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Items: 1 to 50 of 74

1.

Neuronal impact of patient-specific aberrant NRXN1α splicing.

Flaherty E, Zhu S, Barretto N, Cheng E, Deans PJM, Fernando MB, Schrode N, Francoeur N, Antoine A, Alganem K, Halpern M, Deikus G, Shah H, Fitzgerald M, Ladran I, Gochman P, Rapoport J, Tsankova NM, McCullumsmith R, Hoffman GE, Sebra R, Fang G, Brennand KJ.

Nat Genet. 2019 Dec;51(12):1679-1690. doi: 10.1038/s41588-019-0539-z. Epub 2019 Nov 29.

PMID:
31784728
2.

Synergistic effects of common schizophrenia risk variants.

Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ.

Nat Genet. 2019 Oct;51(10):1475-1485. doi: 10.1038/s41588-019-0497-5. Epub 2019 Sep 23.

PMID:
31548722
3.

Pioglitazone improves working memory performance when administered in chronic TBI.

McGuire JL, Correll EA, Lowery AC, Rhame K, Anwar FN, McCullumsmith RE, Ngwenya LB.

Neurobiol Dis. 2019 Dec;132:104611. doi: 10.1016/j.nbd.2019.104611. Epub 2019 Sep 9. Review.

4.

Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia.

Bentea E, Depasquale EAK, O'Donovan SM, Sullivan CR, Simmons M, Meador-Woodruff JH, Zhou Y, Xu C, Bai B, Peng J, Song H, Ming GL, Meller J, Wen Z, McCullumsmith RE.

Mol Omics. 2019 Jun 10;15(3):173-188. doi: 10.1039/c8mo00173a.

5.

RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin.

Gordon DM, Blomquist TM, Miruzzi SA, McCullumsmith R, Stec DE, Hinds TD Jr.

Physiol Genomics. 2019 Jun 1;51(6):234-240. doi: 10.1152/physiolgenomics.00028.2019. Epub 2019 May 10.

PMID:
31074682
6.

Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia.

Sullivan CR, Mielnik CA, Funk A, O'Donovan SM, Bentea E, Pletnikov M, Ramsey AJ, Wen Z, Rowland LM, McCullumsmith RE.

Sci Rep. 2019 Mar 25;9(1):5087. doi: 10.1038/s41598-019-41572-9.

7.

Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments.

Sullivan CR, Mielnik CA, O'Donovan SM, Funk AJ, Bentea E, DePasquale EA, Alganem K, Wen Z, Haroutunian V, Katsel P, Ramsey AJ, Meller J, McCullumsmith RE.

Mol Neurobiol. 2019 Jun;56(6):4492-4517. doi: 10.1007/s12035-018-1390-4. Epub 2018 Oct 18.

PMID:
30338483
8.

Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence.

Alasmari F, Goodwani S, McCullumsmith RE, Sari Y.

Prog Neurobiol. 2018 Dec;171:32-49. doi: 10.1016/j.pneurobio.2018.10.001. Epub 2018 Oct 11. Review.

9.

Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies.

McGuire JL, Ngwenya LB, McCullumsmith RE.

Mol Psychiatry. 2019 Jul;24(7):995-1012. doi: 10.1038/s41380-018-0239-6. Epub 2018 Sep 13. Review.

PMID:
30214042
10.

Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury.

McGuire JL, DePasquale EAK, Watanabe M, Anwar F, Ngwenya LB, Atluri G, Romick-Rosendale LE, McCullumsmith RE, Evanson NK.

Mol Neurobiol. 2019 Apr;56(4):2908-2921. doi: 10.1007/s12035-018-1276-5. Epub 2018 Aug 1.

PMID:
30069831
11.

Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia.

O'Donovan SM, Franco-Villanueva A, Ghisays V, Caldwell JL, Haroutunian V, Privette Vinnedge LM, McCullumsmith RE, Solomon MB.

Schizophr Res. 2018 Dec;202:188-194. doi: 10.1016/j.schres.2018.07.010. Epub 2018 Jul 13.

12.

Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia.

Sullivan CR, Koene RH, Hasselfeld K, O'Donovan SM, Ramsey A, McCullumsmith RE.

Mol Psychiatry. 2019 Sep;24(9):1319-1328. doi: 10.1038/s41380-018-0035-3. Epub 2018 Mar 1.

13.

Cell-subtype-specific changes in adenosine pathways in schizophrenia.

O'Donovan SM, Sullivan C, Koene R, Devine E, Hasselfeld K, Moody CL, McCullumsmith RE.

Neuropsychopharmacology. 2018 Jul;43(8):1667-1674. doi: 10.1038/s41386-018-0028-6. Epub 2018 Feb 26.

14.

Defects in Bioenergetic Coupling in Schizophrenia.

Sullivan CR, O'Donovan SM, McCullumsmith RE, Ramsey A.

Biol Psychiatry. 2018 May 1;83(9):739-750. doi: 10.1016/j.biopsych.2017.10.014. Epub 2017 Oct 24. Review.

15.

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders.

O'Donovan SM, Sullivan CR, McCullumsmith RE.

