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Large deletions induced by Cas9 cleavage.

Adikusuma F, Piltz S, Corbett MA, Turvey M, McColl SR, Helbig KJ, Beard MR, Hughes J, Pomerantz RT, Thomas PQ.

Nature. 2018 Aug;560(7717):E8-E9. doi: 10.1038/s41586-018-0380-z. Epub 2018 Aug 8. No abstract available.


The Emerging Complexity of γδT17 Cells.

McKenzie DR, Comerford I, Silva-Santos B, McColl SR.

Front Immunol. 2018 Apr 20;9:796. doi: 10.3389/fimmu.2018.00796. eCollection 2018. Review.


Atypical chemokine receptor 4 shapes activated B cell fate.

Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR.

J Exp Med. 2018 Mar 5;215(3):801-813. doi: 10.1084/jem.20171067. Epub 2018 Jan 31.


Redirecting adult mesenchymal stromal cells to the brain: a new approach for treating CNS autoimmunity and neuroinflammation?

Wilson JJ, Foyle KL, Foeng J, Norton T, McKenzie DR, Payne N, Bernard CC, McColl SR, Comerford I.

Immunol Cell Biol. 2018 Apr;96(4):347-357. doi: 10.1111/imcb.12014. Epub 2018 Mar 2. Review.


Chemokine-Driven CD4+ T Cell Homing: New Concepts and Recent Advances.

Gregor CE, Foeng J, Comerford I, McColl SR.

Adv Immunol. 2017;135:119-181. doi: 10.1016/ Epub 2017 Apr 28. Review.


Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.


IL-17-producing γδ T cells switch migratory patterns between resting and activated states.

McKenzie DR, Kara EE, Bastow CR, Tyllis TS, Fenix KA, Gregor CE, Wilson JJ, Babb R, Paton JC, Kallies A, Nutt SL, Brüstle A, Mack M, Comerford I, McColl SR.

Nat Commun. 2017 Jun 5;8:15632. doi: 10.1038/ncomms15632.


Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells.

Boyle ST, Gieniec KA, Gregor CE, Faulkner JW, McColl SR, Kochetkova M.

Mol Cancer. 2017 Jan 31;16(1):19. doi: 10.1186/s12943-017-0592-0.


The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine.

David SC, Lau J, Singleton EV, Babb R, Davies J, Hirst TR, McColl SR, Paton JC, Alsharifi M.

Vaccine. 2017 Feb 15;35(7):1071-1079. doi: 10.1016/j.vaccine.2016.12.044. Epub 2017 Jan 18.


Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine.

Babb R, Chen A, Ogunniyi AD, Hirst TR, Kara EE, McColl SR, Alsharifi M, Paton JC.

Clin Sci (Lond). 2017 Jan 1;131(2):169-180. doi: 10.1042/CS20160475. Epub 2016 Nov 24.


CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A, Yu D.

Nat Immunol. 2016 Oct;17(10):1187-96. doi: 10.1038/ni.3543. Epub 2016 Aug 3.


Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses.

Babb R, Chen A, Hirst TR, Kara EE, McColl SR, Ogunniyi AD, Paton JC, Alsharifi M.

Clin Sci (Lond). 2016 May;130(9):697-710. doi: 10.1042/CS20150699. Epub 2016 Feb 1.


Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge.

Chan J, Babb R, David SC, McColl SR, Alsharifi M.

Scand J Immunol. 2016 Mar;83(3):165-73. doi: 10.1111/sji.12410.


IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR.

J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4.


CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells.

Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KP, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR.

Nat Commun. 2015 Oct 29;6:8644. doi: 10.1038/ncomms9644.


Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.

Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel TM.

J Biol Chem. 2015 Sep 11;290(37):22385-97. doi: 10.1074/jbc.M115.675108. Epub 2015 Jul 27.


Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR.

Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23.


Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.


The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.

Boyle ST, Faulkner JW, McColl SR, Kochetkova M.

Mol Cancer. 2015 Jun 6;14:115. doi: 10.1186/s12943-015-0394-1.


Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.

Snyder KA, Hughes MR, Hedberg B, Brandon J, Hernaez DC, Bergqvist P, Cruz F, Po K, Graves ML, Turvey ME, Nielsen JS, Wilkins JA, McColl SR, Babcook JS, Roskelley CD, McNagny KM.

Breast Cancer Res. 2015 Mar 27;17:46. doi: 10.1186/s13058-015-0562-7.


The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells.

Boyle ST, Ingman WV, Poltavets V, Faulkner JW, Whitfield RJ, McColl SR, Kochetkova M.

