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Items: 1 to 50 of 55


WNK4 limits distal calcium losses following acute furosemide treatment.

Ferdaus MZ, Gratreak BDK, Miller L, Si J, McCormick JA, Yang CL, Ellison DH, Terker AS.

Physiol Rep. 2019 Sep;7(17):e14195. doi: 10.14814/phy2.14195.


Mg2+ restriction downregulates NCC through NEDD4-2 and prevents its activation by hypokalemia.

Ferdaus MZ, Mukherjee A, Nelson JW, Blatt PJ, Miller LN, Terker AS, Staub O, Lin DH, McCormick JA.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F825-F838. doi: 10.1152/ajprenal.00216.2019. Epub 2019 Jul 31.


Cullin-Ring ubiquitin ligases in kidney health and disease.

Cornelius RJ, Ferdaus MZ, Nelson JW, McCormick JA.

Curr Opin Nephrol Hypertens. 2019 Sep;28(5):490-497. doi: 10.1097/MNH.0000000000000527.


Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.

Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD.

JCI Insight. 2019 Jun 11;5. pii: 129793. doi: 10.1172/jci.insight.129793.


Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis.

Saritas T, Cuevas CA, Ferdaus MZ, Kuppe C, Kramann R, Moeller MJ, Floege J, Singer JD, McCormick JA.

Sci Rep. 2019 Mar 14;9(1):4596. doi: 10.1038/s41598-019-40795-0.


Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.

Saritas T, Puelles VG, Su XT, McCormick JA, Welling PA, Ellison DH.

Cell Rep. 2018 Dec 4;25(10):2668-2675.e3. doi: 10.1016/j.celrep.2018.11.021.


With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo.

Terker AS, Castañeda-Bueno M, Ferdaus MZ, Cornelius RJ, Erspamer KJ, Su XT, Miller LN, McCormick JA, Wang WH, Gamba G, Yang CL, Ellison DH.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F781-F790. doi: 10.1152/ajprenal.00485.2017. Epub 2018 Feb 7.


Mechanisms and controversies in mutant Cul3-mediated familial hyperkalemic hypertension.

Ferdaus MZ, McCormick JA.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F915-F920. doi: 10.1152/ajprenal.00593.2017. Epub 2018 Jan 17. Review.


Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.

Wang MX, Cuevas CA, Su XT, Wu P, Gao ZX, Lin DH, McCormick JA, Yang CL, Wang WH, Ellison DH.

Kidney Int. 2018 Apr;93(4):893-902. doi: 10.1016/j.kint.2017.10.023. Epub 2018 Jan 6.


Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.

Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA.

JCI Insight. 2017 Dec 21;2(24). pii: 96700. doi: 10.1172/jci.insight.96700.


Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension.

Nelson JW, Ferdaus MZ, McCormick JA, Minnier J, Kaul S, Ellison DH, Barnes AP.

Physiol Genomics. 2018 Feb 1;50(2):104-116. doi: 10.1152/physiolgenomics.00111.2017. Epub 2018 Jan 8.


Nephron Remodeling Underlies Hyperkalemia in Familial Hyperkalemic Hypertension.

McCormick JA, Ellison DH.

J Am Soc Nephrol. 2017 Sep;28(9):2555-2557. doi: 10.1681/ASN.2017060660. Epub 2017 Jul 13. No abstract available.


Potassium Sensing by Renal Distal Tubules Requires Kir4.1.

Cuevas CA, Su XT, Wang MX, Terker AS, Lin DH, McCormick JA, Yang CL, Ellison DH, Wang WH.

J Am Soc Nephrol. 2017 Jun;28(6):1814-1825. doi: 10.1681/ASN.2016090935. Epub 2017 Jan 4.


Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms.

Blankenstein KI, Borschewski A, Labes R, Paliege A, Boldt C, McCormick JA, Ellison DH, Bader M, Bachmann S, Mutig K.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F489-F501. doi: 10.1152/ajprenal.00575.2016. Epub 2016 Dec 21.


The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy.

