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KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.

Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201908353. doi: 10.1073/pnas.1908353116. [Epub ahead of print]


Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors Through Autocrine FGFR Pathway Activation.

Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Bernards R, Lito P, Settleman J, McCormick F, Flaherty KT.

Clin Cancer Res. 2019 Sep 12. pii: clincanres.2779.2018. doi: 10.1158/1078-0432.CCR-18-2779. [Epub ahead of print]


Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder.

Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD Jr, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17290-17297. doi: 10.1073/pnas.1905516116. Epub 2019 Aug 9.


Removing Disincentives to Kidney Donation: A Quantitative Analysis.

McCormick F, Held PJ, Chertow GM, Peters TG, Roberts JP.

J Am Soc Nephrol. 2019 Aug;30(8):1349-1357. doi: 10.1681/ASN.2019030242. Epub 2019 Jul 25. No abstract available.


Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.

Dharmaiah S, Tran TH, Messing S, Agamasu C, Gillette WK, Yan W, Waybright T, Alexander P, Esposito D, Nissley DV, McCormick F, Stephen AG, Simanshu DK.

Sci Rep. 2019 Jul 19;9(1):10512. doi: 10.1038/s41598-019-46846-w.


Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer.

Wang MT, Fer N, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F.

Nat Commun. 2019 Jul 11;10(1):3055. doi: 10.1038/s41467-019-11044-9.


Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors.

Bai RY, Esposito D, Tam AJ, McCormick F, Riggins GJ, Wade Clapp D, Staedtke V.

Gene Ther. 2019 Jun;26(6):277-286. doi: 10.1038/s41434-019-0080-9. Epub 2019 May 24.


Normotensive scleroderma renal crisis after silicone breast implant rupture.

Powell RO, Singh A, McCormick F, King J, Houlberg K, Connor A.

Kidney Int. 2019 Jun;95(6):1520. doi: 10.1016/j.kint.2018.10.014. No abstract available.


Evaluating strategies and outcomes following rotator cuff tears.

Amoo-Achampong K, Krill MK, Acheampong D, Nwachukwu BU, McCormick F.

Shoulder Elbow. 2019 May;11(1 Suppl):4-18. doi: 10.1177/1758573218768099. Epub 2018 Apr 26. Review.


Four millennia of dairy surplus and deposition revealed through compound-specific stable isotope analysis and radiocarbon dating of Irish bog butters.

Smyth J, Berstan R, Casanova E, McCormick F, Mulhall I, Sikora M, Synnott C, Evershed RP.

Sci Rep. 2019 Mar 14;9(1):4559. doi: 10.1038/s41598-019-40975-y.


RIT1 oncoproteins escape LZTR1-mediated proteolysis.

Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F.

Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444.


KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.

Agamasu C, Ghirlando R, Taylor T, Messing S, Tran TH, Bindu L, Tonelli M, Nissley DV, McCormick F, Stephen AG.

Biophys J. 2019 Mar 19;116(6):1049-1063. doi: 10.1016/j.bpj.2019.02.004. Epub 2019 Feb 15.


MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.

Lee CS, Lee LC, Yuan TL, Chakka S, Fellmann C, Lowe SW, Caplen NJ, McCormick F, Luo J.

Proc Natl Acad Sci U S A. 2019 Feb 1. pii: 201817494. doi: 10.1073/pnas.1817494116. [Epub ahead of print]


Progress in targeting RAS with small molecule drugs.

McCormick F.

Biochem J. 2019 Jan 31;476(2):365-374. doi: 10.1042/BCJ20170441. Review.


Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.

Lakshman B, Messing S, Schmid EM, Clogston JD, Gillette WK, Esposito D, Kessing B, Fletcher DA, Nissley DV, McCormick F, Stephen AG, Jean-Francois FL.

J Biol Chem. 2019 Feb 8;294(6):2193-2207. doi: 10.1074/jbc.RA118.005669. Epub 2018 Dec 17.


Would government compensation of living kidney donors exploit the poor? An empirical analysis.

Held PJ, McCormick F, Chertow GM, Peters TG, Roberts JP.

PLoS One. 2018 Nov 28;13(11):e0205655. doi: 10.1371/journal.pone.0205655. eCollection 2018.


Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.

Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S.

