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Items: 49

1.

Downregulation of the Central Noradrenergic System by Toxoplasma gondii Infection.

Alsaady I, Tedford E, Alsaad M, Bristow G, Kohli S, Murray M, Reeves M, Vijayabaskar MS, Clapcote SJ, Wastling J, McConkey GA.

Infect Immun. 2019 Jan 24;87(2). pii: e00789-18. doi: 10.1128/IAI.00789-18. Print 2019 Feb.

2.

Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.

McConkey GA, Bedingfield PTP, Burrell DR, Chambers NC, Cunningham F, Prior TJ, Fishwick CWG, Boa AN.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3878-3882. doi: 10.1016/j.bmcl.2017.06.052. Epub 2017 Jun 21.

3.

Experimental Toxoplasmosis in Rats Induced Orally with Eleven Strains of Toxoplasma gondii of Seven Genotypes: Tissue Tropism, Tissue Cyst Size, Neural Lesions, Tissue Cyst Rupture without Reactivation, and Ocular Lesions.

Dubey JP, Ferreira LR, Alsaad M, Verma SK, Alves DA, Holland GN, McConkey GA.

PLoS One. 2016 May 26;11(5):e0156255. doi: 10.1371/journal.pone.0156255. eCollection 2016.

4.

Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells.

Martin HL, Alsaady I, Howell G, Prandovszky E, Peers C, Robinson P, McConkey GA.

Neuroscience. 2015 Oct 15;306:50-62. doi: 10.1016/j.neuroscience.2015.08.005. Epub 2015 Aug 20.

5.

Reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity.

McConkey GA, Peers C, Prandovszky E.

Infect Immun. 2015 Aug;83(8):3334-5. doi: 10.1128/IAI.00605-15. No abstract available.

6.

Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6345-53. doi: 10.1128/AAC.02640-14. Epub 2014 Jul 21.

7.

Toxoplasma gondii infection and behaviour - location, location, location?

McConkey GA, Martin HL, Bristow GC, Webster JP.

J Exp Biol. 2013 Jan 1;216(Pt 1):113-9. doi: 10.1242/jeb.074153. Review.

8.

Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?

Webster JP, Kaushik M, Bristow GC, McConkey GA.

J Exp Biol. 2013 Jan 1;216(Pt 1):99-112. doi: 10.1242/jeb.074716.

9.

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP.

J Med Chem. 2012 Jun 28;55(12):5841-50. doi: 10.1021/jm300157n. Epub 2012 Jun 15.

PMID:
22621375
10.

The neurotropic parasite Toxoplasma gondii increases dopamine metabolism.

Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA.

PLoS One. 2011;6(9):e23866. doi: 10.1371/journal.pone.0023866. Epub 2011 Sep 21.

11.

Gene function prediction using semantic similarity clustering and enrichment analysis in the malaria parasite Plasmodium falciparum.

Tedder PM, Bradford JR, Needham CJ, McConkey GA, Bulpitt AJ, Westhead DR.

Bioinformatics. 2010 Oct 1;26(19):2431-7. doi: 10.1093/bioinformatics/btq450. Epub 2010 Aug 6.

PMID:
20693320
12.

MetNetMaker: a free and open-source tool for the creation of novel metabolic networks in SBML format.

Forth T, McConkey GA, Westhead DR.

Bioinformatics. 2010 Sep 15;26(18):2352-3. doi: 10.1093/bioinformatics/btq425. Epub 2010 Jul 29.

PMID:
20671147
13.

Toxoplasma gondii-altered host behaviour: clues as to mechanism of action.

Webster JP, McConkey GA.

Folia Parasitol (Praha). 2010 Jun;57(2):95-104. Review.

14.

PlasmoPredict: a gene function prediction website for Plasmodium falciparum.

Tedder PM, Bradford JR, McConkey GA, Bulpitt AJ, Westhead DR.

Trends Parasitol. 2010 Mar;26(3):107-10. doi: 10.1016/j.pt.2009.12.004. Epub 2010 Jan 19.

PMID:
20089451
15.

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1284-7. doi: 10.1016/j.bmcl.2009.11.079. Epub 2009 Nov 27.

PMID:
20034791
16.

Alio intuitu: the automated reconstruction of the metabolic networks of parasites.

Whitaker JW, Westhead DR, McConkey GA.

Trends Parasitol. 2009 Sep;25(9):396-7. doi: 10.1016/j.pt.2009.06.001. Epub 2009 Aug 28. No abstract available.

PMID:
19717343
17.

Prediction of horizontal gene transfers in eukaryotes: approaches and challenges.

Whitaker JW, McConkey GA, Westhead DR.

Biochem Soc Trans. 2009 Aug;37(Pt 4):792-5. doi: 10.1042/BST0370792. Review. Erratum in: Biochem Soc Trans. 2009 Oct;37(Pt 5):1145.

PMID:
19614596
18.

The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes.

Whitaker JW, McConkey GA, Westhead DR.

Genome Biol. 2009;10(4):R36. doi: 10.1186/gb-2009-10-4-r36. Epub 2009 Apr 15.

19.

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP.

J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t.

PMID:
19351152
20.

A unique dual activity amino acid hydroxylase in Toxoplasma gondii.

Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA.

PLoS One. 2009;4(3):e4801. doi: 10.1371/journal.pone.0004801. Epub 2009 Mar 11.

21.

metaTIGER: a metabolic evolution resource.

Whitaker JW, Letunic I, McConkey GA, Westhead DR.

Nucleic Acids Res. 2009 Jan;37(Database issue):D531-8. doi: 10.1093/nar/gkn826. Epub 2008 Oct 25.