Ferdaus MZ, McCormick JA.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1389-96. doi: 10.1152/ajprenal.00132.2016. Epub 2016 Apr 13.


SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.

Ferdaus MZ, Barber KW, López-Cayuqueo KI, Terker AS, Argaiz ER, Gassaway BM, Chambrey R, Gamba G, Rinehart J, McCormick JA.

J Physiol. 2016 Sep 1;594(17):4945-66. doi: 10.1113/JP272311. Epub 2016 May 29.


Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport.

Terker AS, Yarbrough B, Ferdaus MZ, Lazelle RA, Erspamer KJ, Meermeier NP, Park HJ, McCormick JA, Yang CL, Ellison DH.

J Am Soc Nephrol. 2016 Aug;27(8):2436-45. doi: 10.1681/ASN.2015070815. Epub 2015 Dec 28.


Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter.

Borschewski A, Himmerkus N, Boldt C, Blankenstein KI, McCormick JA, Lazelle R, Willnow TE, Jankowski V, Plain A, Bleich M, Ellison DH, Bachmann S, Mutig K.

J Am Soc Nephrol. 2016 Jan;27(1):107-19. doi: 10.1681/ASN.2014070728. Epub 2015 May 12.


Distal convoluted tubule.

McCormick JA, Ellison DH.

Compr Physiol. 2015 Jan;5(1):45-98. doi: 10.1002/cphy.c140002. Review.


Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.

Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH.

Cell Metab. 2015 Jan 6;21(1):39-50. doi: 10.1016/j.cmet.2014.12.006.


Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.

McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH.

J Clin Invest. 2014 Nov;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24.


Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.

Terker AS, Yang CL, McCormick JA, Meermeier NP, Rogers SL, Grossmann S, Trompf K, Delpire E, Loffing J, Ellison DH.

Hypertension. 2014 Jul;64(1):178-84. doi: 10.1161/HYPERTENSIONAHA.114.03335. Epub 2014 May 5.


Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2.

Park HJ, Curry JN, McCormick JA.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1687-96. doi: 10.1152/ajprenal.00211.2013. Epub 2013 Oct 16.


SPAK differentially mediates vasopressin effects on sodium cotransporters.

Saritas T, Borschewski A, McCormick JA, Paliege A, Dathe C, Uchida S, Terker A, Himmerkus N, Bleich M, Demaretz S, Laghmani K, Delpire E, Ellison DH, Bachmann S, Mutig K.

J Am Soc Nephrol. 2013 Feb;24(3):407-18. doi: 10.1681/ASN.2012040404. Epub 2013 Feb 7.


Pathogenesis of calcineurin inhibitor-induced hypertension.

Hoorn EJ, Walsh SB, McCormick JA, Zietse R, Unwin RJ, Ellison DH.

J Nephrol. 2012 May-Jun;25(3):269-75. doi: 10.5301/jn.5000174. Review.


Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.

Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D.

Mol Endocrinol. 2011 Dec;25(12):2106-18. doi: 10.1210/me.2010-0329. Epub 2011 Oct 6.


The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension.

Hoorn EJ, Walsh SB, McCormick JA, Fürstenberg A, Yang CL, Roeschel T, Paliege A, Howie AJ, Conley J, Bachmann S, Unwin RJ, Ellison DH.

Nat Med. 2011 Oct 2;17(10):1304-9. doi: 10.1038/nm.2497.


A SPAK isoform switch modulates renal salt transport and blood pressure.

McCormick JA, Mutig K, Nelson JH, Saritas T, Hoorn EJ, Yang CL, Rogers S, Curry J, Delpire E, Bachmann S, Ellison DH.

Cell Metab. 2011 Sep 7;14(3):352-64. doi: 10.1016/j.cmet.2011.07.009.


Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension.

McCormick JA, Nelson JH, Yang CL, Curry JN, Ellison DH.

Hypertension. 2011 Nov;58(5):888-94. doi: 10.1161/HYPERTENSIONAHA.110.167809. Epub 2011 Sep 6.


