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Items: 1 to 50 of 53

1.

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes.

Strokappe NM, Hock M, Rutten L, Mccoy LE, Back JW, Caillat C, Haffke M, Weiss RA, Weissenhorn W, Verrips T.

Antibodies (Basel). 2019 Jun 18;8(2). pii: E38. doi: 10.3390/antib8020038.

2.

Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes.

Gach JS, Mara KJV, LaBranche CC, van Gils MJ, McCoy LE, Klasse PJ, Montefiori DC, Sanders RW, Moore JP, Forthal DN.

J Virol. 2019 Sep 30;93(20). pii: e01188-19. doi: 10.1128/JVI.01188-19. Print 2019 Oct 15.

PMID:
31375582
3.

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.

Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Picado J, Nijhuis M, Wensing AMJ, Lee H, Grant P, Nastouli E, Lambert J, Pace M, Salasc F, Monit C, Innes AJ, Muir L, Waters L, Frater J, Lever AML, Edwards SG, Gabriel IH, Olavarria E.

Nature. 2019 Apr;568(7751):244-248. doi: 10.1038/s41586-019-1027-4. Epub 2019 Mar 5.

4.

Reprogramming the antigen specificity of B cells using genome-editing technologies.

Voss JE, Gonzalez-Martin A, Andrabi R, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton DR.

Elife. 2019 Jan 17;8. pii: e42995. doi: 10.7554/eLife.42995.

5.

The expanding array of HIV broadly neutralizing antibodies.

McCoy LE.

Retrovirology. 2018 Oct 16;15(1):70. doi: 10.1186/s12977-018-0453-y. Review.

6.

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.

Bianchi M, Turner HL, Nogal B, Cottrell CA, Oyen D, Pauthner M, Bastidas R, Nedellec R, McCoy LE, Wilson IA, Burton DR, Ward AB, Hangartner L.

Immunity. 2018 Aug 21;49(2):288-300.e8. doi: 10.1016/j.immuni.2018.07.009. Epub 2018 Aug 7.

7.

Circulating and intrahepatic antiviral B cells are defective in hepatitis B.

Burton AR, Pallett LJ, McCoy LE, Suveizdyte K, Amin OE, Swadling L, Alberts E, Davidson BR, Kennedy PT, Gill US, Mauri C, Blair PA, Pelletier N, Maini MK.

J Clin Invest. 2018 Oct 1;128(10):4588-4603. doi: 10.1172/JCI121960. Epub 2018 Aug 9.

8.

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

Schiffner T, Pallesen J, Russell RA, Dodd J, de Val N, LaBranche CC, Montefiori D, Tomaras GD, Shen X, Harris SL, Moghaddam AE, Kalyuzhniy O, Sanders RW, McCoy LE, Moore JP, Ward AB, Sattentau QJ.

PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May.

9.

Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy.

Zangari P, Palma P, Cotugno N, Rojo P, Tagarro A, Pepponi I, De Rossi A, Kuhn L, Pahwa S, Cameron M, Nastouli E, Watters S, Marceline AG, McCoy LE, Persaud D, Violari A, Chan M, Babiker AG, Foster C, Ananworanich J, Giaquinto C, Rossi P.

J Virus Erad. 2018 Jan 1;4(1):51-54. No abstract available.

10.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, Burton DR.

Cell Rep. 2018 Jan 23;22(4):1103. doi: 10.1016/j.celrep.2017.10.089. Epub 2018 Jan 28. No abstract available.

11.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, Burton DR.

Cell Rep. 2017 Oct 3;21(1):222-235. doi: 10.1016/j.celrep.2017.09.024. Erratum in: Cell Rep. 2018 Jan 23;22(4):1103.

12.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.

13.

Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights.

Gray ER, Brookes JC, Caillat C, Turbé V, Webb BLJ, Granger LA, Miller BS, McCoy LE, El Khattabi M, Verrips CT, Weiss RA, Duffy DM, Weissenhorn W, McKendry RA.

ACS Infect Dis. 2017 Jul 14;3(7):479-491. doi: 10.1021/acsinfecdis.6b00189. Epub 2017 Jun 26.

PMID:
28591513
14.

Lessons learned from humoral responses of HIV patients.

McCoy LE, McKnight Á.

Curr Opin HIV AIDS. 2017 May;12(3):195-202. doi: 10.1097/COH.0000000000000361. Review.

PMID:
28422783
15.

Identification and specificity of broadly neutralizing antibodies against HIV.

McCoy LE, Burton DR.

Immunol Rev. 2017 Jan;275(1):11-20. doi: 10.1111/imr.12484. Review.

16.

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR.

Immunity. 2016 Sep 20;45(3):483-496. doi: 10.1016/j.immuni.2016.08.016. Epub 2016 Sep 8.

17.

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

McCoy LE, van Gils MJ, Ozorowski G, Messmer T, Briney B, Voss JE, Kulp DW, Macauley MS, Sok D, Pauthner M, Menis S, Cottrell CA, Torres JL, Hsueh J, Schief WR, Wilson IA, Ward AB, Sanders RW, Burton DR.

