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Correlation between model observers in uniform background and human observers in patient liver background for a low-contrast detection task in CT.

Gong H, Yu L, Leng S, Dilger S, Zhou W, Ren L, McCollough CH.

Proc SPIE Int Soc Opt Eng. 2018 Feb;10577. pii: 105770M. doi: 10.1117/12.2294955. Epub 2018 Mar 7.


150-μm Spatial Resolution Using Photon-Counting Detector Computed Tomography Technology: Technical Performance and First Patient Images.

Leng S, Rajendran K, Gong H, Zhou W, Halaweish AF, Henning A, Kappler S, Baer M, Fletcher JG, McCollough CH.

Invest Radiol. 2018 May 28. doi: 10.1097/RLI.0000000000000488. [Epub ahead of print]


Evaluation of projection- and dual-energy-based methods for metal artifact reduction in CT using a phantom study.

Long Z, Bruesewitz MR, DeLone DR, Morris JM, Amrami KK, Adkins MC, Glazebrook KN, Kofler JM, Leng S, McCollough CH, Fletcher JG, Halaweish AF, Yu L.

J Appl Clin Med Phys. 2018 Jul;19(4):252-260. doi: 10.1002/acm2.12347. Epub 2018 May 10.


Targeted Imaging of Renal Fibrosis Using Antibody-Conjugated Gold Nanoparticles in Renal Artery Stenosis.

Zhu XY, Zou X, Mukherjee R, Yu Z, Ferguson CM, Zhou W, McCollough CH, Lerman LO.

Invest Radiol. 2018 Apr 28. doi: 10.1097/RLI.0000000000000476. [Epub ahead of print]


Three-Material Decomposition in Multi-energy CT: Impact of Prior Information on Noise and Bias.

Ren L, McCollough CH, Yu L.

Proc SPIE Int Soc Opt Eng. 2018 Mar;10573. pii: 105731G. doi: 10.1117/12.2294953.


Imaging findings of mammary and systemic silicone deposition secondary to breast implants.

Samreen N, Glazebrook KN, Bhatt A, Venkatesh SK, McMenomy BP, Chandra A, Leng S, Adler KE, McCollough CH.

Br J Radiol. 2018 May 10:20180098. doi: 10.1259/bjr.20180098. [Epub ahead of print]


Validation of imaging-based quantification of glenohumeral joint kinematics using an unmodified clinical biplane fluoroscopy system.

Mozingo JD, Akbari Shandiz M, Marquez FM, Schueler BA, Holmes DR 3rd, McCollough CH, Zhao KD.

J Biomech. 2018 Apr 11;71:306-312. doi: 10.1016/j.jbiomech.2018.02.012. Epub 2018 Feb 13.


Characterization of Urinary Stone Composition by Use of Whole-body, Photon-counting Detector CT.

Ferrero A, Gutjahr R, Halaweish AF, Leng S, McCollough CH.

Acad Radiol. 2018 Feb 14. pii: S1076-6332(18)30019-9. doi: 10.1016/j.acra.2018.01.007. [Epub ahead of print]


The Changing Incidence and Presentation of Urinary Stones Over 3 Decades.

Kittanamongkolchai W, Vaughan LE, Enders FT, Dhondup T, Mehta RA, Krambeck AE, McCollough CH, Vrtiska TJ, Lieske JC, Rule AD.

Mayo Clin Proc. 2018 Mar;93(3):291-299. doi: 10.1016/j.mayocp.2017.11.018. Epub 2018 Feb 14.


Intrarenal fat deposition does not interfere with the measurement of single-kidney perfusion in obese swine using multi-detector computed tomography.

Ferguson CM, Eirin A, Michalak GJ, Hedayat AF, Abumoawad A, Saad A, Zhu X, Textor SC, McCollough CH, Lerman LO.

J Cardiovasc Comput Tomogr. 2018 Mar - Apr;12(2):149-152. doi: 10.1016/j.jcct.2018.01.003. Epub 2018 Jan 10.


