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Items: 1 to 50 of 219

1.

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ.

Cell Host Microbe. 2019 Sep 11;26(3):385-399.e9. doi: 10.1016/j.chom.2019.08.009.

PMID:
31513773
2.

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.

De Souza DP, Achuthan A, Lee MK, Binger KJ, Lee MC, Davidson S, Tull DL, McConville MJ, Cook AD, Murphy AJ, Hamilton JA, Fleetwood AJ.

J Clin Invest. 2019 Sep 4. pii: 127597. doi: 10.1172/JCI127597. [Epub ahead of print]

3.

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Kennedy K, Cobbold SA, Hanssen E, Birnbaum J, Spillman NJ, McHugh E, Brown H, Tilley L, Spielmann T, McConville MJ, Ralph SA.

PLoS Biol. 2019 Jul 18;17(7):e3000376. doi: 10.1371/journal.pbio.3000376. eCollection 2019 Jul.

4.

Changes in plasma lipids predict pravastatin efficacy in secondary prevention.

Jayawardana KS, Mundra PA, Giles C, Barlow CK, Nestel PJ, Barnes EH, Kirby A, Thompson P, Sullivan DR, Alshehry ZH, Mellett NA, Huynh K, McConville MJ, Zoungas S, Hillis GS, Chalmers J, Woodward M, Marschner IC, Wong G, Kingwell BA, Simes J, Tonkin AM, Meikle PJ; LIPID Study Investigators.

JCI Insight. 2019 Jul 11;4(13). pii: 128438. doi: 10.1172/jci.insight.128438. eCollection 2019 Jul 11.

5.

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.

Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dähling S, Kastenmüller W, Jönsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, Bedoui S.

Immunity. 2019 Aug 20;51(2):285-297.e5. doi: 10.1016/j.immuni.2019.06.002. Epub 2019 Jul 1.

PMID:
31272808
6.

Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.

Wangchuk P, Kouremenos K, Eichenberger RM, Pearson M, Susianto A, Wishart DS, McConville MJ, Loukas A.

Metabolomics. 2019 Jun 28;15(7):101. doi: 10.1007/s11306-019-1561-y.

PMID:
31254203
7.

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii.

Yang L, Uboldi AD, Seizova S, Wilde ML, Coffey MJ, Katris NJ, Yamaryo-Botté Y, Kocan M, Bathgate RAD, Stewart RJ, McConville MJ, Thompson PE, Botté CY, Tonkin CJ.

J Biol Chem. 2019 May 31;294(22):8959-8972. doi: 10.1074/jbc.RA118.005491. Epub 2019 Apr 16.

PMID:
30992368
8.

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.

Simpfendorfer KR, Wang N, Tull DL, De Souza DP, Nahid A, Mu A, Hocking DM, Pedersen JS, Wijburg OLC, McConville MJ, Strugnell RA.

Mol Med. 2019 Apr 3;25(1):12. doi: 10.1186/s10020-019-0077-2.

9.

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.

Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C.

Sci Rep. 2019 Mar 14;9(1):4428. doi: 10.1038/s41598-019-40353-8.

10.

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.

Jiang JH, Bhuiyan MS, Shen HH, Cameron DR, Rupasinghe TWT, Wu CM, Le Brun AP, Kostoulias X, Domene C, Fulcher AJ, McConville MJ, Howden BP, Lieschke GJ, Peleg AY.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3722-3727. doi: 10.1073/pnas.1812066116. Epub 2019 Feb 11.

11.

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family.

Parker KER, Fairweather SJ, Rajendran E, Blume M, McConville MJ, Bröer S, Kirk K, van Dooren GG.

PLoS Pathog. 2019 Feb 11;15(2):e1007577. doi: 10.1371/journal.ppat.1007577. eCollection 2019 Feb.

12.

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.

Wangchuk P, Shepherd C, Constantinoiu C, Ryan RYM, Kouremenos KA, Becker L, Jones L, Buitrago G, Giacomin P, Wilson D, Daly N, McConville MJ, Miles JJ, Loukas A.

Infect Immun. 2019 Mar 25;87(4). pii: e00851-18. doi: 10.1128/IAI.00851-18. Print 2019 Apr.

