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MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome.

Emgård J, Bergsten H, McCormick JK, Barrantes I, Skrede S, Sandberg JK, Norrby-Teglund A.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25923-25931. doi: 10.1073/pnas.1910883116. Epub 2019 Nov 26.


Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk.

Kasper KJ, Manoharan I, Hallam B, Coleman CE, Koivu SL, Weir MA, Delport J, McCormick JK, Silverman MS.

PLoS One. 2019 Sep 19;14(9):e0223079. doi: 10.1371/journal.pone.0223079. eCollection 2019.


A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk.

Kasper KJ, Manoharan I, Hallam B, Coleman CE, Koivu SL, Weir MA, McCormick JK, Silverman MS.

PLoS One. 2019 Aug 9;14(8):e0219777. doi: 10.1371/journal.pone.0219777. eCollection 2019. Erratum in: PLoS One. 2019 Sep 19;14(9):e0223079.


Regulation of toxic shock syndrome toxin-1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins.

Tuffs SW, Herfst CA, Baroja ML, Podskalniy VA, DeJong EN, Coleman CEM, McCormick JK.

Mol Microbiol. 2019 Oct;112(4):1163-1177. doi: 10.1111/mmi.14353. Epub 2019 Jul 30.


Evaluation of a Rapid Syphilis Test in an Emergency Department Setting in Detroit, Michigan.

Fakile YF, Markowitz N, Zhu W, Mumby K, Dankerlui D, McCormick JK, Ham DC, Hopkins A, Manteuffel J, Sun Y, Huang YA, Peters PJ, Hoover KW.

Sex Transm Dis. 2019 Jul;46(7):429-433. doi: 10.1097/OLQ.0000000000000993.


Toxins and Superantigens of Group A Streptococci.

Shannon BA, McCormick JK, Schlievert PM.

Microbiol Spectr. 2019 Jan;7(1). doi: 10.1128/microbiolspec.GPP3-0054-2018.


Bacterial Superantigens Expand and Activate, Rather than Delete or Incapacitate, Preexisting Antigen-Specific Memory CD8+ T Cells.

Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SMM.

J Infect Dis. 2019 Apr 8;219(8):1307-1317. doi: 10.1093/infdis/jiy647.


Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.

Tuffs SW, Haeryfar SMM, McCormick JK.

Pathogens. 2018 May 29;7(2). pii: E53. doi: 10.3390/pathogens7020053. Review.


Streptococcal pharyngitis and rheumatic heart disease: the superantigen hypothesis revisited.

Hurst JR, Kasper KJ, Sule AN, McCormick JK.

Infect Genet Evol. 2018 Jul;61:160-175. doi: 10.1016/j.meegid.2018.03.006. Epub 2018 Mar 9. Review.


Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.

Li Z, Zeppa JJ, Hancock MA, McCormick JK, Doherty TM, Hendy GN, Madrenas J.

J Immunol. 2018 Feb 15;200(4):1471-1479. doi: 10.4049/jimmunol.1701212. Epub 2018 Jan 15.


Validation of an Algorithm to Identify Infective Endocarditis in People Who Inject Drugs.

Ball LJ, Sherazi A, Laczko D, Gupta K, Koivu S, Weir MA, Mele T, Tirona R, McCormick JK, Silverman M.

Med Care. 2018 Oct;56(10):e70-e75. doi: 10.1097/MLR.0000000000000838.


Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells.

Zeppa JJ, Kasper KJ, Mohorovic I, Mazzuca DM, Haeryfar SMM, McCormick JK.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10226-10231. doi: 10.1073/pnas.1700858114. Epub 2017 Aug 9.


MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.

Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SMM.

PLoS Biol. 2017 Jun 20;15(6):e2001930. doi: 10.1371/journal.pbio.2001930. eCollection 2017 Jun.


Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.

Szabo PA, Goswami A, Mazzuca DM, Kim K, O'Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM.

J Immunol. 2017 Apr 1;198(7):2805-2818. doi: 10.4049/jimmunol.1601366. Epub 2017 Feb 20.


Invariant Natural Killer T Cells Are Pathogenic in the HLA-DR4-Transgenic Humanized Mouse Model of Toxic Shock Syndrome and Can Be Targeted to Reduce Morbidity.

Szabo PA, Rudak PT, Choi J, Xu SX, Schaub R, Singh B, McCormick JK, Haeryfar SMM.

J Infect Dis. 2017 Mar 1;215(5):824-829. doi: 10.1093/infdis/jiw646.


Identification of a two-component Class IIb bacteriocin in Streptococcus pyogenes by recombinase-based in vivo expression technology.

Armstrong BD, Herfst CA, Tonial NC, Wakabayashi AT, Zeppa JJ, McCormick JK.

