.

Srivastava K, Pickard A, McDade S, McCance DJ.

Oncotarget. 2017 Mar 7;8(10):16202-16219. doi: 10.18632/oncotarget.3892.


Functional and genetic analysis of the colon cancer network.

Emmert-Streib F, de Matos Simoes R, Glazko G, McDade S, Haibe-Kains B, Holzinger A, Dehmer M, Campbell F.

BMC Bioinformatics. 2014;15 Suppl 6:S6. doi: 10.1186/1471-2105-15-S6-S6. Epub 2014 May 16.


Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.

McDade SS, Patel D, Moran M, Campbell J, Fenwick K, Kozarewa I, Orr NJ, Lord CJ, Ashworth AA, McCance DJ.

Nucleic Acids Res. 2014 Jun;42(10):6270-85. doi: 10.1093/nar/gku299. Epub 2014 May 13.


Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP.

Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021. Epub 2014 Apr 17.


BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.

Savage KI, Matchett KB, Barros EM, Cooper KM, Irwin GW, Gorski JJ, Orr KS, Vohhodina J, Kavanagh JN, Madden AF, Powell A, Manti L, McDade SS, Park BH, Prise KM, McIntosh SA, Salto-Tellez M, Richard DJ, Elliott CT, Harkin DP.

Cancer Res. 2014 May 15;74(10):2773-2784. doi: 10.1158/0008-5472.CAN-13-2611. Epub 2014 Mar 17.


Geographic mobility advances careers: study of the Executive Leadership in Academic Medicine (ELAM) program for women.

McLean MR, Morahan PS, Dannels SA, McDade SA.

Acad Med. 2013 Nov;88(11):1700-6. doi: 10.1097/ACM.0b013e3182a7f60e.


AKT in stromal fibroblasts controls invasion of epithelial cells.

Cichon AC, Pickard A, McDade SS, Sharpe DJ, Moran M, James JA, McCance DJ.

Oncotarget. 2013 Jul;4(7):1103-16.


Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner.

Ray S, Johnston R, Campbell DC, Nugent S, McDade SS, Waugh D, Panov KI.

Gene. 2013 Aug 15;526(1):46-53. doi: 10.1016/j.gene.2013.04.018. Epub 2013 Apr 19.


Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.

Orr N, Lemnrau A, Cooke R, Fletcher O, Tomczyk K, Jones M, Johnson N, Lord CJ, Mitsopoulos C, Zvelebil M, McDade SS, Buck G, Blancher C; KConFab Consortium, Trainer AH, James PA, Bojesen SE, Bokmand S, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Giannini G, Hollestelle A, Ouweland AM, Novaković S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Easton DF, Pharoah PD, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Houlston RS, Garcia-Closas M, Ashworth A, Swerdlow AJ.

Nat Genet. 2012 Nov;44(11):1182-4. doi: 10.1038/ng.2417. Epub 2012 Sep 23.


Gender-related differences in the pathway to and characteristics of U.S. medical school deanships.

White FS, McDade S, Yamagata H, Morahan PS.

Acad Med. 2012 Aug;87(8):1015-23. doi: 10.1097/ACM.0b013e31825d3495.


Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

McDade SS, Henry AE, Pivato GP, Kozarewa I, Mitsopoulos C, Fenwick K, Assiotis I, Hakas J, Zvelebil M, Orr N, Lord CJ, Patel D, Ashworth A, McCance DJ.

Nucleic Acids Res. 2012 Aug;40(15):7190-206. doi: 10.1093/nar/gks389. Epub 2012 May 9.


A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

Natrajan R, Mackay A, Lambros MB, Weigelt B, Wilkerson PM, Manie E, Grigoriadis A, A'Hern R, van der Groep P, Kozarewa I, Popova T, Mariani O, Turaljic S, Furney SJ, Marais R, Rodruigues DN, Flora AC, Wai P, Pawar V, McDade S, Carroll J, Stoppa-Lyonnet D, Green AR, Ellis IO, Swanton C, van Diest P, Delattre O, Lord CJ, Foulkes WD, Vincent-Salomon A, Ashworth A, Stern MH, Reis-Filho JS.