PMID:
30670556
13.

Determining the Mode of Action of Antimalarial Drugs Using Time-Resolved LC-MS-Based Metabolite Profiling.

Cobbold SA, McConville MJ.

Methods Mol Biol. 2019;1859:225-239. doi: 10.1007/978-1-4939-8757-3_12.

PMID:
30421232
14.

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease.

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, Kanojia K, Kouremenos KA, De Souza DP, McConville MJ, Flavell RA, Gerlic M, Kile BT, Papenfuss AT, Putoczki TL, Radford-Smith GL, Masters SL.

Nat Commun. 2018 Sep 13;9(1):3728. doi: 10.1038/s41467-018-06125-0.

15.

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii.

Uboldi AD, Wilde ML, McRae EA, Stewart RJ, Dagley LF, Yang L, Katris NJ, Hapuarachchi SV, Coffey MJ, Lehane AM, Botte CY, Waller RF, Webb AI, McConville MJ, Tonkin CJ.

PLoS Biol. 2018 Sep 12;16(9):e2005642. doi: 10.1371/journal.pbio.2005642. eCollection 2018 Sep.

16.

Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention.

Mundra PA, Barlow CK, Nestel PJ, Barnes EH, Kirby A, Thompson P, Sullivan DR, Alshehry ZH, Mellett NA, Huynh K, Jayawardana KS, Giles C, McConville MJ, Zoungas S, Hillis GS, Chalmers J, Woodward M, Wong G, Kingwell BA, Simes J, Tonkin AM, Meikle PJ; LIPID Study Investigators.

JCI Insight. 2018 Sep 6;3(17). pii: 121326. doi: 10.1172/jci.insight.121326. eCollection 2018 Sep 6.

17.

Identification of novel lipid modifications and intermembrane dynamics in Corynebacterium glutamicum using high-resolution mass spectrometry.

Klatt S, Brammananth R, O'Callaghan S, Kouremenos KA, Tull D, Crellin PK, Coppel RL, McConville MJ.

J Lipid Res. 2018 Jul;59(7):1190-1204. doi: 10.1194/jlr.M082784. Epub 2018 May 3.

18.

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium.

Husna AU, Wang N, Cobbold SA, Newton HJ, Hocking DM, Wilksch JJ, Scott TA, Davies MR, Hinton JC, Tree JJ, Lithgow T, McConville MJ, Strugnell RA.

J Biol Chem. 2018 Jun 15;293(24):9506-9519. doi: 10.1074/jbc.RA118.002592. Epub 2018 May 2.

19.

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus.

Liebscher S, Ambrose RL, Aktepe TE, Mikulasova A, Prier JE, Gillespie LK, Lopez-Denman AJ, Rupasinghe TWT, Tull D, McConville MJ, Mackenzie JM.

PLoS Pathog. 2018 Apr 30;14(4):e1007029. doi: 10.1371/journal.ppat.1007029. eCollection 2018 Apr.

20.

Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis.

Emery SJ, Baker L, Ansell BRE, Mirzaei M, Haynes PA, McConville MJ, Svärd SG, Jex AR.

Gigascience. 2018 Apr 1;7(4). doi: 10.1093/gigascience/giy024.

21.

Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages.

Boyce KJ, De Souza DP, Dayalan S, Pasricha S, Tull D, McConville MJ, Andrianopoulos A.

mSphere. 2018 Mar 21;3(2). pii: e00056-18. doi: 10.1128/mSphere.00056-18. eCollection 2018 Mar-Apr.

22.

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.

Tonkin-Hill GQ, Trianty L, Noviyanti R, Nguyen HHT, Sebayang BF, Lampah DA, Marfurt J, Cobbold SA, Rambhatla JS, McConville MJ, Rogerson SJ, Brown GV, Day KP, Price RN, Anstey NM, Papenfuss AT, Duffy MF.

PLoS Biol. 2018 Mar 12;16(3):e2004328. doi: 10.1371/journal.pbio.2004328. eCollection 2018 Mar.

23.

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.