Measuring arterial wall perfusion using photon-counting computed tomography (CT): improving CT number accuracy of artery wall using image deconvolution.

Rajendran K, Leng S, Jorgensen SM, Anderson JL, Halaweish AF, Abdurakhimova D, Ritman EL, McCollough CH.

J Med Imaging (Bellingham). 2017 Oct;4(4):044006. doi: 10.1117/1.JMI.4.4.044006. Epub 2017 Dec 8.


CT Dental Artifact: Comparison of an Iterative Metal Artifact Reduction Technique with Weighted Filtered Back-Projection.

Diehn FE, Michalak GJ, DeLone DR, Kotsenas AL, Lindell EP, Campeau NG, Halaweish AF, McCollough CH, Fletcher JG.

Acta Radiol Open. 2017 Nov 26;6(11):2058460117743279. doi: 10.1177/2058460117743279. eCollection 2017 Nov.


Phase-contrast imaging with a compact x-ray light source: system design.

Sung Y, Gupta R, Nelson B, Leng S, McCollough CH, Graves WS.

J Med Imaging (Bellingham). 2017 Oct;4(4):043503. doi: 10.1117/1.JMI.4.4.043503. Epub 2017 Nov 23.


Lung nodule volume quantification and shape differentiation with an ultra-high resolution technique on a photon-counting detector computed tomography system.

Zhou W, Montoya J, Gutjahr R, Ferrero A, Halaweish A, Kappler S, McCollough C, Leng S.

J Med Imaging (Bellingham). 2017 Oct;4(4):043502. doi: 10.1117/1.JMI.4.4.043502. Epub 2017 Nov 16.


Reproducible imaging features of biologically aggressive gastrointestinal stromal tumors of the small bowel.

Maldonado FJ, Sheedy SP, Iyer VR, Hansel SL, Bruining DH, McCollough CH, Harmsen WS, Barlow JM, Fletcher JG.

Abdom Radiol (NY). 2018 Jul;43(7):1567-1574. doi: 10.1007/s00261-017-1370-6.


Validation of proton stopping power ratio estimation based on dual energy CT using fresh tissue samples.

Taasti VT, Michalak GJ, Hansen DC, Deisher AJ, Kruse JJ, Krauss B, Muren LP, Petersen JBB, McCollough CH.

Phys Med Biol. 2017 Dec 14;63(1):015012. doi: 10.1088/1361-6560/aa952f.


Low-dose CT for the detection and classification of metastatic liver lesions: Results of the 2016 Low Dose CT Grand Challenge.

McCollough CH, Bartley AC, Carter RE, Chen B, Drees TA, Edwards P, Holmes DR 3rd, Huang AE, Khan F, Leng S, McMillan KL, Michalak GJ, Nunez KM, Yu L, Fletcher JG.

Med Phys. 2017 Oct;44(10):e339-e352. doi: 10.1002/mp.12345.


Low kV versus dual-energy virtual monoenergetic CT imaging for proven liver lesions: what are the advantages and trade-offs in conspicuity and image quality? A pilot study.

Hanson GJ, Michalak GJ, Childs R, McCollough B, Kurup AN, Hough DM, Frye JM, Fidler JL, Venkatesh SK, Leng S, Yu L, Halaweish AF, Harmsen WS, McCollough CH, Fletcher JG.

Abdom Radiol (NY). 2018 Jun;43(6):1404-1412. doi: 10.1007/s00261-017-1327-9.


Use of a channelized Hotelling observer to assess CT image quality and optimize dose reduction for iteratively reconstructed images.

Favazza CP, Ferrero A, Yu L, Leng S, McMillan KL, McCollough CH.

J Med Imaging (Bellingham). 2017 Jul;4(3):031213. doi: 10.1117/1.JMI.4.3.031213. Epub 2017 Oct 3.