NPJ Schizophr. 2017 Sep 21;3(1):32. doi: 10.1038/s41537-017-0037-1. Review.

16.

Abnormalities of signal transduction networks in chronic schizophrenia.

McGuire JL, Depasquale EA, Funk AJ, O'Donnovan SM, Hasselfeld K, Marwaha S, Hammond JH, Hartounian V, Meador-Woodruff JH, Meller J, McCullumsmith RE.

NPJ Schizophr. 2017 Sep 12;3(1):30. doi: 10.1038/s41537-017-0032-6.

17.

Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression.

LaCrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA.

J Neurosci. 2017 Jun 14;37(24):5809-5821. doi: 10.1523/JNEUROSCI.3717-16.2017. Epub 2017 May 11.

18.

Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia.

Funk AJ, Mielnik CA, Koene R, Newburn E, Ramsey AJ, Lipska BK, McCullumsmith RE.

Schizophr Bull. 2017 Jul 1;43(4):891-899. doi: 10.1093/schbul/sbw173.

19.

Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression.

Dorsett CR, McGuire JL, Niedzielko TL, DePasquale EA, Meller J, Floyd CL, McCullumsmith RE.

J Neurotrauma. 2017 Jan 1;34(1):220-234. doi: 10.1089/neu.2015.4372. Epub 2016 Jul 19.

20.

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury.

Dorsett CR, McGuire JL, DePasquale EA, Gardner AE, Floyd CL, McCullumsmith RE.

J Neurotrauma. 2017 Jan 15;34(2):263-272. doi: 10.1089/neu.2015.4373. Epub 2016 Jul 6. Review.

21.

Shaping plasticity: Alterations in glutamate transporter localization as a pathophysiological mechanism in severe mental illness.

McCullumsmith RE, O'Donovan SM, Drummond JB, Benesh FS, Simmons M, Roberts R, Lauriat T, Haroutunian V, Meador-Woodruff JH.

Mol Psychiatry. 2016 Jun;21(6):723. doi: 10.1038/mp.2016.79. No abstract available.

PMID:
27198660
22.

Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.

Pinner AL, Tucholski J, Haroutunian V, McCullumsmith RE, Meador-Woodruff JH.

Schizophr Res. 2016 Nov;177(1-3):78-87. doi: 10.1016/j.schres.2016.01.054. Epub 2016 Feb 11.

23.

Systematic evaluation of data-independent acquisition for sensitive and reproducible proteomics-a prototype design for a single injection assay.

Heaven MR, Funk AJ, Cobbs AL, Haffey WD, Norris JL, McCullumsmith RE, Greis KD.

J Mass Spectrom. 2016 Jan;51(1):1-11. doi: 10.1002/jms.3716.

24.

Tyrosine hydroxylase localization in the nucleus accumbens in schizophrenia.

McCollum LA, McCullumsmith RE, Roberts RC.

Brain Struct Funct. 2016 Dec;221(9):4451-4458. Epub 2016 Jan 6.

PMID:
26740229
25.

Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia.

McMeekin LJ, Lucas EK, Meador-Woodruff JH, McCullumsmith RE, Hendrickson RC, Gamble KL, Cowell RM.

Schizophr Bull. 2016 Jul;42(4):1009-17. doi: 10.1093/schbul/sbv184. Epub 2015 Dec 17.

26.

Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?

McCullumsmith RE, O'Donovan SM, Drummond JB, Benesh FS, Simmons M, Roberts R, Lauriat T, Haroutunian V, Meador-Woodruff JH.

Mol Psychiatry. 2016 Jun;21(6):823-30. doi: 10.1038/mp.2015.148. Epub 2015 Sep 29.

PMID:
26416546
27.

Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia.

O'Donovan SM, Hasselfeld K, Bauer D, Simmons M, Roussos P, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Transl Psychiatry. 2015 Jun 9;5:e579. doi: 10.1038/tp.2015.74.

28.

Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide.

Dean B, Gibbons AS, Boer S, Uezato A, Meador-Woodruff J, Scarr E, McCullumsmith RE.

Aust N Z J Psychiatry. 2016 Mar;50(3):275-83. doi: 10.1177/0004867415586601. Epub 2015 May 26.

PMID:
26013316
29.

Purinergic signaling and energy homeostasis in psychiatric disorders.

Lindberg D, Shan D, Ayers-Ringler J, Oliveros A, Benitez J, Prieto M, McCullumsmith R, Choi DS.

Curr Mol Med. 2015;15(3):275-95. Review.

30.

Evidence for schizophrenia as a disorder of neuroplasticity.

McCullumsmith RE.

Am J Psychiatry. 2015 Apr;172(4):312-3. doi: 10.1176/appi.ajp.2015.15010069. No abstract available.

PMID:
25827028
31.

Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia.

Sullivan CR, Funk AJ, Shan D, Haroutunian V, McCullumsmith RE.

PLoS One. 2015 Mar 31;10(3):e0123158. doi: 10.1371/journal.pone.0123158. eCollection 2015.

32.

Postmortem brain: an underutilized substrate for studying severe mental illness.