Best SA, De Souza DP, Kersbergen A, Policheni AN, Dayalan S, Tull D, Rathi V, Gray DH, Ritchie ME, McConville MJ, Sutherland KD.

Cell Metab. 2018 Apr 3;27(4):935-943.e4. doi: 10.1016/j.cmet.2018.02.006. Epub 2018 Mar 8.

24.

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models.

Saunders EC, Naderer T, Chambers J, Landfear SM, McConville MJ.

Mol Microbiol. 2018 Apr;108(2):143-158. doi: 10.1111/mmi.13923. Epub 2018 Mar 2.

PMID:
29411460
25.

DExSI: a new tool for the rapid quantitation of 13C-labelled metabolites detected by GC-MS.

Dagley MJ, McConville MJ.

Bioinformatics. 2018 Jun 1;34(11):1957-1958. doi: 10.1093/bioinformatics/bty025.

26.

Comparative Metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum Reveals Fundamental Differences in Active Metabolic Pathways and Suggests Novel Gene Annotations.

Masukagami Y, De Souza DP, Dayalan S, Bowen C, O'Callaghan S, Kouremenos K, Nijagal B, Tull D, Tivendale KA, Markham PF, McConville MJ, Browning GF, Sansom FM.

mSystems. 2017 Oct 10;2(5). pii: e00055-17. doi: 10.1128/mSystems.00055-17. eCollection 2017 Sep-Oct.

27.

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei.

Pasricha S, MacRae JI, Chua HH, Chambers J, Boyce KJ, McConville MJ, Andrianopoulos A.

Front Cell Infect Microbiol. 2017 Aug 17;7:368. doi: 10.3389/fcimb.2017.00368. eCollection 2017.

28.

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.

Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D.

Mol Cell. 2017 Aug 3;67(3):457-470.e5. doi: 10.1016/j.molcel.2017.06.014. Epub 2017 Jul 14.

29.

Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).

Vodstrcil LA, Rupasinghe TWT, Kong FYS, Tull D, Worthington K, Chen MY, Huston WM, Timms P, McConville MJ, Fairley CK, Bradshaw CS, Tabrizi SN, Hocking JS.

PLoS One. 2017 May 12;12(5):e0177615. doi: 10.1371/journal.pone.0177615. eCollection 2017.

30.

Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines.

Ansell BR, Baker L, Emery SJ, McConville MJ, Svärd SG, Gasser RB, Jex AR.

Front Microbiol. 2017 Mar 17;8:398. doi: 10.3389/fmicb.2017.00398. eCollection 2017.

31.

Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men.

Kong FY, Rupasinghe TW, Simpson JA, Vodstrcil LA, Fairley CK, McConville MJ, Hocking JS.

PLoS One. 2017 Mar 28;12(3):e0174372. doi: 10.1371/journal.pone.0174372. eCollection 2017.

32.

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens.

Hapuarachchi SV, Cobbold SA, Shafik SH, Dennis AS, McConville MJ, Martin RE, Kirk K, Lehane AM.

PLoS Pathog. 2017 Feb 8;13(2):e1006180. doi: 10.1371/journal.ppat.1006180. eCollection 2017 Feb.

33.

Identification of a Membrane Protein Required for Lipomannan Maturation and Lipoarabinomannan Synthesis in Corynebacterineae.

Cashmore TJ, Klatt S, Yamaryo-Botte Y, Brammananth R, Rainczuk AK, McConville MJ, Crellin PK, Coppel RL.

J Biol Chem. 2017 Mar 24;292(12):4976-4986. doi: 10.1074/jbc.M116.772202. Epub 2017 Feb 6.

34.

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.

Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP.

PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.

35.

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum.

Dickerman BK, Elsworth B, Cobbold SA, Nie CQ, McConville MJ, Crabb BS, Gilson PR.

Sci Rep. 2016 Nov 22;6:37502. doi: 10.1038/srep37502.

36.

Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

Stewart RJ, Whitehead L, Nijagal B, Sleebs BE, Lessene G, McConville MJ, Rogers KL, Tonkin CJ.

Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12685. Epub 2017 Jan 9.

PMID:
27781359
37.

Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes Mellitus.