Dual Energy CT Kidney Stone Differentiation in Photon Counting Computed Tomography.

Gutjahr R, Polster C, Henning A, Kappler S, Leng S, McCollough CH, Sedlmair MU, Schmidt B, Krauss B, Flohr TG.

Proc SPIE Int Soc Opt Eng. 2017 Mar;10132. pii: 1013237. doi: 10.1117/12.2252021.


Practical implementation of Channelized Hotelling Observers: Effect of ROI size.

Ferrero A, Favazza CP, Yu L, Leng S, McCollough CH.

Proc SPIE Int Soc Opt Eng. 2017 Mar;10132. pii: 101320G. doi: 10.1117/12.2255530.


A comparison of relative proton stopping power measurements across patient size using dual- and single-energy CT.

Michalak G, Taasti V, Krauss B, Deisher A, Halaweish A, McCollough C.

Acta Oncol. 2017 Nov;56(11):1465-1471. doi: 10.1080/0284186X.2017.1372625. Epub 2017 Sep 8.


Spectral performance of a whole-body research photon counting detector CT: quantitative accuracy in derived image sets.

Leng S, Zhou W, Yu Z, Halaweish A, Krauss B, Schmidt B, Yu L, Kappler S, McCollough C.

Phys Med Biol. 2017 Aug 21;62(17):7216-7232. doi: 10.1088/1361-6560/aa8103.


Estimation of signal and noise for a whole-body research photon-counting CT system.

Li Z, Leng S, Yu Z, Kappler S, McCollough CH.

J Med Imaging (Bellingham). 2017 Apr;4(2):023505. doi: 10.1117/1.JMI.4.2.023505. Epub 2017 Jun 22.


Utility of single-energy and dual-energy computed tomography in clot characterization: An in-vitro study.

Brinjikji W, Michalak G, Kadirvel R, Dai D, Gilvarry M, Duffy S, Kallmes DF, McCollough C, Leng S.

Interv Neuroradiol. 2017 Jun;23(3):279-284. doi: 10.1177/1591019917694479. Epub 2017 Jan 1.


Cochlear Implant Electrode Localization Using an Ultra-High Resolution Scan Mode on Conventional 64-Slice and New Generation 192-Slice Multi-Detector Computed Tomography.

Carlson ML, Leng S, Diehn FE, Witte RJ, Krecke KN, Grimes J, Koeller KK, Bruesewitz MR, McCollough CH, Lane JI.

Otol Neurotol. 2017 Aug;38(7):978-984. doi: 10.1097/MAO.0000000000001463.


Correlation between a 2D channelized Hotelling observer and human observers in a low-contrast detection task with multislice reading in CT.

Yu L, Chen B, Kofler JM, Favazza CP, Leng S, Kupinski MA, McCollough CH.

Med Phys. 2017 Aug;44(8):3990-3999. doi: 10.1002/mp.12380. Epub 2017 Jul 13.


Estimating patient dose from CT exams that use automatic exposure control: Development and validation of methods to accurately estimate tube current values.

McMillan K, Bostani M, Cagnon CH, Yu L, Leng S, McCollough CH, McNitt-Gray MF.

Med Phys. 2017 Aug;44(8):4262-4275. doi: 10.1002/mp.12314. Epub 2017 Jun 30.


Renal Stone Characterization using High Resolution Imaging Mode on a Photon Counting Detector CT System.

Ferrero A, Gutjahr R, Henning A, Kappler S, Halaweish A, Abdurakhimova D, Peterson Z, Montoya J, Leng S, McCollough C.

Proc SPIE Int Soc Opt Eng. 2017 Mar 9;10132. pii: 101323J. doi: 10.1117/12.2255651. Epub 2017 Feb 11.


Detection of increased vasa vasorum in artery walls: Improving CT number accuracy using image deconvolution.

Rajendran K, Leng S, Jorgensen SM, Abdurakhimova D, Ritman EL, McCollough CH.

Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10132. pii: 101323O. doi: 10.1117/12.2255676. Epub 2017 Mar 9.


Consistency of Renal Stone Volume Measurements Across CT Scanner Model and Reconstruction Algorithm Configurations.

Huang AE, Montoya JC, Shiung M, Leng S, McCollough CH.

AJR Am J Roentgenol. 2017 Jul;209(1):116-121. doi: 10.2214/AJR.16.16940. Epub 2017 Apr 12.


Evaluation of a projection-domain lung nodule insertion technique in thoracic computed tomography.

Ma C, Yu L, Chen B, Koo CW, Takahashi EA, Fletcher JG, Levin DL, Kuzo RS, Viers LD, Vincent-Sheldon SA, Leng S, McCollough CH.

J Med Imaging (Bellingham). 2017 Jan;4(1):013510. doi: 10.1117/1.JMI.4.1.013510. Epub 2017 Mar 31.


Ultra-High Spatial Resolution, Multi-Energy CT using Photon Counting Detector Technology.

Leng S, Gutjahr R, Ferrero A, Kappler S, Henning A, Halaweish A, Zhou W, Montoya J, McCollough C.

Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10132. pii: 101320Y. doi: 10.1117/12.2255589. Epub 2017 Mar 9.


A virtual clinical trial using projection-based nodule insertion to determine radiologist reader performance in lung cancer screening CT.

Yu L, Hu Q, Koo CW, Takahashi EA, Levin DL, Johnson TF, Hora MJ, Dirks S, Chen B, McMillan K, Leng S, Fletcher JG, McCollough CH.

Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10132. pii: 101321R. doi: 10.1117/12.2255593. Epub 2017 Mar 9.


Lung Nodule Volume Quantification and Shape Differentiation with an Ultra-High Resolution Technique on a Photon Counting Detector CT System.

Zhou W, Montoya J, Gutjahr R, Ferrero A, Halaweish A, Kappler S, McCollough C, Leng S.

Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10132. pii: 101323Q. doi: 10.1117/12.2255736. Epub 2017 Mar 9.


Selection of optimal tube potential settings for dual-energy CT virtual mono-energetic imaging of iodine in the abdomen.

Michalak G, Grimes J, Fletcher J, Halaweish A, Yu L, Leng S, McCollough C.

Abdom Radiol (NY). 2017 Sep;42(9):2289-2296. doi: 10.1007/s00261-017-1122-7.


Estimation of Observer Performance for Reduced Radiation Dose Levels in CT: Eliminating Reduced Dose Levels That Are Too Low Is the First Step.

Fletcher JG, Yu L, Fidler JL, Levin DL, DeLone DR, Hough DM, Takahashi N, Venkatesh SK, Sykes AG, White D, Lindell RM, Kotsenas AL, Campeau NG, Lehman VT, Bartley AC, Leng S, Holmes DR 3rd, Toledano AY, Carter RE, McCollough CH.

Acad Radiol. 2017 Jul;24(7):876-890. doi: 10.1016/j.acra.2016.12.017. Epub 2017 Mar 2.


Technical Note: Insertion of digital lesions in the projection domain for dual-source, dual-energy CT.

Ferrero A, Chen B, Li Z, Yu L, McCollough C.

Med Phys. 2017 May;44(5):1655-1660. doi: 10.1002/mp.12185. Epub 2017 Apr 17.


An effective noise reduction method for multi-energy CT images that exploit spatio-spectral features.

Li Z, Leng S, Yu L, Manduca A, McCollough CH.

Med Phys. 2017 May;44(5):1610-1623. doi: 10.1002/mp.12174. Epub 2017 Apr 12.


Reducing Iodine Contrast Volume in CT Angiography of the Abdominal Aorta Using Integrated Tube Potential Selection and Weight-Based Method Without Compromising Image Quality.

Vasconcelos R, Vrtiska TJ, Foley TA, Macedo TA, Cardona JC, Williamson EE, McCollough CH, Fletcher JG.

