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Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation.

Briggs E, Crouch K, Lemgruber L, Hamilton G, Lapsley C, McCulloch R.

Nucleic Acids Res. 2019 Jul 27. pii: gkz644. doi: 10.1093/nar/gkz644. [Epub ahead of print]


A HaemSTAR-led, UK-wide 'flash-mob' audit of -intravenous immunoglobulin use in immune -thrombocytopenia.

Nicolson P, Perry R, Fisher A, Scott G, Magill L, Chan-Lam D, Thorpe A, Macheta M, Carter-Brzezinski L, Ackroyd S, Katumba A, Bradbury C, Jen S, Camillieri M, Besser M, Bull T, Leighton K, Ayalew Y, Willan J, Watson E, Oshinyemi P, Upadhye Y, Pickard K, Swart-Rimmer I, Knott C, Chown S, Crolla F, Quinn D, McLeod-Kennedy L, Oun H, McDermott C, Walker M, Mullally R, Herlihy N, Shah G, Doyle A, Robinson S, Sayar Z, Pryor R, Peet C, Shenouda A, Venkatadasari I, Cartier J, Akay M, Tsitsikas D, Sivapalaratnam S, Cooper N, Lentaigne C, Bailey C, Xu DM, Janum S, Mohan A, Kimberger K, Kgologolo M, Sevillano B, Hanina S, Danga A, Mustafa C, Wilding C, Trikha R, Wang H, Crossette-Thambiah C, Hastings A, Sreedhara S, Wright D, Batey L, Atkin A, Davis S, Jaafar S, Ejaz A, Biss T, Swieton J, Noh MSM, Gibson H, Freeman T, Badaguma U, Kreze O, Kirkpatrick S, Suntharalingam S, Kmonicek M, Joffe M, Halperin D, Desborough M, Rampotas A, Dhillon E, Greaves P, Blacker E, Aiken L, Boot J, Prasannan N, Kerr J, Martin A, Wexler S, Burney C, Melly M, Nolan R, Hipkins R, Kaddam I, Elmoamly S, Darlow J, Plews D, Shrubsole C, Loizou E, Garth L, Peter H, Wolf J, Walia S, MacDonald V, Zaidi A, Dunk R, Miah H, Miah A, Tucker D, Skinner T, Cakmak S, Cakmak I, Hussein H, Buka R, Wilson L, Talbot G, Qureshi H, Wharin S, Dillon A, Bailiff B, McIlroy G, Murray D, Seymour F, Graham J, Harrison S, Salhan B, Sharpe D, Thomas W, McCulloch R, Crosbie N, Lowe G, Hill Q.

Clin Med (Lond). 2019 Jun;19(Suppl 3):82-83. doi: 10.7861/clinmedicine.19-3-s82. No abstract available.


Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes.

Nenarokova A, Záhonová K, Krasilnikova M, Gahura O, McCulloch R, Zíková A, Yurchenko V, Lukeš J.

MBio. 2019 Jul 16;10(4). pii: e01541-19. doi: 10.1128/mBio.01541-19.


Rapid detection of explosive vapors by thermal desorption atmospheric pressure photoionization differential mobility analysis tandem mass spectrometry.

McCulloch RD, Amo-González M.

Rapid Commun Mass Spectrom. 2019 Sep 30;33(18):1455-1463. doi: 10.1002/rcm.8492.


Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.

Jayaraman S, Harris C, Paxton E, Donachie AM, Vaikkinen H, McCulloch R, Hall JPJ, Kenny J, Lenzi L, Hertz-Fowler C, Cobbold C, Reeve R, Michoel T, Morrison LJ.

PLoS Negl Trop Dis. 2019 Apr 3;13(4):e0007262. doi: 10.1371/journal.pntd.0007262. eCollection 2019 Apr.


Parallel planning and the paediatric critical care patient.

Sidgwick P, Fraser J, Fortune PM, McCulloch R.

Arch Dis Child. 2019 Jan 31. pii: archdischild-2018-315222. doi: 10.1136/archdischild-2018-315222. [Epub ahead of print] Review.


Influence of lateral pedal translation on muscle recruitment and kinematics in cyclists.