Sci Rep. 2016 Nov 3;6:36233. doi: 10.1038/srep36233.


The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus.

Baroja ML, Herfst CA, Kasper KJ, Xu SX, Gillett DA, Li J, Reid G, McCormick JK.

J Bacteriol. 2016 Sep 9;198(19):2732-42. doi: 10.1128/JB.00425-16. Print 2016 Oct 1.


Rapid detection of meticillin-resistant Staphylococcus aureus bacteraemia using combined three-hour short-incubation matrix-assisted laser desorption/ionization time-of-flight MS identification and Alere Culture Colony PBP2a detection test.

Delport JA, Mohorovic I, Burn S, McCormick JK, Schaus D, Lannigan R, John M.

J Med Microbiol. 2016 Jul;65(7):626-631. doi: 10.1099/jmm.0.000285. Epub 2016 May 23.


Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome.

Szabo PA, Goswami A, Memarnejadian A, Mallett CL, Foster PJ, McCormick JK, Haeryfar SM.

J Infect Dis. 2016 Jun 15;213(12):1990-5. doi: 10.1093/infdis/jiw050. Epub 2016 Feb 9.


Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity.

Zeppa JJ, Wakabayashi AT, Kasper KJ, Xu SX, Haeryfar SMM, McCormick JK.

Methods Mol Biol. 2016;1396:95-107. doi: 10.1007/978-1-4939-3344-0_8.


CD1d- and MR1-Restricted T Cells in Sepsis.

Szabo PA, Anantha RV, Shaler CR, McCormick JK, Haeryfar SM.

Front Immunol. 2015 Aug 12;6:401. doi: 10.3389/fimmu.2015.00401. eCollection 2015. Review.


Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization.

Xu SX, Kasper KJ, Zeppa JJ, McCormick JK.

Toxins (Basel). 2015 May 22;7(5):1821-36. doi: 10.3390/toxins7051821.


Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study.

Anantha RV, Jegatheswaran J, Pepe DL, Priestap F, Delport J, Haeryfar SM, McCormick JK, Mele T.

CMAJ Open. 2014 Oct 1;2(4):E352-9. doi: 10.9778/cmajo.20140018. eCollection 2014 Oct.


Recalcitrant prosthetic valve endocarditis requiring repeated reconstruction: running out of options.

Pepe DL, Anantha RV, Currie ME, McCormick JK, Mele T, Chu MW.

Can J Cardiol. 2014 Dec;30(12):1732.e5-8. doi: 10.1016/j.cjca.2014.09.003. Epub 2014 Sep 6.


Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1.

Sayedyahossein S, Xu SX, Rudkouskaya A, McGavin MJ, McCormick JK, Dagnino L.

FASEB J. 2015 Feb;29(2):711-23. doi: 10.1096/fj.14-262774. Epub 2014 Nov 21.


T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis.

Anantha RV, Mazzuca DM, Xu SX, Porcelli SA, Fraser DD, Martin CM, Welch I, Mele T, Haeryfar SM, McCormick JK.

Clin Exp Immunol. 2014 Nov;178(2):292-309. doi: 10.1111/cei.12404.


Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo.

Xu SX, Gilmore KJ, Szabo PA, Zeppa JJ, Baroja ML, Haeryfar SM, McCormick JK.

Infect Immun. 2014 Sep;82(9):3588-98. doi: 10.1128/IAI.02110-14. Epub 2014 Jun 9.


Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

Kasper KJ, Zeppa JJ, Wakabayashi AT, Xu SX, Mazzuca DM, Welch I, Baroja ML, Kotb M, Cairns E, Cleary PP, Haeryfar SM, McCormick JK.

PLoS Pathog. 2014 May 29;10(5):e1004155. doi: 10.1371/journal.ppat.1004155. eCollection 2014 May.


Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen.

Patterson KG, Dixon Pittaro JL, Bastedo PS, Hess DA, Haeryfar SM, McCormick JK.

PLoS One. 2014 Apr 15;9(4):e95200. doi: 10.1371/journal.pone.0095200. eCollection 2014.


A robust scoring system to evaluate sepsis severity in an animal model.

Shrum B, Anantha RV, Xu SX, Donnelly M, Haeryfar SM, McCormick JK, Mele T.

BMC Res Notes. 2014 Apr 12;7:233. doi: 10.1186/1756-0500-7-233.


Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides.

Scinocca M, Bell DA, Racapé M, Joseph R, Shaw G, McCormick JK, Gladman DD, Pope J, Barra L, Cairns E.

J Rheumatol. 2014 Feb;41(2):270-9. doi: 10.3899/jrheum.130742. Epub 2014 Jan 15.


Fournier's gangrene of the penis caused by Streptococcus dysgalactiae subspecies equisimilis: case report and incidence study in a tertiary-care hospital.