Nat Med. 2019 Jan;25(1):111-118. doi: 10.1038/s41591-018-0264-7. Epub 2018 Nov 26.


The Terrible Toll of the Kidney Shortage.

McCormick F, Held PJ, Chertow GM.

J Am Soc Nephrol. 2018 Dec;29(12):2775-2776. doi: 10.1681/ASN.2018101030. Epub 2018 Nov 12. No abstract available.


SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.

Young LC, Hartig N, Boned Del Río I, Sari S, Ringham-Terry B, Wainwright JR, Jones GG, McCormick F, Rodriguez-Viciana P.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10576-E10585. doi: 10.1073/pnas.1720352115. Epub 2018 Oct 22.


Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F.

Am J Med Genet A. 2018 Dec;176(12):2924-2929. doi: 10.1002/ajmg.a.40632. Epub 2018 Oct 10.


Therapy services and specialized devices for conjoined twins: Unique challenges with conjoined twins and the importance of physical and occupational therapy.

Cugini K, McCormick FB Jr, Mitchell C, Psencik E, Sarduy S, Masuoka I, Toruno R, Davies J.

Semin Perinatol. 2018 Oct;42(6):361-368. doi: 10.1053/j.semperi.2018.07.010. Epub 2018 Jul 26. Review.


Family-focused recovery: Perspectives from individuals with a mental illness.

Waller S, Reupert A, Ward B, McCormick F, Kidd S.

Int J Ment Health Nurs. 2019 Feb;28(1):247-255. doi: 10.1111/inm.12528. Epub 2018 Aug 24.


Reoperation Rates After Cartilage Restoration Procedures in the Knee: Analysis of a Large US Commercial Database.

Frank RM, McCormick F, Rosas S, Amoo-Achampong K, Erickson B, Bach BR Jr, Cole BJ.

Am J Orthop (Belle Mead NJ). 2018 Jun;47(6). doi: 10.12788/ajo.2018.0040.


Anthropogenic changes to the Holocene nitrogen cycle in Ireland.

Guiry E, Beglane F, Szpak P, Schulting R, McCormick F, Richards MP.

Sci Adv. 2018 Jun 13;4(6):eaas9383. doi: 10.1126/sciadv.aas9383. eCollection 2018 Jun.


Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics.

Ye X, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV, McCormick F, Whiteley GR, Blonder J.

Oncotarget. 2018 May 29;9(41):26431-26452. doi: 10.18632/oncotarget.25449. eCollection 2018 May 29.


Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M; Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N.

Cell. 2018 Apr 5;173(2):321-337.e10. doi: 10.1016/j.cell.2018.03.035.


Differential Effector Engagement by Oncogenic KRAS.

Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L, Bess M, Cheng KT, Lee CS, Lee LC, Fellmann C, Stephens R, Luo J, Lowe SW, Benes CH, McCormick F.

Cell Rep. 2018 Feb 13;22(7):1889-1902. doi: 10.1016/j.celrep.2018.01.051.


c-Raf in KRas Mutant Cancers: A Moving Target.

McCormick F.

Cancer Cell. 2018 Feb 12;33(2):158-159. doi: 10.1016/j.ccell.2018.01.017.


Developing a model of family focused practice with consumers, families, practitioners and managers: a community based participatory research approach.

Reupert A, Ward B, McCormick F, Ward C, Waller S, Kidd S.

BMC Health Serv Res. 2018 Jan 30;18(1):66. doi: 10.1186/s12913-018-2844-0.


Dual gene activation and knockout screen reveals directional dependencies in genetic networks.

Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.

Nat Biotechnol. 2018 Feb;36(2):170-178. doi: 10.1038/nbt.4062. Epub 2018 Jan 15.


Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH.

Nat Commun. 2017 Dec 19;8(1):2200. doi: 10.1038/s41467-017-02287-5.


A concise evidence-based physical examination for diagnosis of acromioclavicular joint pathology: a systematic review.

Krill MK, Rosas S, Kwon K, Dakkak A, Nwachukwu BU, McCormick F.

Phys Sportsmed. 2018 Feb;46(1):98-104. doi: 10.1080/00913847.2018.1413920. Epub 2017 Dec 13. Review.


Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT.

Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1.


Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ.