AJR Am J Roentgenol. 2017 Mar;208(3):552-563. doi: 10.2214/AJR.16.16613.


Low-Dose CT for Craniosynostosis: Preserving Diagnostic Benefit with Substantial Radiation Dose Reduction.

Montoya JC, Eckel LJ, DeLone DR, Kotsenas AL, Diehn FE, Yu L, Bartley AC, Carter RE, McCollough CH, Fletcher JG.

AJNR Am J Neuroradiol. 2017 Apr;38(4):672-677. doi: 10.3174/ajnr.A5063. Epub 2017 Feb 9.


Advocating for use of the ALARA principle in the context of medical imaging fails to recognize that the risk is hypothetical and so serves to reinforce patients' fears of radiation.

Siegel JA, McCollough CH, Orton CG.

Med Phys. 2017 Jan;44(1):3-6. doi: 10.1002/mp.12012. Epub 2017 Jan 3. No abstract available.


Dose-efficient ultrahigh-resolution scan mode using a photon counting detector computed tomography system.

Leng S, Yu Z, Halaweish A, Kappler S, Hahn K, Henning A, Li Z, Lane J, Levin DL, Jorgensen S, Ritman E, McCollough C.

J Med Imaging (Bellingham). 2016 Oct;3(4):043504. doi: 10.1117/1.JMI.3.4.043504. Epub 2016 Dec 22.


Anatomic modeling using 3D printing: quality assurance and optimization.

Leng S, McGee K, Morris J, Alexander A, Kuhlmann J, Vrieze T, McCollough CH, Matsumoto J.

3D Print Med. 2017;3(1):6. doi: 10.1186/s41205-017-0014-3. Epub 2017 Apr 26.


Subjective and objective heterogeneity scores for differentiating small renal masses using contrast-enhanced CT.

Leng S, Takahashi N, Gomez Cardona D, Kitajima K, McCollough B, Li Z, Kawashima A, Leibovich BC, McCollough CH.

Abdom Radiol (NY). 2017 May;42(5):1485-1492. doi: 10.1007/s00261-016-1014-2.


Noise performance of low-dose CT: comparison between an energy integrating detector and a photon counting detector using a whole-body research photon counting CT scanner.

Yu Z, Leng S, Kappler S, Hahn K, Li Z, Halaweish AF, Henning A, McCollough CH.

J Med Imaging (Bellingham). 2016 Oct;3(4):043503. doi: 10.1117/1.JMI.3.4.043503. Epub 2016 Dec 14.


Technical Note: Display window setting: An important factor for detecting subtle but clinically relevant artifacts in daily CT quality control.

Long Z, Bruesewitz MR, Sheedy EN, Powell MA, Kramer JC, Supalla RR, Colvin CM, Bechel JR, Favazza CP, Kofler JM, Leng S, McCollough CH, Yu L.

Med Phys. 2016 Dec;43(12):6413.


Arterial Wall Perfusion Measured with Photon Counting Spectral X-ray CT.

Jorgensen SM, Korinek MJ, Vercnocke AJ, Anderson JL, Halaweish A, Leng S, McCollough CH, Ritman EL.

Proc SPIE Int Soc Opt Eng. 2016 Aug 28;9967. pii: 99670B. Epub 2016 Oct 4.


Evaluation of a photon counting Medipix3RX CZT spectral x-ray detector.

Jorgensen SM, Vercnocke AJ, Rundle DS, Butler PH, McCollough CH, Ritman EL.

Proc SPIE Int Soc Opt Eng. 2016 Aug 28;9969. pii: 99690J. Epub 2016 Oct 3.


The Role of Dynamic (4D) CT in the Detection of Scapholunate Ligament Injury.

Kakar S, Breighner RE, Leng S, McCollough CH, Moran SL, Berger RA, Zhao KD.

J Wrist Surg. 2016 Nov;5(4):306-310. Epub 2016 Jan 18.

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