McCullumsmith RE, Hammond JH, Shan D, Meador-Woodruff JH.

Neuropsychopharmacology. 2015 Mar 13;40(5):1307. doi: 10.1038/npp.2014.337. No abstract available.

33.

Regulation of extrasynaptic glutamate levels as a pathophysiological mechanism in disorders of motivation and addiction.

McCullumsmith RE, Sanacora G.

Neuropsychopharmacology. 2015 Jan;40(1):254-5. doi: 10.1038/npp.2014.218. Review. No abstract available.

34.

Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia.

Funk AJ, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Schizophr Res. 2014 Oct;159(1):130-5. doi: 10.1016/j.schres.2014.07.040. Epub 2014 Aug 19.

35.

Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study.

Roberts RC, Roche JK, McCullumsmith RE.

Neuroscience. 2014 Sep 26;277:522-40. doi: 10.1016/j.neuroscience.2014.07.019. Epub 2014 Jul 24.

36.

Altered serine/threonine kinase activity in schizophrenia.

McGuire JL, Hammond JH, Yates SD, Chen D, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Brain Res. 2014 Jun 3;1568:42-54. doi: 10.1016/j.brainres.2014.04.029. Epub 2014 Apr 26.

37.

Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia.

Shan D, Mount D, Moore S, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Schizophr Res. 2014 Apr;154(1-3):1-13. doi: 10.1016/j.schres.2014.01.028. Epub 2014 Feb 21.

38.

Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches.

Marballi KK, McCullumsmith RE, Yates S, Escamilla MA, Leach RJ, Raventos H, Walss-Bass C.

J Neural Transm (Vienna). 2014 May;121(5):479-90. doi: 10.1007/s00702-013-1142-6. Epub 2014 Jan 1.

39.

Postmortem brain: an underutilized substrate for studying severe mental illness.

McCullumsmith RE, Hammond JH, Shan D, Meador-Woodruff JH.

Neuropsychopharmacology. 2014 Jan;39(1):65-87. doi: 10.1038/npp.2013.239. Epub 2013 Oct 4. Review. Erratum in: Neuropsychopharmacology. 2015 Apr;40(5):1307.

40.

Update on the neurobiology of schizophrenia: a role for extracellular microdomains.

Shan D, Yates S, Roberts RC, McCullumsmith RE.

Minerva Psichiatr. 2012 Sep 1;53(3):233-249.

41.

Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia.

Tucholski J, Simmons MS, Pinner AL, Haroutunian V, McCullumsmith RE, Meador-Woodruff JH.

Schizophr Res. 2013 May;146(1-3):177-83. doi: 10.1016/j.schres.2013.01.031. Epub 2013 Feb 23.

42.

Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy.

Eid T, Lee TS, Wang Y, Perez E, Drummond J, Lauritzen F, Bergersen LH, Meador-Woodruff JH, Spencer DD, de Lanerolle NC, McCullumsmith RE.

Epilepsia. 2013 Feb;54(2):228-38. doi: 10.1111/epi.12008. Epub 2012 Nov 13. Erratum in: Epilepsia. 2013 Jun;54(6):1140. Peréz, Edgar [corrected to Perez, Edgar].

43.

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia.

Shan D, Lucas EK, Drummond JB, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Schizophr Res. 2013 Mar;144(1-3):1-8. doi: 10.1016/j.schres.2012.12.019. Epub 2013 Jan 26.

44.

AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia.

Hammond JC, Meador-Woodruff JH, Haroutunian V, McCullumsmith RE.

PLoS One. 2012;7(6):e39190. doi: 10.1371/journal.pone.0039190. Epub 2012 Jun 14.

45.

Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia.

Shan D, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Neuroreport. 2012 Mar 7;23(4):224-7. doi: 10.1097/WNR.0b013e3283500987.

46.

Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia.

McCullumsmith RE, Hammond J, Funk A, Meador-Woodruff JH.

Curr Pharm Biotechnol. 2012 Jun;13(8):1535-42. Review.

47.

Regional differences in expression of β-tubulin isoforms in schizophrenia.

Moehle MS, Luduena RF, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.

Schizophr Res. 2012 Mar;135(1-3):181-6. doi: 10.1016/j.schres.2011.12.010. Epub 2012 Jan 20.

48.

Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia.

Funk AJ, McCullumsmith RE, Haroutunian V, Meador-Woodruff JH.

Neuropsychopharmacology. 2012 Mar;37(4):896-905. doi: 10.1038/npp.2011.267. Epub 2011 Nov 2.

49.

Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia.

Hammond JC, McCullumsmith RE, Haroutunian V, Meador-Woodruff JH.

Schizophr Res. 2011 Aug;130(1-3):260-5. doi: 10.1016/j.schres.2011.04.029. Epub 2011 May 14.

50.

Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia.

Sodhi MS, Simmons M, McCullumsmith R, Haroutunian V, Meador-Woodruff JH.

Biol Psychiatry. 2011 Oct 1;70(7):646-54. doi: 10.1016/j.biopsych.2011.02.022. Epub 2011 May 6.

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