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Items: 1 to 50 of 95


Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation.

Intagliata S, Alsharif WF, Mesangeau C, Fazio N, Seminerio M, Xu YT, Matsumoto RR, McCurdy CR.

Eur J Med Chem. 2019 Mar 1;165:250-257. doi: 10.1016/j.ejmech.2019.01.019. Epub 2019 Jan 9.


Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia.

Singh D, Narayanan S, Müller CP, Swogger MT, Chear NJY, Dzulkapli EB, Yusoff NSM, Ramachandram DS, León F, McCurdy CR, Vicknasingam B.

J Ethnopharmacol. 2019 Apr 6;233:34-40. doi: 10.1016/j.jep.2018.12.038. Epub 2018 Dec 28.


Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom).

Kamble SH, Sharma A, King TI, León F, McCurdy CR, Avery BA.

Xenobiotica. 2018 Dec 14:1-31. doi: 10.1080/00498254.2018.1552819. [Epub ahead of print]


Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives.

Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2019 Feb;368(2):272-281. doi: 10.1124/jpet.118.253484. Epub 2018 Dec 7.


Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats.

Avery BA, Boddu SP, Sharma A, Furr EB, Leon F, Cutler SJ, McCurdy CR.

Planta Med. 2019 Mar;85(4):340-346. doi: 10.1055/a-0770-3683. Epub 2018 Nov 16.


The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

Polli JW, McCurdy CR, Wurster DE, DeSilva BS, Bak A, Bendayan R, Meibohm B, Templeton AC, Weiser W; AAPS Leadership.

AAPS J. 2018 Nov 3;21(1):2. doi: 10.1208/s12248-018-0273-y. No abstract available.


The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

Polli JW, McCurdy CR, Wurster DE, DeSilva BS, Bak A, Bendayan R, Meibohm B, Templeton AC, Weiser W; AAPS Leadership.

AAPS PharmSciTech. 2018 Nov;19(8):3325-3327. doi: 10.1208/s12249-018-1200-3. Epub 2018 Nov 3. No abstract available.


Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report.

Cipriano PW, Lee SW, Yoon D, Shen B, Tawfik VL, Curtin CM, Dragoo JL, James ML, McCurdy CR, Chin FT, Biswal S.

J Pain Res. 2018 Oct 12;11:2353-2357. doi: 10.2147/JPR.S167839. eCollection 2018.


Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists.

Pandey P, Roy KK, Liu H, Ma G, Pettaway S, Alsharif WF, Gadepalli RS, Rimoldi JM, McCurdy CR, Cutler SJ, Doerksen RJ.

Molecules. 2018 Oct 13;23(10). pii: E2630. doi: 10.3390/molecules23102630.


Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.

Hemby SE, McIntosh S, Leon F, Cutler SJ, McCurdy CR.

Addict Biol. 2018 Jun 27. doi: 10.1111/adb.12639. [Epub ahead of print]


Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel.

Liu X, Fu Y, Yang H, Mavlyutov T, Li J, McCurdy CR, Guo LW, Pattnaik BR.

Oncotarget. 2017 Jul 26;8(35):59345-59358. doi: 10.18632/oncotarget.19581. eCollection 2017 Aug 29.


Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI.

Shen B, Behera D, James ML, Reyes ST, Andrews L, Cipriano PW, Klukinov M, Lutz AB, Mavlyutov T, Rosenberg J, Ruoho AE, McCurdy CR, Gambhir SS, Yeomans DC, Biswal S, Chin FT.

Theranostics. 2017 Jul 8;7(11):2794-2805. doi: 10.7150/thno.19378. eCollection 2017.


Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans.

Hjørnevik T, Cipriano PW, Shen B, Park JH, Gulaka P, Holley D, Gandhi H, Yoon D, Mittra ES, Zaharchuk G, Gambhir SS, McCurdy CR, Chin FT, Biswal S.

J Nucl Med. 2017 Dec;58(12):2004-2009. doi: 10.2967/jnumed.117.192641. Epub 2017 Jun 1.


Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats.

Townsend EA, Naylor JE, Negus SS, Edwards SR, Qureshi HN, McLendon HW, McCurdy CR, Kapanda CN, do Carmo JM, da Silva FS, Hall JE, Sufka KJ, Freeman KB.