Cell Rep. 2016 Aug 30;16(9):2327-38. doi: 10.1016/j.celrep.2016.07.074. Epub 2016 Aug 18.

18.

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design.

Andrabi R, Voss JE, Liang CH, Briney B, McCoy LE, Wu CY, Wong CH, Poignard P, Burton DR.

Immunity. 2015 Nov 17;43(5):959-73. doi: 10.1016/j.immuni.2015.10.014.

19.

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.

McCoy LE, Falkowska E, Doores KJ, Le K, Sok D, van Gils MJ, Euler Z, Burger JA, Seaman MS, Sanders RW, Schuitemaker H, Poignard P, Wrin T, Burton DR.

PLoS Pathog. 2015 Aug 12;11(8):e1005110. doi: 10.1371/journal.ppat.1005110. eCollection 2015 Aug.

20.

Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.

Barbian HJ, Decker JM, Bibollet-Ruche F, Galimidi RP, West AP Jr, Learn GH, Parrish NF, Iyer SS, Li Y, Pace CS, Song R, Huang Y, Denny TN, Mouquet H, Martin L, Acharya P, Zhang B, Kwong PD, Mascola JR, Verrips CT, Strokappe NM, Rutten L, McCoy LE, Weiss RA, Brown CS, Jackson R, Silvestri G, Connors M, Burton DR, Shaw GM, Nussenzweig MC, Bjorkman PJ, Ho DD, Farzan M, Hahn BH.

MBio. 2015 Apr 21;6(2). pii: e00296-15. doi: 10.1128/mBio.00296-15.

21.

Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.

McCoy LE, Groppelli E, Blanchetot C, de Haard H, Verrips T, Rutten L, Weiss RA, Jolly C.

Retrovirology. 2014 Oct 2;11:83. doi: 10.1186/s12977-014-0083-y.

22.

Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

McCoy LE, Rutten L, Frampton D, Anderson I, Granger L, Bashford-Rogers R, Dekkers G, Strokappe NM, Seaman MS, Koh W, Grippo V, Kliche A, Verrips T, Kellam P, Fassati A, Weiss RA.

PLoS Pathog. 2014 Dec 18;10(12):e1004552. doi: 10.1371/journal.ppat.1004552. eCollection 2014 Dec.

23.

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

Lutje Hulsik D, Liu YY, Strokappe NM, Battella S, El Khattabi M, McCoy LE, Sabin C, Hinz A, Hock M, Macheboeuf P, Bonvin AM, Langedijk JP, Davis D, Forsman Quigley A, Aasa-Chapman MM, Seaman MS, Ramos A, Poignard P, Favier A, Simorre JP, Weiss RA, Verrips CT, Weissenhorn W, Rutten L.

PLoS Pathog. 2013 Mar;9(3):e1003202. doi: 10.1371/journal.ppat.1003202. Epub 2013 Mar 7.

24.

Neutralizing antibodies to HIV-1 induced by immunization.

McCoy LE, Weiss RA.

J Exp Med. 2013 Feb 11;210(2):209-23. doi: 10.1084/jem.20121827. Review.

25.

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization.

McCoy LE, Quigley AF, Strokappe NM, Bulmer-Thomas B, Seaman MS, Mortier D, Rutten L, Chander N, Edwards CJ, Ketteler R, Davis D, Verrips T, Weiss RA.

J Exp Med. 2012 Jun 4;209(6):1091-103. doi: 10.1084/jem.20112655. Epub 2012 May 28.

26.

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

Benfield CT, Mansur DS, McCoy LE, Ferguson BJ, Bahar MW, Oldring AP, Grimes JM, Stuart DI, Graham SC, Smith GL.

J Biol Chem. 2011 Jun 10;286(23):20727-35. doi: 10.1074/jbc.M111.231381. Epub 2011 Apr 7.

27.

Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor kappaB activation.

McCoy LE, Fahy AS, Chen RA, Smith GL.

J Gen Virol. 2010 Sep;91(Pt 9):2216-20. doi: 10.1099/vir.0.022343-0. Epub 2010 May 5.

28.

Differentiated nursing practice: assessing the state-of-the-science.

Baker CM, Lamm GM, Winter AR, Robbeloth VB, Ransom CA, Conly F, Carpenter KC, McCoy LE.

Nurs Econ. 1997 Sep-Oct;15(5):253-61, 264. Review.

PMID:
9362868
29.

Treatment of cerebral ischemia with Dextran-40 or Fluosol DA 20%.

Kline RA, Negendank W, McCoy LE.

Biomater Artif Cells Immobilization Biotechnol. 1992;20(2-4):979-83.

PMID:
1382645
30.

Acute severe carbon monoxide exposure in the rat: effects of hyperglycemia and hypoglycemia on mortality, recovery, and neurologic deficit.

Penney DG, Helfman CC, Dunbar JC Jr, McCoy LE.

