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Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity.

Yang C, Briones M, Chiou J, Lei L, Patton MJ, Ma L, McClarty G, Caldwell HD.

MBio. 2019 Apr 23;10(2). pii: e00595-19. doi: 10.1128/mBio.00595-19.


Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Chlamydia trachomatis Biovars.

Patton MJ, Chen CY, Yang C, McCorrister S, Grant C, Westmacott G, Yuan XY, Ochoa E, Fariss R, Whitmire WM, Carlson JH, Caldwell HD, McClarty G.

MBio. 2018 Jan 30;9(1). pii: e02164-17. doi: 10.1128/mBio.02164-17.


Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host-pathogen interactions.

Yang C, Kari L, Sturdevant GL, Song L, Patton MJ, Couch CE, Ilgenfritz JM, Southern TR, Whitmire WM, Briones M, Bonner C, Grant C, Hu P, McClarty G, Caldwell HD.

Pathog Dis. 2017 Apr 1;75(3). doi: 10.1093/femspd/ftx035.


Chlamydial Protease-Like Activity Factor and Type III Secreted Effectors Cooperate in Inhibition of p65 Nuclear Translocation.

Patton MJ, McCorrister S, Grant C, Westmacott G, Fariss R, Hu P, Zhao K, Blake M, Whitmire B, Yang C, Caldwell HD, McClarty G.

MBio. 2016 Sep 27;7(5). pii: e01427-16. doi: 10.1128/mBio.01427-16.


Chlamydia trachomatis virulence factor CT135 is stable in vivo but highly polymorphic in vitro.

Bonner C, Caldwell HD, Carlson JH, Graham MR, Kari L, Sturdevant GL, Tyler S, Zetner A, McClarty G.

Pathog Dis. 2015 Aug;73(6):ftv043. doi: 10.1093/femspd/ftv043. Epub 2015 Jun 24.


Plasmid-mediated transformation tropism of chlamydial biovars.

Song L, Carlson JH, Zhou B, Virtaneva K, Whitmire WM, Sturdevant GL, Porcella SF, McClarty G, Caldwell HD.

Pathog Dis. 2014 Mar;70(2):189-93. doi: 10.1111/2049-632X.12104. Epub 2013 Nov 11.


Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes.

Song L, Carlson JH, Whitmire WM, Kari L, Virtaneva K, Sturdevant DE, Watkins H, Zhou B, Sturdevant GL, Porcella SF, McClarty G, Caldwell HD.

Infect Immun. 2013 Mar;81(3):636-44. doi: 10.1128/IAI.01305-12. Epub 2013 Jan 14.


Generation of targeted Chlamydia trachomatis null mutants.

Kari L, Goheen MM, Randall LB, Taylor LD, Carlson JH, Whitmire WM, Virok D, Rajaram K, Endresz V, McClarty G, Nelson DE, Caldwell HD.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7189-93. doi: 10.1073/pnas.1102229108. Epub 2011 Apr 11.


Phylogenetic analysis of Chlamydia trachomatis Tarp and correlation with clinical phenotype.

Lutter EI, Bonner C, Holland MJ, Suchland RJ, Stamm WE, Jewett TJ, McClarty G, Hackstadt T.

Infect Immun. 2010 Sep;78(9):3678-88. doi: 10.1128/IAI.00515-10. Epub 2010 Jul 6.


Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations.

Kari L, Whitmire WM, Carlson JH, Crane DD, Reveneau N, Nelson DE, Mabey DC, Bailey RL, Holland MJ, McClarty G, Caldwell HD.

J Infect Dis. 2008 Feb 1;197(3):449-56. doi: 10.1086/525285.


Structure of the high-valent FeIIIFeIV state in ribonucleotide reductase (RNR) of Chlamydia trachomatis--combined EPR, 57Fe-, 1H-ENDOR and X-ray studies.

Voevodskaya N, Galander M, Högbom M, Stenmark P, McClarty G, Gräslund A, Lendzian F.

