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Items: 18


Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.

Perazzolo S, Shireman LM, Koehn J, McConnachie LA, Kraft JC, Shen DD, Ho RJY.

J Pharm Sci. 2018 Dec;107(12):3153-3162. doi: 10.1016/j.xphs.2018.07.032. Epub 2018 Aug 16.


Extended cell and plasma drug levels after one dose of a three-in-one nanosuspension containing lopinavir, efavirenz, and tenofovir in nonhuman primates.

Koehn J, Iwamoto JF, Kraft JC, McConnachie LA, Collier AC, Ho RJY.

AIDS. 2018 Nov 13;32(17):2463-2467. doi: 10.1097/QAD.0000000000001969.


Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection.

McConnachie LA, Kinman LM, Koehn J, Kraft JC, Lane S, Lee W, Collier AC, Ho RJY.

J Pharm Sci. 2018 Jul;107(7):1787-1790. doi: 10.1016/j.xphs.2018.03.005. Epub 2018 Mar 13.


Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation.

Kraft JC, McConnachie LA, Koehn J, Kinman L, Sun J, Collier AC, Collins C, Shen DD, Ho RJY.

J Control Release. 2018 Apr 10;275:229-241. doi: 10.1016/j.jconrel.2018.02.003. Epub 2018 Feb 10.


Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook.

Mu Q, Yu J, McConnachie LA, Kraft JC, Gao Y, Gulati GK, Ho RJY.

J Drug Target. 2018 Jun - Jul;26(5-6):435-447. doi: 10.1080/1061186X.2017.1419363. Epub 2018 Jan 10.


Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma.

Kraft JC, McConnachie LA, Koehn J, Kinman L, Collins C, Shen DD, Collier AC, Ho RJ.

AIDS. 2017 Mar 27;31(6):765-770. doi: 10.1097/QAD.0000000000001405.


Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains.

Scoville DK, White CC, Botta D, McConnachie LA, Zadworny ME, Schmuck SC, Hu X, Gao X, Yu J, Dills RL, Sheppard L, Delaney MA, Griffith WC, Beyer RP, Zangar RC, Pounds JG, Faustman EM, Kavanagh TJ.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):240-50. doi: 10.1016/j.taap.2015.09.019. Epub 2015 Oct 21.


The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

McConnachie LA, Botta D, White CC, Weldy CS, Wilkerson HW, Yu J, Dills R, Yu X, Griffith WC, Faustman EM, Farin FM, Gill SE, Parks WC, Hu X, Gao X, Eaton DL, Kavanagh TJ.

PLoS One. 2013 May 27;8(5):e64165. doi: 10.1371/journal.pone.0064165. Print 2013.


Heme oxygenase expression as a biomarker of exposure to amphiphilic polymer-coated CdSe/ZnS quantum dots.

McConnachie LA, White CC, Botta D, Zadworny ME, Cox DP, Beyer RP, Hu X, Eaton DL, Gao X, Kavanagh TJ.

Nanotoxicology. 2013 Mar;7(2):181-91. doi: 10.3109/17435390.2011.648224. Epub 2012 Jan 20.


Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.

Nakamura BN, Mohar I, Lawson GW, Cortés MM, Hoang YD, Ortiz L, Patel R, Rau BA, McConnachie LA, Kavanagh TJ, Luderer U.

Toxicol Sci. 2012 Mar;126(1):227-41. doi: 10.1093/toxsci/kfs017. Epub 2012 Jan 17.


Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.

Nakamura BN, Fielder TJ, Hoang YD, Lim J, McConnachie LA, Kavanagh TJ, Luderer U.

Endocrinology. 2011 Jul;152(7):2806-15. doi: 10.1210/en.2011-0207. Epub 2011 May 10.


Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.

Mohar I, Botta D, White CC, McConnachie LA, Kavanagh TJ.

Curr Protoc Toxicol. 2009 Feb;Chapter 6:Unit6.16. doi: 10.1002/0471140856.tx0616s39.


Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice.

Botta D, White CC, Vliet-Gregg P, Mohar I, Shi S, McGrath MB, McConnachie LA, Kavanagh TJ.

Drug Metab Rev. 2008;40(3):465-77. doi: 10.1080/03602530802186587 . Review.


Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C, Chatterton-Kirchmeier S, White CC, Pierce RH, Kavanagh TJ.

Toxicol Sci. 2007 Oct;99(2):628-36. Epub 2007 Jun 21.


Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium.

Toxicol Sci. 2007 Sep;99(1):326-37. Epub 2007 Jun 11.


Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency.

Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG.

Mol Pharmacol. 2006 Dec;70(6):2116-26. Epub 2006 Sep 25.


An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number.

McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ.

Genet Test. 2004 Fall;8(3):313-8.


Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.

McConnachie LA, Phillips B, Bajpai M, Shen DD, Ho RJ.

Drug Metab Dispos. 2003 Sep;31(9):1103-7.


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