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Items: 34


Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3.

Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S.

J Appl Physiol (1985). 2019 Oct 1;127(4):1117-1127. doi: 10.1152/japplphysiol.00003.2019. Epub 2019 Sep 12.


Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action.

Martins VF, Begur M, Lakkaraju S, Svensson K, Park J, Hetrick B, McCurdy CE, Schenk S.

Am J Physiol Cell Physiol. 2019 Aug 28. doi: 10.1152/ajpcell.00159.2019. [Epub ahead of print]


Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome.

Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Needham KW, Comrada LN, Minson CT.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E172-E182. doi: 10.1152/ajpendo.00549.2018. Epub 2019 May 28.


Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.

Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA, Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P, Gannon M.

Mol Metab. 2019 Jul;25:73-82. doi: 10.1016/j.molmet.2019.03.010. Epub 2019 Apr 12.


Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1024-E1035. doi: 10.1152/ajpendo.00497.2018. Epub 2019 Mar 19.


Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28.


Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase.

Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE.

Front Physiol. 2018 Jun 27;9:789. doi: 10.3389/fphys.2018.00789. eCollection 2018.


LpA-II:B:C:D:E: a new immunochemically-defined acute phase lipoprotein in humans.

Bagdade JD, Jilma B, Hudgins LC, Alaupovic P, McCurdy CE.

Lipids Health Dis. 2018 May 28;17(1):127. doi: 10.1186/s12944-018-0769-6.


Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice.

Clayton ZS, McCurdy CE.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R627-R637. doi: 10.1152/ajpregu.00364.2017. Epub 2018 May 23.


Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help?

Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Minson CT.

Temperature (Austin). 2017 Nov 10;5(1):9-21. doi: 10.1080/23328940.2017.1384089. eCollection 2018. Review.


Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity.

Stocks B, Dent JR, Joanisse S, McCurdy CE, Philp A.

Front Physiol. 2017 Dec 4;8:941. doi: 10.3389/fphys.2017.00941. eCollection 2017.


Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.

Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD.

J Endocrinol. 2017 Mar;232(3):475-491. doi: 10.1530/JOE-16-0123. Epub 2017 Jan 4.


Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model.

Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM.

Sci Rep. 2016 Nov 4;6:36123. doi: 10.1038/srep36123.


Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.

McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE.

JCI Insight. 2016 Oct 6;1(16):e86612. doi: 10.1172/jci.insight.86612.


p300 is not required for metabolic adaptation to endurance exercise training.

LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S.

FASEB J. 2016 Apr;30(4):1623-33. doi: 10.1096/fj.15-281741. Epub 2015 Dec 28.


Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance.

White AT, LaBarge SA, McCurdy CE, Schenk S.

Mol Metab. 2015 May 13;4(8):569-75. doi: 10.1016/j.molmet.2015.05.001. eCollection 2015 Aug.


High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.

White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E764-72. doi: 10.1152/ajpendo.00001.2014. Epub 2014 Aug 26.


Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?

McCurdy CE, Klemm DJ.

Adipocyte. 2013 Jul 1;2(3):135-42. doi: 10.4161/adip.24645. Epub 2013 Apr 16.


Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice.

White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S.

Diabetologia. 2013 Jul;56(7):1629-37. doi: 10.1007/s00125-013-2912-2. Epub 2013 Apr 19.


Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice.

McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE.

Diabetes. 2012 Oct;61(10):2495-505. Epub 2012 Jun 14.


Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.

Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM.

J Clin Invest. 2011 Nov;121(11):4281-8. doi: 10.1172/JCI58554. Epub 2011 Oct 10.


Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S.

J Biol Chem. 2011 Sep 2;286(35):30561-70. doi: 10.1074/jbc.M111.261685. Epub 2011 Jul 11.


Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.

Barbour LA, McCurdy CE, Hernandez TL, Friedman JE.

J Clin Endocrinol Metab. 2011 May;96(5):1431-41. doi: 10.1210/jc.2010-2116. Epub 2011 Feb 2.


Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR.

Biochem J. 2011 Feb 1;433(3):505-14. doi: 10.1042/BJ20100791.


In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice.

Moriarty MW, McCurdy CE, Janssen RC, Shaw T, Leitner JW, Friedman JE, Draznin B.

Horm Metab Res. 2009 Oct;41(10):757-61. doi: 10.1055/s-0029-1225363. Epub 2009 Jul 13.


Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.

McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL.

J Clin Invest. 2009 Feb;119(2):323-35. doi: 10.1172/JCI32661. Epub 2009 Jan 19.


Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. doi: 10.2337/db07-1839. Epub 2008 Oct 24. Erratum in: Diabetes. 2010 Mar;59(3):756.


Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes.

Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE.

Diabetes Care. 2007 Jul;30 Suppl 2:S112-9. No abstract available. Erratum in: Diabetes Care. 2007 Dec;30(12):3154.


Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.


Early foetal programming of hepatic gluconeogenesis: Glucocorticoids strike back.

McCurdy CE, Friedman JE.

Diabetologia. 2006 Jun;49(6):1138-41. No abstract available.


Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.


Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle.

McCurdy CE, Davidson RT, Cartee GD.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E996-E1001. Epub 2004 Dec 21.


Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle.

McCurdy CE, Davidson RT, Cartee GD.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E693-700. Epub 2003 Jun 10.

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