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Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex.

Chronister WD, Burbulis IE, Wierman MB, Wolpert MJ, Haakenson MF, Smith ACB, Kleinman JE, Hyde TM, Weinberger DR, Bekiranov S, McConnell MJ.

Cell Rep. 2019 Jan 22;26(4):825-835.e7. doi: 10.1016/j.celrep.2018.12.107.


The effect of rho kinase inhibition on morphological and electrophysiological maturity in iPSC-derived neurons.

Harbom LJ, Rudisill TL, Michel N, Litwa KA, Beenhakker MP, McConnell MJ.

Cell Tissue Res. 2018 Nov 8. doi: 10.1007/s00441-018-2942-7. [Epub ahead of print]


Peptidoglycan recycling contributes to intrinsic resistance to fosfomycin in Acinetobacter baumannii.

Gil-Marqués ML, Moreno-Martínez P, Costas C, Pachón J, Blázquez J, McConnell MJ.

J Antimicrob Chemother. 2018 Nov 1;73(11):2960-2968. doi: 10.1093/jac/dky289.


Improved molecular karyotyping in glioblastoma.

Burbulis IE, Wierman MB, Wolpert M, Haakenson M, Lopes MB, Schiff D, Hicks J, Loe J, Ratan A, McConnell MJ.

Mutat Res. 2018 Sep;811:16-26. doi: 10.1016/j.mrfmmm.2018.06.002. Epub 2018 Jul 8.


Extracellular vesicles and immune modulation.

McConnell MJ.

Immunol Cell Biol. 2018 Jul 20. doi: 10.1111/imcb.12188. [Epub ahead of print] No abstract available.


Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice.

Przanowski P, Wasko U, Zheng Z, Yu J, Sherman R, Zhu LJ, McConnell MJ, Tushir-Singh J, Green MR, Bhatnagar S.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7991-7996. doi: 10.1073/pnas.1803792115. Epub 2018 Jul 16.


Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia.

Pulido MR, Moreno-Martínez P, González-Galán V, Fernández Cuenca F, Pascual Á, Garnacho-Montero J, Antonelli M, Dimopoulos G, Lepe JA, McConnell MJ, Cisneros JM; MagicBullet Working Group.

Clin Microbiol Infect. 2018 Nov;24(11):1213.e1-1213.e4. doi: 10.1016/j.cmi.2018.06.001. Epub 2018 Jun 12.


Immunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection.

Pulido MR, García-Quintanilla M, Pachón J, McConnell MJ.

Vaccine. 2018 Jul 5;36(29):4153-4156. doi: 10.1016/j.vaccine.2018.05.113. Epub 2018 Jun 7.


Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii.

Carretero-Ledesma M, García-Quintanilla M, Martín-Peña R, Pulido MR, Pachón J, McConnell MJ.

Virulence. 2018 Dec 31;9(1):930-942. doi: 10.1080/21505594.2018.1460187.


Exploring opportunities to prevent cirrhosis admissions in the emergency department: A multicenter multidisciplinary survey.

Siddique SM, Lane-Fall M, McConnell MJ, Jakhete N, Crismale J, Porges S, Khungar V, Mehta SJ, Goldberg D, Li Z, Schiano T, Regan L, Orloski C, Shea JA.

Hepatol Commun. 2018 Jan 26;2(3):237-244. doi: 10.1002/hep4.1141. eCollection 2018 Mar.


Single-cell analysis of diversity in human stem cell-derived neurons.

Harbom LJ, Michel N, McConnell MJ.

Cell Tissue Res. 2018 Jan;371(1):171-179. doi: 10.1007/s00441-017-2728-3. Epub 2017 Nov 29. Review.


Mitochondrial transfer between cells: Methodological constraints in cell culture and animal models.

Berridge MV, Herst PM, Rowe MR, Schneider R, McConnell MJ.

Anal Biochem. 2018 Jul 1;552:75-80. doi: 10.1016/j.ab.2017.11.008. Epub 2017 Nov 21.


High incidence of pandrug-resistant Acinetobacter baumannii isolates collected from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial.

Nowak J, Zander E, Stefanik D, Higgins PG, Roca I, Vila J, McConnell MJ, Cisneros JM, Seifert H; MagicBullet Working Group WP4.

J Antimicrob Chemother. 2017 Dec 1;72(12):3277-3282. doi: 10.1093/jac/dkx322.


Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas.

Feldman LA, Fabre MS, Grasso C, Reid D, Broaddus WC, Lanza GM, Spiess BD, Garbow JR, McConnell MJ, Herst PM.

PLoS One. 2017 Sep 5;12(9):e0184250. doi: 10.1371/journal.pone.0184250. eCollection 2017.


High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells.

Castro ML, Carson GM, McConnell MJ, Herst PM.

Antioxidants (Basel). 2017 Jul 22;6(3). pii: E58. doi: 10.3390/antiox6030058.


The Mincle ligand trehalose dibehenate differentially modulates M1-like and M2-like macrophage phenotype and function via Syk signaling.

Kodar K, Harper JL, McConnell MJ, Timmer MSM, Stocker BL.