Psychopharmacology (Berl). 2017 Sep;234(17):2597-2605. doi: 10.1007/s00213-017-4652-3. Epub 2017 May 31.


The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL.

J Biol Chem. 2017 Jul 7;292(27):11250-11261. doi: 10.1074/jbc.M116.774075. Epub 2017 May 11.


Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146.

Shen B, Park JH, Hjørnevik T, Cipriano PW, Yoon D, Gulaka PK, Holly D, Behera D, Avery BA, Gambhir SS, McCurdy CR, Biswal S, Chin FT.

Mol Imaging Biol. 2017 Oct;19(5):779-786. doi: 10.1007/s11307-017-1064-z.


A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR.

Handb Exp Pharmacol. 2017;244:177-218. doi: 10.1007/164_2016_94. Review.


Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study.

Avery BA, Vuppala PK, Jamalapuram S, Sharma A, Mesangeau C, Chin FT, McCurdy CR.

Drug Test Anal. 2017 Aug;9(8):1236-1242. doi: 10.1002/dta.2156. Epub 2017 Apr 11.


Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine.

Lydecker AG, Sharma A, McCurdy CR, Avery BA, Babu KM, Boyer EW.

J Med Toxicol. 2016 Dec;12(4):341-349. Epub 2016 Oct 17.


Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.

Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR.

J Pharmacol Exp Ther. 2016 Jul;358(1):109-24. doi: 10.1124/jpet.116.232728. Epub 2016 Apr 21.


The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.

Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE.

EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov.


Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma.

Nicholson H, Mesangeau C, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. doi: 10.1124/jpet.115.228387. Epub 2015 Nov 16.


Further validation to support clinical translation of [(18)F]FTC-146 for imaging sigma-1 receptors.

Shen B, James ML, Andrews L, Lau C, Chen S, Palner M, Miao Z, Arksey NC, Shuhendler AJ, Scatliffe S, Kaneshige K, Parsons SM, McCurdy CR, Salehi A, Gambhir SS, Chin FT.

EJNMMI Res. 2015 Dec;5(1):49. doi: 10.1186/s13550-015-0122-2. Epub 2015 Sep 17.


In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower.

Kumarihamy M, León F, Pettaway S, Wilson L, Lambert JA, Wang M, Hill C, McCurdy CR, ElSohly MA, Cutler SJ, Muhammad I.

J Ethnopharmacol. 2015 Nov 4;174:57-65. doi: 10.1016/j.jep.2015.08.006. Epub 2015 Aug 7.


Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity.

Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. doi: 10.1124/jpet.115.224105. Epub 2015 Jun 1.


Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.

Abdelazeem AH, Khan SI, White SW, Sufka KJ, McCurdy CR.

Bioorg Med Chem. 2015 Jul 1;23(13):3248-59. doi: 10.1016/j.bmc.2015.04.057. Epub 2015 Apr 25.


Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.

Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR.

J Med Chem. 2014 Nov 13;57(21):8903-27. doi: 10.1021/jm500989n. Epub 2014 Oct 21.


Flavanones from Miconia prasina.

Tarawneh AH, León F, Ibrahim MA, Pettaway S, McCurdy CR, Cutler SJ.

Phytochem Lett. 2014 Feb;7:130-132.


Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents.

Abdelazeem AH, Abdelatef SA, El-Saadi MT, Omar HA, Khan SI, McCurdy CR, El-Moghazy SM.

Eur J Pharm Sci. 2014 Oct 1;62:197-211. doi: 10.1016/j.ejps.2014.05.025. Epub 2014 Jun 4.


SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.

Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR.

Exp Neurol. 2014 Apr;254:180-9. doi: 10.1016/j.expneurol.2014.01.020. Epub 2014 Feb 6.


Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.

Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR.

Eur J Pharmacol. 2014 Feb 5;724:193-203. doi: 10.1016/j.ejphar.2013.12.039. Epub 2013 Dec 28.


Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET.

James ML, Shen B, Nielsen CH, Behera D, Buckmaster CL, Mesangeau C, Zavaleta C, Vuppala PK, Jamalapuram S, Avery BA, Lyons DM, McCurdy CR, Biswal S, Gambhir SS, Chin FT.