Oncogene. 2016 Jan 7;35(1):105-15. doi: 10.1038/onc.2015.66. Epub 2015 Mar 16.


p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.

Turvey ME, Klingler-Hoffmann M, Hoffmann P, McColl SR.

Immunol Cell Biol. 2015 Sep;93(8):735-43. doi: 10.1038/icb.2015.35. Epub 2015 Mar 10.


MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney.

Gustafsson OJ, Briggs MT, Condina MR, Winderbaum LJ, Pelzing M, McColl SR, Everest-Dass AV, Packer NH, Hoffmann P.

Anal Bioanal Chem. 2015 Mar;407(8):2127-39. doi: 10.1007/s00216-014-8293-7. Epub 2014 Dec 2.


The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.

Harata-Lee Y, Turvey ME, Brazzatti JA, Gregor CE, Brown MP, Smyth MJ, Comerford I, McColl SR.

Immunol Cell Biol. 2014 Nov;92(10):815-24. doi: 10.1038/icb.2014.58. Epub 2014 Jul 15.


Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis.

Turvey ME, Koudelka T, Comerford I, Greer JM, Carroll W, Bernard CC, Hoffmann P, McColl SR.

J Proteome Res. 2014 Aug 1;13(8):3655-70. doi: 10.1021/pr500158r. Epub 2014 Jul 1.


CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development.

Bunting MD, Comerford I, Kara EE, Korner H, McColl SR.

Immunol Cell Biol. 2014 Jul;92(6):489-98. doi: 10.1038/icb.2014.14. Epub 2014 Mar 18.


Tailored immune responses: novel effector helper T cell subsets in protective immunity.

Kara EE, Comerford I, Fenix KA, Bastow CR, Gregor CE, McKenzie DR, McColl SR.

PLoS Pathog. 2014 Feb 20;10(2):e1003905. doi: 10.1371/journal.ppat.1003905. eCollection 2014 Feb. Review.


Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking.

Comerford I, Kara EE, McKenzie DR, McColl SR.

Br J Haematol. 2014 Feb;164(3):329-41. doi: 10.1111/bjh.12616. Epub 2013 Oct 26. Review.


Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites.

Kara EE, Comerford I, Bastow CR, Fenix KA, Litchfield W, Handel TM, McColl SR.

J Immunol. 2013 Aug 1;191(3):1110-7. doi: 10.4049/jimmunol.1203089. Epub 2013 Jun 24.


A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic cells but delays CD8+ T cell activation and impairs viral clearance.

Wikstrom ME, Fleming P, Comerford I, McColl SR, Andoniou CE, Degli-Esposti MA.

J Virol. 2013 Jul;87(14):7911-20. doi: 10.1128/JVI.00187-13. Epub 2013 May 8.


The basophil: resolved questions and new avenues of investigation.

Kara EE, McColl SR, Comerford I.

Bioessays. 2013 Aug;35(8):670. doi: 10.1002/bies.201300044. Epub 2013 May 2. No abstract available.


CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse.

Wiede F, Fromm PD, Comerford I, Kara E, Bannan J, Schuh W, Ranasinghe C, Tarlinton D, Winkler T, McColl SR, Körner H.

Immunol Cell Biol. 2013 May;91(5):335-9. doi: 10.1038/icb.2013.14. Epub 2013 Apr 16.


A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system.

Comerford I, Harata-Lee Y, Bunting MD, Gregor C, Kara EE, McColl SR.

Cytokine Growth Factor Rev. 2013 Jun;24(3):269-83. doi: 10.1016/j.cytogfr.2013.03.001. Epub 2013 Apr 12. Review.


The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.

Ghasemzadeh M, Kaplan ZS, Alwis I, Schoenwaelder SM, Ashworth KJ, Westein E, Hosseini E, Salem HH, Slattery R, McColl SR, Hickey MJ, Ruggeri ZM, Yuan Y, Jackson SP.

Blood. 2013 May 30;121(22):4555-66. doi: 10.1182/blood-2012-09-459636. Epub 2013 Apr 2.


Matrix-assisted laser desorption/ionization imaging protocol for in situ characterization of tryptic peptide identity and distribution in formalin-fixed tissue.

Gustafsson OJ, Eddes JS, Meding S, McColl SR, Oehler MK, Hoffmann P.

Rapid Commun Mass Spectrom. 2013 Mar 30;27(6):655-70. doi: 10.1002/rcm.6488.


Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line.