Immun Inflamm Dis. 2017 Dec;5(4):503-514. doi: 10.1002/iid3.186. Epub 2017 Jul 19.


Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.


Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2017 Mar 17;8:15047. doi: 10.1038/ncomms15047. No abstract available.


Using bacterial genomes and essential genes for the development of new antibiotics.

Fields FR, Lee SW, McConnell MJ.

Biochem Pharmacol. 2017 Jun 15;134:74-86. doi: 10.1016/j.bcp.2016.12.002. Epub 2016 Dec 8. Review.


Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles.

Connor LM, Tang SC, Cognard E, Ochiai S, Hilligan KL, Old SI, Pellefigues C, White RF, Patel D, Smith AA, Eccles DA, Lamiable O, McConnell MJ, Ronchese F.

J Exp Med. 2017 Jan;214(1):125-142. doi: 10.1084/jem.20160470. Epub 2016 Dec 2.


Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?

Berridge MV, Schneider RT, McConnell MJ.

Cell Metab. 2016 Sep 13;24(3):376-378. doi: 10.1016/j.cmet.2016.08.023.


Iterative sorting reveals CD133+ and CD133- melanoma cells as phenotypically distinct populations.

Grasso C, Anaka M, Hofmann O, Sompallae R, Broadley K, Hide W, Berridge MV, Cebon J, Behren A, McConnell MJ.

BMC Cancer. 2016 Sep 9;16(1):726. doi: 10.1186/s12885-016-2759-2.


Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2016 Jun 14;7:12020. doi: 10.1038/ncomms12020. No abstract available.


Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii.

García-Quintanilla M, Caro-Vega JM, Pulido MR, Moreno-Martínez P, Pachón J, McConnell MJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9. doi: 10.1128/AAC.00407-16. Print 2016 Aug.


Rapid Detection of Antibiotic Resistance in Gram-Negative Bacteria Through Assessment of Changes in Cellular Morphology.

Otero F, Santiso R, Tamayo M, Fernández JL, Bou G, Lepe JA, McConnell MJ, Gosálvez J, Cisneros JM.

Microb Drug Resist. 2017 Mar;23(2):157-162. doi: 10.1089/mdr.2016.0023. Epub 2016 Jun 3.


Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches.

Berridge MV, McConnell MJ, Grasso C, Bajzikova M, Kovarova J, Neuzil J.

Curr Opin Genet Dev. 2016 Jun;38:75-82. doi: 10.1016/j.gde.2016.04.003. Epub 2016 May 21. Review.


Clinical validation of a real-time polymerase chain reaction assay for rapid detection of Acinetobacter baumannii colonization.

Blanco-Lobo P, González-Galán V, García-Quintanilla M, Valencia R, Cazalla A, Martín C, Alonso I, Pérez-Romero P, Cisneros JM, Aznar J, McConnell MJ.

J Hosp Infect. 2016 Sep;94(1):68-71. doi: 10.1016/j.jhin.2016.04.008. Epub 2016 Apr 23.


Impaired growth under iron-limiting conditions associated with the acquisition of colistin resistance in Acinetobacter baumannii.

López-Rojas R, García-Quintanilla M, Labrador-Herrera G, Pachón J, McConnell MJ.

Int J Antimicrob Agents. 2016 Jun;47(6):473-7. doi: 10.1016/j.ijantimicag.2016.03.010. Epub 2016 Apr 22.


Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.

Jones NM, Rowe MR, Shepherd PR, McConnell MJ.

Int J Oncol. 2016 Jul;49(1):207-16. doi: 10.3892/ijo.2016.3510. Epub 2016 May 9.


N,N-Bis(glycityl)amines as anti-cancer drugs.

Waghorne CL, Corkran HM, Hunt-Painter AA, Niktab E, Baty JW, Berridge MV, Munkacsi AB, McConnell MJ, Timmer MSM, Stocker BL.

Bioorg Med Chem. 2016 Sep 1;24(17):3932-3939. doi: 10.1016/j.bmc.2016.04.016. Epub 2016 Apr 9.


Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJE, Parylak SL, Paquola ACM, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2016 Apr 19;7:11022. doi: 10.1038/ncomms11022. Erratum in: Nat Commun. 2016 Jun 14;7:12020. Nat Commun. 2017 Mar 17;8:15047.


Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design.

Blanco-Lobo P, Bulnes-Ramos Á, McConnell MJ, Navarro D, Pérez-Romero P.

Drug Discov Today. 2016 Apr;21(4):674-81. doi: 10.1016/j.drudis.2016.03.005. Epub 2016 Mar 11. Review.


A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis.

Sharlow ER, Leimgruber S, Lira A, McConnell MJ, Norambuena A, Bloom GS, Epperly MW, Greenberger JS, Lazo JS.

ACS Chem Biol. 2016 May 20;11(5):1428-37. doi: 10.1021/acschembio.5b00909. Epub 2016 Mar 14.


Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Song S, Miranda CJ, Braun L, Meyer K, Frakes AE, Ferraiuolo L, Likhite S, Bevan AK, Foust KD, McConnell MJ, Walker CM, Kaspar BK.

