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Items: 24

1.

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.

Garton NS, Barker MD, Davis RP, Douault C, Hooper-Greenhill E, Jones E, Lewis HD, Liddle J, Lugo D, McCleary S, Preston AGS, Ramirez-Molina C, Neu M, Shipley TJ, Somers DO, Watson RJ, Wilson DM.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4606-4612. doi: 10.1016/j.bmcl.2016.08.070. Epub 2016 Aug 23.

PMID:
27578246
2.

The tunics of Glisson.

Helling TS, McCleary SP.

Surgery. 2016 Jul;160(1):94-99. doi: 10.1016/j.surg.2016.02.010. Epub 2016 Apr 1. No abstract available.

PMID:
27046701
3.

Novel quantitative TaqMan® MGB real-time PCR for sensitive detection of Vibrio aestuarianus in Crassostrea gigas.

McCleary S, Henshilwood K.

Dis Aquat Organ. 2015 Jun 3;114(3):239-48. doi: 10.3354/dao02869.

PMID:
26036831
4.

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Ackermann JA, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz VL.

J Immunol. 2015 May 15;194(10):4650-6. doi: 10.4049/jimmunol.1500461. Epub 2015 Apr 10.

5.

Phylogenetic analysis of infectious pancreatic necrosis virus in Ireland reveals the spread of a virulent genogroup 5 subtype previously associated with imports.

Ruane NM, McCleary SJ, McCarthy LJ, Henshilwood K.

Arch Virol. 2015 Mar;160(3):817-24. doi: 10.1007/s00705-014-2307-9. Epub 2014 Dec 12.

PMID:
25504359
6.

Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy.

Joy JM, Gundermann DM, Lowery RP, Jäger R, McCleary SA, Purpura M, Roberts MD, Wilson SM, Hornberger TA, Wilson JM.

Nutr Metab (Lond). 2014 Jun 16;11:29. doi: 10.1186/1743-7075-11-29. eCollection 2014.

7.

Detection of salmonid alphavirus RNA in Celtic and Irish Sea flatfish.

McCleary S, Giltrap M, Henshilwood K, Ruane NM.

Dis Aquat Organ. 2014 Apr 23;109(1):1-7. doi: 10.3354/dao02719.

PMID:
24781791
8.

An outbreak of francisellosis in wild-caught Celtic Sea Atlantic cod, Gadus morhua L., juveniles reared in captivity.

Ruane NM, Bolton-Warberg M, Rodger HD, Colquhoun DJ, Geary M, McCleary SJ, O'Halloran K, Maher K, O'Keeffe D, Mirimin L, Henshilwood K, Geoghegan F, Fitzgerald RD.

J Fish Dis. 2015 Jan;38(1):97-102. doi: 10.1111/jfd.12210. Epub 2013 Nov 21. No abstract available.

PMID:
24261672
9.

Clinical cardiomyopathy syndrome in Atlantic salmon, Salmo salar L.

Rodger HD, McCleary SJ, Ruane NM.

J Fish Dis. 2014 Oct;37(10):935-9. doi: 10.1111/jfd.12186. Epub 2013 Oct 7. No abstract available.

PMID:
24117690
10.

Effects of 8 weeks of Xpand® 2X pre workout supplementation on skeletal muscle hypertrophy, lean body mass, and strength in resistance trained males.

Lowery RP, Joy JM, Dudeck JE, Oliveira de Souza E, McCleary SA, Wells S, Wildman R, Wilson JM.

J Int Soc Sports Nutr. 2013 Oct 9;10(1):44. doi: 10.1186/1550-2783-10-44.

11.

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Schweighoffer E, Vanes L, Nys J, Cantrell D, McCleary S, Smithers N, Tybulewicz VL.

Immunity. 2013 Mar 21;38(3):475-88. doi: 10.1016/j.immuni.2012.11.015. Epub 2013 Feb 28.

12.

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

Seal J, Lamotte Y, Donche F, Bouillot A, Mirguet O, Gellibert F, Nicodeme E, Krysa G, Kirilovsky J, Beinke S, McCleary S, Rioja I, Bamborough P, Chung CW, Gordon L, Lewis T, Walker AL, Cutler L, Lugo D, Wilson DM, Witherington J, Lee K, Prinjha RK.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. doi: 10.1016/j.bmcl.2012.02.041. Epub 2012 Feb 24.

PMID:
22437115
13.

Identification of 5-HT(2C) mediated mechanisms involved in urethral sphincter reflexes in a guinea-pig model of urethral function.

Conlon K, Miner W, McCleary S, McMurray G.

BJU Int. 2012 Jul;110(2 Pt 2):E113-7. doi: 10.1111/j.1464-410X.2011.10756.x. Epub 2011 Dec 22.

14.

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.

Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP, Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E, Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG, Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ, Weingarten GG.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. doi: 10.1016/j.bmcl.2011.07.082. Epub 2011 Aug 12.

PMID:
21903390
15.

Characterisation of myosin heavy chain gene variants in the fast and slow muscle fibres of gammarid amphipods.

Whiteley NM, Magnay JL, McCleary SJ, Nia SK, El Haj AJ, Rock J.

Comp Biochem Physiol A Mol Integr Physiol. 2010 Oct;157(2):116-22. doi: 10.1016/j.cbpa.2010.05.014. Epub 2010 Jun 4.

PMID:
20570748
16.

Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI.

Pohlmann A, Tilling LC, Robinson A, Woolmer O, McCleary S, Kruidenier L, Warnock LC, Lewis HD, Hobson AR, James MF.

Inflamm Bowel Dis. 2009 Apr;15(4):534-45. doi: 10.1002/ibd.20800.

PMID:
19058230
17.

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.

Ashwood VA, Field MJ, Horwell DC, Julien-Larose C, Lewthwaite RA, McCleary S, Pritchard MC, Raphy J, Singh L.

J Med Chem. 2001 Jul 5;44(14):2276-85.

PMID:
11428921
18.

Ovariohysterectomy in the rat: a model of surgical pain for evaluation of pre-emptive analgesia?

Gonzalez MI, Field MJ, Bramwell S, McCleary S, Singh L.

Pain. 2000 Oct;88(1):79-88.

PMID:
11098102
20.

Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain.

Field MJ, Carnell AJ, Gonzalez MI, McCleary S, Oles RJ, Smith R, Hughes J, Singh L.

Pain. 1999 Mar;80(1-2):383-9.

PMID:
10204752
21.

Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.

Field MJ, McCleary S, Boden P, Suman-Chauhan N, Hughes J, Singh L.

J Pharmacol Exp Ther. 1998 Jun;285(3):1226-32.

PMID:
9618426
22.

Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain.

Field MJ, Holloman EF, McCleary S, Hughes J, Singh L.

J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6.

PMID:
9316831
23.

Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents.

Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L.

Br J Pharmacol. 1997 Aug;121(8):1513-22.

24.

Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.

Lunec J, Blake DR, McCleary SJ, Brailsford S, Bacon PA.

J Clin Invest. 1985 Dec;76(6):2084-90.

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