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Items: 1 to 50 of 81

1.

AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo.

Powell SK, Samulski RJ, McCown TJ.

Mol Ther. 2020 Mar 17. pii: S1525-0016(20)30141-6. doi: 10.1016/j.ymthe.2020.03.007. [Epub ahead of print]

PMID:
32213322
2.

Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons.

Weinberg MS, Criswell HE, Powell SK, Bhatt AP, McCown TJ.

Mol Ther. 2017 Apr 5;25(4):928-934. doi: 10.1016/j.ymthe.2017.01.016. Epub 2017 Feb 13.

3.

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism.

Powell SK, Khan N, Parker CL, Samulski RJ, Matsushima G, Gray SJ, McCown TJ.

Gene Ther. 2016 Nov;23(11):807-814. doi: 10.1038/gt.2016.62. Epub 2016 Sep 15.

4.

N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.

Francis JS, Wojtas I, Markov V, Gray SJ, McCown TJ, Samulski RJ, Bilaniuk LT, Wang DJ, De Vivo DC, Janson CG, Leone P.

Neurobiol Dis. 2016 Dec;96:323-334. doi: 10.1016/j.nbd.2016.10.001. Epub 2016 Oct 4.

5.

Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.

Cook JB, Werner DF, Maldonado-Devincci AM, Leonard MN, Fisher KR, O'Buckley TK, Porcu P, McCown TJ, Besheer J, Hodge CW, Morrow AL.

J Neurosci. 2014 Apr 23;34(17):5824-34. doi: 10.1523/JNEUROSCI.4733-13.2014.

6.

Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility.

Weinberg MS, Blake BL, McCown TJ.

Exp Neurol. 2013 Sep;247:429-37. doi: 10.1016/j.expneurol.2013.01.011. Epub 2013 Jan 16.

7.

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates.

Gray SJ, Nagabhushan Kalburgi S, McCown TJ, Jude Samulski R.

Gene Ther. 2013 Apr;20(4):450-9. doi: 10.1038/gt.2012.101. Epub 2013 Jan 10. Erratum in: Gene Ther. 2013 Apr;20(4):465.

8.

Adeno-associated virus (AAV) gene therapy for neurological disease.

Weinberg MS, Samulski RJ, McCown TJ.

Neuropharmacology. 2013 Jun;69:82-8. doi: 10.1016/j.neuropharm.2012.03.004. Epub 2012 Mar 17. Review.

PMID:
22465202
9.

Current prospects and challenges for epilepsy gene therapy.

Weinberg MS, McCown TJ.

Exp Neurol. 2013 Jun;244:27-35. doi: 10.1016/j.expneurol.2011.10.003. Epub 2011 Oct 8. Review.

10.

Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration.

Gray SJ, Choi VW, Asokan A, Haberman RA, McCown TJ, Samulski RJ.

Curr Protoc Neurosci. 2011 Oct;Chapter 4:Unit 4.17. doi: 10.1002/0471142301.ns0417s57.

11.

Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice.

Hayes DM, Fee JR, McCown TJ, Knapp DJ, Breese GR, Cubero I, Carvajal F, Lerma-Cabrera JM, Navarro M, Thiele TE.

Addict Biol. 2012 Mar;17(2):338-50. doi: 10.1111/j.1369-1600.2011.00336.x. Epub 2011 Jul 18.

12.

The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.

Weinberg MS, Blake BL, Samulski RJ, McCown TJ.

Gene Ther. 2011 Oct;18(10):961-8. doi: 10.1038/gt.2011.49. Epub 2011 Apr 14.

13.

Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors.

Gray SJ, Foti SB, Schwartz JW, Bachaboina L, Taylor-Blake B, Coleman J, Ehlers MD, Zylka MJ, McCown TJ, Samulski RJ.

Hum Gene Ther. 2011 Sep;22(9):1143-53. doi: 10.1089/hum.2010.245. Epub 2011 Jun 1.

14.

Adeno-Associated Virus (AAV) Vectors in the CNS.

McCown TJ.

Curr Gene Ther. 2011 Jun;11(3):181-8. Review.

PMID:
21453285
15.

The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy.

McCown TJ.

Drug News Perspect. 2010 Jun;23(5):281-6. doi: 10.1358/dnp.2010.23.5.1468393. Review.

PMID:
20603651
16.

Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction.

Johnson JS, Li C, DiPrimio N, Weinberg MS, McCown TJ, Samulski RJ.

J Virol. 2010 Sep;84(17):8888-902. doi: 10.1128/JVI.00687-10. Epub 2010 Jun 23.

17.

Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).

Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ, Li W.

Mol Ther. 2010 Mar;18(3):570-8. doi: 10.1038/mt.2009.292. Epub 2009 Dec 29. Erratum in: Mol Ther. 2010 May;18(5):1054. Li, Wuping [added].

18.

Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment.

Koh MT, Haberman RP, Foti S, McCown TJ, Gallagher M.

Neuropsychopharmacology. 2010 Mar;35(4):1016-25. doi: 10.1038/npp.2009.207. Epub 2009 Dec 23.

19.

Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Foti SB, Samulski RJ, McCown TJ.

Gene Ther. 2009 Nov;16(11):1314-9. doi: 10.1038/gt.2009.106. Epub 2009 Sep 3.

20.

Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity.

McCown TJ.

Neurotherapeutics. 2009 Apr;6(2):307-11. doi: 10.1016/j.nurt.2009.01.004. Review.

21.
22.

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.

Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Eugene Redmond D Jr, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ.