Nat Med. 2016 Apr;22(4):397-403. doi: 10.1038/nm.4052. Epub 2016 Feb 29.


Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons.

Krishnaswami SR, Grindberg RV, Novotny M, Venepally P, Lacar B, Bhutani K, Linker SB, Pham S, Erwin JA, Miller JA, Hodge R, McCarthy JK, Kelder M, McCorrison J, Aevermann BD, Fuertes FD, Scheuermann RH, Lee J, Lein ES, Schork N, McConnell MJ, Gage FH, Lasken RS.

Nat Protoc. 2016 Mar;11(3):499-524. doi: 10.1038/nprot.2016.015. Epub 2016 Feb 18.


Single neuron transcriptome analysis can reveal more than cell type classification: Does it matter if every neuron is unique?

Harbom LJ, Chronister WD, McConnell MJ.

Bioessays. 2016 Feb;38(2):157-61. doi: 10.1002/bies.201500097. Epub 2016 Jan 8. Review.


Identifying targets for antibiotic development using omics technologies.

Pulido MR, García-Quintanilla M, Gil-Marqués ML, McConnell MJ.

Drug Discov Today. 2016 Mar;21(3):465-72. doi: 10.1016/j.drudis.2015.11.014. Epub 2015 Dec 12. Review.


Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.


Vaccines for Antibiotic-Resistant Bacteria: Possibility or Pipe Dream?

García-Quintanilla M, Pulido MR, Carretero-Ledesma M, McConnell MJ.

Trends Pharmacol Sci. 2016 Feb;37(2):143-152. doi: 10.1016/ Epub 2015 Nov 10. Review.


A combination of tyrosine kinase inhibitors, crizotinib and dasatinib for the treatment of glioblastoma multiforme.

Nehoff H, Parayath NN, McConnell MJ, Taurin S, Greish K.

Oncotarget. 2015 Nov 10;6(35):37948-64. doi: 10.18632/oncotarget.5698.


Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.

McConnell MJ, Durand L, Langley E, Coste-Sarguet L, Zelent A, Chomienne C, Kouzarides T, Licht JD, Guidez F.

Epigenetics Chromatin. 2015 Sep 24;8:38. doi: 10.1186/s13072-015-0030-8. eCollection 2015.


Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii.

García-Quintanilla M, Carretero-Ledesma M, Moreno-Martínez P, Martín-Peña R, Pachón J, McConnell MJ.

Int J Antimicrob Agents. 2015 Dec;46(6):696-702. doi: 10.1016/j.ijantimicag.2015.07.017. Epub 2015 Sep 7.


Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model.

Grasso C, Fabre MS, Collis SV, Castro ML, Field CS, Schleich N, McConnell MJ, Herst PM.

Front Oncol. 2014 Dec 15;4:356. doi: 10.3389/fonc.2014.00356. eCollection 2014.


Immunization with lipopolysaccharide-deficient whole cells provides protective immunity in an experimental mouse model of Acinetobacter baumannii infection.

García-Quintanilla M, Pulido MR, Pachón J, McConnell MJ.

PLoS One. 2014 Dec 8;9(12):e114410. doi: 10.1371/journal.pone.0114410. eCollection 2014.


Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells.

Authier A, Farrand KJ, Broadley KW, Ancelet LR, Hunn MK, Stone S, McConnell MJ, Hermans IF.

Int J Cancer. 2015 Jun 1;136(11):2566-78. doi: 10.1002/ijc.29309. Epub 2014 Nov 12.


Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific.

Castro ML, McConnell MJ, Herst PM.

Free Radic Biol Med. 2014 Sep;74:200-9. doi: 10.1016/j.freeradbiomed.2014.06.022. Epub 2014 Jun 30.


Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae.

Olaya-Abril A, Prados-Rosales R, McConnell MJ, Martín-Peña R, González-Reyes JA, Jiménez-Munguía I, Gómez-Gascón L, Fernández J, Luque-García JL, García-Lidón C, Estévez H, Pachón J, Obando I, Casadevall A, Pirofski LA, Rodríguez-Ortega MJ.

J Proteomics. 2014 Jun 25;106:46-60. doi: 10.1016/j.jprot.2014.04.023. Epub 2014 Apr 24.


Activity of host antimicrobials against multidrug-resistant Acinetobacter baumannii acquiring colistin resistance through loss of lipopolysaccharide.

García-Quintanilla M, Pulido MR, Moreno-Martínez P, Martín-Peña R, López-Rojas R, Pachón J, McConnell MJ.

Antimicrob Agents Chemother. 2014 May;58(5):2972-5. doi: 10.1128/AAC.02642-13. Epub 2014 Feb 24.


Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene.

Szakacs TA, Kalan L, McConnell MJ, Eshaghi A, Shahinas D, McGeer A, Wright GD, Low DE, Patel SN.

J Clin Microbiol. 2014 May;52(5):1682-6. doi: 10.1128/JCM.03563-13. Epub 2014 Feb 12.


Ascorbate combination therapy: new tool in the anticancer toolbox?

McConnell MJ, Herst PM.

Sci Transl Med. 2014 Feb 5;6(222):222fs6. doi: 10.1126/scitranslmed.3008488.


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