The WNK kinase network regulating sodium, potassium, and blood pressure.

Hoorn EJ, Nelson JH, McCormick JA, Ellison DH.

J Am Soc Nephrol. 2011 Apr;22(4):605-14. doi: 10.1681/ASN.2010080827. Epub 2011 Mar 24. Review.


High tail-cuff blood pressure in mice 1 week after shipping: the need for longer acclimation.

Hoorn EJ, McCormick JA, Ellison DH.

Am J Hypertens. 2011 May;24(5):534-6. doi: 10.1038/ajh.2011.7. Epub 2011 Feb 3.


The WNKs: atypical protein kinases with pleiotropic actions.

McCormick JA, Ellison DH.

Physiol Rev. 2011 Jan;91(1):177-219. doi: 10.1152/physrev.00017.2010. Review.


Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation.

Farrow EG, Summers LJ, Schiavi SC, McCormick JA, Ellison DH, White KE.

J Endocrinol. 2010 Oct;207(1):67-75. doi: 10.1677/JOE-10-0181. Epub 2010 Jul 30.


Akt2 and SGK3 are both determinants of postnatal hair follicle development.

Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D.

FASEB J. 2009 Sep;23(9):3193-202. doi: 10.1096/fj.08-123729. Epub 2009 May 11.


WNK kinases and renal sodium transport in health and disease: an integrated view.

McCormick JA, Yang CL, Ellison DH.

Hypertension. 2008 Mar;51(3):588-96. doi: 10.1161/HYPERTENSIONAHA.107.103788. Epub 2008 Jan 22. Review. No abstract available.


NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.

Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D.

Am J Physiol Renal Physiol. 2007 Jun;292(6):F1741-50. Epub 2007 Mar 13.


WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.

Subramanya AR, Yang CL, McCormick JA, Ellison DH.

Kidney Int. 2006 Aug;70(4):630-4. Epub 2006 Jul 5. Review.


Renal function of gene-targeted mice lacking both SGK1 and SGK3.

Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F.

Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R945-50.


Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.

Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F.

Behav Brain Res. 2006 Feb 15;167(1):75-86. Epub 2005 Oct 24.


Decreased intestinal glucose transport in the sgk3-knockout mouse.

Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F.

Pflugers Arch. 2005 Dec;451(3):437-44. Epub 2005 Jun 22.


The dynamics of single chains within a model polymer melt.

McCormick JA, Hall CK, Khan SA.

J Chem Phys. 2005 Mar 15;122(11):114902.


Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.

Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F.

J Physiol. 2005 Jun 1;565(Pt 2):381-90. Epub 2005 Mar 17.


SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.

McCormick JA, Bhalla V, Pao AC, Pearce D.

Physiology (Bethesda). 2005 Apr;20:134-9. Review.


Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.

McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D.

Mol Biol Cell. 2004 Sep;15(9):4278-88. Epub 2004 Jul 7.


Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.

Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG.

Hypertension. 2004 Apr;43(4):866-71. Epub 2004 Mar 8.


Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.

Lai M, McCormick JA, Chapman KE, Kelly PA, Seckl JR, Yau JL.

Neuroscience. 2003;118(4):975-84.


Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1.

Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D.

Mol Endocrinol. 2002 Jul;16(7):1629-37.


5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events.

McCormick JA, Lyons V, Jacobson MD, Noble J, Diorio J, Nyirenda M, Weaver S, Ester W, Yau JL, Meaney MJ, Seckl JR, Chapman KE.

Mol Endocrinol. 2000 Apr;14(4):506-17.


Tissue-specific differences in rat glucocorticoid receptor gene transcriptional regulation.

McCormick JA, Lyons V, Noble J, Ester W, Meaney MJ, Seckl JR, Chapman KE.

Biochem Soc Trans. 1998 Aug;26(3):S207. No abstract available.


Effects of attention training on information processing in schizophrenia.

Benedict RH, Harris AE, Markow T, McCormick JA, Nuechterlein KH, Asarnow RF.

Schizophr Bull. 1994;20(3):537-46.


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