Anantha RV, Kasper KJ, Patterson KG, Zeppa JJ, Delport J, McCormick JK.

BMC Infect Dis. 2013 Aug 20;13:381. doi: 10.1186/1471-2334-13-381.


Influence of the vaginal microbiota on toxic shock syndrome toxin 1 production by Staphylococcus aureus.

MacPhee RA, Miller WL, Gloor GB, McCormick JK, Hammond JA, Burton JP, Reid G.

Appl Environ Microbiol. 2013 Mar;79(6):1835-42. doi: 10.1128/AEM.02908-12. Epub 2013 Jan 11.


Staphylococcal superantigens in colonization and disease.

Xu SX, McCormick JK.

Front Cell Infect Microbiol. 2012 Apr 17;2:52. doi: 10.3389/fcimb.2012.00052. eCollection 2012. Review.


CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens.

Hayworth JL, Mazzuca DM, Maleki Vareki S, Welch I, McCormick JK, Haeryfar SM.

Immunol Cell Biol. 2012 Aug;90(7):699-709. doi: 10.1038/icb.2011.90. Epub 2011 Nov 1.


Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci.

Li J, Wang W, Xu SX, Magarvey NA, McCormick JK.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3360-5. doi: 10.1073/pnas.1017431108. Epub 2011 Jan 31.


What is the quality of life in the oldest old?

Lapid MI, Rummans TA, Boeve BF, McCormick JK, Pankratz VS, Cha RH, Smith GE, Ivnik RJ, Tangalos EG, Petersen RC.

Int Psychogeriatr. 2011 Aug;23(6):1003-10. doi: 10.1017/S1041610210002462. Epub 2011 Feb 1.


The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.

Nur-ur Rahman AK, Bonsor DA, Herfst CA, Pollard F, Peirce M, Wyatt AW, Kasper KJ, Madrenas J, Sundberg EJ, McCormick JK.

J Biol Chem. 2011 Feb 11;286(6):4871-81. doi: 10.1074/jbc.M110.189068. Epub 2010 Dec 2.


Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.

Hayworth JL, Kasper KJ, Leon-Ponte M, Herfst CA, Yue D, Brintnell WC, Mazzuca DM, Heinrichs DE, Cairns E, Madrenas J, Hoskin DW, McCormick JK, Haeryfar SM.

Clin Exp Immunol. 2009 Jul;157(1):60-70. doi: 10.1111/j.1365-2249.2009.03963.x.


Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome.

Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vinés ED, Kubes P, Haeryfar SM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J.

Nat Med. 2009 Jun;15(6):641-8. doi: 10.1038/nm.1965.


Molecular requirements for MHC class II alpha-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C.

Kasper KJ, Xi W, Rahman AK, Nooh MM, Kotb M, Sundberg EJ, Madrenas J, McCormick JK.

J Immunol. 2008 Sep 1;181(5):3384-92.


Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats.

Yang X, Buonpane RA, Moza B, Rahman AK, Wang N, Schlievert PM, McCormick JK, Sundberg EJ, Kranz DM.

J Infect Dis. 2008 Aug 1;198(3):344-8. doi: 10.1086/589776.


A novel loop domain in superantigens extends their T cell receptor recognition site.

Günther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ.

J Mol Biol. 2007 Aug 3;371(1):210-21. Epub 2007 May 18.


Rash and neurological symptoms.

McCormick JK, Nadel ES, Brown DF.

J Emerg Med. 2007 Apr;32(3):299-303. Epub 2007 Mar 8. No abstract available.


T cell signalling induced by bacterial superantigens.

Bueno C, Criado G, McCormick JK, Madrenas J.

Chem Immunol Allergy. 2007;93:161-180. doi: 10.1159/000100894. Review.


Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens.

Brouillard JN, Günther S, Varma AK, Gryski I, Herfst CA, Rahman AK, Leung DY, Schlievert PM, Madrenas J, Sundberg EJ, McCormick JK.

J Mol Biol. 2007 Apr 6;367(4):925-34. Epub 2007 Jan 12.


Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.

Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ.

EMBO J. 2007 Feb 21;26(4):1187-97. Epub 2007 Feb 1.


Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.

Rahman AK, Herfst CA, Moza B, Shames SR, Chau LA, Bueno C, Madrenas J, Sundberg EJ, McCormick JK.

J Immunol. 2006 Dec 15;177(12):8595-603.


Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway.

Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J.

Immunity. 2006 Jul;25(1):67-78.


Long-range cooperative binding effects in a T cell receptor variable domain.

Moza B, Buonpane RA, Zhu P, Herfst CA, Rahman AK, McCormick JK, Kranz DM, Sundberg EJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9867-72. Epub 2006 Jun 20.

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