J Nucl Med. 2014 Jan;55(1):147-53. doi: 10.2967/jnumed.113.120261. Epub 2013 Dec 12.


Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.

Vuppala PK, Jamalapuram S, Furr EB, McCurdy CR, Avery BA.

Biomed Chromatogr. 2013 Dec;27(12):1726-32. doi: 10.1002/bmc.2986. Epub 2013 Jul 25.


Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands.

Bhat R, Fishback JA, Matsumoto RR, Poupaert JH, McCurdy CR.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):5011-3. doi: 10.1016/j.bmcl.2013.06.032. Epub 2013 Jun 29.


σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.

Robson MJ, Seminerio MJ, McCurdy CR, Coop A, Matsumoto RR.

Pharmacol Rep. 2013;65(2):343-9.


SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.

Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR.

Exp Neurol. 2013 Sep;247:134-42. doi: 10.1016/j.expneurol.2013.04.009. Epub 2013 Apr 28.


Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics.

Jamalapuram S, Vuppala PK, Abdelazeem AH, McCurdy CR, Avery BA.

Biomed Chromatogr. 2013 Aug;27(8):1034-40. doi: 10.1002/bmc.2901. Epub 2013 Apr 5.


Heteroatom analogues of hydrocodone: synthesis and biological activity.

Giacometti RD, Duchek J, Werner L, Husni AS, McCurdy CR, Cutler SJ, Cox DP, Hudlicky T.

J Org Chem. 2013 Apr 5;78(7):2914-25. doi: 10.1021/jo3026753. Epub 2013 Mar 6.


The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.

Seminerio MJ, Hansen R, Kaushal N, Zhang HT, McCurdy CR, Matsumoto RR.

Int J Neuropsychopharmacol. 2013 Jun;16(5):1033-44. doi: 10.1017/S1461145712000831. Epub 2012 Aug 29.


Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia.

Harden MT, Smith SE, Niehoff JA, McCurdy CR, Taylor GT.

Behav Pharmacol. 2012 Oct;23(7):710-5. doi: 10.1097/FBP.0b013e3283586189.


Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.

Kaushal N, Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR.

Eur Neuropsychopharmacol. 2013 Aug;23(8):960-71. doi: 10.1016/j.euroneuro.2012.08.005. Epub 2012 Aug 24.


A 96-well filtration method for radioligand binding analysis of σ receptor ligands.

Fishback JA, Rosen A, Bhat R, McCurdy CR, Matsumoto RR.

J Pharm Biomed Anal. 2012 Dec;71:157-61. doi: 10.1016/j.jpba.2012.07.023. Epub 2012 Aug 9.


New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects.

James ML, Shen B, Zavaleta CL, Nielsen CH, Mesangeau C, Vuppala PK, Chan C, Avery BA, Fishback JA, Matsumoto RR, Gambhir SS, McCurdy CR, Chin FT.

J Med Chem. 2012 Oct 11;55(19):8272-8282. doi: 10.1021/jm300371c. Epub 2012 Sep 20.


Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus.

Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR.

Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9. doi: 10.1016/j.ejphar.2012.07.029. Epub 2012 Jul 20.


Nonpeptide ligands of neuropeptide FF: current status and structural insights.

Mankus JV, McCurdy CR.

Future Med Chem. 2012 Jun;4(9):1085-92. doi: 10.4155/fmc.12.67. Review.


SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group.

Nieto MJ, Pierini AB, Singh N, McCurdy CR, Manzo RH, Mazzieri MR.

Med Chem. 2012 May;8(3):349-60.


Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.

Jamalapuram S, Vuppala PK, Mesangeau C, McCurdy CR, Avery BA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:1-6. doi: 10.1016/j.jchromb.2011.12.013. Epub 2011 Dec 20.


CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.

Xu YT, Robson MJ, Szeszel-Fedorowicz W, Patel D, Rooney R, McCurdy CR, Matsumoto RR.

Pharmacol Biochem Behav. 2012 Mar;101(1):174-80. doi: 10.1016/j.pbb.2011.12.016. Epub 2011 Dec 30.


Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.

Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR.

AAPS J. 2012 Mar;14(1):43-51. doi: 10.1208/s12248-011-9311-8. Epub 2011 Dec 20.

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