McCulloch RS.

J Exerc Sci Fit. 2018 Aug;16(2):62-67. doi: 10.1016/j.jesf.2018.06.002. Epub 2018 Jun 11.


Nonparametric competing risks analysis using Bayesian Additive Regression Trees.

Sparapani R, Logan BR, McCulloch RE, Laud PW.

Stat Methods Med Res. 2019 Jan 7:962280218822140. doi: 10.1177/0962280218822140. [Epub ahead of print]


Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain.

Ashwell M, Freire M, O'Nan AT, Benito J, Hash J, McCulloch RS, Lascelles BDX.

Vet J. 2019 Jan;243:42-47. doi: 10.1016/j.tvjl.2018.11.008. Epub 2018 Nov 19.


Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads.

McCulloch RS, Mente PL, O'Nan AT, Ashwell MS.

BMC Musculoskelet Disord. 2018 Dec 22;19(1):449. doi: 10.1186/s12891-018-2374-2.


Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.

Briggs E, Crouch K, Lemgruber L, Lapsley C, McCulloch R.

PLoS Genet. 2018 Dec 13;14(12):e1007729. doi: 10.1371/journal.pgen.1007729. eCollection 2018 Dec.


Receiving treatment at a specialist centre confers an overall survival benefit for patients with mantle cell lymphoma.

McCulloch R, Smith A, Crosbie N, Patmore R, Rule S.

Br J Haematol. 2019 Jun;185(5):1002-1004. doi: 10.1111/bjh.15696. Epub 2018 Nov 26. No abstract available.


The DNA damage response is developmentally regulated in the African trypanosome.

Vieira-da-Rocha JP, Passos-Silva DG, Mendes IC, Rocha EA, Gomes DA, Machado CR, McCulloch R.

DNA Repair (Amst). 2019 Jan;73:78-90. doi: 10.1016/j.dnarep.2018.11.005. Epub 2018 Nov 14.


Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.

da Silva MS, Hovel-Miner GA, Briggs EM, Elias MC, McCulloch R.

PLoS Pathog. 2018 Nov 15;14(11):e1007321. doi: 10.1371/journal.ppat.1007321. eCollection 2018 Nov. Review.


The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.

Gomes Passos Silva D, da Silva Santos S, Nardelli SC, Mendes IC, Freire ACG, Repolês BM, Resende BC, Costa-Silva HM, da Silva VS, Oliveira KA, Oliveira CFB, Vilela LFF, Nagem RAP, Franco GR, Macedo AM, Pena SDJ, Tahara EB, Sales Junior PA, Moreira DS, Teixeira SMR, McCulloch R, Virgilio S, Tosi LRO, Schenkman S, Andrade LO, Murta SMF, Machado CR.

PLoS Negl Trop Dis. 2018 Nov 13;12(11):e0006875. doi: 10.1371/journal.pntd.0006875. eCollection 2018 Nov.


Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania.

Damasceno JD, Obonaga R, Silva GLA, Reis-Cunha JL, Duncan SM, Bartholomeu DC, Mottram JC, McCulloch R, Tosi LRO.

Nucleic Acids Res. 2018 Dec 14;46(22):11835-11846. doi: 10.1093/nar/gky1017.


Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome.

Briggs E, Hamilton G, Crouch K, Lapsley C, McCulloch R.

Nucleic Acids Res. 2018 Dec 14;46(22):11789-11805. doi: 10.1093/nar/gky928.


Emerging challenges in understanding trypanosome antigenic variation.

McCulloch R, Cobbold CA, Figueiredo L, Jackson A, Morrison LJ, Mugnier MR, Papavasiliou N, Schnaufer A, Matthews K.

Emerg Top Life Sci. 2017 Dec 22;1(6):585-592. doi: 10.1042/ETLS20170104.


Chromosomal copy number variation analysis by next generation sequencing confirms ploidy stability in Trypanosoma brucei subspecies.

Almeida LV, Coqueiro-Dos-Santos A, Rodriguez-Luiz GF, McCulloch R, Bartholomeu DC, Reis-Cunha JL.

Microb Genom. 2018 Oct;4(10). doi: 10.1099/mgen.0.000223. Epub 2018 Sep 27.