J Pathol. 2012 May;227(1):29-41. doi: 10.1002/path.4003. Epub 2012 Feb 23.


Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs.

Chacko AD, McDade SS, Chanduloy S, Church SW, Kennedy R, Price J, Hall PA, Russell SE.

Cell Oncol (Dordr). 2012 Apr;35(2):85-93. doi: 10.1007/s13402-011-0066-0. Epub 2012 Jan 26.


Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

Gorski JJ, Savage KI, Mulligan JM, McDade SS, Blayney JK, Ge Z, Harkin DP.

Nucleic Acids Res. 2011 Dec;39(22):9536-48. doi: 10.1093/nar/gkr679. Epub 2011 Aug 31.


Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.

Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D.

J Virol. 2011 Nov;85(21):10999-1006. doi: 10.1128/JVI.00160-11. Epub 2011 Aug 24.


p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels.

McDade SS, Patel D, McCance DJ.

J Cell Sci. 2011 May 15;124(Pt 10):1635-43. doi: 10.1242/jcs.084723. Epub 2011 Apr 21.


Role of DeltaNp63gamma in epithelial to mesenchymal transition.

Lindsay J, McDade SS, Pickard A, McCloskey KD, McCance DJ.

J Biol Chem. 2011 Feb 4;286(5):3915-24. doi: 10.1074/jbc.M110.162511. Epub 2010 Dec 2.


MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.

McKenna DJ, McDade SS, Patel D, McCance DJ.

J Virol. 2010 Oct;84(20):10644-52. doi: 10.1128/JVI.00703-10. Epub 2010 Aug 11.


The role of p63 in epidermal morphogenesis and neoplasia.

McDade SS, McCance DJ.

Biochem Soc Trans. 2010 Feb;38(Pt 1):223-8. doi: 10.1042/BST0380223.


Dental school deans' perceptions of the organizational culture and impact of the ELAM program on the culture and advancement of women faculty.

Dannels SA, McLaughlin JM, Gleason KA, Dolan TA, McDade SA, Richman RC, Morahan PS.

J Dent Educ. 2009 Jun;73(6):676-88.


Medical school deans' perceptions of organizational climate: useful indicators for advancement of women faculty and evaluation of a leadership program's impact.

Dannels S, McLaughlin J, Gleason KA, McDade SA, Richman R, Morahan PS.

Acad Med. 2009 Jan;84(1):67-79. doi: 10.1097/ACM.0b013e3181906d37.


A catastrophe model for the prospect-utility theory question.

Oliva TA, McDade SR.

Nonlinear Dynamics Psychol Life Sci. 2008 Jul;12(3):261-80.


Evaluating a leadership program: a comparative, longitudinal study to assess the impact of the Executive Leadership in Academic Medicine (ELAM) Program for Women.

Dannels SA, Yamagata H, McDade SA, Chuang YC, Gleason KA, McLaughlin JM, Richman RC, Morahan PS.

Acad Med. 2008 May;83(5):488-95. doi: 10.1097/ACM.0b013e31816be551.


Translational control of SEPT9 isoforms is perturbed in disease.

McDade SS, Hall PA, Russell SE.

Hum Mol Genet. 2007 Apr 1;16(7):742-52.


The septin-binding protein anillin is overexpressed in diverse human tumors.

Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, Hillan KJ, Russell SE.

Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6780-6.


SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.

Chacko AD, Hyland PL, McDade SS, Hamilton PW, Russell SH, Hall PA.

J Pathol. 2005 Aug;206(4):458-65.


Advancing women and closing the leadership gap: the Executive Leadership in Academic Medicine (ELAM) program experience.

Richman RC, Morahan PS, Cohen DW, McDade SA.

J Womens Health Gend Based Med. 2001 Apr;10(3):271-7.


Training future leaders of academic medicine: internal programs at three academic health centers.

Morahan PS, Kasperbauer D, McDade SA, Aschenbrener CA, Triolo PK, Monteleone PL, Counte M, Meyer MJ.

Acad Med. 1998 Nov;73(11):1159-68.


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