Can J Physiol Pharmacol. 1991 Aug;69(8):1168-77.

PMID:
1782598
31.

MRI quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa3 oxidation state.

Kline RA, Negendank WG, McCoy LE, Lester M, Berguer R.

Magn Reson Med. 1990 Feb;13(2):319-23.

PMID:
2156126
32.

In vitro measurement of tissue vascular space by 19F NMR of a perfluorocarbon blood substitute.

Negendank WG, McCoy LE, Crowley MG, Corbett TH, Schmidt EL.

Biomater Artif Cells Artif Organs. 1990;18(1):119-23. No abstract available.

PMID:
2334811
33.

Role of Fluosol-DA 20% in prehospital resuscitation.

Elliott LA, Ledgerwood AM, Lucas CE, McCoy LE, McGonigal M, Sullivan MW.

Crit Care Med. 1989 Feb;17(2):166-72.

PMID:
2914450
34.

Regenerative responses to exchange perfusion.

McCoy LE, Elliott LA, Lucas CE, Ledgerwood AM.

Biomater Artif Cells Artif Organs. 1988;16(1-3):575-83.

PMID:
3179490
35.

Endothelial response to perfluorochemical perfusion.

McCoy LE, Becker CA, Goodin TH, Barnhart MI.

Scan Electron Microsc. 1984;(Pt 1):311-9.

PMID:
6740233
36.

A method for evaluation of blood substitutes in the conscious animal.

Goodin TH, Clarke WP, Taylor K, Eccles R, Geyer RP, McCoy LE.

Am J Physiol. 1983 Sep;245(3):H519-23.

PMID:
6412570
37.

Primary structure of human platelet factor 4.

Walz DA, Wu VY, de Lamo R, Dene H, McCoy LE.

Thromb Res. 1977 Dec;11(6):893-8. No abstract available.

PMID:
601757
38.

Platelet factor 3: quantitation and characterization.

Wu VY, McCoy LE.

Thromb Res. 1977 Nov;11(5):581-93. No abstract available.

PMID:
929508
39.

Purification and characterization of human and bovine platelet factor 4.

Wu VY, Walz DA, McCoy LE.

Prep Biochem. 1977;7(6):479-93.

PMID:
343096
40.

Proceedings: Human and bovine prothrombin: sequence homology.

Walz DA, Hewett-Emmett D, Reuterby J, McCoy LE, Seegers WH.

Thromb Diath Haemorrh. 1975 Nov 15;34(2):591. No abstract available.

PMID:
1239093
41.

The amino acid sequence of PR fragment (NH2-terminal fragment) of bovine prothrombin.

Hewett-Emmett DH, Walz DA, Reuterby J, McCoy LE, Seegers WH.

Thromb Res. 1975 Jul;7(1):227-34. No abstract available.

PMID:
1171533
42.

Phospholipid requirements of tissue thromboplastin in blood coagulation.

Liu DT, McCoy LE.

Thromb Res. 1975 Jul;7(1):213-221. No abstract available.

PMID:
1154339
43.

Tissue extract thromboplastin: quantitation, fractionation and characterization of protein components.

Liu DT, McCoy LE.

Thromb Res. 1975 Jul;7(1):199. No abstract available.

PMID:
1154338
44.

Isolation of thrombin-E and the evolution of enzyme activity from prothrombin.

Seegers WH, McCoy LE, Walz DA, Reuterby J, Andary TJ.

Experientia. 1974 Oct 15;30(10):1130-2. No abstract available.

PMID:
4435111
45.

A partial gene duplication in the evolution of prothrombin?

Hewett-Emmett D, McCoy LE, Hassouna HI, Teuterby J, Walz DA, Seegers WH.

Thromb Res. 1974 Sep;5(3):421-30. No abstract available.

PMID:
4439376
46.

Isolation and some properties of thrombin-E and other prothrombin derivatives.

Seegers WH, Walz DA, Reuterby J, McCoy LE.

Thromb Res. 1974 Jun;4(6):829-60. No abstract available.

PMID:
4858455
47.

Amino acid sequence of O fragment of bovine prothrombin.

Reuterby J, Walz DA, McCoy LE, Seegers WH.

Thromb Res. 1974 Jun;4(6):885-90. No abstract available.

PMID:
4276683
48.

Proteolytic specificity of thrombin.

Walz DA, Seegers WH, Reuterby J, McCoy LE.

Thromb Res. 1974 May;4(5):713-7. No abstract available.

PMID:
4838251
49.

Communication: An x-ray crystallographic study of thrombin.

Tsernoglou D, Walz DA, McCoy LE, Seegers WH.

J Biol Chem. 1974 Feb 10;249(3):999. No abstract available.

50.

Some effects of calcium and strontium ions on three basic reactions of blood coagulation.

Sakuragawa N, McCoy LE, Seegers WH.

Thromb Diath Haemorrh. 1972 Apr 30;27(2):234-40. No abstract available.

PMID:
5065647

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