Niu M, Klingler-Hoffmann M, Brazzatti JA, Forbes B, Akekawatchai C, Hoffmann P, McColl SR.

Proteome Sci. 2013 Jan 15;11(1):4. doi: 10.1186/1477-5956-11-4.


CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity.

Bunting MD, Comerford I, Seach N, Hammett MV, Asquith DL, Körner H, Boyd RL, Nibbs RJ, McColl SR.

Blood. 2013 Jan 3;121(1):118-28. doi: 10.1182/blood-2012-06-434886. Epub 2012 Nov 14.


PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.

Comerford I, Litchfield W, Kara E, McColl SR.

PLoS One. 2012;7(9):e45095. doi: 10.1371/journal.pone.0045095. Epub 2012 Sep 13.


Visualisation in imaging mass spectrometry using the minimum noise fraction transform.

Stone G, Clifford D, Gustafsson JO, McColl SR, Hoffmann P.

BMC Res Notes. 2012 Aug 7;5:419. doi: 10.1186/1756-0500-5-419.


Internal calibrants allow high accuracy peptide matching between MALDI imaging MS and LC-MS/MS.

Gustafsson JO, Eddes JS, Meding S, Koudelka T, Oehler MK, McColl SR, Hoffmann P.

J Proteomics. 2012 Aug 30;75(16):5093-105. doi: 10.1016/j.jprot.2012.04.054. Epub 2012 May 23.


Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis.

Brazzatti JA, Klingler-Hoffmann M, Haylock-Jacobs S, Harata-Lee Y, Niu M, Higgins MD, Kochetkova M, Hoffmann P, McColl SR.

Oncogene. 2012 May 3;31(18):2350-61. doi: 10.1038/onc.2011.414. Epub 2011 Sep 26.


PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation.

Haylock-Jacobs S, Comerford I, Bunting M, Kara E, Townley S, Klingler-Hoffmann M, Vanhaesebroeck B, Puri KD, McColl SR.

J Autoimmun. 2011 May;36(3-4):278-87. doi: 10.1016/j.jaut.2011.02.006. Epub 2011 Mar 10.


MALDI Imaging Mass Spectrometry (MALDI-IMS)-application of spatial proteomics for ovarian cancer classification and diagnosis.

Gustafsson JO, Oehler MK, Ruszkiewicz A, McColl SR, Hoffmann P.

Int J Mol Sci. 2011 Jan 21;12(1):773-94. doi: 10.3390/ijms12010773. Review.


Mini-review series: focus on chemokines.

Comerford I, McColl SR.

Immunol Cell Biol. 2011 Feb;89(2):183-4. doi: 10.1038/icb.2010.164. No abstract available.


In Vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin.

Wang H, Paton AW, McColl SR, Paton JC.

Infect Immun. 2011 Apr;79(4):1671-9. doi: 10.1128/IAI.01204-10. Epub 2011 Jan 31.


A combined free-flow electrophoresis and DIGE approach to identify proteins regulated by butyrate in HT29 cells.

Fung KY, Cursaro C, Lewanowitsch T, Brierley GV, McColl SR, Lockett T, Head R, Hoffmann P, Cosgrove L.

Proteomics. 2011 Mar;11(5):964-71. doi: 10.1002/pmic.201000429. Epub 2011 Jan 31.


Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response.

Fung KY, Brierley GV, Henderson S, Hoffmann P, McColl SR, Lockett T, Head R, Cosgrove L.

J Proteome Res. 2011 Apr 1;10(4):1860-9. doi: 10.1021/pr1011125. Epub 2011 Mar 3.


Finding their niche: chemokines directing cell migration in the thymus.

Bunting MD, Comerford I, McColl SR.

Immunol Cell Biol. 2011 Feb;89(2):185-96. doi: 10.1038/icb.2010.142. Epub 2010 Dec 7. Review.


An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation?: CCR6/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease.

Comerford I, Bunting M, Fenix K, Haylock-Jacobs S, Litchfield W, Harata-Lee Y, Turvey M, Brazzatti J, Gregor C, Nguyen P, Kara E, McColl SR.

Bioessays. 2010 Dec;32(12):1067-76. doi: 10.1002/bies.201000063. Epub 2010 Oct 15. Review.


Multiple functions of CXCL12 in a syngeneic model of breast cancer.

Williams SA, Harata-Lee Y, Comerford I, Anderson RL, Smyth MJ, McColl SR.

Mol Cancer. 2010 Sep 17;9:250. doi: 10.1186/1476-4598-9-250.

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