22.

Metabolic reconstruction and analysis for parasite genomes.

Pinney JW, Papp B, Hyland C, Wambua L, Westhead DR, McConkey GA.

Trends Parasitol. 2007 Nov;23(11):548-54. Epub 2007 Oct 22. Review.

PMID:
17950669
23.

Nucleoside transport as a potential target for chemotherapy in malaria.

Baldwin SA, McConkey GA, Cass CE, Young JD.

Curr Pharm Des. 2007;13(6):569-80. Review.

PMID:
17346175
24.

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA.

J Med Chem. 2007 Jan 25;50(2):186-91.

PMID:
17228860
25.

metaSHARK: a WWW platform for interactive exploration of metabolic networks.

Hyland C, Pinney JW, McConkey GA, Westhead DR.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W725-8.

26.

Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.

McRobert L, Jiang S, Stead A, McConkey GA.

Exp Parasitol. 2005 Nov;111(3):178-81. Epub 2005 Sep 6.

PMID:
16140296
27.
28.

Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase.

Boa AN, Canavan SP, Hirst PR, Ramsey C, Stead AM, McConkey GA.

Bioorg Med Chem. 2005 Mar 15;13(6):1945-67.

PMID:
15727850
29.

Annotating the Plasmodium genome and the enigma of the shikimate pathway.

McConkey GA, Pinney JW, Westhead DR, Plueckhahn K, Fitzpatrick TB, Macheroux P, Kappes B.

Trends Parasitol. 2004 Feb;20(2):60-5. Review.

PMID:
14747018
30.

Petri Net representations in systems biology.

Pinney JW, Westhead DR, McConkey GA.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1513-5. Review.

PMID:
14641101
31.

RNA interference (RNAi) inhibits growth of Plasmodium falciparum.

McRobert L, McConkey GA.

Mol Biochem Parasitol. 2002 Feb;119(2):273-8.

PMID:
11814579
32.

Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy.

Parker MD, Hyde RJ, Yao SY, McRobert L, Cass CE, Young JD, McConkey GA, Baldwin SA.

Biochem J. 2000 Jul 1;349(Pt 1):67-75.

33.

Expression of TetC fusion proteins from Salmonella in a gaseous environment that models conditions found in mammalian tissues.

Heal KG, McConkey GA, Hormaeche CE, Hollingdale MR, Khan CM, Taylor-Robinson AW.

Biotechniques. 2000 Feb;28(2):228-30, 232. No abstract available.

34.
35.

Identification of the transcription initiation site of the asexually expressed rRNA genes of the malaria parasite Plasmodium berghei.

van Spaendonk RM, McConkey GA, Ramesar J, Gabrielian A, McCutchan TF, Janse CJ, Waters AP.

Mol Biochem Parasitol. 1999 Apr 30;99(2):193-205.

PMID:
10340484
36.

Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.

McConkey GA.

Antimicrob Agents Chemother. 1999 Jan;43(1):175-7.

37.
38.

Parasite diversity in an endemic region for avian malaria and identification of a parasite causing penguin mortality.

McConkey GA, Li J, Rogers MJ, Seeley DC Jr, Graczyk TK, Cranfield MR, McCutchan TF.

J Eukaryot Microbiol. 1996 Sep-Oct;43(5):393-9.

PMID:
8822810
39.
40.

The ribosomal DNA loci in Plasmodium falciparum accumulate mutations independently.

Rogers MJ, McConkey GA, Li J, McCutchan TF.

J Mol Biol. 1995 Dec 15;254(5):881-91.

PMID:
7500358
41.

Plasmodium: genus-conserved primers for species identification and quantitation.

Li J, Wirtz RA, McConkey GA, Sattabongkot J, Waters AP, Rogers MJ, McCutchan TF.

Exp Parasitol. 1995 Sep;81(2):182-90.

PMID:
7556560
42.

The cytoplasmic ribosomal RNAs of Plasmodium spp.

McCutchan TF, Li J, McConkey GA, Rogers MJ, Waters AP.

Parasitol Today. 1995 Apr;11(4):134-8.

PMID:
15275356
43.

Mechanisms of pyrimethamine resistance in two different strains of Plasmodium berghei.

van Dijk MR, McConkey GA, Vinkenoog R, Waters AP, Janse CJ.

Mol Biochem Parasitol. 1994 Nov;68(1):167-71. No abstract available.

PMID:
7891743
44.

Plasmodium: the developmentally regulated ribosome.

Li J, McConkey GA, Rogers MJ, Waters AP, McCutchan TR.

Exp Parasitol. 1994 Jun;78(4):437-41. Review. No abstract available.

PMID:
8206146
45.

Transition of Plasmodium vivax ribosome types corresponds to sporozoite differentiation in the mosquito.

Li J, Wirtz RA, McConkey GA, Sattabongkot J, McCutchan TF.

Mol Biochem Parasitol. 1994 Jun;65(2):283-9.

PMID:
7969269
46.

Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth.

McConkey GA, Ittarat I, Meshnick SR, McCutchan TF.

Proc Natl Acad Sci U S A. 1994 May 10;91(10):4244-8.

47.

The generation of genetic diversity in malaria parasites.

McConkey GA, Waters AP, McCutchan TF.

Annu Rev Microbiol. 1990;44:479-98. Review.

PMID:
2252391
48.

TFIIIA binds with equal affinity to somatic and major oocyte 5S RNA genes.

McConkey GA, Bogenhagen DF.

Genes Dev. 1988 Feb;2(2):205-14.

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