Mol Ther. 2008 Jul;16(7):1252-1260. doi: 10.1038/mt.2008.100. Epub 2016 Dec 8.

PMID:
28178482
23.

Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles.

Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Redmond DE Jr, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ.

Mol Ther. 2008 Jul;16(7):1252-60. doi: 10.1038/mt.2008.100. Epub 2008 May 20.

24.

Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration.

Choi VW, Asokan A, Haberman RA, McCown TJ, Samulski RJ.

Curr Protoc Neurosci. 2006 May;Chapter 4:Unit 4.17. doi: 10.1002/0471142301.ns0417s35.

PMID:
18428636
25.

Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.

Foti S, Haberman RP, Samulski RJ, McCown TJ.

Gene Ther. 2007 Nov;14(21):1534-6. Epub 2007 Aug 23.

27.

A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors.

Cockrell AS, Ma H, Fu K, McCown TJ, Kafri T.

Mol Ther. 2006 Aug;14(2):276-84. Epub 2006 Mar 3.

28.

Adeno-associated virus (AAV) vectors in the CNS.

McCown TJ.

Curr Gene Ther. 2005 Jun;5(3):333-8. Review.

PMID:
15975010
29.

The clinical potential of antiepileptic gene therapy.

McCown TJ.

Expert Opin Biol Ther. 2004 Nov;4(11):1771-6. Review.

PMID:
15500405
30.

Transactivator and structurally optimized inducible lentiviral vectors.

Haack K, Cockrell AS, Ma H, Israeli D, Ho SN, McCown TJ, Kafri T.

Mol Ther. 2004 Sep;10(3):585-96.

31.

Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion.

Haberman RP, Samulski RJ, McCown TJ.

Nat Med. 2003 Aug;9(8):1076-80. Epub 2003 Jul 13.

PMID:
12858168
32.

Regulation of gene expression in adeno-associated virus vectors in the brain.

Haberman RP, McCown TJ.

Methods. 2002 Oct;28(2):219-26. Review.

PMID:
12413420
33.

Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery.

Fu H, Samulski RJ, McCown TJ, Picornell YJ, Fletcher D, Muenzer J.

Mol Ther. 2002 Jan;5(1):42-9.

34.

Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors.

Xu K, Ma H, McCown TJ, Verma IM, Kafri T.

Mol Ther. 2001 Jan;3(1):97-104.

35.
36.

Interactive role for neurosteroids in ethanol enhancement of gamma-aminobutyric acid-gated currents from dissociated substantia nigra reticulata neurons.

Criswell HE, McCown TJ, Ming Z, Mueller RA, Breese GR.

J Pharmacol Exp Ther. 1999 Dec;291(3):1054-9. Erratum in: J Pharmacol Exp Ther 2000 Sep;294(3):following 1224.

PMID:
10565824
37.

Inducible long-term gene expression in brain with adeno-associated virus gene transfer.

Haberman RP, McCown TJ, Samulski RJ.

Gene Ther. 1998 Dec;5(12):1604-11.

38.

Selective and rapid uptake of adeno-associated virus type 2 in brain.

Bartlett JS, Samulski RJ, McCown TJ.

Hum Gene Ther. 1998 May 20;9(8):1181-6.

PMID:
9625257
39.

Action of zolpidem on responses to GABA in relation to mRNAs for GABA(A) receptor alpha subunits within single cells: evidence for multiple functional GABA(A) isoreceptors on individual neurons.

Criswell HE, McCown TJ, Moy SS, Oxford GS, Mueller RA, Morrow AL, Breese GR.

Neuropharmacology. 1997 Nov-Dec;36(11-12):1641-52.

PMID:
9517435
40.
41.
42.

Gene transfer by adeno-associated virus vectors into the central nervous system.

Xiao X, Li J, McCown TJ, Samulski RJ.

Exp Neurol. 1997 Mar;144(1):113-24. Review.

PMID:
9126160
43.

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

McCown TJ, Xiao X, Li J, Breese GR, Samulski RJ.

Brain Res. 1996 Mar 25;713(1-2):99-107.

PMID:
8724980
44.

Metabolic and functional mapping of the neural network subserving inferior collicular seizure generalization.

McCown TJ, Duncan GE, Johnson KB, Breese GR.

Brain Res. 1995 Dec 1;701(1-2):117-28.

PMID:
8925273
45.

Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions.

Criswell HE, Simson PE, Knapp DJ, Devaud LL, McCown TJ, Duncan GE, Morrow AL, Breese GR.

J Pharmacol Exp Ther. 1995 Apr;273(1):526-36.

PMID:
7714808
46.

Distribution of [3H]zolpidem binding sites in relation to messenger RNA encoding the alpha 1, beta 2 and gamma 2 subunits of GABAA receptors in rat brain.

Duncan GE, Breese GR, Criswell HE, McCown TJ, Herbert JS, Devaud LL, Morrow AL.

Neuroscience. 1995 Feb;64(4):1113-28.

PMID:
7753379
47.
48.

Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: generalization to other ligand-gated ion channels.

Criswell HE, Simson PE, Duncan GE, McCown TJ, Herbert JS, Morrow AL, Breese GR.

J Pharmacol Exp Ther. 1993 Oct;267(1):522-37.

PMID:
8229784
49.

The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis.

Breese GR, Morrow AL, Simson PE, Criswell HE, McCown TJ, Duncan GE, Keir WJ.

Alcohol Alcohol Suppl. 1993;2:309-13. Review.

PMID:
7538301

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