Biochim Biophys Acta. 2007 Oct;1774(10):1254-63. Epub 2007 Jul 17.


Phenotypic rescue of Chlamydia trachomatis growth in IFN-gamma treated mouse cells by irradiated Chlamydia muridarum.

Nelson DE, Taylor LD, Shannon JG, Whitmire WM, Crane DD, McClarty G, Su H, Kari L, Caldwell HD.

Cell Microbiol. 2007 Sep;9(9):2289-98. Epub 2007 May 15.


Chlamydial interferon gamma immune evasion influences infection tropism.

McClarty G, Caldwell HD, Nelson DE.

Curr Opin Microbiol. 2007 Feb;10(1):47-51. Epub 2007 Jan 5. Review.


In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions.

Carlson JH, Wood H, Roshick C, Caldwell HD, McClarty G.

Mol Microbiol. 2006 Mar;59(6):1678-91.


Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells.

Roshick C, Wood H, Caldwell HD, McClarty G.

Infect Immun. 2006 Jan;74(1):225-38.


Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains.

Carlson JH, Porcella SF, McClarty G, Caldwell HD.

Infect Immun. 2005 Oct;73(10):6407-18.


Chlamydial IFN-gamma immune evasion is linked to host infection tropism.

Nelson DE, Virok DP, Wood H, Roshick C, Johnson RM, Whitmire WM, Crane DD, Steele-Mortimer O, Kari L, McClarty G, Caldwell HD.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10658-63. Epub 2005 Jul 14.


Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.

Griffin J, Roshick C, Iliffe-Lee E, McClarty G.

J Biol Chem. 2005 Feb 18;280(7):5456-67. Epub 2004 Dec 8.


Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates.

Carlson JH, Hughes S, Hogan D, Cieplak G, Sturdevant DE, McClarty G, Caldwell HD, Belland RJ.

Infect Immun. 2004 Dec;72(12):7063-72.


The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass.

Högbom M, Stenmark P, Voevodskaya N, McClarty G, Gräslund A, Nordlund P.

Science. 2004 Jul 9;305(5681):245-8.


Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization.

Stenmark P, Högbom M, Roshick C, McClarty G, Nordlund P.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):376-8. Epub 2004 Jan 23.


Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis.

Greene W, Xiao Y, Huang Y, McClarty G, Zhong G.

Infect Immun. 2004 Jan;72(1):451-60.


Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.

Su H, McClarty G, Dong F, Hatch GM, Pan ZK, Zhong G.

J Biol Chem. 2004 Mar 5;279(10):9409-16. Epub 2003 Dec 15.


Regulation of tryptophan synthase gene expression in Chlamydia trachomatis.

Wood H, Fehlner-Gardner C, Berry J, Fischer E, Graham B, Hackstadt T, Roshick C, McClarty G.

Mol Microbiol. 2003 Sep;49(5):1347-59.


Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.

Caldwell HD, Wood H, Crane D, Bailey R, Jones RB, Mabey D, Maclean I, Mohammed Z, Peeling R, Roshick C, Schachter J, Solomon AW, Stamm WE, Suchland RJ, Taylor L, West SK, Quinn TC, Belland RJ, McClarty G.

J Clin Invest. 2003 Jun;111(11):1757-69.


Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae.

Read TD, Myers GS, Brunham RC, Nelson WC, Paulsen IT, Heidelberg J, Holtzapple E, Khouri H, Federova NB, Carty HA, Umayam LA, Haft DH, Peterson J, Beanan MJ, White O, Salzberg SL, Hsia RC, McClarty G, Rank RG, Bavoil PM, Fraser CM.

Nucleic Acids Res. 2003 Apr 15;31(8):2134-47.


Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase.

Fehlner-Gardiner C, Roshick C, Carlson JH, Hughes S, Belland RJ, Caldwell HD, McClarty G.

J Biol Chem. 2002 Jul 26;277(30):26893-903. Epub 2002 May 13.


Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate.

Iliffe-Lee ER, McClarty G.

Mol Microbiol. 2002 May;44(3):819-28.


Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes.

Belland RJ, Scidmore MA, Crane DD, Hogan DM, Whitmire W, McClarty G, Caldwell HD.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13984-9. Epub 2001 Nov 13.


Radical changes to chlamydial taxonomy are not necessary just yet.

Schachter J, Stephens RS, Timms P, Kuo C, Bavoil PM, Birkelund S, Boman J, Caldwell H, Campbell LA, Chernesky M, Christiansen G, Clarke IN, Gaydos C, Grayston JT, Hackstadt T, Hsia R, Kaltenboeck B, Leinonnen M, Ojcius D, McClarty G, Orfila J, Peeling R, Puolakkainen M, Quinn TC, Rank RG, Raulston J, Ridgeway GL, Saikku P, Stamm WE, Taylor-Robinson DT, Wang SP, Wyrick PB.

Int J Syst Evol Microbiol. 2001 Jan;51(Pt 1):249; author reply 251-3. No abstract available. Erratum in: Int J Syst Evol Microbiol. 2006 Mar;56(Pt 3):677. Ocjius, D [corrected to Ojcius, D].


Regulation of carbon metabolism in Chlamydia trachomatis.

Iliffe-Lee ER, McClarty G.

Mol Microbiol. 2000 Oct;38(1):20-30.


Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.

Roshick C, Iliffe-Lee ER, McClarty G.

J Biol Chem. 2000 Dec 1;275(48):38111-9.


The potential for vaccine development against chlamydial infection and disease.

Brunham RC, Zhang DJ, Yang X, McClarty GM.

J Infect Dis. 2000 Jun;181 Suppl 3:S538-43. Review.


Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.

Read TD, Brunham RC, Shen C, Gill SR, Heidelberg JF, White O, Hickey EK, Peterson J, Utterback T, Berry K, Bass S, Linher K, Weidman J, Khouri H, Craven B, Bowman C, Dodson R, Gwinn M, Nelson W, DeBoy R, Kolonay J, McClarty G, Salzberg SL, Eisen J, Fraser CM.

Nucleic Acids Res. 2000 Mar 15;28(6):1397-406.


Glucose metabolism in Chlamydia trachomatis: the 'energy parasite' hypothesis revisited.

Iliffe-Lee ER, McClarty G.

Mol Microbiol. 1999 Jul;33(1):177-87.


Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation.

Fan T, Lu H, Hu H, Shi L, McClarty GA, Nance DM, Greenberg AH, Zhong G.

J Exp Med. 1998 Feb 16;187(4):487-96.


Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis.

Wylie JL, Hatch GM, McClarty G.

J Bacteriol. 1997 Dec;179(23):7233-42.


DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.

Zhang D, Yang X, Berry J, Shen C, McClarty G, Brunham RC.

J Infect Dis. 1997 Oct;176(4):1035-40.


Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production.

Rusnak A, Mangat R, Xu F, McClarty G, Hatch GM.

J Bioenerg Biomembr. 1997 Jun;29(3):291-8.


Chlamydia trachomatis CTP synthetase: molecular characterization and developmental regulation of expression.

Wylie JL, Berry JD, McClarty G.

Mol Microbiol. 1996 Nov;22(4):631-42.


A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine.

Wylie JL, Wang LL, Tipples G, McClarty G.

J Biol Chem. 1996 Jun 28;271(26):15393-400.


Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase.

Tipples G, McClarty G.

J Biol Chem. 1995 Apr 7;270(14):7908-14.


Identification of the Chlamydia trachomatis RecA-encoding gene.

Zhang DJ, Fan H, McClarty G, Brunham RC.

Infect Immun. 1995 Feb;63(2):676-80.


Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.

Wang LL, Henson E, McClarty G.

Mol Microbiol. 1994 Oct;14(2):271-81.


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