Is It Time We Changed How We Measure Length of Stay for Hip and Knee Arthroplasty?

McCulloch R, Cottingham P, Chrismas B, Pearce O.

J Am Acad Orthop Surg Glob Res Rev. 2017 Oct 9;1(6):e032. doi: 10.5435/JAAOSGlobal-D-17-00032. eCollection 2017 Sep.


Alterations in kinematics and muscle activation patterns with the addition of a kipping action during a pull-up activity.

Dinunzio C, Porter N, Van Scoy J, Cordice D, McCulloch RS.

Sports Biomech. 2018 May 16:1-14. doi: 10.1080/14763141.2018.1452971. [Epub ahead of print]


Conservation and Variation in Strategies for DNA Replication of Kinetoplastid Nuclear Genomes.

Marques CA, McCulloch R.

Curr Genomics. 2018 Feb;19(2):98-109. doi: 10.2174/1389202918666170815144627. Review.


What is the optimal initial management of the younger mantle cell lymphoma patient?

McCulloch R, Rule S.

Best Pract Res Clin Haematol. 2018 Mar;31(1):90-98. doi: 10.1016/j.beha.2017.10.008. Epub 2017 Nov 1. Review.


Decision making and uncertainty quantification for individualized treatments using Bayesian Additive Regression Trees.

Logan BR, Sparapani R, McCulloch RE, Laud PW.

Stat Methods Med Res. 2019 Apr;28(4):1079-1093. doi: 10.1177/0962280217746191. Epub 2017 Dec 18.


Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems.

da Silva MS, Pavani RS, Damasceno JD, Marques CA, McCulloch R, Tosi LRO, Elias MC.

Trends Parasitol. 2017 Nov;33(11):858-874. doi: 10.1016/ Epub 2017 Aug 24. Review.


Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.

Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC, McCulloch R.

PLoS Pathog. 2017 Jul 24;13(7):e1006477. doi: 10.1371/journal.ppat.1006477. eCollection 2017 Jul.


RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse.

Fernandez-Cortes F, Serafim TD, Wilkes JM, Jones NG, Ritchie R, McCulloch R, Mottram JC.

Sci Rep. 2017 Jul 21;7(1):6156. doi: 10.1038/s41598-017-06501-8.


Use of buccal morphine in the management of pain in children with life-limiting conditions: Results of a laboratory study.

McCulloch R, Sattar M, Henderson EM, Lane ME, Bluebond-Langner M.

Palliat Med. 2018 Feb;32(2):554-558. doi: 10.1177/0269216317717192. Epub 2017 Jun 20.


Field-Free Atmospheric Pressure Photoionization-Liquid Chromatography-Mass Spectrometry for the Analysis of Steroids within Complex Biological Matrices.

McCulloch RD, Robb DB.

Anal Chem. 2017 Apr 4;89(7):4169-4176. doi: 10.1021/acs.analchem.7b00157. Epub 2017 Mar 16.


Estimating the genetic merit of sires by using pooled DNA from progeny of undetermined pedigree.

Bell AM, Henshall JM, Porto-Neto LR, Dominik S, McCulloch R, Kijas J, Lehnert SA.

Genet Sel Evol. 2017 Feb 28;49(1):28. doi: 10.1186/s12711-017-0303-8.


Application of Hybrid Genetic Algorithm Routine in Optimizing Food and Bioengineering Processes.

Tumuluru JS, McCulloch R.

Foods. 2016 Nov 9;5(4). pii: E76. doi: 10.3390/foods5040076.


Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM.

PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016.


Genomic analyses of tropical beef cattle fertility based on genotyping pools of Brahman cows with unknown pedigree.

Reverter A, Porto-Neto LR, Fortes MR, McCulloch R, Lyons RE, Moore S, Nicol D, Henshall J, Lehnert SA.

J Anim Sci. 2016 Oct;94(10):4096-4108. doi: 10.2527/jas.2016-0675.


Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Devlin R, Marques CA, McCulloch R.

Curr Genet. 2017 Jun;63(3):441-449. doi: 10.1007/s00294-016-0662-7. Epub 2016 Nov 7. Review.


Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania.

Damasceno JD, Obonaga R, Santos EV, Scott A, McCulloch R, Tosi LR.

Mol Microbiol. 2016 Sep;101(6):1054-68. doi: 10.1111/mmi.13441. Epub 2016 Jul 19.


Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation.

Devlin R, Marques CA, Paape D, Prorocic M, Zurita-Leal AC, Campbell SJ, Lapsley C, Dickens N, McCulloch R.

Elife. 2016 May 26;5. pii: e12765. doi: 10.7554/eLife.12765.


The protozoan nucleus.

McCulloch R, Navarro M.

Mol Biochem Parasitol. 2016 Sep - Oct;209(1-2):76-87. doi: 10.1016/j.molbiopara.2016.05.002. Epub 2016 May 12. Review.


Development of a next-generation field-free atmospheric pressure photoionization source for liquid chromatography/mass spectrometry.

McCulloch RD, Robb D, Blades M.

Rapid Commun Mass Spectrom. 2016 Jan 30;30(2):333-9.


The scarcity heuristic impacts reward processing within the medial-frontal cortex.

Williams CC, Saffer BY, McCulloch RB, Krigolson OE.

Neuroreport. 2016 May 4;27(7):522-6. doi: 10.1097/WNR.0000000000000575.


Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.

Marques CA, Tiengwe C, Lemgruber L, Damasceno JD, Scott A, Paape D, Marcello L, McCulloch R.

Nucleic Acids Res. 2016 Jun 2;44(10):4763-84. doi: 10.1093/nar/gkw147. Epub 2016 Mar 6.


Nonparametric survival analysis using Bayesian Additive Regression Trees (BART).

Sparapani RA, Logan BR, McCulloch RE, Laud PW.

Stat Med. 2016 Jul 20;35(16):2741-53. doi: 10.1002/sim.6893. Epub 2016 Feb 7.


Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe.

Marques CA, Dickens NJ, Paape D, Campbell SJ, McCulloch R.

Genome Biol. 2015 Oct 19;16:230. doi: 10.1186/s13059-015-0788-9.


Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP.

Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17.


The within-host dynamics of African trypanosome infections.

Matthews KR, McCulloch R, Morrison LJ.

Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675). pii: 20140288. doi: 10.1098/rstb.2014.0288. Review.


DNA Recombination Strategies During Antigenic Variation in the African Trypanosome.

McCulloch R, Morrison LJ, Hall JPJ.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0016-2014. doi: 10.1128/microbiolspec.MDNA3-0016-2014. Review.


Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.

Grazielle-Silva V, Zeb TF, Bolderson J, Campos PC, Miranda JB, Alves CL, Machado CR, McCulloch R, Teixeira SM.

PLoS Negl Trop Dis. 2015 Jun 17;9(6):e0003870. doi: 10.1371/journal.pntd.0003870. eCollection 2015 Jun.


Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication.

Dong Y, Zhang X, Xie M, Arefnezhad B, Wang Z, Wang W, Feng S, Huang G, Guan R, Shen W, Bunch R, McCulloch R, Li Q, Li B, Zhang G, Xu X, Kijas JW, Salekdeh GH, Wang W, Jiang Y.

BMC Genomics. 2015 Jun 5;16:431. doi: 10.1186/s12864-015-1606-1.


Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei.

McCulloch R, Field MC.

Trends Parasitol. 2015 Aug;31(8):346-9. doi: 10.1016/ Epub 2015 May 18.


In vivo experimental drug resistance study in Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia.

Dagnachew S, Terefe G, Abebe G, Barry D, McCulloch R, Goddeeris B.

Acta Trop. 2015 Jun;146:95-100. doi: 10.1016/j.actatropica.2015.03.014. Epub 2015 Mar 16.


Pharmacological interventions for pain in children and adolescents with life-limiting conditions.

Beecham E, Candy B, Howard R, McCulloch R, Laddie J, Rees H, Vickerstaff V, Bluebond-Langner M, Jones L.

Cochrane Database Syst Rev. 2015 Mar 13;(3):CD010750. doi: 10.1002/14651858.CD010750.pub2. Review.

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