Sci Signal. 2017 Sep 26;10(498). pii: eaao3332. doi: 10.1126/scisignal.aao3332.


RAS Proteins and Their Regulators in Human Disease.

Simanshu DK, Nissley DV, McCormick F.

Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009. Review.


Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes.

Stephens RM, Yi M, Kessing B, Nissley DV, McCormick F.

Cancer Inform. 2017 Jun 8;16:1176935117711944. doi: 10.1177/1176935117711944. eCollection 2017.


Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient.

Wang SJ, Asthana S, van Zante A, Heaton CM, Phuchareon J, Stein L, Higuchi S, Kishimoto T, Chiu CY, Olshen AB, McCormick F, Tetsu O.

Oral Oncol. 2017 Jun;69:1-10. doi: 10.1016/j.oraloncology.2017.03.020. Epub 2017 Apr 3.


Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.

Novotny CJ, Hamilton GL, McCormick F, Shokat KM.

ACS Chem Biol. 2017 Jul 21;12(7):1956-1962. doi: 10.1021/acschembio.7b00374. Epub 2017 Jun 19.


A practical, evidence-based, comprehensive (PEC) physical examination for diagnosing pathology of the long head of the biceps.

Rosas S, Krill MK, Amoo-Achampong K, Kwon K, Nwachukwu BU, McCormick F.

J Shoulder Elbow Surg. 2017 Aug;26(8):1484-1492. doi: 10.1016/j.jse.2017.03.002. Epub 2017 May 4. Review.


Trends in sports-related concussion diagnoses in the USA: a population-based analysis using a private-payor database.

Amoo-Achampong K, Rosas S, Schmoke N, Accilien YD, Nwachukwu BU, McCormick F.

Phys Sportsmed. 2017 Sep;45(3):239-244. doi: 10.1080/00913847.2017.1327304. Epub 2017 May 17.


ETS-targeted therapy: can it substitute for MEK inhibitors?

Tetsu O, McCormick F.

Clin Transl Med. 2017 Dec;6(1):16. doi: 10.1186/s40169-017-0147-4. Epub 2017 May 2. Review.


Family-focused practice within a recovery framework: practitioners' qualitative perspectives.

Ward B, Reupert A, McCormick F, Waller S, Kidd S.

BMC Health Serv Res. 2017 Mar 24;17(1):234. doi: 10.1186/s12913-017-2146-y.


In-hospital mortality risk of intertrochanteric hip fractures: a comprehensive review of the US Medicare database from 2005 to 2010.

Kiriakopoulos E, McCormick F, Nwachukwu BU, Erickson BJ, Caravella J.

Musculoskelet Surg. 2017 Dec;101(3):213-218. doi: 10.1007/s12306-017-0470-3. Epub 2017 Mar 2. Review.


Prospective Evaluation of Surgical Treatment of Humeral Avulsions of the Glenohumeral Ligament.

Provencher MT, McCormick F, LeClere L, Sanchez G, Golijanin P, Anthony S, Dewing CB.

Am J Sports Med. 2017 Apr;45(5):1134-1140. doi: 10.1177/0363546516680608. Epub 2016 Dec 28.


Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface.

Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J.

Oncotarget. 2016 Dec 27;7(52):86948-86971. doi: 10.18632/oncotarget.13566.


Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6766-E6775. Epub 2016 Oct 17.


An orthopedist's guide to shoulder ultrasound: a systematic review of examination protocols.

Amoo-Achampong K, Nwachukwu BU, McCormick F.

Phys Sportsmed. 2016 Nov;44(4):407-416. Epub 2016 Aug 22.


Rating a Sports Medicine Surgeon's "Quality" in the Modern Era: an Analysis of Popular Physician Online Rating Websites.

Nwachukwu BU, Adjei J, Trehan SK, Chang B, Amoo-Achampong K, Nguyen JT, Taylor SA, McCormick F, Ranawat AS.

HSS J. 2016 Oct;12(3):272-277. Epub 2016 Aug 17.


Authors' Reply.

Schairer WW, Nwachukwu BU, McCormick F, Lyman S, Mayman DJ.

Arthroscopy. 2016 Aug;32(8):1493-4. doi: 10.1016/j.arthro.2016.05.030. No abstract available.


The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation.

Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113. Epub 2016 Jun 16.

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