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Items: 44


Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.

Pickhardt M, Neumann T, Schwizer D, Callaway K, Vendruscolo M, Schenk D, St George-Hyslop P, Mandelkow EM, Dobson CM, McConlogue L, Mandelkow E, Tóth G.

Curr Alzheimer Res. 2015;12(9):814-28.


Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L.

PLoS One. 2014 Feb 14;9(2):e87133. doi: 10.1371/journal.pone.0087133. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99274.


Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.

Gardai SJ, Mao W, Schüle B, Babcock M, Schoebel S, Lorenzana C, Alexander J, Kim S, Glick H, Hilton K, Fitzgerald JK, Buttini M, Chiou SS, McConlogue L, Anderson JP, Schenk DB, Bard F, Langston JW, Yednock T, Johnston JA.

PLoS One. 2013 Aug 23;8(8):e71634. doi: 10.1371/journal.pone.0071634. eCollection 2013.


Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.

Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D.

PLoS One. 2011 Apr 29;6(4):e19338. doi: 10.1371/journal.pone.0019338.


Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.

Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP.

J Biol Chem. 2009 Jan 30;284(5):2598-602. doi: 10.1074/jbc.C800206200. Epub 2008 Nov 12.


Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.


BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.

Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS.

Neurobiol Aging. 2008 Jun;29(6):861-73. Epub 2007 Feb 28.


Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.

Basi G, Frigon N, Barbour R, Doan T, Gordon G, McConlogue L, Sinha S, Zeller M.

J Biol Chem. 2003 Aug 22;278(34):31512-20. Epub 2003 Jun 11.


Key signaling pathways regulate the biological activities and accumulation of amyloid-beta.

Wyss-Coray T, McConlogue L, Kindy M, Schmidt AM, Du Yan S, Stern DM.

Neurobiol Aging. 2001 Nov-Dec;22(6):967-73. Review. No abstract available.


BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.


TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L.

Nat Med. 2001 May;7(5):612-8.


Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.

Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L.

J Biol Chem. 2001 Jun 8;276(23):20267-79. Epub 2001 Mar 7.


Recent advances in the understanding of the processing of APP to beta amyloid peptide.

Sinha S, Anderson J, John V, McConlogue L, Basi G, Thorsett E, Schenk D.

Ann N Y Acad Sci. 2000;920:206-8. Review. No abstract available.


A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.

Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG.

Nature. 2000 Dec 21-28;408(6815):975-9.


Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.

Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E.

Am J Pathol. 2000 Dec;157(6):2003-10.


High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L.

J Neurosci. 2000 Jun 1;20(11):4050-8.


Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.

Nature. 1999 Dec 2;402(6761):537-40.


Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3228-33.


Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.

Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L.

Nature. 1997 Oct 9;389(6651):603-6.


Individual isoforms of the amyloid beta precursor protein demonstrate differential adhesive potentials to constituents of the extracellular matrix.

Gillian AM, McFarlane I, Lucy FM, Overly C, McConlogue L, Breen KC.

J Neurosci Res. 1997 Jul 15;49(2):154-60.


Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.

Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L.

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1550-5.


Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.

Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L.

J Biol Chem. 1996 Dec 6;271(49):31407-11.


Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.

McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA.

J Biol Chem. 1996 Jan 19;271(3):1343-8.


Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.

Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L.

J Biol Chem. 1995 Nov 24;270(47):28257-67.


The potential utility of transgenic mice harboring beta-amyloid precursor protein.

Schenk D, Games KD, McConlogue L.

Neurobiol Aging. 1995 Jul-Aug;16(4):711-3; discussion 715-8. No abstract available.


Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases.

Knops J, Suomensaari S, Lee M, McConlogue L, Seubert P, Sinha S.

J Biol Chem. 1995 Feb 10;270(6):2419-22.


Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells.

Kosik KS, McConlogue L.

Cell Motil Cytoskeleton. 1994;28(3):195-8. Review.


Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ.

Nature. 1992 Dec 17;360(6405):672-4.


The beta-amyloid precursor protein is not processed by the regulated secretory pathway.

Overly CC, Fritz LC, Lieberburg I, McConlogue L.

Biochem Biophys Res Commun. 1991 Dec 16;181(2):513-9.


Overexpression of tau in a nonneuronal cell induces long cellular processes.

Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L.

J Cell Biol. 1991 Aug;114(4):725-33.


Isolation of baculovirus-derived secreted and full-length beta-amyloid precursor protein.

Knops J, Johnson-Wood K, Schenk DB, Sinha S, Lieberburg I, McConlogue L.

J Biol Chem. 1991 Apr 15;266(11):7285-90.


Structure-independent DNA amplification by PCR using 7-deaza-2'-deoxyguanosine.

McConlogue L, Brow MA, Innis MA.

Nucleic Acids Res. 1988 Oct 25;16(20):9869. No abstract available.


Mouse ornithine decarboxylase gene: cloning, structure, and expression.

Brabant M, McConlogue L, van Daalen Wetters T, Coffino P.

Proc Natl Acad Sci U S A. 1988 Apr;85(7):2200-4.


Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells.

Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P.

Proc Natl Acad Sci U S A. 1985 Sep;82(17):5761-5.


Molecular cloning and expression of the mouse ornithine decarboxylase gene.

McConlogue L, Gupta M, Wu L, Coffino P.

Proc Natl Acad Sci U S A. 1984 Jan;81(2):540-4.


A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.

McConlogue L, Coffino P.

J Biol Chem. 1983 Oct 25;258(20):12083-6.


Radioimmune assay of induction and removal of uv lesions in total and staphylococcal nuclease-resistant DNA of mammalian chromatin.

McConlogue LC, Ward JF, Lewis HL, Norman A.

Radiat Res. 1982 Feb;89(2):381-95. No abstract available.


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