Alshehry ZH, Mundra PA, Barlow CK, Mellett NA, Wong G, McConville MJ, Simes J, Tonkin AM, Sullivan DR, Barnes EH, Nestel PJ, Kingwell BA, Marre M, Neal B, Poulter NR, Rodgers A, Williams B, Zoungas S, Hillis GS, Chalmers J, Woodward M, Meikle PJ.

Circulation. 2016 Nov 22;134(21):1637-1650. Epub 2016 Oct 18.

38.

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry.

Foletta VC, Palmieri M, Kloehn J, Mason S, Previs SF, McConville MJ, Sieber OM, Bruce CR, Kowalski GM.

Metabolites. 2016 Oct 13;6(4). pii: E34.

39.

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.

Creek DJ, Chua HH, Cobbold SA, Nijagal B, MacRae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6650-6663. doi: 10.1128/AAC.01226-16. Print 2016 Nov.

40.

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

Amiar S, MacRae JI, Callahan DL, Dubois D, van Dooren GG, Shears MJ, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y, Botté CY.

PLoS Pathog. 2016 Aug 4;12(8):e1005765. doi: 10.1371/journal.ppat.1005765. eCollection 2016 Aug.

41.

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice.

Hortle E, Nijagal B, Bauer DC, Jensen LM, Ahn SB, Cockburn IA, Lampkin S, Tull D, McConville MJ, McMorran BJ, Foote SJ, Burgio G.

Blood. 2016 Sep 1;128(9):1290-301. doi: 10.1182/blood-2015-09-666834. Epub 2016 Jul 27.

42.

Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis.

Ansell BR, McConville MJ, Baker L, Korhonen PK, Emery SJ, Svärd SG, Gasser RB, Jex AR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6034-45. doi: 10.1128/AAC.00977-16. Print 2016 Oct.

43.

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.

44.

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis.

Kowalski GM, Hamley S, Selathurai A, Kloehn J, De Souza DP, O'Callaghan S, Nijagal B, Tull DL, McConville MJ, Bruce CR.

Sci Rep. 2016 Jun 7;6:27541. doi: 10.1038/srep27541.

45.

Metabolic Crosstalk between Leishmania and the Macrophage Host.

McConville MJ.

Trends Parasitol. 2016 Sep;32(9):666-668. doi: 10.1016/j.pt.2016.05.005. Epub 2016 May 24.

PMID:
27234812
46.

Using metabolomics to dissect host-parasite interactions.

Kloehn J, Blume M, Cobbold SA, Saunders EC, Dagley MJ, McConville MJ.

Curr Opin Microbiol. 2016 Aug;32:59-65. doi: 10.1016/j.mib.2016.04.019. Epub 2016 May 17. Review.

PMID:
27200489
47.

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

Sedger LM, Tull DL, McConville MJ, De Souza DP, Rupasinghe TW, Williams SJ, Dayalan S, Lanzer D, Mackie H, Lam TC, Boyages J.

PLoS One. 2016 May 16;11(5):e0154650. doi: 10.1371/journal.pone.0154650. eCollection 2016.

48.

Overexpression of Striated Muscle Activator of Rho Signaling (STARS) Increases C2C12 Skeletal Muscle Cell Differentiation.

Wallace MA, Della Gatta PA, Ahmad Mir B, Kowalski GM, Kloehn J, McConville MJ, Russell AP, Lamon S.

Front Physiol. 2016 Feb 8;7:7. doi: 10.3389/fphys.2016.00007. eCollection 2016.

49.

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.

Rolando M, Escoll P, Nora T, Botti J, Boitez V, Bedia C, Daniels C, Abraham G, Stogios PJ, Skarina T, Christophe C, Dervins-Ravault D, Cazalet C, Hilbi H, Rupasinghe TW, Tull D, McConville MJ, Ong SY, Hartland EL, Codogno P, Levade T, Naderer T, Savchenko A, Buchrieser C.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1901-6. doi: 10.1073/pnas.1522067113. Epub 2016 Feb 1.

50.

Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii.

Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ.

Cell Host Microbe. 2015 Dec 9;18(6):670-81. doi: 10.1016/j.chom.2015.11.004.

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